224 research outputs found
Progressive associative phonagnosia: A neuropsychological analysis
AbstractThere are few detailed studies of impaired voice recognition, or phonagnosia. Here we describe two patients with progressive phonagnosia in the context of frontotemporal lobar degeneration. Patient QR presented with behavioural decline and increasing difficulty recognising familiar voices, while patient KL presented with progressive prosopagnosia. In a series of neuropsychological experiments we assessed the ability of QR and KL to recognise and judge the familiarity of voices, faces and proper names, to recognise vocal emotions, to perceive and discriminate voices, and to recognise environmental sounds and musical instruments. The patients were assessed in relation to a group of healthy age-matched control subjects. QR exhibited severe impairments of voice identification and familiarity judgments with relatively preserved recognition of difficulty-matched faces and environmental sounds; recognition of musical instruments was impaired, though better than recognition of voices. In contrast, patient KL exhibited severe impairments of both voice and face recognition, with relatively preserved recognition of musical instruments and environmental sounds. Both patients demonstrated preserved ability to analyse perceptual properties of voices and to recognise vocal emotions. The voice processing deficit in both patients could be characterised as associative phonagnosia: in the case of QR, this was relatively selective for voices, while in the case of KL, there was evidence for a multimodal impairment of person knowledge. The findings have implications for current cognitive models of voice recognition
Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency.
Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the magnitude of upcoming reward drawn from distributions with different SDs. After each prediction, participants received a reward, yielding trial-by-trial prediction errors. In line with the notion of adaptive coding, BOLD response slopes in the Substantia Nigra/Ventral Tegmental Area (SN/VTA) and ventral striatum were steeper for prediction errors occurring in distributions with smaller SDs. SN/VTA adaptation was not instantaneous but developed across trials. Adaptive prediction error coding was paralleled by behavioral adaptation, as reflected by SD-dependent changes in learning rate. Crucially, increased SN/VTA and ventral striatal adaptation was related to improved task performance. These results suggest that adaptive coding facilitates behavioral adaptation and supports efficient learning.This study was supported by the Wellcome Trust (W.S., P.C.F.), Bernard Wolfe Health Neuroscience Fund (P.C.F.) and the Niels Stensen Foundation (K.M.J.D.). We thank William Stauffer, Armin Lak and Joost Haarsma for useful discussions.This is the final version of the article. It first appeared from Cell Press via http://dx.doi.org/10.1016/j.neuron.2016.04.01
SDSS 0956+5128: A Broad-line Quasar with Extreme Velocity Offsets
We report on the discovery of a Type 1 quasar, SDSS 0956+5128, with a
surprising combination of extreme velocity offsets. SDSS 0956+5128 is a
broad-lined quasar exhibiting emission lines at three substantially different
redshifts: a systemic redshift of z ~ 0.714 based on narrow emission lines, a
broad MgII emission line centered 1200 km/s bluer than the systemic velocity,
at z ~ 0.707, and broad H\alpha and H\beta emission lines centered at z ~
0.690. The Balmer line peaks are 4100 km/s bluer than the systemic redshift.
There are no previously known objects with such an extreme difference between
broad MgII and broad Balmer emission. The two most promising explanations are
either an extreme disk emitter or a high-velocity black hole recoil. However,
neither explanation appears able to explain all of the observed features of
SDSS 0956+5128, so the object may provide a challenge to our general
understanding of quasar physics.Comment: ApJ, accepte
Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group
INTRODUCTION: Despite improvements in medical science and public health, mortality of community-acquired pneumonia (CAP) has barely changed throughout the last 15Â years. The current SARS-CoV-2 pandemic has once again highlighted the central importance of acute respiratory infections to human health. The ânetwork of excellence on Community Acquired Pneumoniaâ (CAPNETZ) hosts the most comprehensive CAP database worldwide including more than 12,000 patients. CAPNETZ connects physicians, microbiologists, virologists, epidemiologists, and computer scientists throughout Europe. Our aim was to summarize the current situation in CAP research and identify the most pressing unmet needs in CAP research. METHODS: To identify areas of future CAP research, CAPNETZ followed a multiple-step procedure. First, research members of CAPNETZ were individually asked to identify unmet needs. Second, the top 100 experts in the field of CAP research were asked for their insights about the unmet needs in CAP (Delphi approach). Third, internal and external experts discussed unmet needs in CAP at a scientific retreat. RESULTS: Eleven topics for future CAP research were identified: detection of causative pathogens, next generation sequencing for antimicrobial treatment guidance, imaging diagnostics, biomarkers, risk stratification, antiviral and antibiotic treatment, adjunctive therapy, vaccines and prevention, systemic and local immune response, comorbidities, and long-term cardio-vascular complications. CONCLUSION: Pneumonia is a complex disease where the interplay between pathogens, immune system and comorbidities not only impose an immediate risk of mortality but also affect the patientsâ risk of developing comorbidities as well as mortality for up to a decade after pneumonia has resolved. Our review of unmet needs in CAP research has shown that there are still major shortcomings in our knowledge of CAP
Hubble Space Telescope Ultraviolet Spectroscopy of Fourteen Low-Redshift Quasars
We present low-resolution ultraviolet spectra of 14 low redshift (z<0.8)
quasars observed with HST/STIS as part of a Snap project to understand the
relationship between quasar outflows and luminosity. By design, all
observations cover the CIV emission line. Nine of the quasars are from the
Hamburg-ESO catalog, three are from the Palomar-Green catalog, and one is from
the Parkes catalog. The sample contains a few interesting quasars including two
broad absorption line (BAL) quasars (HE0143-3535, HE0436-2614), one quasar with
a mini-BAL (HE1105-0746), and one quasar with associated narrow absorption
(HE0409-5004). These BAL quasars are among the brightest known (though not the
most luminous) since they lie at z<0.8. We compare the properties of these BAL
quasars to the z1.4 Large Bright Quasar samples. By
design, our objects sample luminosities in between these two surveys, and our
four absorbed objects are consistent with the v ~ L^0.62 relation derived by
Laor & Brandt (2002). Another quasar, HE0441-2826, contains extremely weak
emission lines and our spectrum is consistent with a simple power-law
continuum. The quasar is radio-loud, but has a steep spectral index and a
lobe-dominated morphology, which argues against it being a blazar. The unusual
spectrum of this quasar resembles the spectra of the quasars PG1407+265,
SDSSJ1136+0242, and PKS1004+13 for which several possible explanations have
been entertained.Comment: Uses aastex.cls, 21 pages in preprint mode, including 6 figures and 2
tables; accepted for publication in The Astronomical Journal (projected vol
133
An 800-million-solar-mass black hole in a significantly neutral Universe at redshift 7.5
Quasars are the most luminous non-transient objects known and as a result
they enable studies of the Universe at the earliest cosmic epochs. Despite
extensive efforts, however, the quasar ULAS J1120+0641 at z=7.09 has remained
the only one known at z>7 for more than half a decade. Here we report
observations of the quasar ULAS J134208.10+092838.61 (hereafter J1342+0928) at
redshift z=7.54. This quasar has a bolometric luminosity of 4e13 times the
luminosity of the Sun and a black hole mass of 8e8 solar masses. The existence
of this supermassive black hole when the Universe was only 690 million years
old---just five percent of its current age---reinforces models of early
black-hole growth that allow black holes with initial masses of more than about
1e4 solar masses or episodic hyper-Eddington accretion. We see strong evidence
of absorption of the spectrum of the quasar redwards of the Lyman alpha
emission line (the Gunn-Peterson damping wing), as would be expected if a
significant amount (more than 10 per cent) of the hydrogen in the intergalactic
medium surrounding J1342+0928 is neutral. We derive a significant fraction of
neutral hydrogen, although the exact fraction depends on the modelling.
However, even in our most conservative analysis we find a fraction of more than
0.33 (0.11) at 68 per cent (95 per cent) probability, indicating that we are
probing well within the reionization epoch of the Universe.Comment: Updated to match the final journal versio
Observational constraints on the co-evolution of supermassive black holes and galaxies
The star formation rate (SFR) and black hole accretion rate (BHAR) functions
are measured to be proportional to each other at z < ~3. This close
correspondence between SF and BHA would naturally yield a BH mass-galaxy mass
correlation, whereas a BH mass-bulge mass correlation is observed. To explore
this apparent contradiction we study the SF in spheroid-dominated galaxies
between z=1 and the present day. We use 903 galaxies from the COMBO-17 survey
with M* >2x10^10M_sun, ultraviolet and infrared-derived SFRs from Spitzer and
GALEX, and morphologies from GEMS HST/ACS imaging. Using stacking techniques,
we find that <25% of all SF occurs in spheroid-dominated galaxies (Sersic index
n>2.5), while the BHAR that we would expect if the global scalings held is
three times higher. This rules out the simplest picture of co-evolution, in
which SF and BHA trace each other at all times. These results could be
explained if SF and BHA occur in the same events, but offset in time, for
example at different stages of a merger event. However, one would then expect
to see the corresponding star formation activity in early-stage mergers, in
conflict with observations. We conclude that the major episodes of SF and BHA
occur in different events, with the bulk of SF happening in isolated disks and
most BHA occurring in major mergers. The apparent global co-evolution results
from the regulation of the BH growth by the potential well of the galactic
spheroid, which includes a major contribution from disrupted disk stars.Comment: 14 pages, 5 figures, accepted for publication in Ap
The characterization of the distant blazar GB6 J1239+0443 from flaring and low activity periods
In 2008 AGILE and Fermi detected gamma-ray flaring activity from the
unidentified EGRET source 3EG J1236+0457, recently associated with a flat
spectrum radio quasar GB6 J1239+0443 at z=1.762. The optical counterpart of the
gamma-ray source underwent a flux enhancement of a factor 15-30 in 6 years, and
of ~10 in six months. We interpret this flare-up in terms of a transition from
an accretion-disk dominated emission to a synchrotron-jet dominated one. We
analysed a Sloan Digital Sky Survey (SDSS) archival optical spectrum taken
during a period of low radio and optical activity of the source. We estimated
the mass of the central black hole using the width of the CIV emission line. In
our work, we have also investigated SDSS archival optical photometric data and
UV GALEX observations to estimate the thermal-disk emission contribution of GB6
J1239+0443. Our analysis of the gamma-ray data taken during the flaring
episodes indicates a flat gamma-ray spectrum, with an extension of up to 15
GeV, with no statistically-relevant sign of absorption from the broad line
region, suggesting that the blazar-zone is located beyond the broad line
region. This result is confirmed by the modeling of the broad-band spectral
energy distribution (well constrained by the available multiwavelength data) of
the flaring activity periods and by the accretion disk luminosity and black
hole mass estimated by us using archival data.Comment: 30 pages, 7 figures, 4 tables MNRAS Accepted on 2012 June 1
Viruses in extreme environments
The original publication is available at www.springerlink.comInternational audienceThe tolerance limits of extremophiles in term of temperature, pH, salinity, desiccation, hydrostatic pressure, radiation, anaerobiosis far exceed what can support non-extremophilic organisms. Like all other organisms, extremophiles serve as hosts for viral replication. Many lines of evidence suggest that viruses could no more be regarded as simple infectious ââfragments of life'' but on the contrary as one of the major components of the biosphere. The exploration of niches with seemingly harsh life conditions as hypersaline and soda lakes, Sahara desert, polar environments or hot acid springs and deep sea hydrothermal vents, permitted to track successfully the presence of viruses. Substantial populations of double-stranded DNA virus that can reach 109 particles per milliliter were recorded. All these viral communities, with genome size ranging from 14 kb to 80 kb, seem to be genetically distinct, suggesting specific niche adaptation. Nevertheless, at this stage of the knowledge, very little is known of their origin, activity, or importance to the in situ microbial dynamics. The continuous attempts to isolate and to study viruses that thrive in extreme environments will be needed to address such questions. However, this topic appears to open a new window on an unexplored part of the viral world
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