25 research outputs found
Successful treatment of lichen planus with sulfasalazine in 20 patients
Lichen planus (LP) is a disturbing pruritic cutaneous disease that
may have an spontaneous resolution or exhibit a more chronic course during some
weeks or months. OBJECTIVE: Our objective was to demonstrate that sulfasalazine
is effective in the treatment of LP. METHODS: Twenty patients were diagnosed in
our department with LP of the skin and/or mucosa between 1985 and 2001 on the
basis of clinical and histologic findings. RESULTS: All patients were treated
with sulfasalzine at initial doses of 1.5 g/day, increasing by 0.5 g/week to 3
g/day for 4-16 weeks. Some patients also received descendent doses for 2-12
months. Complete responses were observed in 13 patients and partial responses in
seven patients. All patients reported an early resolution of the pruritus. No
changes were detected in mucosal LP. Most of the patients tolerated the treatment
well and only eight patients presented some minor side-effects. CONCLUSION:
Sulfasalazine is a successful therapeutic option for cutaneous LP, constituting
an alternative to corticosteroids and retinoid
Adverse Drug Reactions in Children—A Systematic Review
Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided
Dermoscopic description of a patient with thrombocythemia and factor V Leiden mutation-associated Degos’ disease
Reconstructive Surgery of the Medial Zygomatic Region of the Cheek: Presentation of 5 Cases
Malignant atrophic papulosis. A report of two cases with altered fibrinolysis and platelet function
Malignant atrophic papulosis is a systemic vaso-occlusive disorder characterized by typical skin lesions. We report two new cases with impairment of blood fibrinolytic activity and alterations in platelet function. The first case showed an increase in plasminogen activator inhibitor-1 (PAI-1) activity, and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen. The impairment of blood fibrinolytic activity and platelet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis