A latitude-dependent wind model for Mira's cometary head

We present a 3D numerical simulation of the recently discovered cometary structure produced as Mira travels through the galactic ISM. In our simulation, we consider that Mira ejects a steady, latitude-dependent wind, which interacts with a homogeneous, streaming environment. The axisymmetry of the problem is broken by the lack of alignment between the direction of the relative motion of the environment and the polar axis of the latitude-dependent wind. With this model, we are able to produce a cometary head with a ``double bow shock'' which agrees well with the structure of the head of Mira's comet. We therefore conclude that a time-dependence in the ejected wind is not required for reproducing the observed double bow shock.Comment: 4 pages, 4 figures, accepted for publication in ApJ

3D numerical model of the Omega Nebula (M17): simulated thermal X-ray emission

We present 3D hydrodynamical simulations of the superbubble M17, also known as the Omega nebula, carried out with the adaptive grid code yguazu'-a, which includes radiative cooling. The superbubble is modelled considering the winds of 11 individual stars from the open cluster inside the nebula (NGC 6618), for which there are estimates of the mass loss rates and terminal velocities based on their spectral types. These stars are located inside a dense interstellar medium, and they are bounded by two dense molecular clouds. We carried out three numerical models of this scenario, considering different line of sight positions of the stars (the position in the plane of the sky is known, thus fixed). Synthetic thermal X-ray emission maps are calculated from the numerical models and compared with ROSAT observations of this astrophysical object. Our models reproduce successfully both the observed X-ray morphology and the total X-ray luminosity, without taking into account thermal conduction effects.Comment: 8 pages, 6 figures, accepted for publication in MNRA

Controlled Anisotropic Deformation of Ag Nanoparticles by Si Ion Irradiation

The shape and alignment of silver nanoparticles embedded in a glass matrix is controlled using silicon ion irradiation. Symmetric silver nanoparticles are transformed into anisotropic particles whose larger axis is along the ion beam. Upon irradiation, the surface plasmon resonance of symmetric particles splits into two resonances whose separation depends on the fluence of the ion irradiation. Simulations of the optical absorbance show that the anisotropy is caused by the deformation and alignment of the nanoparticles, and that both properties are controlled with the irradiation fluence.Comment: Submitted to Phys. Rev. Lett. (October 14, 2005

A model of Mira's cometary head/tail entering the Local Bubble

We model the cometary structure around Mira as the interaction of an AGB wind from Mira A, and a streaming environment. Our simulations introduce the following new element: we assume that after 200 kyr of evolution in a dense environment Mira entered the Local Bubble (low density coronal gas). As Mira enters the bubble, the head of the comet expands quite rapidly, while the tail remains well collimated for a 100 kyr timescale. The result is a broad-head/narrow-tail structure that resembles the observed morphology of Mira's comet. The simulations were carried out with our new adaptive grid code WALICXE, which is described in detail.Comment: 12 pages, 8 figures (4 in color). Accepted for publication in The Astrophysical Journa

Winds from clu\sters with non-uniform stellar distributions

We present analytic and numerical models of the `cluster wind' resulting from the multiple interactions of the winds ejected by the stars of a dense cluster of massive stars. We consider the case in which the distribution of stars (i.e., the number of stars per unit volume) within the cluster is spherically symmetric, has a power-law radial dependence, and drops discontinuously to zero at the outer radius of the cluster. We carry out comparisons between an analytic model (in which the stars are considered in terms of a spatially continuous injection of mass and energy) and 3D gasdynamic simulations (in which we include 100 stars with identical winds, located in 3D space by statistically sampling the stellar distribution function). From the analytic model, we find that for stellar distributions with steep enough radial dependencies the cluster wind flow develops a very high central density and a non-zero central velocity, and for steeper dependencies it becomes fully supersonic throughout the volume of the cluster (these properties are partially reproduced by the 3D numerical simulations). Therefore, the wind solutions obtained for stratified clusters can differ dramatically from the case of a homogeneous stellar distribution (which produces a cluster wind with zero central velocity, and a fully subsonic flow within the cluster radius). Finally, from our numerical simulations we compute predictions of X-ray emission maps and luminosities, which can be directly compared with observations of cluster wind flows.Comment: 10 pages, 11 figures. MNRAS - Accepted 2007 June 29. Received 2007 June 28; in original form 2007 May 2

X-ray emission and dynamics from large diameter superbubbles: The case of N 70 superbubble

The morphology, dynamics and thermal X-ray emission of the superbubble N70 is studied by means of 3D hydrodynamical simulations, carried out with the {\sc{yguaz\'u-a}} code. We have considered different scenarios: the superbubble being the product of a single supernova remnant, of the stellar winds from an OB association, or the result of the joint action of stellar winds and a supernova event. Our results show that, in spite that all scenarios produce bubbles with the observed physical size, only those where the bubble is driven by stellar winds and a SN event are successful to explain the general morphology, dynamics and the X-ray luminosity of N70. Our models predict temperatures in excess of $10^8 \mathrm{K}$ at the interior of the superbubble, however the density is too low and the emission in thermal X-ray above $2 \mathrm{keV}$ is too faint to be detected.Comment: 9 pages, 11 figures, ApJ accepte

Biocompatible polymeric microparticles produced by a simple biomimetic approach

The use of superhydrophobic surfaces to produce polymeric particles proves to be biologically friendly since it entails the pipetting and subsequent cross-linking of polymeric solutions under mild experimental conditions. Moreover, it renders encapsulation efficiencies of ∼100%. However, the obtained particles are 1 to 2 mm in size, hindering to a large extent their application in clinical trials. Improving on this technique, we propose the fabrication of polymeric microparticles by spraying a hydrogel precursor over superhydrophobic surfaces followed by photo-cross-linking. The particles were produced from methacrylamide chitosan (MA-CH) and characterized in terms of their size and morphology. As demonstrated by optical and fluorescence microscopy, spraying followed by photo-cross-linking led, for the first time, to the production of spherical particles with diameters on the order of micrometers, nominal sizes not attainable by pipetting. Particles such as these are suitable for medical applications such as drug delivery and tissue engineering.We thank Ivo Aroso and Ana Isabel Neto for their valuable support with FTIR and compression experiments, respectively. A.M.S.C. thanks FCT for financial support through grant BIM/PTDC/CTM-BPC/112774/2009_02. M.A.-M. thanks CONACyT (Mexico) for financial support through post-doc grant no. 203732. N.M.O. thanks FCT for financial support through Ph.D. scholarship no. SFRH/BD/73172/2010. This work was funded by the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. REGPOT-CT2012-316331-POLARIS, by FEDER through the Competitive Factors Operation Program-COMPETE, and by national funds through FCT - Fundacao para a Ciencia e a Tecnologia in the scope of project PTDC/CTM-BIO/1814/2012

MEGARA, the new intermediate-resolution optical IFU and MOS for GTC: getting ready for the telescope

MEGARA (Multi-Espectrógrafo en GTC de Alta Resolución para Astronomía) is an optical Integral-Field Unit (IFU) and Multi-Object Spectrograph (MOS) designed for the GTC 10.4m telescope in La Palma that is being built by a Consortium led by UCM (Spain) that also includes INAOE (Mexico), IAA-CSIC (Spain), and UPM (Spain). The instrument is currently finishing AIV and will be sent to GTC on November 2016 for its on-sky commissioning on April 2017. The MEGARA IFU fiber bundle (LCB) covers 12.5x11.3 arcsec2 with a spaxel size of 0.62 arcsec while the MEGARA MOS mode allows observing up to 92 objects in a region of 3.5x3.5 arcmin2 around the IFU. The IFU and MOS modes of MEGARA will provide identical intermediate-to-high spectral resolutions (RFWHM~6,000, 12,000 and 18,700, respectively for the low-, mid- and high-resolution Volume Phase Holographic gratings) in the range 3700-9800ÅÅ. An x-y mechanism placed at the pseudo-slit position allows (1) exchanging between the two observing modes and (2) focusing the spectrograph for each VPH setup. The spectrograph is a collimator-camera system that has a total of 11 VPHs simultaneously available (out of the 18 VPHs designed and being built) that are placed in the pupil by means of a wheel and an insertion mechanism. The custom-made cryostat hosts a 4kx4k 15-μm CCD. The unique characteristics of MEGARA in terms of throughput and versatility and the unsurpassed collecting are of GTC make of this instrument the most efficient tool to date to analyze astrophysical objects at intermediate spectral resolutions. In these proceedings we present a summary of the instrument characteristics and the results from the AIV phase. All subsystems have been successfully integrated and the system-level AIV phase is progressing as expected

Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain

BACKGROUND: Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Autonomous Region of Valencia, Spain, is around 40%, as the rotavirus vaccine is not funded by the National Health System. Despite this low-medium vaccine coverage, rotavirus vaccination has substantially reduced hospitalizations due to rotavirus infection and hospital-related costs. However, there are very few studies evaluating symptomatic rotavirus infections not requiring hospitalization in vaccinated children. The objective of this study was to investigate symptomatic rotavirus infections among vaccinated children in the health area served by the Hospital Clínico Universitario of Valencia, Spain, from 2013 to 2015. METHODS: A total of 133 children younger than 5 years of age with rotavirus infection were studied. Demographic and epidemiological data were collected and informed consent from their caretakers obtained. Rotavirus infection was detected by immunological methods and G/P rotavirus genotypes were determined by RT-PCR, following standard procedures from the EuroRotaNet network. RESULTS: Forty infants (30.1%; 95% CI: 22.3-37.9) out of 133 were diagnosed with symptomatic rotavirus infection despite having been previously vaccinated, either with RotaTeq (85%) or with Rotarix (15%). Children fully vaccinated against rotavirus (24.8%), partially vaccinated (5.3%) and unvaccinated (69.9%) were found. The infecting genotypes showed high G-type diversity, although no significant differences were found between the G/P genotypes infecting vaccinated and unvaccinated children during the same time period. G9P[8], G12P[8] and G1P[8] were the most prevalent genotypes. Severity of gastroenteritis symptoms required 28 (66.6%) vaccinated and 67 (73.6%) unvaccinated children to be attended at the Emergency Room. CONCLUSION: Rotavirus vaccine efficacy in reducing the incidence of severe rotavirus infection has been well documented, but symptomatic rotavirus infection can sometimes occur in vaccinees