Scientific approach for ozone absorption in blood during systemic indirect endovenous ozonetherapy

Introduction. Reading reference ozone books from Dra. Menendez, Dra. Viebhan, Dra. Borrelli and Dr. Bocci, proper timing for mixing ozone in blood during autohemotherapy is not calculated in a scientific way, having only an estimation of it based on changes in the blood color, more related to oxygen absorption than on ozone itself. Material and methods. We decided to reproduce a reduced model of great autohemotherapy or recently renamed as systemic indirect endovenous ozonotherapy (SIEVO) by the World Federation of Ozone Therapy ? WFOT, using syringes to simplify the experiment. Our model consisted of a 20 mL syringe filled with 10 mL of blood withdrawn from healthy volunteers and mixed it gently but in controlled way with 10 mL medical ozone at different concentrations; after 5 and 8 seconds, the remaining gas was analyzed by an spectrophotometer based ozone detector to check the amount of ozone. Data were analyzed using a linear regression model. Results. Results show that even for 60 mcgr/mL ozone concentration, 8 seconds is enough to let all ozone absorbed in blood. Discussion and Conclusions. The experiment shows how quick ozone reacts with blood and claims for a trial with real SIEVO devices to achieve a real timing

Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)

Objective: To study the association between serum anti-Mullerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5.2-12.1 mu g/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol. Design: Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5.0-14.9 pmol/l; higher stratum: 15.0-44.9 pmol/l). Patients: Infertile women of good prognosis (n = 265). Measurements: Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH. Results: Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P = 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients. Conclusions: Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS

Integration of genetic data on fisheries management models. The European hake case.

The European hake is one of the major commercially important species in Western Europe fisheries. Currently its management is divided into different functional units in the Mediterranean (GFCM, General Fisheries Commission for the Mediterranean) and two stocks in the Atlantic: the Southern and the Northern Stock. The basis for the definition of this management stock structure is under permanent discussion and in the latest years there were an increased amount of genetic studies addressing this topic. Integrated ecosystem assessment requires an improved understanding of the marine ecosystem to provide an effective advice. To this end we have gathered hake genetic information from different studies with the aim of developing a spatial assessment model that links the current stocks. These studies show a restricted gene flow between Southern hake and Mediterranean hake, although a smaller genetic distance between Southern and Northern stocks than one expected from two independent populations, suggesting the presence of a major gene flow from northern grounds core stock (Porcupine and Great Sole Banks) towards the Bay of Biscay and the northwest coast of the Iberian Peninsula. However the quantitative implementation of genetic metrics (such as Fst, migration rates, etc) into population dynamic models is not straightforward given the different nature and assumptions behind these different approaches. In this work we discuss the problems to link these different disciplines suggesting ways to overcome them. These include ways to improve future genetic sampling and developing plausible scenarios for genetic connectivity in population dynamic models

Particle Patterning on Lithium Niobate waveguides via photovoltaic tweezers

Successful micro and nano-particle patterning on iron doped lithium niobate waveguides using photovoltaic fields is reported. This technique previously used in bulk crystals is here applied to waveguide configuration. Well defined particle patterns are obtained using two types of planar waveguides (by proton exchanged and swift heavy ion irradiation) and metallic and dielectric neutral particles. The use of waveguide configuration has allowed a reduction of the light exposure time until 3 s, two orders of magnitude smaller than typical values used in bulk

Photorefractive nonlinear propagation of single beams in undoped LiNbO3: Self-defocusing and beam break-up

Beam propagation in photorefractive LiNbO3 planar waveguides has been studied at different beam intensities and propagation lengths. Self-defocusing and beam break-up have been observed and explained using BPM simulations under a 2-centre band transport model

Personality traits, theory of mind and their relationship with multiple suicide attempts in a sample of first episode psychosis patients: One-year follow-up study

BACKGROUND: High rates of suicidal behaviour (SB) have been found in first episode psychosis (FEP) patients. It has been suggested that the presence of multiple suicide attempts (mSA) increases the risk of later SA and the risk of eventual death by suicide. OBJECTIVE: Our main objective was to study the baseline factors associated with the presence of mSA during the first year after FEP. In addition, a second aim was to find out whether there were any differences between single and multiple suicide attempters in the timing of the first SA after FEP. METHOD: A total of 65 FEP patients were evaluated. The presence of SAs were recorded at two different times after FEP. Bivariate and multivariate analyses were performed to explore the relationship between SA with sociodemographic and clinical variables. RESULTS: Multiple linear regression showed that mSA was associated with the presence of increased symptom severity (B?=?0.35; t?=?3.67; p < 0.01) and errors in first-order false-belief task (B?=?0.48; t?=?2.11; p?=?0.04). There were significant differences in the timing of first SA after FEP between multiple and single suicide attempters. CONCLUSIONS: Theory of mind impairments along with more severe symptoms during the first contact with mental health services for psychotic symptoms appeared to be important predictors of mSA. On the other hand, multiple suicide attempters tend to make a first SA after FEP earlier than single suicide attempters. These results could contribute to the implementation of preventive suicidal programs, however they must be confirmed by additional research.Funding: This study was funded by Ministry of Science and Innovation grant ISC PI11/0233

Application of a robust QFT linear control method to the course changing manoeuvring of a ship

This paper describes in detail the design methodology of a robust QFT (Quantitative Feedback Theory) controller for the control of the course changing of a ship. A linear model is used with uncertainty in the parameters. The system is designed to fulfil the specifications of robust stability and robust tracking of a reference system

HvPap-1 C1A Protease Participates Differentially in the Barley Response to a Pathogen and an Herbivore

Co-evolutionary processes in plant–pathogen/herbivore systems indicate that protease inhibitors have a particular value in biotic interactions. However, little is known about the defensive role of their targets, the plant proteases. C1A cysteine proteases are the most abundant enzymes responsible for the proteolytic activity during different processes like germination, development and senescence in plants. To identify and characterize C1A cysteine proteases of barley with a potential role in defense, mRNA and protein expression patterns were analyzed in response to biotics stresses. A barley cysteine protease, HvPap-1, previously related to abiotic stresses and grain germination, was particularly induced by flagellin or chitosan elicitation, and biotic stresses such as the phytopathogenic fungus Magnaporthe oryzae or the phytophagous mite Tetranychus urticae. To elucidate the in vivo participation of this enzyme in defense, transformed barley plants overexpressing or silencing HvPap-1 encoding gene were subjected to M. oryzae infection or T. urticae infestation. Whereas overexpressing plants were less susceptible to the fungus than silencing plants, the opposite behavior occurred to the mite. This unexpected result highlights the complexity of the regulatory events leading to the response to a particular biotic stress

Niveles de fósforo disponible aparente en pollas Leghorn blanca durante las etapas de iniciación, crecimiento, desarrollo e inicio de postura

Phosphorus (P) is important for the growth and metabolism of pullets and young laying hens, although the requeriments of this mineral could be overvalued. An experiment was conducted with 750 Hy-line W-36 pullets to evaluate the effects of apparent available phosphorus (aaP) levels during starter (1 d to 6 wk), growing (7 to 12 wk), development (13 to 18 wk), and initial laying period. The analyzed variables were: body weight (BW), feed intake (FI), percentage of P in excreta (PPE) and tibia bone (TBP), tibia breaking strength (TBS), egg mass (EM), and specific gravity (SG). The evaluated aaP levels had no effect (P>0.05) on FI, FP, TBP, RB, or EM in the stages under study. There was a difference (P0.05) in the starter period, the optimum biological levels for growing and finishing stages were 0.28 and 0.26 % of aaP, respectively. It was concluded that the requirements of apparent available phosphorus could be lower than the value suggested by NRC (1994) for the growth stages and the variables measured, without affecting the body condition and bone mineralization of pullets.El fósforo es importante en el metabolismo y desarrollo de las pollitas de reemplazo, aunque las necesidades de este mineral pueden estar sobrevaloradas. Se realizó un experimento con 750 pollas de la lí­nea Hy-line W-36, para evaluar los efectos de niveles de fósforo disponible aparente (Pda) durante las etapas de iniciación (1 dí­a a 6 semanas), crecimiento (7 a 12 semanas), desarrollo (13 a 18 semanas) y de inicio a pico de postura. Las caracterí­sticas estudiadas fueron: peso vivo (PV), consumo de alimento (CA), porcentaje de fósforo total en excretas y tibias (PTE y PT), resistencia a ruptura de tibias (RR), masa de huevo (MH) y gravedad especí­fica (GE). El nivel de Pda no afectó (P>0.05) el CA, PTE, PT, RR y MH en las etapas estudiadas. Hubo diferencias (P0.05), mientras que los niveles óptimos biológicos para PV en crecimiento fueron con 0.28 % y desarrollo 0.26 %. Se concluye que las necesidades de fósforo disponible aparente pueden ser menores a lo sugerido por el NRC (1994), durante las etapas y caracterí­sticas medidas, sin afectar la condición corporal y mineralización ósea de las aves