Genome Sequence of Halomonas sp. Strain A3H3, Isolated from Arsenic-Rich Marine Sediments

We report the genome sequence of Halomonas sp. strain A3H3, a bacterium with a high tolerance to arsenite, isolated from multicontaminated sediments of the l'Estaque harbor in Marseille, France. The genome is composed of a 5,489,893-bp chromosome and a 157,085-bp plasmid

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy

Myotonic dystrophy (DM) is caused by the expression of mutant RNAs containing expanded CUG repeats that sequester muscleblind-like (MBNL) proteins, leading to alternative splicing changes. Cardiac alterations, characterized by conduction delays and arrhythmia, are the second most common cause of death in DM. Using RNA sequencing, here we identify novel splicing alterations in DM heart samples, including a switch from adult exon 6B towards fetal exon 6A in the cardiac sodium channel, SCN5A. We find that MBNL1 regulates alternative splicing of SCN5A mRNA and that the splicing variant of SCN5A produced in DM presents a reduced excitability compared with the control adult isoform. Importantly, reproducing splicing alteration of Scn5a in mice is sufficient to promote heart arrhythmia and cardiac-conduction delay, two predominant features of myotonic dystrophy. In conclusion, misregulation of the alternative splicing of SCN5A may contribute to a subset of the cardiac dysfunctions observed in myotonic dystrophy.Peer reviewe

Sur la construction des modèles cristallins

Deux procédés principaux : 1) troncatures, 2) développement plan puis formation du polyèdre. Utilisation au maximum du moulage (plâtre, ciment, aluminium) ; obtention successive de formes hémièdres puis holoèdres. Industrialisation possible par moulage « en coquille » et extension possible aux matières plastiques. Les modèles correspondent dans chaque système à une forme primitive unique, leur précision atteint ou dépasse 1°. Ils peuvent servir de base à l'enseignement des calculs cristallographiques (goniomètre d'application).Vicaire P. Sur la construction des modèles cristallins. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 77, 10-12, 1954. pp. 1410-1417

Sand bodies and sand transport paths at the English Channel-North Sea border: Morphology, hydrodynamics and radioactive tracing

Surficial sediments and detailed submarine morphology of the southern Strait of Dover have been mapped using different complementary techniques: side-scan sonar survey, bottom sediment sampling, and bathymetry. The geometry and regional pattern of sand bodies - sand waves, megaripples, sand ribbons, etc. - as well as current-meter data and eight radioactive tracing experiments in different settings, are presented and analyzed. The mean regional net sand transport is 0.2 m super(3)/linear metre/day. The strong tidal currents of the region studied are considered as the main factor responsible for sand transport, while the swell plays an important but local role in maintaining particulate matter in suspension

La Grande Vasière : architecture, mise en place et estimation des facteurs de son évolution.

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