Interactive book reading to accelerate word learning in bilingual children with developmental language disorder: A preliminary intervention approach

This article will describe a bilingual preliminary treatment method currently being utilized in a clinical research study to teach vocabulary to bilingual (Spanish/English) preschool aged (four to six year-old) children with Developmental Language Disorder (DLD). The objective of this treatment method is to advance English vocabulary while supporting the native language abilities of English Learners (ELs). In this bilingual treatment method, Spanish and English are used within the session, which includes the reading of books in English and Spanish and the teaching of vocabulary in English and Spanish

Interactive Book Reading to Accelerate Word Learning in Bilingual Children with Specific Language Impairment

The current project sought to add to the limited body of research on treatment for native Spanish-speaking English language learners (ELLs) with language impairments. In particular, the current study explored the effectiveness of three bilingual treatment methods aimed at increasing the vocabulary knowledge of ELLs in English and Spanish. The goal was to find an appropriate treatment method that advances English and Spanish vocabulary while supporting an ELL’s bilingual abilities. Typically, ELLs with language impairment receive intervention only in the majority language (English) due to the limited availability of bilingual speech-language pathologists (SLPs). As a result, although gains may be made in English, the attrition of the first language (L1) may occur due to the lack of support of the L1 during treatment. In the current study, different combinations of English and Spanish were utilized in order to get closer to determining the most appropriate amount or intensity of the L1 to use as a means to increase an ELL’s English and Spanish vocabulary knowledge. Native Spanish-speaking preschool-aged ELLs with language impairments participated in a storybook-reading intervention study aimed at increasing vocabulary knowledge. The children were randomized into one of three bilingual treatment groups, which included two blocking conditions and a bridging condition. Treatment took place three to four days per week for a total of 26 sessions. In both blocking conditions, the language of intervention (Spanish/English) alternated on each day. In one blocking condition (Blocking: English First), English was used on the first day, followed by Spanish in day two, English on day three, and Spanish on day four. The other blocking condition (Blocking: Spanish First) was the opposite of the first one and, therefore, began with Spanish on day one. The Bridging condition consisted of treatment provided in English and Spanish during each session, with the percentage of each language use alternating on each day, such that on days one and three, approximately 75% Spanish and 25% English were used, and on days two and four, approximately 75% English and 25% Spanish were used. Measurements of the children’s vocabulary knowledge were taken in English and Spanish immediately after each session to determine how much vocabulary learning took place in both languages. The results of the current study suggest that the Blocking: Spanish First condition was ineffective at increasing vocabulary knowledge in English and Spanish, the Blocking: English First condition was effective at increasing vocabulary knowledge in English only, and the Bridging condition was the most effective at promoting vocabulary growth in both English and Spanish in ELL preschoolers with SLI

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms is observed in the majority of HNSCCs. Here, we unveiled a ΔNp63-dependent transcriptional program able to regulate the metabolism and the signaling of hyaluronic acid (HA), the major component of the extracellular matrix (ECM). We found that ∆Np63 is capable of sustaining the production of HA levels in cell culture and in vivo by regulating the expression of the HA synthase HAS3 and two hyaluronidase genes, HYAL-1 and HYAL-3. In addition, ∆Np63 directly regulates the expression of CD44, the major HA cell membrane receptor. By controlling this transcriptional program, ∆Np63 sustains the epithelial growth factor receptor (EGF-R) activation and the expression of ABCC1 multidrug transporter gene, thus contributing to tumor cell proliferation and chemoresistance. Importantly, p63 expression is positively correlated with CD44, HAS3, and ABCC1 expression in squamous cell carcinoma datasets and p63-HA pathway is a negative prognostic factor of HNSCC patient survival. Altogether, our data shed light on a ∆Np63-dependent pathway functionally important to the regulation of HNSCC progression

Gestion de recursos de informacion un enfoque historico

95 p.Así como las empresas administran sus recursos financieros, sus recursos físicos, sus recursos humanos, etc. para mejorar su productividad y competitividad, hoy en día los Recursos de Información se reconocen como una herramienta competitiva y también requieren de ser administrados eficientemente. La actividad informática se expande progresivamente en la empresa, cubriendo casi todas las actividades operacionales y desplazándose a los niveles tácticos y estratégicos. Nuestro enfoque de trabajo estará determinado por las directrices de la teoría de la administración, con el fin de establecer un formato metodológico que permita obtener un compendio de gestión de recursos de información, con una estructura semejante al establecido para otros recursos de la empresa. Todo lo anterior, descrito bajo el enfoque histórico que ha sufrido la introducción del computador en la empresa, a partir de los años sesenta, primero bajo el paradigma de Procesamiento de Datos, que concibe al computador como un medio de automatización de actividades rutinarias, luego, el enfoque de los Sistemas de Información Administrativos, que ayudaron a mejorar la efectividad en la administración, para llegar al enfoque Estratégico, donde los recursos de información cambiaron fundamentalmente la forma como manejar los negocios. La estructura del trabajo se divide en cuatro capítulos. El primer capitulo es de carácter teórico y nos introduce en los principales conceptos de la administración. El segundo capitulo se enfoca en la identificación y conceptualización de los componentes del termino recursos de información. El tercer capitulo se refiere a la evolución sufrida desde la introducción en las organizaciones de las aplicaciones computacionales hasta el use estratégico que hoy se hace de ellas. El cuarto capitulo comprende la identificación de los elementos de gestión aplicados al dominio de los recursos de información, con un enfoque evolutivo histórico

The Long Non-Coding RNA NEAT1 Is a ΔNp63 Target Gene Modulating Epidermal Differentiation

The transcription factor ΔNp63 regulates epithelial stem cell function and maintains the integrity of stratified epithelial tissues by acting as transcriptional repressor or activator towards a distinct subset of protein-coding genes and microRNAs. However, our knowledge of the functional link between ∆Np63 transcriptional activity and long non-coding RNAs (lncRNAs) expression is quite limited. Here, we show that in proliferating human keratinocytes ∆Np63 represses the expression of the lncRNA NEAT1 by recruiting the histone deacetylase HDAC1 to the proximal promoter of NEAT1 genomic locus. Upon induction of differentiation, ∆Np63 down-regulation is associated by a marked increase of NEAT1 RNA levels, resulting in an increased assembly of paraspeckles foci both in vitro and in human skin tissues. RNA-seq analysis associated with global DNA binding profile (ChIRP-seq) revealed that NEAT1 associates with the promoter of key epithelial transcription factors sustaining their expression during epidermal differentiation. These molecular events might explain the inability of NEAT1-depleted keratinocytes to undergo the proper formation of epidermal layers. Collectively, these data uncover the lncRNA NEAT1 as an additional player of the intricate network orchestrating epidermal morphogenesis

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe