Coverage of the 2011 Q fever vaccination campaign in the Netherlands, using retrospective population-based prevalence estimation of cardiovascular risk-conditions for chronic Q fever

Background: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking, standing in the way of adequate planning and coverage estimation. We aimed to obtain prevalence rates retrospectively in order to estimate coverage of the Q fever vaccination campaign. Methods: With broad search terms for these predefined risk-conditions, we extracted patient-records from a large longitudinal general-practice research-database in the Netherlands (IPCI-database). Afte

Coverage of the 2011 Q fever vaccination campaign in the Netherlands, using retrospective population-based prevalence estimation of cardiovascular risk-conditions for chronic Q fever

Background: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking, standing in the way of adequate planning and coverage estimation. We aimed to obtain prevalence rates retrospectively in order to estimate coverage of the Q fever vaccination campaign. Methods: With broad search terms for these predefined risk-conditions, we extracted patient-records from a large longitudinal general-practice research-database in the Netherlands (IPCI-database). Afte

Generalized Molluscum Contagiosum Successfully Treated with Interferon-Alpha in a Patient with Folliculotropic Mycosis Fungoides

We present the case of a 50-year-old patient with folliculotropic mycosis fungoides (FMF) unresponsive to retinoids and the chemotherapeutic regimens CHOP, gemcitabine, and brentuximab-vedotin. During immunosuppressive therapy, the patient developed extensive progressive molluscum contagiosum. The mollusca did not respond to topical imiquimod but showed a swift complete response to interferon-alpha 2a (IFNa). Recently, the patient started with alemtuzumab as induction therapy for an allogenic stem cell transplantation and simultaneously continued IFNa therapy

Cultural Heritage:From Soestdijk Palace to Sinterklaas

This course gives an overview of the field of cultural heritage

Adopted children’s behavioral adjustment over time: Pre-adoption experiences and adoptive parenting

We tested whether adoptive parenting played a role in the association between pre-adoption experiences and children’s adaptive (responsiveness) and maladaptive (internalizing and externalizing behavioral problems, attention and sleep problems) behavioral adjustment over time. Ten-year-old girls, adopted at 13 months from institutional care (n = 50) or foster care (n = 42) in China to the Netherlands, participated 2 months (Time 1, N = 92), 6 months (Time 2, N = 92), and 9 years after adoption (Time 3, N = 87). At Times 1 and 2, the adoptees showed significantly fewer behavioral problems in many areas than non-adopted youth, with medium to large effect sizes. At Time 3, the adoptees showed similar rates of behavioral problems as non-adopted youth, with the exception of somewhat elevated levels of internalizing problems. Pre-adoption experiences were not associated with their behavioral adjustment. Furthermore, adoptive parenting did not moderate the association between pre-adoption experiences and behavioral adjustment over time. Nevertheless, the finding that the adoptees generally did not show above-average levels of behavioral problems illustrates that adoption had a positive impact on their development.status: publishe

Children’s Catch-up in Cognitive Competence after Adoption

status: publishe

Remarkable cognitive catch-up in Chinese adoptees nine years after adoption

We investigated (1) whether 10-year-old internationally adopted Chinese girls who, on average, showed below-average intellectual functioning two and six months after adoption (Times 1–2, N = 92), showed catch-up in intellectual functioning, school achievement, and executive functioning nine years later (Time 3, N = 87). We tested (2) effects of type of pre-adoption care (institutional versus foster care), and effects of parental sensitivity (factor score for supportive presence and for intrusiveness compiling all three time points), and we examined (3) whether the latter buffered the effects of type of care. The children showed significant recovery and complete catch-up in intellectual functioning at Time 3, and did not lag behind at school compared to non-adopted children. Contrary to the results of Times 1 and 2, type of care was not associated with cognitive development at Time 3. Parental sensitivity did not buffer the link between type of care and cognitive development.status: Published onlin

Performance of the Brighton collaboration case definition for hypotonic-hyporesponsive episode (HHE) on reported collapse reactions following infant vaccinations in the Netherlands.

We reviewed collapse (sudden onset of pallor, limpness and hyporesponsiveness) following the first infant (DPTP+Hib) vaccination reported to the enhanced passive surveillance system of the Netherlands in 1994-2003. All 1303 reports identified by the current RIVM (National Institute for Public Health and Environment) case definition were captured by the Brighton Collaboration (BC) case definition, with in 17 (1.3%) reports insufficient information. Over the years the proportion of the highest level of diagnostic certainty (level 1) increased due to more complete data from 70% to over 90%. We checked the BC case definition also on a sample of cases (with pallor or hyporesponsiveness) not meeting RIVM's case definition for collapse at the time. Sixty out of 200 cases were captured by BC but again rejected by RIVM. The sensitivity BC levels 2 and 3 appeared too high. We recommend a more restrict case definition by the Brighton Collaboration with certain exclusion criteria to make it more specific. Furthermore a change in the specifications for levels 2 and 3 will increase specificity and accommodate for the loss of sensitivity