Mitigatory Effects of Quercetin on Bisphenol A-Induced Oxidative Stress in Testis of Swiss Albino Mice

Background: Bisphenol A is a well-known xenoestrogen, mainly used in plastics and food can liners manufacture. Hence, it becomes an integral part of the food chain. Experimental studies shows negative health effects. Quercetin is one of the most effective antioxidants of the flavonoids, generally present in food stuff. The present study was an attempt to assess the mitigatory effects of quer on BPA–induced reduction in fertility of mice.Materials and methods: Inbred male Swiss strain albino mice were orally administered with various doses of BPA for 45 days. In another experiment quer along with high dose of BPA was administered to study the mitigatory consequence.Result: Administration of BPA caused significant (P0.05) and dose-dependent increase in oxidative stress compared to control groups. Administration of quer along with high dose of BPA caused amelioration in enzymatic and non-enzymatic antioxidant. Histopathological alteration was also seen in BPA treated groups, which were ameliorated on administration of quer.Conclusion: Quer is potent enough to mitigate the toxic effect of BPA. Biochemical alteration was mitigated by quer and dose dependent increase in fertility was observed

Rhizobacterial influence on healthy stand establishment of canola grown in Rhizoctonia solani infested fields of Saskatchewan

Non-Peer ReviewedPre-emergence seedling damping-off, seedling blight, and brown girdling root rot caused by R. solani are important diseases of canola/rape seed in western Canada. Annual yield losses in excess of 20-30% have been reported in several infected fields. Cultural control methods or resistant cultivars are currently unavailable for these diseases. Chemical fungicides have been developed for use to control the disease, but the success rate has been varied. However, the use of chemicals is becoming less acceptable from an environmental point of view. Several studies indicated that biological control using plant growth promoting rhizobacteria may also be effective in controlling R. solani. Field plots were established in Saskatoon, Regina and Melfort, SK, in 1990, 1991 and 1992 to evaluate the potential of rhizobacterial strains as seed treatments to increase the healthy stand of canola CV. Westar grown in R. solani infested field. The bacteria were formulated either in sterile peat or in a liquid carrier and applied to seed just before planting. Bacterized seed were mechanically planted in replicated field plots artificially infested with R. solani. Final healthy stand was measured 30 days after planting. Grain yields were determined by harvesting the plots. Seed bacterization significantly increased the final healthy stand compared to non-bacterized controls. Strains which increased stand showed in vitro antagonistic activity to not only R. solani but also other pathogens such as Pythium ultimum, Fusarium solani and F. oxysporum. Some of these strains induced root elongation of canola under laboratory conditions. Rhizosphere colonization, chemical compatibility and shelf-life of the important bacteria will be discussed

The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis

The structure of the MarR-family regulator NMB1585 from N. meningitidis has been solved using data extending to 2.1 Å resolution

Herschel-ATLAS: The angular correlation function of submillimetre galaxies at high and low redshift

Original article can be found at: http://www.aanda.org/ Copyright The European Southern ObservatoryWe present measurements of the angular correlation function of galaxies selected from the first field of the H-ATLAS survey. Careful removal of the background from galactic cirrus is essential, and currently dominates the uncertainty in our measurements. For our 250 μm-selected sample we detect no significant clustering, consistent with the expectation that the 250 μm-selected sources are mostly normal galaxies at z 1. For our 350 μm and 500 μm-selected samples we detect relatively strong clustering with correlation amplitudes A of 0.2 and 1.2 at 1', but with relatively large uncertainties. For samples which preferentially select high redshift galaxies at z~2–3 we detect significant strong clustering, leading to an estimate of r0 ~ 7–11 h-1 Mpc. The slope of our clustering measurements is very steep, δ ~ 2. The measurements are consistent with the idea that sub-mm sources consist of a low redshift population of normal galaxies and a high redshift population of highly clustered star-bursting galaxies.Peer reviewe

Mask formulas for cograssmannian Kazhdan-Lusztig polynomials

We give two contructions of sets of masks on cograssmannian permutations that can be used in Deodhar's formula for Kazhdan-Lusztig basis elements of the Iwahori-Hecke algebra. The constructions are respectively based on a formula of Lascoux-Schutzenberger and its geometric interpretation by Zelevinsky. The first construction relies on a basis of the Hecke algebra constructed from principal lower order ideals in Bruhat order and a translation of this basis into sets of masks. The second construction relies on an interpretation of masks as cells of the Bott-Samelson resolution. These constructions give distinct answers to a question of Deodhar.Comment: 43 page

Intercomparison of an Aerosol Chemical Speciation Monitor (ACSM) with ambient fine aerosol measurements in downtown Atlanta, Georgia

Currently, there are a limited number of field studies that evaluate the long-term performance of the Aerodyne Aerosol Chemical Speciation Monitor (ACSM) against established monitoring networks. In this study, we present seasonal intercomparisons of the ACSM with collocated fine aerosol (PM_2.5) measurements at the Southeastern Aerosol Research and Characterization (SEARCH) Jefferson Street (JST) site near downtown Atlanta, GA, during 2011–2012. Intercomparison of two collocated ACSMs resulted in strong correlations (<i>r</i>² > 0.8) for all chemical species, except chloride (<i>r</i>² = 0.21) indicating that ACSM instruments are capable of stable and reproducible operation. In general, speciated ACSM mass concentrations correlate well (<i>r</i>² > 0.7) with the filter-adjusted continuous measurements from JST, although the correlation for nitrate is weaker (<i>r</i>² = 0.55) in summer. Correlations of the ACSM NR-PM₁ (non-refractory particulate matter with aerodynamic diameter less than or equal to 1 μm) plus elemental carbon (EC) with tapered element oscillating microbalance (TEOM) PM_2.5 and Federal Reference Method (FRM) PM₁ mass are strong with <i>r</i>² > 0.7 and <i>r</i>² > 0.8, respectively. Discrepancies might be attributed to evaporative losses of semi-volatile species from the filter measurements used to adjust the collocated continuous measurements. This suggests that adjusting the ambient aerosol continuous measurements with results from filter analysis introduced additional bias to the measurements. We also recommend to calibrate the ambient aerosol monitoring instruments using aerosol standards rather than gas-phase standards. The fitting approach for ACSM relative ionization for sulfate was shown to improve the comparisons between ACSM and collocated measurements in the absence of calibrated values, suggesting the importance of adding sulfate calibration into the ACSM calibration routine

Non-monotonic variation with salt concentration of the second virial coefficient in protein solutions

The osmotic virial coefficient $B_2$ of globular protein solutions is calculated as a function of added salt concentration at fixed pH by computer simulations of the ``primitive model''. The salt and counter-ions as well as a discrete charge pattern on the protein surface are explicitly incorporated. For parameters roughly corresponding to lysozyme, we find that $B_2$ first decreases with added salt concentration up to a threshold concentration, then increases to a maximum, and then decreases again upon further raising the ionic strength. Our studies demonstrate that the existence of a discrete charge pattern on the protein surface profoundly influences the effective interactions and that non-linear Poisson Boltzmann and Derjaguin-Landau-Verwey-Overbeek (DLVO) theory fail for large ionic strength. The observed non-monotonicity of $B_2$ is compared to experiments. Implications for protein crystallization are discussed.Comment: 43 pages, including 17 figure

Intercomparison of an Aerosol Chemical Speciation Monitor (ACSM) with ambient fine aerosol measurements in downtown Atlanta, Georgia

Currently, there are a limited number of field studies that evaluate the long-term performance of the Aerodyne Aerosol Chemical Speciation Monitor (ACSM) against established monitoring networks. In this study, we present seasonal intercomparisons of the ACSM with collocated fine aerosol (PM2.5) measurements at the Southeastern Aerosol Research and Characterization (SEARCH) Jefferson Street (JST) site near downtown Atlanta, GA, during 2011–2012. Intercomparison of two collocated ACSMs resulted in strong correlations (r2 > 0.8) for all chemical species, except chloride (r2 = 0.21) indicating that ACSM instruments are capable of stable and reproducible operation. In general, speciated ACSM mass concentrations correlate well (r2 > 0.7) with the filter-adjusted continuous measurements from JST, although the correlation for nitrate is weaker (r2 = 0.55) in summer. Correlations of the ACSM NR-PM1 (non-refractory particulate matter with aerodynamic diameter less than or equal to 1 μm) plus elemental carbon (EC) with tapered element oscillating microbalance (TEOM) PM2.5 and Federal Reference Method (FRM) PM1 mass are strong with r2 > 0.7 and r2 > 0.8, respectively. Discrepancies might be attributed to evaporative losses of semi-volatile species from the filter measurements used to adjust the collocated continuous measurements. This suggests that adjusting the ambient aerosol continuous measurements with results from filter analysis introduced additional bias to the measurements. We also recommend to calibrate the ambient aerosol monitoring instruments using aerosol standards rather than gas-phase standards. The fitting approach for ACSM relative ionization for sulfate was shown to improve the comparisons between ACSM and collocated measurements in the absence of calibrated values, suggesting the importance of adding sulfate calibration into the ACSM calibration routine

Large-Eddy Simulations of Magnetohydrodynamic Turbulence in Heliophysics and Astrophysics

We live in an age in which high-performance computing is transforming the way we do science. Previously intractable problems are now becoming accessible by means of increasingly realistic numerical simulations. One of the most enduring and most challenging of these problems is turbulence. Yet, despite these advances, the extreme parameter regimes encountered in space physics and astrophysics (as in atmospheric and oceanic physics) still preclude direct numerical simulation. Numerical models must take a Large Eddy Simulation (LES) approach, explicitly computing only a fraction of the active dynamical scales. The success of such an approach hinges on how well the model can represent the subgrid-scales (SGS) that are not explicitly resolved. In addition to the parameter regime, heliophysical and astrophysical applications must also face an equally daunting challenge: magnetism. The presence of magnetic fields in a turbulent, electrically conducting fluid flow can dramatically alter the coupling between large and small scales, with potentially profound implications for LES/SGS modeling. In this review article, we summarize the state of the art in LES modeling of turbulent magnetohydrodynamic (MHD) ows. After discussing the nature of MHD turbulence and the small-scale processes that give rise to energy dissipation, plasma heating, and magnetic reconnection, we consider how these processes may best be captured within an LES/SGS framework. We then consider several special applications in heliophysics and astrophysics, assessing triumphs, challenges,and future directions