O OLHAR DA MULHER CIGANA: A FOTOGRAFIA HÍBRIDA COMO INSTRUMENTO DE COMUNICAÇÃO, REFLEXÃO E MUDANÇAS

Apesar dos avanços em termos legais e políticos em defesa dos princípios da igualdade, o problema da desigualdade de género e da violência contra a mulher persistem a nível global. Portugal, está abaixo da média europeia nos índices sobre igualdade de género e lidera o ranking dos países europeus em violência doméstica. Vivemos em uma sociedade regulada por princípios misóginos, machistas e patriarcais, que invalidam e menosprezam a atuação das mulheres no meio social, tendo relação direta com o desequilíbrio nas relações de poder estabelecido entre homens e mulheres. Em algumas culturas a marca desses preceitos estão fortemente enraizadas na expressão das tradições, como é o caso da etnia cigana, na qual as suas leis constituem um código de conduta que estrutura as práticas sociais e regula as ações de crianças, jovens e adultos, sendo afirmado desde a infância os valores de submissão das mulheres a autoridade masculina. Com o objetivo de combater essas normas estigmatizantes, além de promover a autoperceção e o bem-estar das participantes, este projeto de intervenção se beneficiou da arte, em especial da fotografia híbrida, como vetor de construção de uma consciência crítica e libertadora ao apresentar as participantes a fotografia como instrumento de comunicação, reflexão e mudanças, através de uma abordagem artística-terapêutica. O projeto utilizou como metodologia de pesquisa a a/r/tografia, que explora a compreensão da experiência do investigador enquanto artista/pesquisador/professor e coloca a criatividade à frente do processo de pesquisa incentivando novas maneiras de interpretar questões teóricas e práticas. Espera-se que essa pesquisa possa contribuir com algumas indicações sobre as especificidades da intervenção com mulheres de etnia cigana no contexto em questão, bem como possíveis sugestões para a sua replicabilidade em projetos futuros

Innate Memory Reprogramming by Gold Nanoparticles Depends on the Microbial Agents That Induce Memory

Inmunidad innata; Agentes microbianos; NanopartículasInnate immunity; Microbial agents; NanoparticlesImmunitat innata; Agents microbians; NanopartículesInnate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. Here, we have evaluated the capacity of engineered gold nanoparticles (AuNPs) to induce a memory response or to modulate the memory responses induced by microbial agents. Microbial agents used were in soluble vs. particulate form (MDP and the gram-positive bacteria Staphylococcus aureus; β-glucan and the β-glucan-producing fungi C. albicans), and as whole microrganisms that were either killed (S. aureus, C. albicans) or viable (the gram-negative bacteria Helicobacter pylori). The memory response was assessed in vitro, by exposing human primary monocytes from 2-7 individual donors to microbial agents with or without AuNPs (primary response), then resting them for 6 days to allow return to baseline, and eventually challenging them with LPS (secondary memory response). Primary and memory responses were tested as production of the innate/inflammatory cytokine TNFα and other inflammatory and anti-inflammatory factors. While inactive on the response induced by soluble microbial stimuli (muramyl dipeptide -MDP-, β-glucan), AuNPs partially reduced the primary response induced by whole microorganisms. AuNPs were also unable to directly induce a memory response but could modulate stimulus-induced memory in a circumscribed fashion, limited to some agents and some cytokines. Thus, the MDP-induced tolerance in terms of TNFα production was further exacerbated by co-priming with AuNPs, resulting in a less inflammatory memory response. Conversely, the H. pylori-induced tolerance was downregulated by AuNPs only relative to the anti-inflammatory cytokine IL-10, which would lead to an overall more inflammatory memory response. These effects of AuNPs may depend on a differential interaction/association between the reactive particle surfaces and the microbial components and agents, which may lead to a change in the exposure profiles. As a general observation, however, the donor-to-donor variability in memory response profiles and reactivity to AuNPs was substantial, suggesting that innate memory depends on the individual history of exposures.This work was supported by the EU Commission H2020 projects PANDORA (GA 671881) and ENDONANO (GA 812661), the Italian MIUR InterOmics Flagship projects MEMORAT and MAME, the Italian MIUR/PRIN-20173ZECCM, the Priority program ACBN (Allergy Cancer BioNano Research Centre) of the University of Salzburg, the Cancer Cluster Salzburg, the Research Grant from the University of Salzburg, and the Austrian Science Fund (FWF) Grant Nr. P 29941

Análisis de la cadena de valor de la ganadería bovina en Oxapampa- Pasco-Perú

El objetivo principal de este trabajo de investigación es analizar la cadena de valor de la ganadería bovina en la provincia de Oxapampa-Pasco-Perú. Ello con el fin de identificar los factores que permitirán aumentar la competitividad de la cadena y, en base a ellos, plantear recomendaciones que permitan reducir las brechas identificadas, así como aprovechar e impulsar oportunidades de mejoras en los procesos. El estudio de la cadena de valor de la ganadería bovina es relevante debido a que representa el 40% del PBA (Producto Bruto Agrario) y es la mayor fuente de ingreso de la población rural en el país. Además, es relevante por el potencial ganadero poco aprovechado que hay en el país, específicamente en la zona de Oxapampa Para ello, se analizará la ganadería bovina de Oxapampa usando una perspectiva de cadena de valor y el Manual Valuelinks 2.0 desarrollado por la Deutsche Gesellschaft Für Internationale Zusammenarbit (GIZ) como herramienta de análisis. Será en base a la metodología ValueLinks que se dará a conocer la estructura de la cadena, sus actores participantes, las relaciones existentes entre ellos y la generación de valor agregado en cada fase del proceso de producción de carne, en la cual se centrará la presente investigación entre todos los productos y subproductos provenientes del bovino. El análisis se concentró en cuatro variables que permitieron entender el estado actual de la cadena de valor de la ganadería bovina en Oxapampa y concluir que el desarrollo de una o más de estas variables permitirá un aumento de la competitividad en la cadena de valor. Dichas variables son; el aumento de la producción, rendimiento y calidad, el desarrollo de modelos ecosostenibles, una mayor inserción al mercado de los ganaderos y la mejora de servicios operacionales. En ese sentido, se plantearon 3 recomendaciones que promovieran el desarrollo de la ganadería bovina en Oxapampa en función de dichas variables. Estas fueron la creación de un cluster ganadero, la implementación de un centro de engorde en Oxapampa y el desarrollo de los sistemas silvopastoriles

Separation and characterization of nonphosphorylated and serine-phosphorylated urokinase. Catalytic properties and sensitivity to plasminogen activator inhibitor type 1.

Urokinase synthesized by human A431 epidermoid carcinoma cells is phosphorylated on serine (Mastronicola, M. R., Stoppelli, M. P., Migliaccio, A., Auricchio, F., and Blasi, F. (1990) FEBS Lett. 266, 109-114). To test the possibility that phosphorylation may have specific effects on urokinase function, the phosphorylated and nonphosphorylated forms of urokinase were separated by Fe(3+)-Sepharose chromatography. Both forms exhibit indistinguishable Km and kcat for plasminogen activation. On the other hand, their sensitivity toward the specific plasminogen activator inhibitor type 1 is different as assessed by measuring both the stability of the covalent complex and the residual enzymatic activity. Phosphorylated urokinase was 50% inhibited at a concentration of plasminogen activator inhibitor type 1 4-fold higher than nonphosphorylated urokinase (0.7 versus 0.15 nM). Furthermore about 10% of phosphorylated urokinase was resistant to plasminogen activator inhibitor type 1 at a concentration as high as 20 nM. Thus, phosphorylation affects urokinase sensitivity to plasminogen activator inhibitor type 1, therefore resulting in a net, although indirect, increase of urokinase activity. These results suggest the existence of a novel cellular regulatory mechanism of extracellular proteolysis

Una aplicación de TV digital para enseñanza en Medicina Veterinaria : Punto por punto suturas

En este artículo se describe el desarrollo y uso de una aplicación de TV digital (video interactivo) destinado a alumnos de la carrera de Medicina Veterinaria de la Universidad Nacional de Río Cuarto. Se analizan las características del producto, su aplicación y se plantean problemas y desafíos para el desarrollo de este tipo de productos y las nuevas posibilidades e impactos de la TV digital, particularmente en su aplicación a la enseñanza.Red de Universidades con Carreras en Informática (RedUNCI

Differentiation between small hepatocellular carcinoma (<3 cm) and benign hepatocellular lesions in patients with Budd-Chiari syndrome: the role of multiparametric MR imaging

ObjectiveTo investigate the value of multiparametric MR imaging to differentiate between small hepatocellular carcinoma (s-HCC) versus benign liver lesions in patients with Budd-Chiari syndrome.Methods12 patients with benign hepatocellular lesions and 32 patients with small (&lt;3 cm) HCCs were assessed. MRI images were reviewed by two radiologists blinded to the patient background information; lesion T1 and T2 signal intensities and ADC values were compared with the background liver. Enhancement of lesion relative to hepatic parenchyma [(T1Enh-T1liver)/T1liver] in the arterial, venous, and delayed phases was also compared between the two groups. A multivariable logistic model was developed using these categorical measures; the predictive value of the model was tested using the Area Under the Receiver operating characteristic (AU-ROC) curve for logistic models. P-values &lt;0.05 were considered statistically significant.ResultsThere were consistent differences in T1lesion/T1liver, and T2lesion/T2liver, and ADClesion/ADCliver between benign hepatocellular lesions versus the sHCC group (p&lt;0.001, p&lt;0.001, p = 0.045, respectively). Lesion-to-background liver enhancement in the portal venous and delayed phases was different between the benign lesions versus sHCC (p=0.001). ROC analysis for the logistic model that included the T1 ratio, T2 ratio, and portal venous enhancement ratio demonstrated excellent discriminatory power with the area under the curve of 0.94.ConclusionMultiparametric MR imaging is a useful method to help differentiate benign liver lesions from sHCC in patients with Budd-Chiari syndrome

Real-world ANASTASE study of atezolizumab+nab-paclitaxel as first-line treatment of PD-L1-positive metastatic triple-negative breast cancer

The combination of atezolizumab and nab-paclitaxel is recommended in the EU as first-line treatment for PD-L1-positive metastatic triple-negative breast cancer (mTNBC), based on the results of phase III IMpassion130 trial. However, ‘real-world’ data on this combination are limited. The ANASTASE study (NCT05609903) collected data on atezolizumab plus nab-paclitaxel in PD-L1-positive mTNBC patients enrolled in the Italian Compassionate Use Program. A retrospective analysis was conducted in 29 Italian oncology centers among patients who completed at least one cycle of treatment. Data from 52 patients were gathered. Among them, 21.1% presented de novo stage IV; 78.8% previously received (neo)adjuvant treatment; 55.8% patients had only one site of metastasis; median number of treatment cycles was five (IQR: 3–8); objective response rate was 42.3% (95% CI: 28.9–55.7%). The median time-to-treatment discontinuation was 5 months (95% CI: 2.8–7.1); clinical benefit at 12 months was 45.8%. The median duration of response was 12.7 months (95% CI: 4.1–21.4). At a median follow-up of 20 months, the median progression-free survival was 6.3 months (95% CI: 3.9–8.7) and the median time to next treatment or death was 8.1 months (95% CI: 5.5–10.7). At 12 months and 24 months, the overall survival rates were 66.3% and 49.1%, respectively. The most common immune-related adverse events included rash (23.1%), hepatitis (11.5%), thyroiditis (11.5%) and pneumonia (9.6%). Within the ANASTASE study, patients with PD-L1-positive mTNBC treated with first-line atezolizumab plus nab-paclitaxel achieved PFS and ORR similar to those reported in the IMpassion130 study, with no unexpected adverse events

Light Sterile Neutrinos: A White Paper

This white paper addresses the hypothesis of light sterile neutrinos based on recent anomalies observed in neutrino experiments and the latest astrophysical data

Lista bibliografica

Questa lista bibliografica contiene il secondo aggiornamento della bibliografia della Lisy e deriva dall’assemblaggio da parte della redazione (M. Serdoz ed E. Panfili) dei contributi parziali stilati dai gruppi regionali