Orígenes y desarrollo de la cardiología en España a través de las publicaciones originales de las primeras revistas especializadas (1920-2000).

RESUMEN La presente tesis doctoral pretende contribuir al conocimiento de los orígenes y desarrollo de la cardiología como especialidad médica en españa a través del análisis de los artículos originales publicados en las primeras revistas españolas especializadas entre los años 1920 y 2000. Siguiendo las líneas de investigación del departamento e instituto de historia de la ciencia y documentación (csic-universidad de valencia) se aborda el estudio a partir de las publicaciones y mediante el empleo de las técnicas bibliométricas. el material de estudio consiste en un total de 5.418 referencias bibliográficas de artículos originales publicados en archivos de cardiología y hematología (431 originales); archivos de las enfermedades del corazón y de los vasos (433 originales) y revista española de cardiología (4.554 originales). se han contabilizado 21.962 firmas que proceden de un total de 6.452 autores con índices de productividad que tienden a ajustarse a las leyes bibliométricas. Los autores que han tenido un mayor protagonismo cubren un período de desarrollo de la cardiología en españa que comienza a principios de la década de 1960 y se mantiene hasta final del siglo xx y son, por este orden: Jordi Soler Soler, Juan Luis Delcán Domínguez, Francisco J. Algarra Vidal, Enric Esplugas Oliveras, Vicente López Merino, Alberto Cabrera Duro, José Luis López Sendón, Manuel Quero Jiménez, José A. Sobrino Daza, Miguel M. Iriarte Ezcurdia, Jaume Candell Riera, Federico Vallés Belsué, Domingo G. Duán Arróm, José Calderón Montero, Felipe Moreno Granado, Javier Suárez de Lezo, Juan Cosín Aguilar, Ramiro Rivera López y F. Javier Chorro Gascó. Cada uno de estos autores ha constituido grupos de colaboración -los denominados colegios invisibles- que integran una media de 141 autores. Se ha encontrado un predominio en las tres revistas de artículos procedentes de instituciones españolas, siendo las áreas geográficas de las instituciones nacionales con mayor producción Madrid seguidas de Cataluña, Andalucía, Comunidad Valenciana y País Vasco. La mayor parte de las materias sobre las que tratan los artículos inventariados corresponden a cardiología en las tres revistas. Entre las materias, las que se corresponden con patología y clínica son las predominantes seguidas de las que se ocupan de terapéutica, siendo los grandes temas que constituyen cuantitativamente el núcleo de los artículos publicados a lo largo de la historia los siguientes: "enfermedades coronarias"; "terapéutica quirúrgica"; "síndromes eléctricos-arritmias"; "enfermedades congénitas"; "enfermedades del endocardio; "terapéutica intervencionista" y "técnicas de diagnóstico por la imagen". la especialización en materias de los autores, grupos de colaboración e instituciones se distribuye de forma diferente sin que exista en todos los casos una clara correspondencia entre ellos. __________________________________________________________________________________________________THE ORIGIN AND DEVELOPMENT OF THE CARDIOLOGY AS A MEDICAL SPECIALITY IN SPAIN THROUGH THE ANALYSIS OF THE ORIGINAL ARTICLES PUBLISHED IN THE FIRST SPANISH SPECIALIZED JOURNALS (1920-2000) THE CURRENT DOCTORAL THESIS TRIES TO CONTRIBUTE TO THE KNOWLEDGE OF THE BEGINNING AND THE DEVELOPMENT OF THE CARDIOLOGY AS A MEDICAL SPECIALITY IN SPAIN THROUGH THE ANALYSIS OF THE ORIGINAL ARTICLES PUBLISHED IN THE FIRST SPANISH SPECIALIZED JOURNALS BETWEEN 1920 AND 2000. FOLLOWING THE INVESTIGATION LINES OF THE SCIENCE HISTORY AND DOCUMENTATION DEPARTMENT OF THE UNIVERSITY OF VALENCIA, THE STUDY IS BASED ON THE PUBLICACIONS AND THROUGH THE USE OF BIBLIOMETRIC TECHNIQUES. THE MATERIAL OF THE STUDY INCLUDES A TOTAL OF 5418 BIBLIOGRAPHIC REFERENCES OF ORIGINAL ARTICLES PUBLISHED IN ARCHIVOS DE CARDIOLOGÍA Y HEMATOLOGÍA (431 ORIGINAL ARTICLES); ARCHIVOS DE LAS ENFERMEDADES DEL CORAZÓN Y DE LOS VASOS (433 ORIGINAL ARTICLES) Y REVISTA ESPAÑOLA DE CARDIOLOGÍA (4.554 ORIGINAL ARTICLES). THERE ARE 21962 SIGNATURES THAT COME FROM A TOTAL OF 6452 AUTHORS WITH PRODUCTIVITY INDEXES THAT TEND TO FIT THE BIBLIOMETRIC RULES. THE AUTHORS WHO HAVE MORE IMPORTANCE FILL A PERIOD OF THE SPANISH CARDIOLOGY THAT STARTS AT THE BEGINING OF 1960 AND REMAINS UNTIL THE END OF THE 20TH CENTURY. THEY ARE, IN THIS ORDER: JORDI SOLER SOLER, JUAN LUIS DELCÁN DOMÍNGUEZ, FRANCISCO J. ALGARRA VIDAL, ENRIC ESPLUGAS OLIVERAS, VICENTE LÓPEZ MERINO, ALBERTO CABRERA DURO, JOSÉ LUIS LÓPEZ SENDÓN, MANUEL QUERO JIMÉNEZ, JOSÉ A. SOBRINO DAZA, MIGUEL M. IRIARTE EZCURDIA, JAUME CANDELL RIERA, FEDERICO VALLÉS BELSUÉ, DOMINGO G. DUÁN ARRÓM, JOSÉ CALDERÓN MONTERO, FELIPE MORENO GRANADO, JAVIER SUÁREZ DE LEZO, JUAN COSÍN AGUILAR, RAMIRO RIVERA LÓPEZ Y F. JAVIER CHORRO GASCÓ. EACH ONE OF THESE AUTHORS HAS CREATED COLABORATION GROUPS INVISIBLE COLLEGES- THAT ARE FORMED BY A MEAN OF 141 AUTHORS. A PREDOMINANCE OF SPANISH INSTITUTIONS HAS BEEN FOUND IN THE THREE JOURNALS, WHERE MADRID FOLLOWED BY CATALUÑA, ANDALUCÍA, COMUNIDAD VALENCIANA Y PAÍS VASCO ARE THE GEOGRAPHIC AREAS WITH THE HIGHER PRODUCTION. THE MOST COMMON SUBJECTS TREATED BY THE ARTICLES STUDIED ARE RELATED TO CARDIOLOGY IN THE THREE JOURNALS. BETWEEN THE SUBJECTS, THE MOST COMMON ARE THE ONES THAT FIT IN PATHOLOGY AND CLINICS FOLLOWED BY THE ONES THAT TREAT THERAPY. THE MOST IMPORTANT THEMES THAT FORM THE CENTRE OF THE PUBLISHED ARTICLES THROUGH THE HISTORY ARE THE FOLLOWING: CORONARY ARTERY DISEASES, SURGYCAL THERAPY, ELECTRICAL SYMDROMES, CONGENITAL HEART DISEASES, ENDOCARDIAL DISEASES, INTERVENTIONAL THERAPY AND IMAGE DIAGNOSIS. THE SUBJECT SPECIALIZATION OF THE AUTHORS, COLABORATION GROUPS AND INSTITUTION IS DISTRIBUTED IN A DIFFERENT FORM WITHOUT ANY CONNECTION BETWEEN THE

Knowledge, attitudes and practices of primary healthcare professionals to female genital mutilation in Valencia, Spain: are we ready for this challenge?

The practice of Female Genital Mutilation (FGM) is a deeply-rooted tradition in 30 Sub-Saharan and Middle-East countries which affects approximately 200 million women and girls worldwide. The practice leads to devastating consequences on the health and quality of life of women and girls in both the short and long term. Globalizing processes and migration flows have recorded cases of this practice worldwide representing for healthcare professionals an emerging challenge on how to approach their healthcare in a transcultural, ethical and respectful way. No survey to assess knowledge, attitudes and practices on FGM among primary healthcare professionals has been conducted in the Valencian region of Spain to date

Retroauricular dermoid cyst associated with Gorlin syndrome. A case report

Background Gorlin syndrome is an autosomal dominant genodermatosis characterized by the early appearance of multiple basal cell carcinomas, odontogenic keratocysts and skeletal abnormalities. It is caused by mutations in the hedgehog signalling pathway, primarily in the tumour suppressor gene PTCH1 (9q22.1-q31). Case summary We present a 14-year-old girl who consulted for asymmetrical ears, in the context of multiple disorders such as mental retardation, snoring, non-specific coagulation abnormalities, retrognathia, pectus excavatum and scaphoid duplication. During the intervention, a retroauricular cystic tumour was found incidentally, reported by Pathology as a dermoid cyst. The syndrome is confirmed by a genetic study with the result of a new pathological variant in PTCH1. Conclusion We describe the coexistence of this entity with a dermoid cyst. Furthermore, it is exceptional in its retroauricular location and the pathological point mutation in the PTCH1 gene, consisting of the pCys56Gly variant

CA 15-3 prognostic biomarker in SARS-CoV-2 pneumonia.

The severity of lung involvement is the main prognostic factor in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Carbohydrate antigen 15-3 (CA 15-3), a marker of lung damage and fibrosis, could help predict the prognosis of SARS-CoV-2 pneumonia. This was a retrospective and observational study. CA 15-3 was analyzed in the blood samples of patients consecutively admitted for SARS-CoV-2 pneumonia and whose blood samples were available in the biobank. Other prognostic markers were also measured (interleukin 6 [IL6], C-reactive protein [CRP], D-dimer, troponin T, and NT-ProBNP). The occurrence of in-hospital complications was registered, including death, the need for medical intensive care, and oxygen therapy at discharge. In this study, 539 patients were recruited (54.9% men, mean age: 59.6 ± 16.4 years). At admission, the mean concentrations of CA 15-3 was 20.5 ± 15.8 U/mL, and the concentration was correlated with male sex, older age, and other severity markers of coronavirus disease of 2019 (COVID-19) (IL6, CRP, D-dimer, troponine T, and NT-ProBNP). CA 15-3 levels were higher in patients who died (n = 56, 10.4%) (35.33 ± 30.45 vs. 18.8 ± 12.11, p < 0.001), who required intensive medical support (n = 78, 14.4%; 31.17 ± 27.83 vs. 18.68 ± 11.83; p < 0.001), and who were discharged with supplemental oxygen (n = 64, 13.3%; 22.65 ± 14.41 vs. 18.2 ± 11.7; p = 0.011). Elevated CA 15-3 levels (above 34.5 U/mL) were a strong predictor of a complicated in-hospital course, in terms of a higher risk of death (adjusted odds ratio [OR] 3.74, 95% confidence interval [CI]: 1.22-11.9, p = 0.022) and need for intensive care (adjusted OR 4.56, 95% CI: 1.37-15.8) after adjusting for all other risk factors. The degree of lung damage and fibrosis evaluated in terms of CA 15-3 concentrations may allow early identification of the increased risk of complications in patients with SARS-CoV-2 pneumonia.S

Report of the Scientific Committee of the Spanish Agency for Consumer Affairs, Food Safety and Nutrition (AECOSAN) on a request for initial assessment for marketing of chia (Salvia hispanica) in chocolate bars under Regulation (EC) No 258/97 on novel foods and novel food ingredients

La empresa Sanchis Mira S.A. ha solicitado la autorización de la comercialización en la Unión Europea de semillas de chía (Salvia hispanica) en chocolate en tabletas. Se trataría de una extensión de los usos autorizados para este nuevo alimento en 2009, 2013 y 2015. El Comité Científico considera que de la información aportada no se deduce que el consumo de las semillas de chía (Salvia hispanica) en chocolate en tabletas, en las condiciones propuestas por el solicitante, pueda producir efectos negativos para la salud, concluyendo que el nuevo alimento cumple los criterios de aceptación establecidos por el Reglamento (CE) Nº 258/97 sobre nuevos alimentos y nuevos ingredientes alimentarios (UE, 1997a).The company Sanchis Mira S.A requested authorization to market chia (Salvia hispanica) seeds in chocolate bars in the European Union. This would be an extension of use of the novel food authorized in 2009, 2013 and 2015. The AECOSAN Scientific Committee takes the view that, according to the information provided, there is no indication that consumption of chia (Salvia hispanica) in chocolate bars, under the conditions proposed by the applicant, can produce adverse effects on health. The Committee concludes that the novel food presented for assessment meets the criteria for acceptance laid down by Regulation (EC) No 258/97 concerning novel foods and novel food ingredients (UE, 1997a)

Report of the Scientific Committee of the Spanish Agency for Consumer Affairs, Food Safety and Nutrition (AECOSAN) on a request for initial assessment for marketing of chia ( Salvia hispanica ) seeds in sterilized ready to serve meals based on cereal, pseudocereals and/or pulse grains under Regulation (EC) No 258/97 on novel foods and novel food ingredients

La empresa Herba Ricemills S.L.U. ha solicitado la autorización de la comercialización en la Unión Europea de semillas de chía (Salvia hispanica) como ingrediente de platos preparados esterilizados elaborados a base de granos de cereales, pseudocereales y/o legumbres. Se trataría de una extensión de los usos autorizados para este nuevo alimento en 2009, 2013 y 2015. El Comité Científico considera que de la información aportada no se deduce que el consumo de las semillas de chía (Salvia hispanica) en platos preparados esterilizados basados en granos de cereales, pseudocereales y/o legumbres, en las condiciones propuestas por el solicitante, pueda producir efectos negativos para la salud, concluyendo que el nuevo alimento cumple los criterios de aceptación establecidos por el Reglamento (CE) Nº 258/97 sobre nuevos alimentos y nuevos ingredientes alimentarios (UE, 1997a).The company Herba Ricemills S.L.U. requested authorization to market chia (Salvia hispanica) seeds in sterilized ready to serve meals based on cereal, pseudocereals and/or pulse grains in the European Union. This would be an extension of use of the novel food authorized in 2009, 2013 and 2015. The AECOSAN Scientific Committee takes the view that, according to the information provided, there is no indication that consumption of chia (Salvia hispanica) seeds in ready to serve meals based on cereal, pseudocereals and/or pulse grains, under the conditions proposed by the applicant, can produce adverse effects on health. The Committee concludes that the novel food presented for assessment meets the criteria for acceptance laid down by Regulation (EC) No 258/97 concerning novel foods and novel food ingredients (UE, 1997a)

Validity of the energy-restricted Mediterranean Diet Adherence Screener

[Background]: Short dietary assessment tools can be useful to estimate food intake and diet quality in large-scale epidemiological studies with time constraints. [Objective]: To determine the concurrent validity of the 17-item energy-restricted Mediterranean Adherence Screener (er-MEDAS) used in the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial and to analyse its capacity to detect 1-year changes in diet and cardiometabolic risk factors. [Methods]: Validation study nested in the PREDIMED-Plus (n = 6760, 55–75 years). Dietary data were collected by the 17-item er-MEDAS and a 143-item validated semiquantitative food frequency questionnaire (FFQ) at baseline and after 1-year intervention. Cardiometabolic risk markers were measured at both time points. A Mediterranean diet (MedDiet) score was derived from both instruments. Concurrent validity was evaluated by Pearson and intra-class correlation coefficients (ICC) and Bland and Altman limits of agreement. Construct validity was evaluated by assessing 1-year changes in FFQ-reported dietary intake and cardiometabolic profile changes in relation to changes in er-MEDAS. [Results]: A moderate to good correlation between the MedDiet score calculated by both measurement instruments was found: r = 0.61 and ICC = 0.60 (both p < 0.001). Agreement of each of the er-MEDAS items ranged from 55.4% to 85.0% with a moderate mean concordance (kappa = 0.41). Between baseline and 1-year follow-up, energy intake measured by the FFQ decreased by 242 kcal, while Mediterranean food consumption increased in participants with the highest increase in the er-MEDAS MedDiet score. An increase in the er-MEDAS MedDiet score ratings was associated with a decrease in BMI, waist circumference, triglycerides, fasting glucose, diastolic blood pressure, and triglycerides/HDL-cholesterol ratio (p < 0.001 for all), and with an increase in HDL-cholesterol (p = 0.006). [Conclusion]: The er-MEDAS shows a modest to good concurrent validity compared with FFQ data. It shows acceptable construct validity, as a greater er-MEDAS score was associated with more favourable dietary and cardiometabolic profiles over time.The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund four coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/ 00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/ 00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/ 00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926; the Special Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física cohorte" PREDIMED-Plus grant to Jordi Salas-Salvadó; the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194); the European Research Council Advanced Research Grant 2013–2018 (340918) granted to Miguel Ángel Martínez-Gonzalez, grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant and FEDER funds (CB06/03) to Josep A. Tur; the Astra Zeneca Young Investigators Award in Category of Obesity and Diabetes 2017 to Dora Romaguera; the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands). JR17/00022 contract to Olga Castaner from ISCIII. CIBERobn (Centros de Investigación Biomedica en Red: Obesidad y Nutrición), CIBEResp (Centros de Investigación Biomedica en Red: Epidemiología y Salud Publica) and CIBERdem (Centros de Investigación Biomedica en Red: Diabetes y Enfermedades). J. Salas-Salvadó gratefully acknowledges the financial support provided by the ICREA Academia programme. None of the funding sources took part in the design, collection, analysis, or interpretation of the data; in writing the manuscript; or in the decision to submit the manuscript for publication

Dynamics of isolated-photon plus jet production in pp collisions at root s=7 TeV with the ATLAS detector

The dynamics of isolated-photon plus jet production in pp collisions at a centre-of-mass energy of 7 TeV has been studied with the ATLAS detector at the LHC using an integrated luminosity of 37 pb(-1). Measurements of isolated-photon plus jet bin-averaged cross sections are presented as functions of photon transverse energy, jet transverse momentum and jet rapidity. In addition, the bin-averaged cross sections as functions of the difference between the azimuthal angles of the photon and the jet, the photon jet invariant mass and the scattering angle in the photon jet centre-of-mass frame have been measured. Next-to-leading-order QCD calculations are compared to the measurements and provide a good description of the data, except for the case of the azimuthal opening angle

Measurement of the cross-section for W boson production in association with b-jets in pp collisions at root s=7 TeV with the ATLAS detector

This paper reports a measurement of the W+b-jets (W+b+X and W+b (b) over bar +X) production cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. These results are based on data corresponding to an integrated luminosity of 4.6 fb(-1), collected with the ATLAS detector. Cross-sections are presented as a function of jet multiplicity and of the transverse momentum of the leading b-jet for both the muon and electron decay modes of the W boson. The W+b-jets cross-section, corrected for all known detector effects, is quoted in a limited kinematic range. Combining the muon and electron channels, the fiducial cross-section for W+b-jets is measured to be 7.1 +/- 0.5 (stat) +/- 1.4 (syst) pb, consistent with the next-to-leading order QCD prediction, corrected for non-perturbative and double-parton interactions (DPI) contributions, of 4.70 +/- 0.09 (stat) (+0.60)(-0.49) (scale) +/- 0.06 (PDF) +/- 0.16 (non-pert) (+0.52)(-0.38) (DPI) pb

Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Background: The COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energy-reduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity. Methods: We assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown. Results: During the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26.3) by electronic means. Participants' follow-up and data collection rates increased across lockdown periods (from ≈10% at onset to ≈80% at the end). Compared to pre-lockdown, waist circumference increased during (0.75 cm [95% CI: 0.60-0.91]) and after (0.72 cm [95% CI: 0.56-0.89]) lockdown. Body weight did not change during lockdown (0.01 kg [95% CI: -0.10 to 0.13) and decreased after lockdown (-0.17 kg [95% CI: -0.30 to -0.04]). Conclusion: Mitigating strategies to enforce the intervention and patient's follow-up during lockdown have been successful in preserving the integrity of the trial and ensuring its continuation, with minor effects on adiposity. Clinical trial registration: https://doi.org/10.1186/ISRCTN89898870, identifier ISRCTN89898870. Keywords: COVID-19; Mediterraean diet; PREDIMED-Plus; clinical trial; lockdown; weight-loss. Copyright © 2023 Paz-Graniel, Fitó, Ros, Buil-Cosiales, Corella, Babio, Martínez, Alonso-Gómez, Wärnberg, Vioque, Romaguera, López-Miranda, Estruch, Tinahones, Lapetra, Serra-Majem, Bueno-Cavanillas, Tur, Martín-Sánchez, Pintó, Gaforio, Matía-Martín, Vidal, Vázquez, Daimiel, García-Gavilán, Toledo, Nishi, Sorlí, Castañer, García-Ríos, García de la Hera, Barón-López, Ruiz-Canela, Morey, Casas, Garrido-Garrido, Tojal-Sierra, Fernández-García, Vázquez-Ruiz, Fernández-Carrión, Goday, Peña-Orihuela, Compañ-Gabucio, Schröder, Martínez-Gonzalez and Salas-Salvadó. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest