776 research outputs found

    Integrating data in a Web and mobile Web application from Movie Theaters' schedules

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    El Trabajo Fin de Grado (TFG) a desarrollar consiste en el estudio en profundidad y prueba de concepto de métodos y técnicas de integración de datos heterogéneos en aplicaciones Web. La prueba de concepto de estos métodos y técnicas se materializarán en la creación de un sitio web donde diferentes fuentes de datos (internas y externas) de distinta naturaleza son utilizadas con el siguiente objetivo: permitir el acceso del usuario final a todos estos datos de forma transparente a su ubicación y formato original, mostrando información de manera integrada. El dominio escogido para la prueba de concepto ha sido el de la cartelera de cine en todo el territorio nacional. Por otro lado, y teniendo en cuenta que el uso de los dispositivos móviles ha aumentado exponencialmente durante la última década, otro punto importante de este TFG es diseñar la aplicación Web no solo para dispositivos PC, sino también para dispositivos móviles, a la que se le denominará a lo largo de este documento como CineSpainThis work studies the main methods and techniques for data integration [1]. Specifically, how to extract data coming from different and heterogeneous external sources is studied. Moreover, how to integrate and show it in a Web application is analyzed. Then, a proof of concept concerning these methods and techniques will be materialized into a web site application where different kinds of data sources are used in order to achieve the following goal: to provide to the end user an easy and integrated way to access the heterogeneous data coming from different sources in a transparent manner. Note that these data could have different original location and format. The Web application domain for the proof of concept is focused in Movie Theaters’ schedules in Spain. This domain specially fits for the proof of concept of this study because there is a lot of scattered data around the World Wide Web about it: performances, cinema locations, films’ details, user opinions, etc. Then, the user sometimes is not able to find the complete schedule, or to locate the physical location of the theaters, etc. Therefore, to provide an application for summarizing all these data coming for different Web services, Web pages or Databases, among others, it is really useful for the final users.The Web application will be compatible with both PC and mobile devices. The functionality will be the same between these two versions, but their interfaces will be adapted to their respective devices.Ingeniería Informátic

    Pengaruh Perkembangan Desa Wisata Dusun Ketingan Terhadap Setting Fisik Lingkungan dan Pola Perilaku Masyarakat Dusun Ketingan

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    Dusun Ketingan adalah salah satu desa wisata yang Kabupaten Sleman, Daerah Istimewa Yogyakarta. Dusun ini memiliki luas 17 ha, yang terdiri dari 1 pedukuhan, 4 RT, 2 RW, dan 267 KK. Dusun Ketingan merupakan area konservasi burung kuntul kerbau yang termasuk salah satu hewan yang dilindungi di Indonesia. Keaslian potensi alam, budaya, dan fauna yang sudah tertanam di dalam kehidupan masyarakat Dusun Ketingan menjadikan Dusun Ketingan menjadi destinasi desa wisata fauna. Munculnya fenomena kejenuhan terhadap bentuk wisata modern dan ingin kembali merasakan kehidupan di alam pedesaan mendukung pembangunan-pembangunan fisik baru di Dusun Ketingan. Penelitian ini dilakukan untuk mengetahui perubahan setting fisik lingkungan Dusun Ketingan dan pengaruhnya pada pola perilaku masyarakat dilihat dari segi sosial, ekonomi, dan budaya. Pendekatan dalam penelitian ini yaitu dengan menggunakan metode kualitatif deskriptif. Metode pengumpulan data yang digunakan dalam penelitian ini adalah (1) Survei dan Observasi Lapangan, (2) Wawancara Mendalam, (3) Studi Literatur, dan (4) Behaviour-Mapping dengan cara Person Centered Mapping. Penelitian ini menemukan pengaruh perkembangan desa wisata Dusun Ketingan  terhadap setting fisik lingkungan dan pola perilaku masyarakat Dusun Ketingan

    A História Ensinada em manuais do Ensino Médio: estudo comparativo acerca do repertório imagético sobre indígenas de uma mesma obra publicada no PNLEM História 2008 e PNLD História 2015

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    Anais do XVII Congresso Internacional das Jornadas de Educaão História - teoria, pesquisa e prática - I Encontro da AIPEDH - Associação Iber-Americana de Pesquisadores em Educação História, realizado pela Universidade Federal da Integração Latino-Americana, entre 02, 03 e 04 de agosto de 2017.A partir da discussão acerca da inclusão étnica, levantada com a aprovação da lei 10.639/2003, que torna obrigatório o ensino da História e Cultura Africana e Afro- brasileira nas salas de aula, em 2008 foi aprovada a lei 11.645/2008, que inclui, também, o ensino de História e Cultura Indígena como obrigatório nas escolas de ensino fundamental e médio de todo o país. A nova lei causou alterações no Artigo 26-A, da Lei de Diretrizes e Bases da Educação Nacional – LDB, Lei 9.394/1996 - inserindo-se no esforço de uma educação intercultural, exigindo mudanças nos conteúdos dos materiais didáticos, dentre eles, o livro didáticoInstituição: LEPEDIH-UNESP/Assis (Laboratório de Estudos e Pesquisas em Didática da História da Universidade Estadual Paulista – campus Assis

    ANALISIS LAPORAN REALISASI ANGGARAN UNTUK MENILAI KINERJA KEUANGAN PADA KANTOR BADAN PENDAPATAN DAERAH KABUPATEN OKU

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    The purpose of the study was to determine the financial performance of the OKU Regency Revenue Agency office analyzed from the 2013-2017 budget realization report. The method used is descriptive quantitative using economic levels, efficiency, and effectiveness. From the results of the analysis it was concluded that the financial performance based on the analysis of economic levels in 2013-2017, namely varied economic rates averaged 89.48% with criteria quite economical, this shows the ability of the government to economize spending is quite good. The level of efficiency in the OKU Regency Revenue Agency increased from year to year, the average efficiency level in 2013-2017 was 62.58% with efficient criteria because the realization of local tax revenue was greater than the costs incurred to collect local taxes, this shows the government's ability to streamline income and expenditure is good. And the level of effectiveness of PAD revenue is fixed or stable from year to year, the average level of effectiveness in 2013-2017 is 114.39% with very effective criteria, this shows the ability of the government to achieve the revenue budget set by the OKU Regency Revenue Agency isvery effective

    Cytokines and Defensins in Tissue Biopsies Obtained by Bronchoscopy from Patients with Post-Intubation Tracheal Stenosis

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    Aims: The objective of our study was to perform the routine analysis of bronchoscopically obtained tracheal samples to determine the appearance and relative distribution of cytokines and antimicrobial proteins in patients with post-intubation tracheal stenosis (PITS). Study Design: Retrospective. Place and Duration of Study: Rīga Stradiņš University, Institute of Anatomy and Anthropology, Pauls Stradiņš Clinical University Hospital, between May 2014 and May 2015. Methodology: Five patients with PITS were involved in this study. Tissue samples were obtained by bronchoscopy from the upper part of trachea, then proceeded for routine histological staining with hematoxylin and eosin. Interleukine-1 (IL-1), interleukine-10 (IL-10) and tumor necrosis factor alpha (TNFα), as well as beta defensin-2 (β def-2) were detected by use of immunohistochemistry (IMH) method. The number of immunoreactive (positive) structures was graded semi-quantitatively. Results: Squamous metaplasia, inflammatory cell infiltration and formation of granulation tissue were observed in all cases. Significant expression of IL-10 and β def-2 was seen as various number of immunoreactive structures in tracheal tissue. Only few scattered IL-1 and TNFα positive macrophages were found in part of cases. Conclusions: The leading role in pathogenesis of post-intubation tracheal stenosis is assumed to be the chronic inflammation, fibrous scarring, as well as the remodeling of tracheal wall due to the ischemia. Compensatory expression of antimicrobial peptide β def-2 and anti-inflammatory cytokine IL-10 indicates the intense local tissue defense reactions. TNFα and IL-1 are not among the most significant factors in pathogenesis of PITS.authorsversionPeer reviewe

    COPD affected lung tissue remodeling due to the local distribution of MMP-2, TIMP-2, TGF-β1 and HSP-70

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    Chronic obstructive pulmonary disease (COPD) is strongly associated with progressive airway limitation where the key mechanism is abnormal airway remodelling of bronchial mucosa maintained by complex crosstalk of tissue remodelling and regulatory factors. The aim of this study was to determine the appearance and local distribution of tissue remodelling factors in COPD affected lung tissue and to compare the findings with the control group. In this study, lung tissue specimens were obtained from 27 patients with COPD and 49 control patients. Tissue samples were examined by routine hematoxylin and eosin staining. Remodelling and regulatory factors matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2), transforming growth factor-β1 (TGF-β1), as well as heat shock protein-70 (Hsp-70) were detected by immunohistochemistry in airway mucosa. The numbers of positive structures were evaluated semiquantitatively. Non-parametrical statistical analysis was performed. Overall COPD-affected lung tissue presented chronic inflammation and tissue remodelling in routine histological analysis. Compared to the control group, statistically significant (P<0.05) difference was calculated between COPD affected lung tissue and control group with overall more immunoreactive cells containing MMP-2, TIMP-2 and TGF-β1 and less Hsp-70 immunoreactive bronchial epithelial cells, subepithelial connective tissue fibroblasts, bronchial smooth muscle cells and secretory cells of bronchial glands with more pronounced findings of TGF-β1, however, less Hsp-70. Study findings suggest pronounced tissue damage and remodelling with the local regulatory environment of up-regulated TGF-β1. Increased numbers of MMP-2, TIMP-2 and TGF-β1 immunoreactive cells suggest the key role of these remodelling factors in COPD pathogenesis. Decrease of Hsp-70 proves increased cell damage in COPD-affected airway mucosa.publishersversionPeer reviewe

    Effect of Vanadium Compounds on the Lipid Organization of Liposomes and Cell Membranes

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    The influence of vanadate on the adsorption properties of Merocyanine 540 (MC540) to UMR cells was studied by means of specrofluorometry. An increment in the fluorescence was observed in the osteoblasts incubated with 0.1 mM vanadate. This effect could be interpreted in terms of vanadate inhibitory effects on aminotraslocase activity. However, vanadate promotes a similar behavior to that found in UMR 106 cells when it was added to lipid vesicles composed of phosphatidylcholine. The effect of vanadium in different oxidation states, such as vanadate(V) and vanadyl(IV) on lipid membrane properties was examined in large unilamellar vesicles by means of spectrofluorometry employing different probes. Merocyanine 540 and 1,6-diphenylhexatriene were used in order to sense the changes at interfacial and hydrophobic core of membranes, respectively. In contrast to vanadate, vanadyl decreased the fluorescence of MC540. Both vanadium compounds slightly perturbed the hydrocarbon core. The results can be interpreted by the specific adsorption of both compounds on the polar head groups of phospholipid and suggest a possible influence of vanadium compounds on the lipid organization of cell membranes

    Expression Analysis of FGF/FGFR and FOX Family Proteins in Mucosal Tissue Obtained from Orofacial Cleft-Affected Children

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    Funding Information: Funding: The present study was funded by Riga Stradinš University (RSU), Project Nb. 5-1/384/2020 (dated 10 September 2020). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Orofacial clefts affect hundreds of thousands of children worldwide annually and are usually corrected by a series of surgeries extending to childhood. The underlying mechanisms that lead to clefts are still unknown, mainly because of the multifactorial etiology and the myriad of interactions between genes and environmental factors. In the present study, we investigated the role and expression of candidate genes belonging to the FGF/FGFR signaling pathway and FOX family in tissue material obtained from 12 pediatric patients undergoing cleft correction surgery. The expression was investigated using immunohistochemistry (IHC) and chromogenic in-situ hybridization (CISH) in three cell/tissue types—epithelial cells, connective tissue, and endothelial cells. We found elevated expression of FGFR1 in epithelial cells while no expression was observed in endothelial cells. Further, our results elucidate the potential pathogenetic role of FGFR1 in cellular proliferation, local site inflammation, and fibrosis in cleft patients. Along with bFGF (also called FGF2), FGFR1 could play a pro-inflammatory role in clefts. Over-amplification of FGFR2 in some patients, along with bFGF, could potentially suggest roles for these genes in angiogenesis. Additionally, increased expression of FOXE1 (also called TTF2) contributes to local site inflammation. Finally, zero to low amplification of FOXO1 could suggest its potential role in inducing oxidative stress in the endothelium along with reduced epithelial apoptosis.publishersversionPeer reviewe

    Perancangan Interior Kafe Dengan Konsep Arsitektur Tionghoa Palembang

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    Perkembangan bisnis di dunia food and Baverages mengalami peningkatan yang cukup pesat khususnya pada bidang kafe &amp; restaurant. Fenomena ini banyak di temui baik dikota besar maupun di kota kecil yang mana mulai bermunculan suatu tempat makan dengan konsep yang lebih kekinian dan terkonsep dengan tujuan lebih menyasar pada anak muda. Stamps Kafe adalah salah satu kafe baru di kota Palembang bergerak di bidang kuliner dengan fokus pada masakan tradisional Palembang. Stamps kafe juga menyediakan mini bar sebagai tempat bagi pecinta kopi untuk menikmati racikan kopi tradisional. Unsur yang akan diterapkan pada kafe ini adalah unsur Tionghoa Palembang yang dikemas dengan konsep yang lebih modern dan kekinian dengan tujuan menampilkan nuansa klasik dan modern yang dibalut oleh tema Tionghoa Palembang menjadi satu kesatuan yang seimbang. Hasil dari penelitian ini berupa gambar rancangan interior kafe secara umum, 3D desain dan Video Animasi Suasana interior didesain dengan dengan didominasi warna cerah dan penataan aksesoris yang didasari pada ciri khas rumah masyarakat Tionghoa Palembang. Dengan interior kafe bertema arsitektur Tionghoa Palembang diharapkan dapat memberikan nilai jual tersendiri dimana interior kafe merupakan salah satu daya tarik yang memiliki nilai komersil tersendiri yang mana dapat memberikan keuntungan pada pemilik kafe.
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