Calidad de vida laboral y autocuidado en personal de enfermería asistencial con alta demanda emocional

Introducción: La Calidad de Vida Laboral del personal sanitario y en este caso del personal de enfermería, ha supuesto desde la década de los 80 un creciente interés y campo de investigación por la magnitud y problemática que supone trabajar en condiciones no saludables, y centrado en que ello supone uno de los factores condicionantes esenciales de la calidad asistencial. El entorno, condiciones laborales y riesgos psicosociales derivados del trabajo son tema de debate a nivel internacional y han pasado al primer plano en la agenda de trabajo política e institucional. La toma de conciencia, y el desarrollo legislativo en materia de salud dan cuenta de este enorme problema que afecta directamente a las personas que trabajan en los distintos centros sanitarios. En este caso, el colectivo de enfermería que atiende directamente a pacientes críticos, de gravedad y sufrimiento, o en situación terminal, ha sido identificado como personal de riesgo en el que los factores psicosociales pueden causar en algunos de los casos, situaciones, estresantes con alto impacto emocional, burnout, fatiga por compasión y situaciones de enfermedad. Sin embargo los factores de riesgo, pueden ser minimizados cuando la atención prestada genera y supone un alto nivel de bienestar y satisfacción. Al mismo tiempo diferentes variables (edad, experiencia, formación específica, autoconciencia, afrontamiento…), pueden actuar como predictoras asociadas de la Calidad de Vida Laboral, entre ellas el «autocuidado» (Physical Self-Care, Inner/ Psychological Self-Care, Spiritual Self-Care, Social Self-Care). Objetivos: Explorar el papel del «autocuidado» en la Calidad de Vida Laboral del personal de Enfermería asistencial. Metodología: La presente investigación tiene un enfoque mixto de forma secuencial. Primeramente cuantitativo a través de un cuestionario a escala nacional, para determinar que variables actúan como predictoras de la Calidad de Vida Laboral, y un posterior enfoque cualitativo mediante el uso de la entrevista semi-estructurada. La muestra estuvo conformada por 123 profesionales de enfermería de cuidados paliativos para el enfoque cuantitativo y para el enfoque cualitativo, de 9 profesionales de diferentes centros sanitarios y servicios (Uci, Reanimación, Unidad de Hospitalización Domiciliaria,Hospital de Día, SAMU, Urgencias, Ayuda Humanitaria, Atención Primaria de Salud, y de Enlace Sindical de trabajadores/as) de la Comunidad Valenciana. Resultados: La parte cuantitativa reveló que existe una relación importante del «autocuidado» como variable predictora de la Calidad de Vida Laboral frente al resto de variables. La parte cualitativa permitió profundizar y valorar la importancia del «autocuidado», con los aspectos más vinculados a la Calidad de Vida Laboral, otorgando mayor importancia a los factores organizativos como barrera para el «autocuidado», y que a su vez pude afectar a la atención prestada a los demás. Por otro lado y como factor protector, se señala el trato directo con las personas enfermas, basado a la satisfacción que genera la relación de ayuda. No obstante la valoración de la Calidad de Vida Laboral manifestada resulta deficiente. Conclusiones: Tras el estudio, se aprecia que la Calidad de Vida Laboral del personal de enfermería no es la deseada. En algunos casos, los factores que influyen son de tipo organizativo referidos a la forma y condiciones de trabajo en situaciones estresantes. Por otro lado, los principales problemas y que más afectan, se refieren al tipo de jornada laboral y los horarios de trabajo (turnos rodados, noches, festivos, guardias…). La atención a pacientes con sufrimiento, en situación de gravedad o terminal, produce una gran satisfacción personal y compensa la situación de desgaste profesional. Las variables estudiadas (el afrontamiento a la muerte, la autoconciencia), y en este caso las dimensiones del «autocuidado», actúan como predictoras y pueden contribuir a mejorar esta situación. Por ello es necesario desarrollar planes formativos y una mayor implicación de las instituciones sanitarias para garantizar y potenciar un «autocuidado» que mejore la Calidad de Vida laboral.Introduction: The Quality of Work Life in health professionals, in this case nursing staff, has since the 1980s augmented, in interest and within the field of research, due to the problematics and the magnitude involved when working in unhealthy conditions, centering on the fact that this is one of the essential conditioning factors of quality of care. The environment, working conditions and psychosocial risks arising from work are a topic of debate at international level, coming to the forefront in political and institutional work agendas. Awareness-raising and legislative development in health care account for this huge problem that directly affects people working in different health centers. In this case, the nursing group that attends directly to critically ill patients, sever and chronic suffering, or in a terminal situation, has been identified as risk personnel in which psychosocial factors can cause in some cases, stressful situations with high emotional impact, burnout, compassion fatigue and disease situations. However, the risk factors can be minimized when the care provided generates a high level of wellness and satisfaction. At the same time, different variables (age, experience, specific training, self-awareness, coping ...) can act as associated predictors of Quality of Work Life, including «self-care» (Physical Self-Care, Inner / Psychological Self-Care, Spiritual Self-Care Self-Care). Objectives: To explore the role of self-care in the Quality of Work Life of nursing care staff. Methodology: This research has a mixed approach sequentially. Firstly quantitative, through a questionnaire at national level, to determine which variables act as predictors of the Quality of Work Life, and later, a qualitative approach, through the use of the semistructured interview. The sample consisted of 123 palliative-care nursing professionals for the quantitative approach and 9 professionals from different health centers (Intensive Care Unit, Resuscitation Unit, Home Hospitalization Unit, Day Hospital, Emergency Medical Service, Hospital Emergency, Humanitarian Aid, Primary Health Care, and Union Link of Workers) of the Valencian Community for the qualitative approach. Results: The quantitative section revealed that there is an important relationship of «selfcare» as a predictor variable of Quality of Work Life versus the other variables. The qualitative part allowed us to deepen and value the importance of "self-care", with many aspects relating to the Quality of Work Life; giving greater importance to organizational factors as a barrier for "self-care", which in turn could affect care given to others. On the other hand, direct involvement with sick people, based on the satisfaction generated by the aid relationship, is indicated as a protective factor. However, the assessment of the Quality of Work Life manifested is deficient. Conclusions: Following this study, it can be seen that the Quality of Work Life of nursing staff is not the desired one. In some cases, the influential factors are organizational in terms of methods and conditions of work in stressful situations. On the other hand, the main problems that affect the most are the type of working day and working hours (shifts, nights, holidays, doubling up ...). The attention to patients suffering, in serious or terminal situation, produces a great personal satisfaction and compensates the situation of professional exhaustion. The variables studied (coping with death, self-awareness), and in this case the dimensions of "self-care", act as predictors and can contribute to improve this situation. That is why it is necessary to develop training programs and a greater involvement of health institutions to guarantee and promote a "self-care" that improves the quality of work life

The Concept of “Sala de Fabrica”: On-Site Museums to Raise Awareness of Cultural Heritage After a Restoration Project

A conservation process usually generates new knowledge and an enormous amount of documentation during the inception and implementation of the project: the information collected from archives and other institutions; the information provided by the preliminary studies carried out prior to the intervention; the data provided in the field during the works and at the end of the process; and the final set of documentation delivered to the institution responsible for the maintenance and management of the monument. The challenge for conservation professionals and cultural heritage managers throughout this process once the works are over is to achieve and transmit this information to the public and specialists in order to raise awareness for better conservation of our built heritage. During the last few years, one of the actions that the Caja Madrid Foundation has activated with its restoration projects has been the opening of permanent on site museums or “Salas de Fábrica”, a place on site to understand the restoration works, to exhibit the remains that have being retrieved during the project and to permit the public to better understand the historical and artistic values of architectural and archaeological heritage as well as the importance of preserving our cultural legacy for the future

Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants

Germline inactivating mutations in BRCA1 and BRCA2 genes are responsible for Hereditary Breast and Ovarian Cancer Syndrome (HBOCS). Genetic testing of these genes is available, although approximately 15% of tests identify variants of uncertain significance (VUS). Classification of these variants into pathogenic or non-pathogenic type is an important challenge in genetic diagnosis and counseling. The aim of the present study is to functionally assess a set of 7 missense VUS (Q1409L, S1473P, E1586G, R1589H, Y1703S, W1718L and G1770V) located in the C-terminal region of BRCA1 by combining in silico prediction tools and structural analysis with a transcription activation (TA) assay. The in silico prediction programs gave discrepant results making its interpretation difficult. Structural analysis of the three variants located in the BRCT domains (Y1703S, W1718L and G1770V) reveals significant alterations of BRCT structure. The TA assay shows that variants Y1703S, W1718L and G1770V dramatically compromise the transcriptional activity of BRCA1, while variants Q1409L, S1473P, E1586G and R1589H behave like wild-type BRCA1. In conclusion, our results suggest that variants Y1703S, W1718L and G1770V can be classified as likely pathogenic BRCA1 mutations

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine

Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. We present the generation and characterization of five distinct MPNST orthoxenograft models for preclinical testing and personalized medicine. Four of the models are patient-derived tumor xenografts (PDTX), two independent MPNSTs from the same NF1 patient and two from different sporadic patients. The fifth model is an orthoxenograft derived from an NF1-related MPNST cell line. All MPNST orthoxenografts were generated by tumor implantation, or cell line injection, next to the sciatic nerve of nude mice, and were perpetuated by 7-10 mouse-to-mouse passages. The models reliably recapitulate the histopathological properties of their parental primary tumors. They also mimic distal dissemination properties in mice. Human stroma was rapidly lost after MPNST engraftment and replaced by murine stroma, which facilitated genomic tumor characterization. Compatible with an origin in a catastrophic event and subsequent genome stabilization, MPNST contained highly altered genomes that remained remarkably stable in orthoxenograft establishment and along passages. Mutational frequency and type of somatic point mutations were highly variable among the different MPNSTs modeled, but very consistent when comparing primary tumors with matched orthoxenografts generated. Unsupervised cluster analysis and principal component analysis (PCA) using an MPNST expression signature of ~1,000 genes grouped together all primary tumor-orthoxenograft pairs. Our work points to differences in the engraftment process of primary tumors compared with the engraftment of established cell lines. Following standardization and extensive characterization and validation, the orthoxenograft models were used for initial preclinical drug testing. Sorafenib (a BRAF inhibitor), in combination with doxorubicin or rapamycin, was found to be the most effective treatment for reducing MPNST growth. The development of genomically well-characterized preclinical models for MPNST allowed the evaluation of novel therapeutic strategies for personalized medicine

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine

Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. We present the generation and characterization of five distinct MPNST orthoxenograft models for preclinical testing and personalized medicine. Four of the models are patient-derived tumor xenografts (PDTX), two independent MPNSTs from the same NF1 patient and two from different sporadic patients. The fifth model is an orthoxenograft derived from an NF1-related MPNST cell line. All MPNST orthoxenografts were generated by tumor implantation, or cell line injection, next to the sciatic nerve of nude mice, and were perpetuated by 7-10 mouse-to-mouse passages. The models reliably recapitulate the histopathological properties of their parental primary tumors. They also mimic distal dissemination properties in mice. Human stroma was rapidly lost after MPNST engraftment and replaced by murine stroma, which facilitated genomic tumor characterization. Compatible with an origin in a catastrophic event and subsequent genome stabilization, MPNST contained highly altered genomes that remained remarkably stable in orthoxenograft establishment and along passages. Mutational frequency and type of somatic point mutations were highly variable among the different MPNSTs modeled, but very consistent when comparing primary tumors with matched orthoxenografts generated. Unsupervised cluster analysis and principal component analysis (PCA) using an MPNST expression signature of ~1,000 genes grouped together all primary tumor-orthoxenograft pairs. Our work points to differences in the engraftment process of primary tumors compared with the engraftment of established cell lines. Following standardization and extensive characterization and validation, the orthoxenograft models were used for initial preclinical drug testing. Sorafenib (a BRAF inhibitor), in combination with doxorubicin or rapamycin, was found to be the most effective treatment for reducing MPNST growth. The development of genomically well-characterized preclinical models for MPNST allowed the evaluation of novel therapeutic strategies for personalized medicine

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis colorectal cancer. These individuals had mismatch repair-proficient tumors and each carried nonsense variant in the FANCD2/FANCI-associated nuclease 1 gene (FAN1), which encodes a nuclease involved in DNA inter-strand cross-link repair. We sequenced FAN1 in 176 additional families with histories of colorectal cancer and performed in vitro functional analyses of the mutant forms of FAN1 identified. We detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutations. These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connection between genome integrity and cancer risk

Current threats faced by amphibian populations in the southern cone of South America

In this work, we update and increase knowledge on the severity and extent of threats affecting 57 populations of 46 amphibian species from Chile and Argentina in southern South America. We analyzed the intrinsic conservation problems that directly impact these populations. We shared a questionnaire among specialists on threats affecting target amphibian populations with information on i) range, ii) historical occurrence and abundance, iii) population trends, iv) local extinctions, v) threats, and vi) ongoing and necessary conservation/research. We assessed association patterns between reported threats and population trends using multiple correspondence analysis. Since 2010, 25 of 57 populations have declined, while 16 experienced local extinctions. These populations were affected by 81% of the threat categories analyzed, with those related to agricultural activities and/or habitat modifications being the most frequently reported. Invasive species, emerging diseases, and activities related to grazing, ranching, or farming were the threats most associated with population declines. Low connectivity was the most frequent intrinsic conservation problem affecting 68% of the target populations, followed by low population numbers, affecting 60%. Ongoing monitoring activity was conducted in 32 (56%) populations and was the most frequent research activity. Threat mitigation was reported in 27 (47%) populations and was the most frequent ongoing management activity. We found that habitat management is ongoing in 5 (9%) populations. At least 44% of the amphibian populations surveyed in Chile and Argentina are declining. More information related to the effect of management actions to restore habitats, recover populations, and eliminate threats such as invasive species is urgently needed to reverse the conservation crisis facing amphibians in this Neotropical region.Fil: Kacoliris, Federico Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Berkunsky, Igor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto Multidisciplinario de Ecosistemas y Desarrollo Sustentable; ArgentinaFil: Acosta, Juan Carlos. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Acosta, Rodrigo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Agostini, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Akmentins, Mauricio Sebastián. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Arellano, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Azat, Claudio. Universidad Andrés Bello; ChileFil: Bach, Nadia Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Blanco, Mirta Blanco. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Calvo, Rodrigo. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Charrier, Andres. Pontificia Universidad Católica de Chile; ChileFil: Corbalán, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Correa, Claudio. Universidad de Concepción. Facultad de Ciencias Naturales y Oceanografía. Departamento de Zoología; ChileFil: Cuello, Maria Elena. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; ArgentinaFil: Deutsch, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Di Pietro, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Gastón, María Soledad. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Gomez Alez, Rodrigo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Kaas, Camila. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Kaas, Nicolas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Lobos, Gabriel. Universidad de Chile; ChileFil: Martínez, Tomás Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Martínez Aguirre, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Mora, Marta. Vida Nativa NGO; ChileFil: Nieva Cocilio, Rodrigo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Pastore, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Administración de Parques Nacionales; ArgentinaFil: Pérez Iglesias, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Laboratorio de Biología; ArgentinaFil: Piaggio Kokot, Lia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Rabanal, Felipe. Universidad Austral de Chile; ChileFil: Rodríguez Muñoz, Melina Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Biología; ArgentinaFil: Sanchez, Laura Cecilia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaFil: Tala, Charif. Ministerio del Medio Ambiente de Chile; ChileFil: Ubeda, Carmen Adria. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; ArgentinaFil: Vaira, Marcos. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Velasco, Melina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; ArgentinaFil: Vidal, Marcela. Universidad del Bio Bio. Facultad de Ciencias. Departamento de Ciencias Basicas; ChileFil: Williams, Jorge Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Herpetología; Argentin

Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum

Non peer reviewe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group