69 research outputs found
High-Level Synthesis Hardware Design for FPGA-Based Accelerators: Models, Methodologies, and Frameworks
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Hardware accelerators based on field programmable gate array (FPGA) and system on chip (SoC) devices have gained attention in recent years. One of the main reasons is that these devices contain reconfigurable logic, which makes them feasible for boosting the performance of applications. High-level synthesis (HLS) tools facilitate the creation of FPGA code from a high level of abstraction using different directives to obtain an optimized hardware design based on performance metrics. However, the complexity of the design space depends on different factors such as the number of directives used in the source code, the available resources in the device, and the clock frequency. Design space exploration (DSE) techniques comprise the evaluation of multiple implementations with different combinations of directives to obtain a design with a good compromise between different metrics. This paper presents a survey of models, methodologies, and frameworks proposed for metric estimation, FPGA-based DSE, and power consumption estimation on FPGA/SoC. The main features, limitations, and trade-offs of these approaches are described. We also present the integration of existing models and frameworks in diverse research areas and identify the different challenges to be addressed
Ensemble Model Compression for~Fast and~Energy-Efficient Ranking on~{FPGAs}
- Author
- Publication venue
- place:GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
- Publication date
- 01/01/2022
- Field of study
We investigate novel SoC-FPGA solutions for fast and energy-efficient ranking based on machine-learned ensembles of decision trees. Since the memory footprint of ranking ensembles limits the effective exploitation of programmable logic for large-scale inference tasks, we investigate binning and quantization techniques to reduce the memory occupation of the learned model and we optimize the state-of-the-art ensemble-traversal algorithm for deployment on low-cost, energy-efficient FPGA devices. The results of the experiments conducted using publicly available Learning-to-Rank datasets, show that our model compression techniques do not impact significantly the accuracy. Moreover, the reduced space requirements allow the models and the logic to be replicated on the FPGA device in order to execute several inference tasks in parallel. We discuss in details the experimental settings and the feasibility of the deployment of the proposed solution in a real setting. The results of the experiments conducted show that our FPGA solution achieves performances at the state of the art and consumes from 9x up to 19.8x less energy than an equivalent multi-threaded CPU implementation
Copernicus Ocean State Report, issue 6
- Author
- Aarne Männik
- Ad Stoffelen
- Adem Akpınar
- Alex Santana
- Alexandre Ganachaud
- Ali Aydogdu
- Andra Whiteside
- Andrea Cipollone
- Anna Teruzzi
- Anna Zacharioudaki
- Annette Breckwoldt
- Annunziata Pirro
- Antoine de Ramon N’Yeurt
- Antoine Mangin
- Antonio Bonaduce
- Antonio Bussani
- Arno Behrens
- Awnesh Singh
- Baptiste Mourre
- Begoñia Pérez Gómez
- Ben Howey
- Celia Laurent
- Cosimo Solidoro
- Cécile Dupouy
- César Mosso
- Daniel Santos Muñoz
- Dany Ghafari
- David Varillon
- Deep Sankar Banerjee
- Derin U. Cetin
- Diana Azevedo
- Dimitra Denaxa
- Donata Melaku Canu
- Doroteaciro Iovino
- Elena Mauri
- Elisabeth Holland
- Elisaveta Peneva
- Emanuela Clementi
- Emil Stanev
- Emily Jane Down
- Emily Smail
- Emma Reyes
- Enrico Zambianchi
- Enrique Alvarez Fanjul
- Eric de Boisseson
- Gerasimos Korres
- Gianluca Coidessa
- Gianpiero Cossarini
- Gilles Garric
- Ginevra Rosati
- Giorgio Bolzon
- Giovanni Coppini
- Giulia Bonino
- Giulio Notarstefano
- Hao Zuo.
- Heath Kelsey
- Hugo Dayan
- Ilja Maljutenko
- Ivan Federico
- Jari Haapala
- Javier García Valdecasas
- Jiping Xie
- Joanna Staneva
- Joaquin Tintore
- Jonathan Baker
- José María García Valdecasas
- Jue Lin-Ye
- Jukka Seppälä
- Julia Selivanova
- Jérôme Aucan
- Karina von Schuckmann
- Keith VanGraafeiland
- Laura Jackson
- Laurent Bertino
- Leonardo Lima
- Leonidas Perivoliotis
- Leopold Haimberger
- Louis Celliers
- Luc Vandenbulcke
- M. Y. Luna Rico
- Maeva Monier
- Magdalena Balmaseda
- Manuel García-León
- Maraja Riechers
- Marc Mestres
- Marcel Ricker
- Marco Reale
- Marcos García Sotillo
- Maria Fernandes
- Maria Sotiropoulou
- Marilaure Gregoire
- Marine Bretagnon
- Martha de Alfonso Alonso-Muñoyerro
- María Máñez Costa
- María Ruíz Gil de la Serna
- Massimo Pacciaroni
- Matilde Pattanaro
- Mehmet Ilicak
- Menghua Wang
- Michael Mayer
- Michalis Ravdas
- Michela Sammartino
- Milena Menna
- Murat Gunduz
- Nadia Pinardi
- Nam Pham
- Naomi Krauzig
- Pablo Lorente Jiménez
- Pascal Douillet
- Peter Land
- Petri Maunula
- Pierpaolo Falco
- Pierre-Marie Poulain
- Pierre-Yves Le Meur
- Pierre-Yves Le Traon
- Pieter Groenemeijer
- Raphael Molina
- Rianne Giesen
- Riccardo Gerin
- Riccardo Martellucci
- Richard Renshaw
- Rita Lecci
- Rivo Uiboupin
- Roland Aznar Lecocq
- Romain Escudier
- Ronan McAdam
- Rosalia Santoleri
- Sabrina Speich
- Salvatore Causio
- Samu Elovaara
- Sathyadev Ramachandran
- Sebastian Ehrhart
- Sebastian Ferse
- Sebastian Grayek
- Seppo Kaitala
- Shubha Sathyendranath
- Signe Aaboe
- Silvia Pardo
- Simon Nicol
- Simon Van Wynsberge
- Simona Masina
- Simone Colella
- Stefan Hendricks
- Stefania A. Ciliberti
- Stefano Salon
- Susana Pérez Rubio
- Susanna Winkelbauer
- Svetlana Verjovkina
- Takamasa Tsubouchi
- Thomas Jackson
- Thomas Lavergne
- Urmas Raudsepp
- Valeria Di Biagio
- Vandhna Kumar
- Vanessa Seitner
- Veronica P. Lance
- Vidar S. Lien
- Vittorio E. Brando
- Vladyslav Lyubartsev
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The 6th issue of the Copernicus OSR incorporates a large range of topics for the blue, white and green ocean for all European regional seas, and the global ocean over 1993–2020 with a special focus on 2020
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
- Author
- Abate Emmanuele
- Abbassi Imed
- Abdoun Ahmed K.
- Abdullaev Abakar
- Abu-Zidan Fikri
- Acheimastos Vasileios
- Agackiran Ibrahim
- Agnoletti Vanni
- Agrusa Antonino
- Agundez María Carmona
- Agus Marcello
- Aizza Giada
- Akin Emrah
- Alconchel Felipe
- Alegre Javier Martínez
- Alemanno Giovanni
- Ali Ali Ben
- Almeida Filipe
- Altinel Yuksel
- Altıntaş Yasemin
- Altintoprak Fatih
- Ambrosi Antonio
- Ammar Houssem
- Anania Gabriele
- Andreuccetti Jacopo
- Andrés María Inmaculada Pérez
- Anestiadou Elissavet
- Ansaloni Luca
- Antona Francisco Blanco
- Aparicio-Sánchez Daniel
- Aprea Giovanni
- Aranaz-Ostariz Veronica
- Aranda-Narváez Jose Manuel
- Ardito Antonella
- Argenio Giulio
- Armellino Mariano Fortunato
- Armento Isabella
- Asti Emanuele Luigi Giuseppe
- Atanasov Boyko
- Atici Semra Demirli
- Augustin Goran
- Aurélien Venara
- Austin Tyler R.
- Avgerinos Konstantinos
- Ayed Karim
- Azzinnaro Antonio
- Bagolini Francesco
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bajul Melinda
- Bala Miklosh
- Balık Emre
- Balla Andrea
- Banchini Filippo
- Bañolas-Suarez Raquel
- Baraket Oussama
- Barberis Andrea
- Bardes James M.
- Bayhan Zulfu
- Bayrak Mehmet
- Belev Nikolay
- Belvedere Angela
- Benzoni Ilaria
- Bernardi Daniele Tiziano
- Berti Stefano
- Bertino Vanessa
- Bertoli Paolo
- Bianchi Valentina
- Biffl Walter L.
- Biloslavo Alan
- Boati Paolo
- Bogdanić Branko
- Bolzon Stefano
- Bombardini Cristina
- Bonati Elena
- Bonilauri Stefano
- Bonomi Alessandro
- Borghi Felice
- Bosch-Ramírez Marina
- Bougard Marie
- Bouliaris Konstantinos
- Boura Maria
- Bourbouteli Eirini
- Bozkurt Mehmet Abdussamet
- Brachini Gioia
- Bradley Alison
- Bravi Francesca
- Bravo Altea Arango
- Buffone Angelica
- Buonfantino Massimo
- Buscemi Salvatore
- Caamaño Aloia Guerreiro
- Cadeo Alessandro
- Cairl Nicholas
- Calu Valentin
- Campa Rossella Domenica
- Campana Juan P.
- Campos-Serra Andrea
- Cannavera Alessandro
- Canton Cassio Alfred Brattig
- Capelli Patrizio
- Capolupo Gabriella Teresa
- Capponi Michela Giulii
- Capuano Marianna
- Carannante Filippo
- Cardamone Eugenia
- Cardoso Paulo Sebastião
- Caricato Marco
- Carmona Zahira Gómez
- Carneiro Carla
- Carvas João
- Casadei Massimiliano
- Casati Massimiliano
- Casiraghi Silvia
- Casole Giovanni
- Castaldo Pasquale
- Catena Fausto
- Cattaneo Gaetano Maria
- Cavallo Fabio
- Cellerino Paola
- Cereda Marco
- Ceresoli Marco
- Chahrour Ali Chaouki
- Chamzin Alexandros
- Charalabopoulos Alexandros
- Chierici Andrea
- Chouillard Elie
- Chrysos Emmanuel
- Cianci Pasquale
- Cicconi Simone
- Cillara Nicola
- Clarizia Guglielmo
- Clerici Federico
- Cloquell Miriam Moratal
- Coccolini Federico
- Coffua Lauren S.
- Coimbra Raul
- Colak Elif
- Conti Luigi
- Corbellini Carlo
- Cordeiro-Fonseca Vinicius
- Cotsoglou Christian
- Cruz Daniel Rios
- Cuellar Jose Aurelio Navas
- Cumplido Paola Lora
- Curtiss William
- Czyżykowski Łukasz
- da Costa Silvia Dantas
- Das Koray
- Dawoud Christopher
- de León Laura Román García
- de los Ángeles Gil Olarte-Marquez Ma
- De Luca Maurizio
- de Manzoni Garberini Andrea
- de Mendonça Nuno Gonçalo Gonçalves
- de Mesquita Tauil Renato
- De Palma Giovanni Domenico
- de Quiros Javier Tomas Morales Bernaldo
- De Sario Giuseppina
- De Simone Belinda
- Degiuli Maurizio
- Del Monte Simone Rossi
- del Pozo Eduardo Perea
- Delgado Edward
- Delvecchio Antonella
- Demetrashvili Zaza
- Demirbas Eren
- Depalma Norma
- Di Buono Giuseppe
- Di Salvo Maria
- Dimov Stefan
- Dimova Ana
- Dinuzzi Vincenza Paola
- Díez-Alonso Manuel
- Domínguez Carlota López
- Dorken Ander
- Dos Barbeito Sandra
- Doudakmanis Christos
- Du Bois María Esther
- Dziakova Jana
- D’Acapito Fabrizio
- D’Alessio Rossella
- D’Ugo Stefano
- Echeverria-Rosario Karla
- Edwards Sara
- Egodage Tanya
- Elizalde Aurea Barbara Rodriguez
- Ercolani Giorgio
- Esposito Francesco
- Esposito Giuseppe
- Esposito Marialusia
- Estaire-Gómez Mercedes
- Fabbri Anna
- Fabbri Nicolò
- Farré Silvia Pérez
- Favi Francesco
- Felsenreich Daniel M.
- Feo Carlo V.
- Fernandes Urânia
- Fernández Rocio Torres
- Ferrara Francesco
- Ferrari Davide
- Ferreira Ana Rita Oliveira
- Ferreira Cátia
- Filippelli Alice
- Firat Necattin
- Fleres Francesco
- Florence Charlotte
- Fnaiech Iskander
- Fogato Luisella
- Fontana Michele
- Fradelos Evangelos
- Fraga Gustavo P.
- Fransvea Pietro
- Frontali Alice
- Frountzas Maximos
- Fumagalli Chiara
- Gachabayov Mahir
- Gambino Giovanni
- García Juan Jesús Rubio
- Garulli Gianluca
- Gasser Elisabeth
- Gattulli Domenico
- Gebran Anthony
- Germani Paola
- Gil-Martínez José
- Gioco Rossella
- Giraudo Giorgio
- Giuffrida Mario
- Gomes Carlos Augusto
- Gomes Felipe Couto
- Gomez Maite Santamaria
- Gonullu Emre
- Gonzaga Ricardo Alessandro Teixeira
- González-Castillo Ana María
- Goulart André
- Grassi Carmine
- Gràcia-Roman Raquel
- Guaitoli Eleonora
- Guercioni Gianluca
- Guerra Enrico
- Guerra Martina
- Guner Ali
- Gupta Rahul
- Hacım Nadir Adnan
- Hamid Hytham K. S.
- Hemmila Mark
- Hentati Hassen
- Hernandez Edgard Efren Lozada
- Hinojosa-Ugarte Diego
- Huguet Jose Mugüerza
- Hyman Theodore S.
- Iglesias Eva
- Ilhan Onur
- Inama Marco
- Ioannidis Orestis
- Isernia Roberta Maria
- Isik Arda
- Jakubauskas Matas
- Jalal-Eldin Sami
- Jimenez-Riera Granada
- Jimenez-Vega Javier
- Jiménez Beatriz Muñoz
- Jovine Elio
- Jusoh Asri Che
- Kafka-Ritsch Reinhold
- Kara Yasin
- Karavokyros Ioannis
- Katunin Jevgeni
- Kavalieratos George
- Kaya Tayfun
- Kchaou Ali
- Kechagias Aristotelis
- Kedar Asaf
- Khalil Hany
- Khan Mansoor
- Khanduri Archana
- Kimpizi Despina
- Kobe Yoshiro
- Kocataş Ali
- Kokkinakis Stamatios
- Korkolis Dimitrios
- Koukoulis Georgios
- Kovachev Nikola
- Koylu Zehra Alan
- Kruger Vitor F.
- Kryzauskas Marius
- Kuzeridis Harilaos
- Kwiatkowski Andrzej
- Lacko Vladimír
- Laforgia Rita
- Lantone Giuliano
- Lantone Giulio
- Lapolla Pierfrancesco
- Latifi Rifat
- Latorraca José
- Lauka Lelde
- Látečková Zuzana
- Leao Pedro
- Lecchi Francesca
- Leo Cosimo Alex
- Lepiane Pasquale
- Lepre Luca
- Lesko Dusan
- Letizia Laface
- Liasis Lampros
- Litvin Andrey
- Livrini Marco
- Lohsiriwat Varut
- Lombardi Raffaele
- Lopez Ana
- Lorusso Leonardo
- Lostoridis Eftychios
- Loutzidou Lydia
- Lovisetto Federico
- Lozano Rafael Calleja
- López Joaquín Ruiz
- López-Sánchez Jaime
- Luppi Davide
- Luzzi Andrea-Pierre
- Magnone Stefano
- Major Piotr
- Manatakis Dimitrios K.
- Manca Giuseppe
- Manigrasso Michele
- Manso Maria Isabel Cerqueira
- Mantoglu Baris
- Manunza Romina
- Margaris Ioannis
- Maria Sotiropoulou
- Marinis Athanasios
- Marino Fabio
- Maroulis Ioannis
- Marques Rita
- Martines Gennaro
- Martínez Manuel Durán
- Martínez-López Elías
- Martínez-Pérez Aleix
- Massucco Paolo
- Mazzini Federico N.
- McClure Amanda
- Meléndez L. Juan José
- Membrilla-Fernández Estela
- Memis Ufuk
- Mendoza-Moreno Fernando
- Mentz Ricardo
- Merabishvili Giorgi
- Meric Serhat
- Michalopoulos Nikolaos
- Micó Silvia Sevila
- Milone Marco
- Mingoli Andrea
- Miron Adrian
- Mitei Mercy
- Moller Elsa García
- Mongkhonsupphawan Aitsariya
- Monroy Jose maria Victor Palomo
- Monsellato Igor
- Morais Henrique Manuel Cardoso
- Morales-Sevillano Xavier
- Moreira Claudia Cristina Lopes
- Moreno Cristina Ruiz
- Moreno Verónica Polaino
- Moretto Gianluigi
- Morić Trpimir
- Mulita Francesk
- Muñoz-Campaña Anna
- Musa Nicola
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Napolitano Lena M.
- Nechay Taras
- Nicolás-López Tatiana
- Nisa Francisca García-Moreno
- Nita Gabriela Elisa
- Notarnicola Margherita
- Oliva Alba
- Olmi Stefano
- Omarov Nail
- Oragano Luigi
- Orio Gianluca
- Osella Giulia
- Oury Jeffrey
- Ozer Nazmi
- Ozkan Zeynep
- O’Sullivan Sara Nuñez
- Palini Gian Marco
- Palisi Marco
- Palmer Amanda
- Palmieri Francesco
- Palomba Giuseppe
- Panebianco Annunziata
- Panis Yves
- Pantalone Desire
- Panyko Arpád
- Papacostantinou Ioannis
- Papagni Vincenzo
- Papis Davide
- Pardo Pablo Sancho
- Parini Dario
- Parker Robert
- Patrocínio Sara Daniela Direito
- Pattacini Gianmaria Casoni
- Pauzas Henrikas
- Pavone Giovanna
- Pellino Gianluca
- Pelloni María
- Pereira Bela
- Pereira Bruno Monteiro
- Pereira Rita Gonçalves
- Perez Aintzane Lizarazu
- Perez Diego Pita
- Perrone Fabrizio
- Perrone Gennaro
- Pesce Antonio
- Petit Nuria Mestres
- Petracca Gabriele Luciano
- Petrakis Georgios
- Petropoulou Thalia
- Petruzzelli Luca
- Pezzoli Isabella
- Pezzolla Angela
- Pędziwiatr Michał
- Picardi Biagio
- Picariello Erika
- Picciariello Arcangelo
- Piccoli Micaela
- Picheo Roberto
- Pighin Marina
- Pignata Giusto
- Pinto Francisca Lima
- Pipia Irakli
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Pisarska-Adamczyk Magdalena
- Podda Mauro
- Polat Suleyman
- Polenta Eleni
- Polydorou Andreas
- Ponce Iñigo Augusto
- Pontarolo Nicholas
- Pontillo Marcelo
- Portale Giuseppe
- Poskus Tomas
- Prando Daniela
- Pujante Antonio
- Quick Jacob A.
- Quiodettis Martha
- Radonak Jozef
- Rahy-Martin Aida Cristina
- Rampini Alessia
- Rana Mridul
- Ranieri Valerio
- Ranketi Sinkeet
- Ratnasekera Asanthi
- Reames Summer
- Reddavid Rossella
- Reis Murat Emre
- Restini Enrico
- Reynaud Alejandro Bañon
- Ricci Claudio
- Riss Stefan
- Rivera-Alonso Daniel
- Rocha Catarina
- Rocha Ricardo
- Rodas María Elisa Valle
- Romacho-López Laura
- Ronconi Maurizio
- Roscio Francesco
- Rossi Giorgio
- Rossi Stefano
- Rottoli Matteo
- Roulet Maxime
- Ruiz Enrique Colás
- Russo Iris Shari
- Salazar Yeniffer Tatiana Moreno
- Salvans Silvia
- Sampietro Gianluca Matteo
- Sangji Naveen F.
- Sarnari Jlenia
- Sarro Giuliano
- Sartelli Massimo
- Sasia Diego
- Sánchez-Guillén Luis
- Scandroglio Ildo
- Scaramuzzo Rosa
- Schaffer Kathryn
- Scheiterle Maximilian
- Schifano Domenico
- Schizas Dimitrios
- Sebastián-Tomás Juan Carlos
- Seker Ahmet
- Sena Giuseppe
- Seng Sirivan Suon
- Serradilla-Martín Mario
- Sganga Gabriele
- Shimamura Fumihiko
- Siannis Ioannis
- Sierra Isabel Blesa
- Simó Ignacio Rey
- Singh Sudhir K.
- Sofia Silvia
- Solaini Leonardo
- Soltes Marek
- Spampinato Marcello
- Spinelli Stefano
- Spolini Alessandro
- Spolverato Ylenia
- Stylianos Kapiris
- Svagzdys Saulius
- Swaminathan Christie
- Syllaios Athanasios
- Tanzanu Marta
- Tarasconi Antonio
- Tartaglia Nicola
- Tasis Nikolaos
- Tebala Giovanni D.
- Termes-Serra Roser
- Theodorou Dimitrios
- Tian Brian W. C. A.
- Titos-García Alberto
- Tlili Ahmed
- Toma Elena Adelina
- Toma Takayuki
- Tonucci Tommaso Panici
- Torre Beatrice
- Torres Álvaro Naranjo
- Totaro Luigi
- Toutouzas Konstantinos
- Triantafyllou Tania
- Trigiante Giuseppe
- Troian Marina
- Trostchansky Ivan
- Truong Hung P.
- Tsouknidas Ioannis
- Tuncer Korhan
- Turrado-Rodriguez Victor
- Tyagunov Alexander
- Uccelli Matteo
- Usta Mehmet Arif
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- Valcárcel Cristina Rey
- Valle Naila Pagès
- Vallicelli Carlo
- Vassiliu Panteleimon
- Velmahos George
- Veneroni Simone
- Veroux Gastone
- Veroux Massimiliano
- Vincenti Leonardo
- Visconti Diego
- Vitón-Herrero Rebeca
- Walędziak Maciej
- Watfah Josef
- Wilson Michael
- Wong Michael Pak-Kai
- Xenaki Sofia
- Yuldashev Anvar
- Zakaria Andee Dzulkarnaen
- Zakaria Muhammad Nazreen
- Zakaria Zaidi
- Zanzi Federico
- Zelić Zdravko
- Zem Leticia Gonçalves
- Zese Monica
- Zilinskas Justas
- Zonta Sandro
- Zribi Imen
- Zuin Matteo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
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- Busch Robert
- Butrymowicz Patrycja
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- Luis M Ruilope
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- M Barendregt J N
- M van Leendert Ruud J
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- Patel Rakesh
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- Satirapoj Bancha
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- Sch\uf6nherr Hans-Robert
- Sch\ufcrholz Thomas
- Scheen Andr\ue9
- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
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- Seco Gilberto
- Seeber Mary
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- Shi Bingyin
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- Smuts Nine
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- Soe Kyaw
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- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
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- Sugiyama Toru
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- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
- T\ue4schner Heidrun
- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
- Tavli Talat
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- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
- Tennankore Karthik
- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
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- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
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- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
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- Vanbelleghem Hilde
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- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
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- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
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- Wang Lihua
- Wang Xinjun
- Wanner Christoph
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- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Barradas-Pires
- Ana Carolina Mgn de Sá
- Ana D González-Alvarez
- Ana Henriques
- Ana I Rito
- Ana Jelaković
- Ana Maria B Menezes
- Ana P Ortiz
- Ana Paula C Cândido
- Anabela Mota-Pinto
- Anar Dushpanova
- Anastasia Markaki
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andrea Gazzinelli
- Andrea Gualtieri
- Andrea Rodriguez-Martinez
- Andrea Rvr Horimoto
- Andrea Schneider
- Andrea Y Rodríguez
- Andrea Zentai
- Andreas Stang
- Andreia N Pizarro
- Andrew Kingston
- Andrew Reynolds
- Andrew Wong
- Andrzej Galbarczyk
- Andrzej Pająk
- Andrzej Więcek
- Anelise Reis Gaya
- Aneta Grajda
- Aneta Weres
- Anette Varbo
- Angel R Gonzalez
- Angela Chetrit
- Angela Döring
- Angela Spinelli
- Angelika Schaffrath Rosario
- Angelique Chan
- Angélica M Ochoa-Avilés
- Anie Marcil
- Anil Poudyal
- Anja L Madsen
- Anja Schienkiewitz
- Anna Bartosiewicz
- Anna Bugge
- Anna Fijalkowska
- Anna Jansson
- Anna V Alieva
- Annamari Lundqvist
- Anne A Bjerregaard
- Anne Chinnock
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette J Dobson
- Annette Peters
- Annika Rosengren
- Anthony Kafatos
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonio M Silva
- Antonio Mistretta
- Antonio Pedro Graça
- Antonio Prista
- Antonis Zampelas
- Antonisamy Belavendra
- Anu Mishra
- Anwar M Batieha
- Archie W Rayner
- Areti Triantafyllou
- Argyro Karakosta
- Ari Voutilainen
- Aristides M Machado-Rodrigues
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Arsalan Khaledifar
- Artur Mazur
- Arvind Pandey
- Arwa M Alshangiti
- Aryeh D Stein
- Asher Fawwad
- Attilio Rigotti
- Atul Trivedi
- Augustin F Beybey
- Augustine N Odili
- Augusto Di Castelnuovo
- Aung Soe Htet
- Ausra Petrauskiene
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- Axel C Carlsson
- Aya Mostafa
- Ayman A Zayed
- Azaliia M Tuliakova
- Azhar Dyussupova
- Azim Nejatizadeh
- Azli Baharudin
- Åsa Ågren
- Badreya Al-Lahou
- Bagher Larijani
- Bahareh Kheiri
- Bahman Cheraghian
- Bakary Jallow
- Baltazar Nunes
- Barbara Heude
- Barbara Thorand
- Barry M Popkin
- Batyrbek Assembekov
- Beatriz D Schaan
- Bee Koon Poh
- Behrooz Hamzeh
- Bekbolat Zholdin
- Belgin Unal
- Belong Cho
- Ben Schöttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Benson M Kazembe
- Bente Sparboe-Nilsen
- Bernard Maire
- Bernardo L Horta
- Bernhard O Boehm
- Bert-Jan van den Born
- Bettina Bringolf-Isler
- Bharathi Viswanathan
- Bhawesh Koirala
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Bing Zhang
- Birgit Linkohr
- Biruta Velika
- Blanca Sandra Ruiz-Betancourt
- Bo Werner
- Boban Mugoša
- Bogdan Wojtyniak
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- Bontha V Babu
- Boyd A Swinburn
- Börge Schmidt
- Branimir Leskošek
- Breige A McNulty
- Brian Oldenburg
- Brooklyn Fraser
- Bruna Gonçalves Cordeiro da Silva
- Buthaina M Alkhatib
- Børge G Nordestgaard
- Caleb Ochimana
- Calogero Saieva
- Calvin Ke
- Camilla T Damsgaard
- Carl Lachat
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- Carlo Maria Barbagallo
- Carlos A Aguilar-Salinas
- Carlos O Mendivil
- Carlos P Boissonnet
- Carmen Iñiguez
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Caroline Ramos de Moura Silva
- Carsten O Schmidt
- Cassiano Ricardo Rech
- Catherine Kyobutungi
- Catterina Ferreccio
- Cecilia Björkelund
- Cecily Kelleher
- Cesar G Victora
- Cézane P Reuter
- Chandini Nekkantti
- Chao Qiang Jiang
- Charalambos A Hadjigeorgiou
- Charles Agyemang
- Charles K Mondo
- Charles Lunogelo
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- Charlie Lim
- Charlotte B Ottendahl
- Charmaine A Duante
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
- Ching-Yu Cheng
- Chinh Nguyen Huu
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- Chongjian Wang
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- Christophe Tzourio
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- Cihangir Erem
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- Clara Homs
- Claudia M Hormiga
- Cláudia S Minderico
- Clicerio González-Villalpando
- Clive Osmond
- Coimbatore Subramaniam Shanthirani
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- Constanta Huidumac Petrescu
- Cora L Craig
- Correia Júnior Marco Aurélio de Valois
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- Crizian G Saar
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- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
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- Daniel Ferrante
- Daniel G Vasques
- Daniel Lemogoum
- Daniel Weghuber
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- Daphne Lai
- Daphne Mirkopoulou
- David A Gonzalez-Chica
- David De Ridder
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- Davide Noto
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- Deena Al Asfoor
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- Dermot O'Reilly
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- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego Salmerón
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- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Dominique Cottel
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- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris Stöckl
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- Dušan Grafnetter
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- Emmanuella Magriplis
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- Ethel Santacruz
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- Eunice Ugel
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- Kyungwon Oh
- Labros S Sidossis
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- Lacramioara Brinduse
- Laetitia Huiart
- Laila El Ammari
- Lalka S Rangelova
- Lariane M Ono
- Larissa Pruner Marques
- Lars Ängquist
- Lars Bo Andersen
- Lars Jøran Kjerpeseth
- Lars Lind
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- Wei-Cheng Lo
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- Weili Yan
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- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira Briceño
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3) : analysis of individual data from 258 cancer registries in 61 countries
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- Publication venue
- The Lancet Publishing Group
- Publication date
- 01/01/2022
- Field of study
Background Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed
data for children (aged 0–14 years) and adults (aged 15–99 years) diagnosed with a haematological malignancy
during 2000–14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and
morphology, in young patients (aged 0–24 years).
Methods We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3
that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0–14 years),
adolescents (15–19 years), and young adults (20–24 years). We categorised leukaemia subtypes according to the
International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases
for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs,
using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by
country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age
survival estimates were standardised to the marginal distribution of young people with leukaemia included in the
analysis.
Findings 164563 young people were included in this analysis: 121328 (73·7%) children, 22963 (14·0%) adolescents, and
20272 (12·3%) young adults. In 2010–14, the most common subtypes were lymphoid leukaemia (28205 [68·2%] patients)
and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and
young adults for all leukaemias combined during 2010–14 varied widely, ranging from 46% in Mexico to more than
85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better
age-standardised survival (from 43% in Ecuador to ≥80% in parts of Europe, North America, Oceania, and Asia) than
those with acute myeloid leukaemia (from 32% in Peru to ≥70% in most high-income countries in Europe,
North America, and Oceania). Throughout 2000–14, survival from all leukaemias combined remained consistently
higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young
adults in most countries.
Interpretation This study offers the first worldwide picture of population-based survival from leukaemia in children,
adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower
survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators
of the quality of cancer management in this age group.peer-reviewe
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
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- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
- Theivendran Kanthan
- Thekkinkattil Dinesh
- Theochari Nikoletta
- Theodoropoulos George
- Theophilidou Elena
- Thereska Dariel
- Thiruchandran Gajendiran
- Thomakos Nikolaos
- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
- Tirloni Luca
- Toia Francesca
- Tokidis Evripidis
- Tokocin Merve
- Tolani Musliu Adetola
- Toma Elena Adelina
- Tomasicchio Giovanni
- Tomlinson James
- Tonini Valeria
- Torre Beatrice
- Torregrosa Cristina
- Torun Bahar Canbay
- Tottman R.
- Tousidonis Manuel
- Trabulsi Nora
- Tranca Sebastian
- Trebol Jacobo
- Trejo-Avila Mario
- Triantafyllou Alexandra
- Triantafyllou Tania
- Trifunovski Aleksandar
- Tripathi Manjul
- Tripathi Prashant
- Tripathy Sujit
- Trivik-Barrientos Felipe
- Trostchansky Ivan
- Trulson Alexander
- Trungu Sokol
- Truss Adam
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsiantoula Paraskevi
- Tsironis Dimitrios
- Tsolakidis Alexandros
- Tsoulfas Georgios
- Tucker Olga
- Tuech Jean Jacques
- Turan Alparslan
- Turi Stefano
- Turna Akif
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
- Valadez Andrea Estefania Cueto
- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
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