Mortalidad y crecimiento vegetativo en la provincia de Guadalajara, 1700-1865

This working paper central purpose is to study the magnitude and the evolution of mortality in the Guadalajara province between 1700 and 1865. The parish registers of baptisms and deaths in a sample of 25 local entities are the main source of data. The principal finding is the slightly downward trend in the gross mortality rate between 1750 and 1830s, only broken by a brisk surge during the first years of the XIX century. The dominant factor in the downward pattern is a pullback in adult mortalit

¿Pasó de largo por la España interior la primera fase de la transición demográfica? La mortalidad en Ávila y Guadalajara, 1700-1895

¿Qué aconteció en la España interior durante la primera fase de la transición demográfica europea? ¿Hubo variaciones significativas en los niveles de mortalidad en el largo plazo? Este artículo trata de dar respuesta a dichos interrogantes. Las fuentes primordiales empleadas en el mismo han sido los libros de bautismos y de difuntos de muestras de localidades de las provincias de Ávila y Guadalajara. Las conclusiones más relevantes son: 1) la España interior no quedó completamente descolgada de la primera fase de la transición demográfica europea, ya que, desde mediados del siglo XVIII, la mortalidad, aunque con importantes interrupciones y altibajos, tendió a declinar en dicho territorio; 2) la contribución dela mortalidad ordinaria a dicho retroceso fue bastante más importante que la de la extraordinaria; 3) la mortalidad infantil y juvenil mostró una fuerte resistencia a la baja, y 4) la mortalidad general se estancó o repuntó ligeramente entre 1860 y 1889

Farmers’ profiles and behaviours toward desalinated seawater for irrigation: Insights from South-east Spain

In South-east Spain the implementation of desalinated seawater for irrigation was planned as an alternative water supply for farmers. However, most high-volume desalination plants are underused as farmers’ current demands are lower than was previously expected. In order to develop programmes promoting an effective behavioural shift of farmers toward desalinated water, it is necessary to first explore their preferences and attitudes. This paper shows the results of a survey examining the attitudes and behaviour of farmers toward the use of desalinated seawater for irrigation in the South-east of Spain. The results show the existence of different farmer typologies regarding desalinated seawater use, as well as their preferences and attitudes. The main finding of this study has been to identify further factors, besides price, that condition the acceptance of the use of desalinated seawater. Finally, a series of measures are proposed to encourage the use of desalinated seawater for irrigation based on the identified profiles. The insights gained from this study could be useful for other regions where the construction of desalination plants has been planned as a measure to increase the availability of irrigation water

Una contribución a la problemática del sexo bioantropológico mediante análisis proteómico del esmalte dental de restos humanos de la Prehistoria reciente de la submeseta norte ibérica

Sex estimation of archaeological human remains has traditionally relied on bioanthropological analysis, assuming the uncertainty that this entails and the impossibility of knowing this significant variable in the case of sub-adult individuals. The development of ancient DNA techniques allows this problem to be solved, but its requirements limit the generalization of its use. In this work, we evaluate the use of proteomic analysis, an alternative method based on the direct detection in dental enamel of dimorphic peptides of amelogenin using liquid chromatography-mass spectrometry, following a well-contrasted protocol. This first approximation is based on a collection of teeth, ten belonging to Cogotas I burials, and six ranging from the Chalcolithic to the Final Bronze Age, all of them from the Iberian Northern Subplateau. Proteomic analysis has allowed the sex determination of these individuals, including subadults (most of the sample). The results provide reliable information that enriches their cultural assessment and opens the way to a deeper understanding of gender and its implications. This essay has also taken into account the controversy, heated in many different disciplines, on the sex-gender relationship and the non-binary nature of both, issues that gravitate on osteological and archaeometric analyses ‒qualified even as performative acts‒, so, after assessing this debate, the decision to use this analysis technique is justified.La determinación sexual de restos humanos arqueológicos ha descansado tradicionalmente en los análisis bioantropológicos, asumiéndose la incertidumbre que ello suponía y la imposibilidad de conocer esta importante variable en el caso de los subadultos. Para mitigar tales inconvenientes, se cuenta hoy con las técnicas de ADN antiguo, pero sus requerimientos impiden su generalización. En este trabajo se ensaya una alternativa, el análisis proteómico, esto es, la detección directa en el esmalte dental de péptidos dimórficos de la amelogenina mediante cromatografía líquida acoplada a espectrometría de masas, con un protocolo bien consolidado. Esta primera aproximación se basa en una colección de dientes, diez de ellos de enterramientos de Cogotas I, y otros seis que van del Calcolítico al Bronce Final, todos ellos de la submeseta norte. El análisis proteómico ha permitido la determinación sexual de esos individuos, incluidos los subadultos ‒el grueso del lote‒, obteniéndose así una información fiable que enriquece su valoración cultural y abre el camino para profundizar en el género y sus implicaciones. Este ensayo también ha tenido en cuenta la controversia, candente en muy diversas disciplinas, sobre la relación sexo-género y el carácter no binario de ambos, problemas que gravitan sobre los análisis osteológicos y también arqueométricos ‒tildados incluso de actos performativos‒, por lo que, tras un acercamiento al debate, se justifica la decisión de utilizar la vía analítica.&nbsp

Dispositivo, sistema y método de localización y seguimiento energéticamente eficiente

Dispositivo de seguimiento y localización energéticamente eficiente, sistema y método que implementa dicho dispositivo, en donde el dispositivo comprende (i) unos primeros medios de posicionamiento vía satélite (1); (ii) unos segundos medios de control de transiciones (2,3) entre zonas de cobertura satélite y zonas de sombra; y (iii) unos terceros medios de comunicación (4,5); en donde dichos medios están controlados desde una unidad central de procesamiento (7) y alimentados por una batería (8).Españ

EducaFarma 4.0

Memoria ID-0264. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (n = 165) generated by backcrossing were treated with doxorubicin and docetaxel. We quantified heart fibrosis using an Ariol slide scanner and intramyocardial levels of IMPs using multiplex bead arrays and QPCR. We identified quantitative trait loci linked to IMPs (ipQTLs) and cdaQTLs via linkage analysis. In three cancer patient cohorts, CDA was quantified using echocardiography or Cardiac Magnetic Resonance. CDA behaves as a complex trait in the mouse cohort. IMP levels in the myocardium were associated with CDA. ipQTLs integrated into genetic models with cdaQTLs account for more CDA phenotypic variation than that explained by cda-QTLs alone. Allelic forms of genes encoding IMPs associated with CDA in mice, including AKT1, MAPK14, MAPK8, STAT3, CAS3, and TP53, are genetic determinants of CDA in patients. Two genetic risk scores for pediatric patients (n = 71) and women with breast cancer (n = 420) were generated using machine-learning Least Absolute Shrinkage and Selection Operator (LASSO) regression. Thus, IMPs associated with heart damage identify genetic markers of CDA risk, thereby allowing more personalized patient management.J.P.L.’s lab is sponsored by Grant PID2020-118527RB-I00 funded by MCIN/AEI/10.13039/ 501100011039; Grant PDC2021-121735-I00 funded by MCIN/AEI/10.13039/501100011039 and by the “European Union Next Generation EU/PRTR”, the Regional Government of Castile and León (CSI144P20). J.P.L. and P.L.S. are supported by the Carlos III Health Institute (PIE14/00066). AGN laboratory and human patients’ studies are supported by an ISCIII project grant (PI18/01242). The Human Genotyping unit is a member of CeGen, PRB3, and is supported by grant PT17/0019 of the PE I + D + i 2013–2016, funded by ISCIII and ERDF. SCLl is supported by MINECO/FEDER research grants (RTI2018-094130-B-100). CH was supported by the Department of Defense (DoD) BCRP, No. BC190820; and the National Cancer Institute (NCI) at the National Institutes of Health (NIH), No. R01CA184476. Lawrence Berkeley National Laboratory (LBNL) is a multi-program national laboratory operated by the University of California for the DOE under contract DE AC02-05CH11231. The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023 of the PE I + D +i, 2017–2020, funded by ISCIII and FEDER. RCC is funded by fellowships from the Spanish Regional Government of Castile and León. NGS is a recipient of an FPU fellowship (MINECO/FEDER). hiPSC-CM studies were funded in part by the “la Caixa” Banking Foundation under the project code HR18-00304 and a Severo Ochoa CNIC Intramural Project (Exp. 12-2016 IGP) to J.J.S

Evolución de Studium. Despliegue de la plataforma moodle 2.x

Memoria ID-2012.001. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Comprensión conceptual de estadística y métodos de decisión utilizando herramientas de gamificación para la adquisición de competencias en los grados de ciencias económicas y empresariales

El objetivo general del proyecto es mejorar la motivación y la actitud de los alumnos de los grados de ciencias sociales hacia las materias cuantitativas, así como su participación activa en el proceso de enseñanza-aprendizaje, individual y en grupo, con la finalidad última de incrementar su nivel de competencias y rendimiento