193 research outputs found
F34 Beekeeper Assist
Alejandro Jauregui is a veteran who now works as a commercial beekeeper. He lost both of his legs during his service. While his current prostheses allow him to fully complete his work, he has found that inspection of the bee boxes causes him severe hip and back pain. Bee box inspection is a critical task for beekeeping, especially since he maintains about 200 hives every day. Our senior project team was tasked with designing and building a device that would help him move the top bee box out of the way to allow for inspection. We performed preliminary research into existing devices, existing practices, and Mr. Jauregui himself to better understand the scope of work for this project. We filtered these inputs into quantifiable wants and needs and generated an actionable problem statement. We followed a timed-out plan which determined what steps we will take to complete this project. As of this report, we have fully completed our final design and fully manufactured the device. We developed and performed test procedures that verified the device’s functionality. From these steps, we now have a device that we know meets all of Mr. Jauregui’s specifications and will greatly improve his quality of life
Developing an Exoskeleton Test Plan for the TALOS Program
As America’s global adversaries increase their capabilities on the battlefield, US military forces must enhance warfighter’s survivability, lethality, and mobility. These needs can be met by augmenting warfighters with additional equipment. The increased use of equipment, however, creates an additional need for an exoskeleton that can support the added equipment, while also augmenting the warfighter’s mobility. Traditionally, exoskeletons have had acceptance issues related to poor operational mobility. USSOCOM is building the Tactical Assault Light Operator Suit (TALOS) as the next generation of these armored exoskeletons. This paper explains the methodology for developing a test plan to ensure adequate mobility for the warfighter wearing the TALOS system. Operational missions were decomposed into tasks which were further broken down into individual movements. Motion capture data was used to determine the angles and angular velocities imposed on relevant joints during these movements. This information was mapped to a set of exercises that were then compiled into a test plan, which can be used during the testing phase to ensure proper mobility for operators utilizing the system
An Open-Publishing Response to the COVID-19 Infodemic
The COVID-19 pandemic catalyzed the rapid dissemination of papers and preprints investigating the disease and its associated virus, SARS-CoV-2. The multifaceted nature of COVID-19 demands a multidisciplinary approach, but the urgency of the crisis combined with the need for social distancing measures present unique challenges to collaborative science. We applied a massive online open publishing approach to this problem using Manubot. Through GitHub, collaborators summarized and critiqued COVID-19 literature, creating a review manuscript. Manubot automatically compiled citation information for referenced preprints, journal publications, websites, and clinical trials. Continuous integration workflows retrieved up-to-date data from online sources nightly, regenerating some of the manuscript\u27s figures and statistics. Manubot rendered the manuscript into PDF, HTML, LaTeX, and DOCX outputs, immediately updating the version available online upon the integration of new content. Through this effort, we organized over 50 scientists from a range of backgrounds who evaluated over 1,500 sources and developed seven literature reviews. While many efforts from the computational community have focused on mining COVID-19 literature, our project illustrates the power of open publishing to organize both technical and non-technical scientists to aggregate and disseminate information in response to an evolving crisis
VC-Dimension of Hyperplanes over Finite Fields
Let be the -dimensional vector space over the finite
field with elements. For a subset and a fixed
nonzero , let , where
is the indicator function of the set . Two of the
authors, with Maxwell Sun, showed in the case that if and is sufficiently large, then the VC-dimension of
is 3. In this paper, we generalize the result to arbitrary
dimension and improve the exponent in the case .Comment: 9 pages, 1 figur
Early Science with the Large Millimeter Telescope: COOL BUDHIES I - a pilot study of molecular and atomic gas at z~0.2
An understanding of the mass build-up in galaxies over time necessitates
tracing the evolution of cold gas (molecular and atomic) in galaxies. To that
end, we have conducted a pilot study called CO Observations with the LMT of the
Blind Ultra-Deep H I Environment Survey (COOL BUDHIES). We have observed 23
galaxies in and around the two clusters Abell 2192 (z = 0.188) and Abell 963 (z
= 0.206), where 12 are cluster members and 11 are slightly in the foreground or
background, using about 28 total hours on the Redshift Search Receiver (RSR) on
the Large Millimeter Telescope (LMT) to measure the CO J = 1 --> 0
emission line and obtain molecular gas masses. These new observations provide a
unique opportunity to probe both the molecular and atomic components of
galaxies as a function of environment beyond the local Universe. For our sample
of 23 galaxies, nine have reliable detections (S/N3.6) of the CO
line, and another six have marginal detections (2.0 < S/N < 3.6). For the
remaining eight targets we can place upper limits on molecular gas masses
roughly between and . Comparing our results to other
studies of molecular gas, we find that our sample is significantly more
abundant in molecular gas overall, when compared to the stellar and the atomic
gas component, and our median molecular gas fraction lies about above
the upper limits of proposed redshift evolution in earlier studies. We discuss
possible reasons for this discrepancy, with the most likely conclusion being
target selection and Eddington bias.Comment: MNRAS, submitte
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.
METHODS: In this multicenter, double-blind, crossover study, 110 patients with heart failure and a preserved ejection fraction were randomly assigned to a 6-week dose-escalation regimen of isosorbide mononitrate (from 30 mg to 60 mg to 120 mg once daily) or placebo, with subsequent crossover to the other group for 6 weeks. The primary end point was the daily activity level, quantified as the average daily accelerometer units during the 120-mg phase, as assessed by patient-worn accelerometers. Secondary end points included hours of activity per day during the 120-mg phase, daily accelerometer units during all three dose regimens, quality-of-life scores, 6-minute walk distance, and levels of N-terminal pro-brain natriuretic peptide (NT-proBNP).
RESULTS: In the group receiving the 120-mg dose of isosorbide mononitrate, as compared with the placebo group, there was a nonsignificant trend toward lower daily activity (-381 accelerometer units; 95% confidence interval [CI], -780 to 17; P=0.06) and a significant decrease in hours of activity per day (-0.30 hours; 95% CI, -0.55 to -0.05; P=0.02). During all dose regimens, activity in the isosorbide mononitrate group was lower than that in the placebo group (-439 accelerometer units; 95% CI, -792 to -86; P=0.02). Activity levels decreased progressively and significantly with increased doses of isosorbide mononitrate (but not placebo). There were no significant between-group differences in the 6-minute walk distance, quality-of-life scores, or NT-proBNP levels.
CONCLUSIONS: Patients with heart failure and a preserved ejection fraction who received isosorbide mononitrate were less active and did not have better quality of life or submaximal exercise capacity than did patients who received placebo. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT02053493.)
The Sensitivity of HAWC to High-Mass Dark Matter Annihilations
The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view
detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in
central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC
will observe gamma rays and cosmic rays with an array of water Cherenkov
detectors. The full HAWC array is scheduled to be operational in Spring 2015.
In this paper, we study the HAWC sensitivity to the gamma-ray signatures of
high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be
sensitive to diverse searches for dark matter annihilation, including
annihilation from extended dark matter sources, the diffuse gamma-ray emission
from dark matter annihilation, and gamma-ray emission from non-luminous dark
matter subhalos. Here we consider the HAWC sensitivity to a subset of these
sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the
Galactic center. We simulate the HAWC response to gamma rays from these sources
in several well-motivated dark matter annihilation channels. If no gamma-ray
excess is observed, we show the limits HAWC can place on the dark matter
cross-section from these sources. In particular, in the case of dark matter
annihilation into gauge bosons, HAWC will be able to detect a narrow range of
dark matter masses to cross-sections below thermal. HAWC should also be
sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The
constraints placed by HAWC on the dark matter cross-section from known sources
should be competitive with current limits in the mass range where HAWC has
similar sensitivity. HAWC can additionally explore higher dark matter masses
than are currently constrained.Comment: 15 pages, 4 figures, version to be published in PR
Fresh-cut carrot (cv. Nantes) quality as affected by abiotic stress (heat shock and UV-C irradiation) pre-treatments
Available at Sciverse ScienceDirectAbiotic stresses such as heat shock and UV-C irradiation can be used to induce synthesis of bioactive
compounds and to prevent decay in fresh-cut fruits and vegetables. This study aimed to evaluate the
effects of heat shock and UV-C radiation stress treatments, applied in whole carrots, on the overall
quality of fresh-cut carrot cv. Nantes during storage (5 C). Heat shock (HS, 100 C/45 s) and UV-C
(0.78 0.36 kJ/m2) treated samples had higher phenolic content and exhibited reduced POD activities
during storage when compared to control (Ctr) samples (200 mg/L free chlorine/1 min). All samples
showed reduced carotenoid content considering raw material. Nonetheless, UV samples registered
a three-fold increase in carotenoid content in subsequent storage. Fresh-cut carrot colour showed
a continuous increase in whiteness index (WI) values during storage regardless of treatment without
impairing visual quality. Respiratory metabolism was affected by both abiotic stress treatments since
reduced O2/CO2 rates were found, more significant in HS samples. The decontamination effect was more
expressive in HS samples, where a 2.5 Log10 cfu/g reduction in initial microbial load and reduced
microbial growth were achieve
The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor
The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4, we disrupted the CRFB4 gene in mice by means of homologous recombination. Mice lacking CRF2-4 show no overt abnormalities, grow normally, and are fertile. CRF2-4 deficient cells are normally responsive to type I and type II interferons, but lack responsiveness to IL-10. By ∼12 wk of age, the majority of mutant mice raised in a conventional facility developed a chronic colitis and splenomegaly. Thus, CRFB4 mutant mice recapitulate the phenotype of IL-10–deficient mice. These findings suggest that CRF2-4 is essential for IL-10–mediated effects and is a subunit of the IL-10 receptor
- …