10 research outputs found
Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype
- Author
- Afdhal Nezam
- Ayala Claudia
- Barritt A. Sidney
- Bass Sheila
- Belle Steven H.
- Betts Michael
- Cardona Danielle
- Cardona-Gonzalez Lupita
- Carithers Robert C.
- Chang Kyong Mi
- Chung Raymond T.
- Cloonan Yona
- Cooper Stewart L.
- Danielson Michelle
- Darling Jama M.
- DeVole Nata
- Di Bisceglie Adrian M.
- Do Son
- Evon Donna
- Feld Jordan
- Fontana Robert J.
- French Samuel
- Fried Michael W.
- Fryzek Nancy
- Ganova-Raeva Lilia Milkova
- Ghany Marc G.
- Haller Tamara
- Han Johanna
- Han Steven Huy B.
- Hassan Mohamed
- Haynes-Williams Vanessa
- Heathcoate Jenny
- Hofmann Charlotte
- Huddleston Leslie
- Janssen Harry L.A.
- Javaid Asad
- Johnson Geoffrey
- Juan Joshua
- Kaza Sravanthi
- Keith James
- Kelley Stephanie
- Khalili Mandana
- Khudyakov Yury
- Kim W. Ray
- King Debra L.
- Kleiner David
- Kowdley Kris V.
- La Danie
- Lau Daryl T.Y.
- Lau Ivy
- Lawlor Sharon
- Lee William M.
- Levine Danielle
- Li Ruosha
- Liang T. Jake
- Lisker-Melman Mauricio
- Liu Lucie
- Lok Anna Suk Fong
- Lombardero Manuel
- Luketic Velimir A.
- MacGregor Joan M.
- Marsh Tiffany
- Mathisen Terri
- McKenna Barbara
- Metheny Vikki
- Minshall Stacey
- Montaner Luis J.
- Mooney Jody
- Morris Nevitt
- Nagy Rosemary A.
- Nasser Imad
- Niu Jianghe
- Oberhelman Kelly
- Olson Emma
- Park Jang June
- Patel Keyur
- Peacock Velma
- Pelesko Andrew
- Perrillo Robert
- Podolskaya Veronika
- Poerzgen Peter
- Punkova Lili T.
- Rivera Elenita
- Roberts Lewis R.
- Rodd Cassandra
- Shuhart Margaret C.
- Smith Coleman I.
- Smith Paula G.
- Stadheim Linda
- Stahler Alisha C.
- Sterling Richard K.
- Stoliker Donna
- Strom Susan
- Teo Chong Gee
- Terrault Norah A.
- Torrey Keith
- Tran Tram T.
- Tsai Naoky
- Ungermann Ashley
- Valiga Mary E.
- Wahed Abdus
- Walters Barbara
- Wang Chia C.
- Wong David K.
- Yim Colina
- Zadorozny Ella
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott
- Abdel Omer
- Abhiram Sharma
- Abigail Patrick
- Adam Wolverson
- Adrian Fawcet
- Adrian Jennings
- Aggarwal
- Ahmed
- Ajaya Mull
- Ajit Abraham
- Ajit Sivasankaranand
- Alan Girling
- Alan Morrison
- Alastair Ankers
- Alastair Rose
- Alexandra Scott
- Alexandra Williams
- Alison Hool
- Alison Pickford
- Alistair Roy
- Alistair Steel
- Alister Myers
- Almas Rehman
- Amanda McCairn
- Amanda Stevens
- Amir Rafi
- Amira Girgis
- Amit Shukla
- Ana Alegria
- Anderson
- Andreas Brodbeck
- Andreou Prematie
- Andrew Brennan
- Andrew Burtenshaw
- Andrew Claxton
- Andrew Lindner
- Andrew Miller
- Andrew Thorniley
- Andrew White
- Andy Thacker
- Anil Hermandes
- Anita Jhamatt
- Anita Sugavanam
- Anitha Holtham
- Anjay Talwar
- Ann Thomson
- Ann Thomson
- Anne Scase
- Anthony Gordon
- Anthony Parsons
- Arnab Bhowmick
- Arnth Engel
- Ash Prabhudesai
- Ashok Raj
- Asif Jah
- Auerbach
- Avninder Chana
- Ayan Banerjea
- Ayodele Obideyi
- Babu Muthuswamy
- Bala Maiya
- Banwari Agarwal
- Barclay Tofte
- Batalden
- Belinda Cornforth
- Benning
- Beth Hale
- Biju Aravind
- Bion
- Brenda Stacey
- Brennan C Kahan
- Brennan Kahan
- Britta O'Carroll-Kuehn
- Bruce Gibson
- Carl Waldmann
- Carmen Correia
- Carol J Peden
- Carol Mcarthur
- Carol Peden
- Carolyn Tarrant
- Carolyn Way
- Catherine Farrow
- Catherine Jardine
- Catherine Pitman
- Catherine Rimmer
- Charles Cartwright
- Charles Knowles
- Chitre Vivek
- Chloe Rochester
- Chris Coldwell
- Chris Dawson
- Chris Horner
- Chris Lewis
- Chris Nutt
- Chris Thorn
- Chris Wilson
- Christine Boyd
- Christine Bronder
- Christopher Macklin
- Clare Stapleton
- Clare Stapleton
- Colin Pow
- Craig Lyness
- Craig Morris
- Dale Vimalchandran
- Damian Laba
- Damschroder
- Dan Broad
- Dan Freshwater-Turner
- Daniel Conway
- Daren Subar
- Dave Murray
- David Bottomley
- David Browell
- David Cromwell
- David Gerrard
- David Humes
- David Inglis
- David Kocman
- David Melville
- David Monk
- David Murray
- David Pogson
- David Riddington
- David Saunders
- David Saunders
- David Stanley
- Davina Ross-Anderson
- Dawn Hales
- Dean Millican
- Debbie Shaw
- Denzil May
- Dewi Williams
- Dhiraj Ali
- Diane Monkhouse
- Diane Murray
- Dileep Lobo
- Dipankar Mukherjee
- Dixon-Woods
- Dolores Mateo
- Dom Hurford
- Dominic Sebastian
- Donna Doyle
- Duncan Wells
- Duncan Wells
- Edward Curtis
- Edward Lams
- Edyta Niebrzegowska
- Elizabeth Hall
- Elizabeth Hall
- Elizabeth Harwood
- Emanuel Cirstea
- Emma Brennan
- Emma Davis
- Emma Durant
- Emma Leno
- Erin Mcilveen
- Essam El-Damatty
- Esther Cook
- Everingham
- Ewen Griffiths
- Ewen Harrison
- Fabian Cook
- Faisal Baig
- Fan Yang
- Fanus Dreyer
- Fenella Welsh
- Ferdinand Adams
- Fiona McMenemie
- Flavia Menezes
- Flora Bailey
- Fran Haigh
- Frances Mosley
- Francesca Rubulotta
- Frankie Dorman
- Gabriele Marangoni
- Gail Stark
- Gail Williams
- Gareth Ackland
- Gareth Moncaster
- Gary Minto
- Gary Minto
- Gavin Bryce
- Geoff Watson
- Georgia Knight
- Gerry Richardson
- Gerry Richardson
- Gethin Williams
- Gill Tierney
- Gillian O'Connell
- Giovanni Brescia
- Glenn Arnold
- Glenn Robert
- Gordon Forbes
- Gordon Milne
- Graham Martin
- Graham Martin
- Graham Martin
- Graham Wilson
- Grainne O'Dwyer
- Grant Sanders
- Greg Lawton
- Gudrun Kunst
- Guy Finch
- Guy Nash
- Guy Rousseau
- Hamish Noble
- Hannah Smith
- Harjeet Narula
- Haynes
- Hazel Stuart
- Heather Pratt
- Helen Agostini
- Helen Black
- Helen Howes
- Helen Langton
- Helen Porter
- Helen Reed
- Helena Stafford
- Hitesh Patel
- Huddart
- Hussey
- Huw Davis
- Iain Anderson
- Iain Christie
- Ian Clement
- Ilona Raulusaite
- Inga Misane
- Ingeborg Welters
- Isabella Karat
- Jack Carmichael
- Jack Parry Jones
- Jagdeep Singh
- James Bromilow
- James Brown
- James Burrow
- James Burrow
- James Harris
- James Kirby-Bott
- James Limb
- Jamie Greenwood
- Jan Hanousek
- Jane Blazeby
- Janindra Warusavitarne
- Jason Cupitt
- Jay Gokhale
- Jay Susarla
- Jennifer Edwards
- Jennifer Spimpolo
- Jenny McLachan
- Jenny Ritzema
- Jenny Wright
- Jens Full
- Jeremy Marwick
- Jessica Thrush
- Jigna Modha
- John Abercrombie
- John Corson
- John Griffith
- John Hopper
- John Mackinnon
- John Tansley
- John Wells
- Jonathan Mccullough
- Jonathan Paddle
- Jonathon Barker
- Jonathon Mole
- Jonny Wilkinson
- Jose Lourtie
- Josef Watfah
- Joseph Silsby
- Jost Mullenheim
- Julian Bion
- Julian Bion
- Julian Sonksen
- Julian Stone
- Julie Colley
- Julie Furneval
- Julie Wakeford
- Julie Wollaston
- Justin Kirk-Bayley
- Justin Waring
- Justin Waring
- Justin Woods
- Jyrki Karvonen
- Kahan
- Kahan
- Kaighan Lynne
- Kamal Aryal
- Karan Verma
- Karen Burns
- Karen Simeson
- Karl Blenk
- Karthik Surendran
- Kate Carey
- Kate Rivett
- Kate Rivett
- Kate Wong
- Katherine Allen
- Kathryn Cain
- Kathryn Gill
- Katie Cooke
- Keiarash Jovestani
- Kenneth Adegoke
- Kerwei Tan
- Kevin Rooney
- Kevin Sim
- Khaled Razouk
- Kim Jemmet
- Kirosh Shankar
- Kirsty Baillie
- Kirsty Everingham
- Krishnamurthy Somasekar
- Kumar Panikkar
- Kuper
- Lampros Liasis
- Langley
- Laura Fitton
- Laura Graham
- Laura Perrin-Brown
- Laura Rooney
- Lawrence Wilson
- Leatherman
- Lee Baldwin
- Leilani Cabreros
- Liam Hudson
- Linda Graham
- Linden Baxter
- Lindsay Bailey
- Lorna Burrows
- Louise Bell
- Lynn Stewart
- Lynn Taylor
- Lynsey Kightly
- Magdy Khater
- Magen Schwarz
- Maitra Ishaan
- Majed Al Shama
- Makvana Sonia
- Malcolm Sim
- Malcolm Watters
- Mallikarjunappa Satisha
- Manab Mohanty
- Mandeep Phull
- Mansoor Akhtar
- Mansoor Sange
- Marcus Wood
- Maria Bews-Hair
- Maria Lawson
- Marion Obichere
- Mark Blunt
- Mark Cartmell
- Mark Coleman
- Mark Edwards
- Mark Henwood
- Mark Munro
- Mark Pulletz
- Mark Snazelle
- Mark Watson
- Mark Wilkinson
- Marta Campbell
- Marta Januszewska
- Martin
- Martin Leuwer
- Martin Leuwer
- Martin Northey
- Martin Stotz
- Martyn Cain
- Massimo Varcada
- Matt Gardner
- Matt Outram
- Matthew Gaughan
- Matthew Tutton
- Maurizio Cecconi
- Megan Griffiths
- Meghna Sharma
- Melanie Tan
- Michael Chadwick
- Michael Crabtree
- Michael Gillies
- Michael Karlikowsk
- Michael Machesney
- Michael Martin
- Michael Protopapas
- Michie
- Mike Bradburn
- Mike Bradburn
- Mike Gay
- Mike Grocott
- Miqdad Asaria
- Moller
- Monty Mythen
- Moraros
- Morgan
- Nabil El-Masry
- Nabua Gerstina
- Nada Hadi
- Nandita Divekar
- Nat Natarajan
- Natalie Dickinson
- Nathan Borgeaud
- Nathan Pushpa
- Nazar Abdul
- Nazzia Mirza
- Neil Cruickshank
- Neil Flint
- Neil Kukreja
- Neil Smith
- Nicholas Watson
- Nick Bunker
- Nick Harper
- Nick Mason
- Nick Watson
- Nicola Cook
- Nicola Lythell
- Nicola Radford
- Nicola Stranix
- Nicole Robin
- Nigel Hollister
- Nigel Suggett
- Niko Van De Velde
- Nikolaos Makris
- Obioha Ukoumunne
- Olga Tucker
- Oliver Hill
- Oliver Zuzan
- Oluremi Odejinmi
- Omar Faiz
- Otto Mohr
- Paddy Collins
- Panna Patel
- Pannick
- Pasupathy Raju
- Paul Harrison
- Paul Hayden
- Paul Mclaren
- Paul Noble
- Paul O'Loughlin
- Paul Ziprin
- Paul Ziprin
- Pedro Cunha
- Peeyush Kumar
- Peter Alexander
- Peter Chan
- Peter Davies
- Peter Fitzgerald
- Peter Holt
- Peter Lamb
- Peter Richardson
- Phil Dodd
- Phil Hopkins
- Phillippa Pemberton
- Phoebe Bodger
- Pieter Bothma
- Pieter Bothma
- Piroska Toth-Tarsoly
- Preeti Kuduvalli
- Presseau
- Qamar Iqbal
- Rachael Craven
- Rachel Bartlett
- Rachel Evley
- Rai Kuldip
- Rajan Patel
- Rajesh Dumpala
- Rajpal Dhingsa
- Rakhee Visavadia
- Raman Guruswamy
- Ramani Moonesinghe
- Rame Sunthareswaran
- Ramesh Rajagopal
- Ranjit Ganepola
- Raoul Benlloch
- Ravi Mahajan
- Razeen Mahroof
- Richard Gibbs
- Richard Hartopp
- Richard Haslop
- Richard Howard-Griffin
- Richard Lilford
- Richard Morgan
- Richard Stevenson
- Richard Wharton
- Ricky Lewis
- Rob Chambers
- Robert DeBrunner
- Robert Shawcross
- Robert Sutcliffe
- Roger Townsend
- Roshan Lal
- Rovan D'souza
- Rowena Felipe
- Roy Fernandes
- Rupert M Pearse
- Rupert Pearse
- Ruth Griffin
- Ruth Thomas
- Sally Kerry
- Sally Kerry
- Sally Roth
- Sam Andrews
- Sam Waddy
- Samer Doughan
- Sami Farhat
- Sami Ijaz
- Sandeep Varma
- Sanjay Wijeykoon
- Sanjiv Patel
- Sara Pick
- Sarada Gurung
- Sarah Beavis
- Sarah Bowery
- Sarah Buckley
- Sarah Downey
- Saravanna Sagadai
- Satish Singh
- Saunders
- Savvas Papagrigoriadis
- Schouten
- Sean Cope
- Sean McAfee
- Sean Mcmullan
- Sean Tighe
- Sedgwick
- Senthil Nadarajavan
- Sergei Vaganov
- Shameem Sarfi
- Sharon Drake
- Sheshagiri Bengeri
- Shrisha Shenoy
- Shubha Vashisht
- Sian Bhardwaj
- Sid Riddington
- Simon Bailey
- Simon Fletcher
- Simon Gibson
- Simon Harris
- Simon Hester
- Simon Howell
- Simon Parrington
- Simon Sleight
- Simon Smart
- Simon Walker
- Singh Gursevak
- Somi Desikan
- Sophie Noblett
- Stacy Hodges
- Stas Janokowski
- Stefan Pulsa
- Stelios Chatzimichail
- Stella Vig
- Stephanie Bell
- Stephanie Brown
- Stephen Baxter
- Stephen Brett
- Stephen Lake
- Stephens
- Steve Fletcher
- Steve Hutchinson
- Steven Henderson
- Stewart Prestwich
- Stuart Mercer
- Sudha Garg
- Surjait Singh
- Susan Dowling
- Susan Jain
- Susan Moug
- Susan Tyson
- Susie Baker
- Syed Iftikhar
- Tabitha Tanqueray
- Taj Saran
- Tamas Szakmany
- Tamas Szakmany
- Tamsin Rope
- Tamzin Cuming
- Tanuja Shah
- Tariq Husain
- Tengberg
- Tezas Stergios
- Therese Murray
- Thomas Evans
- Thomas Medici
- Thomas Parker
- Tim Campbell-Smith
- Tim Geary
- Tim Harvard
- Tim Stephens
- Tim Stephens
- Tim White
- Tom Abbott
- Tom Morgan-Jones
- Tom Owen
- Tom Owen
- Tomas Jovaisa
- Una McNelis
- Valerie Hilton
- Vamsi Velchuru
- Vanessa Linnett
- Vanessa Tucker
- Veena Naik
- Verity Calder
- Vester-Andersen
- Victoria Banks
- Vishal Patil
- Vivek Chitre
- Vlad Kushakovsky
- Wael Khalaf
- Wayne Wrathall
- White
- White
- Will Brady
- Williams
- Xavier Escofet
- Yasser Mohsen
- Ying Hu
- Zakaulla Belagodu
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/10/2018
- Field of study
BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
- Deans Andrew
- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
- Dewar A.
- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
- Docherty Annemarie B.
- Donaldson A.
- Dong T.
- Dormand N.
- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
- Evans H
- Evans J
- Evans R
- Evans Rachael A
- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
- Fabbri L
- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
- Flockton Rachel
- Flynn Margaret
- Foot H
- Foote David
- Ford Amber
- Forton D
- Fraile Eva
- Francis C.
- Francis R
- Francis Susan
- Frankel A.
- Fraser Emily
- Free Rob
- French N.
- Fu X
- Fuld Jonathan
- Furniss J.
- Garner Lucie
- Gautam N
- Geddes John R.
- George J.
- George P.
- Gibbons M
- Gill Mandy
- Gill Rhyan
- Gilmour L.
- Gleeson Fergus
- Glossop Jodie
- Glover Sarah
- Goodman N
- Goodwin Camelia
- Gooptu Bibek
- Gordon Hussain
- Gorsuch T.
- Greatorex M
- Greenhaff P.L.
- Greenhalf William
- Greenhalgh Alan
- Greening Neil J
- Greenwood John P
- Gregory Heidi
- Gregory Rebecca
- Grieve D.
- Griffin Denise
- Griffiths L
- Guerdette Anne-Marie
- Guillen Guio Beatriz
- Gummadi Mahitha
- Gupta Ayushman
- Gurram Sambasivarao
- Guthrie E
- Guy Z
- Hadley K
- Haggar Ahmed
- Hainey Kera
- Hairsine Brigid
- Haldar Pranab
- Hall I
- Hall Lucy
- Halling-Brown Mark
- Hamil R.
- Hancock Alyson
- Hancock Kia
- Hanley N.A.
- Haq Sulaimaan
- Hardwick H.E.
- Hardy E
- Hardy Tim
- Hargadon Beverley
- Harrington Kate
- Harris Edward
- Harris Victoria C
- Harrison Ewen M.
- Harrison P.
- Hart Nicholas
- Harvey Alice
- Harvey M
- Harvie M
- Haslam L
- Hastie Claire
- Havinden-Williams May
- Hawkes Jenny
- Hawkings Nancy
- Haworth Jill
- Hayday A.
- Haynes Matthew
- Hazeldine J
- Hazelton Tracy
- Heaney Liam G.
- Heeley Cheryl
- Heeney J L
- Heightman M
- Heller S.
- Henderson M
- Henson Helen
- Hesselden L
- Hewitt Melanie
- Highett Victoria
- Hillman T
- Hiwot T
- Ho Ling-Pei
- Hoare Amy
- Hoare Michaela
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- Jezzard Peter
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- Lawrie Allan
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- Lilaonitkul W
- Lim Lai
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- Loosley Ronda
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- Lota Harpreet
- Lovegrove Wayne
- Lucey Alice
- Lukaschuk Elena
- Lye Alison
- Lynch Ceri
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- MacGowan G.
- Macharia Irene
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- Macliver L.
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- Madzamba Gladys
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- Manisty Charlotte
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- Marciniak S.
- Marino Philip
- Mariveles Myril
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- McIntosh Jerome
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- McMahon A.
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- McShane H.
- Mears Chloe
- Megson Clare
- Megson Sharon
- Mehta P
- Meiring J
- Melling Lucy
- Mencias Mark
- Menke Ricarda
- Menzies Daniel
- Merida Morillas Marta
- Michael Alice
- Miiler K
- Miller Christopher A
- Miller Karla
- Milligan L.
- Mills Clare
- Mills G
- Mills N.L.
- Milner L
- Misra S
- Mitchell J.
- Mohamed Abdelrahman
- Mohamed Noura
- Mohammed S.
- Molyneaux P.L.
- Monteiro Will
- Moriera Silvia
- Morley Anna
- Morrison Leigh
- Morriss R
- Morrow A.
- Moss Alastair J
- Moss P
- Motohashi K
- Msimanga N
- Mukaetova-Ladinska Elizabeta
- Munawar Unber
- Murira Jennifer
- Nanda U
- Nassa Heeah
- Nasseri Mariam
- Nathu Rashmita
- Neal A
- Needham Robert
- Neill Paula
- Neubauer Stefan
- Newby D E
- Newell Helen
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- Newman Tom
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- Nolan C.M.
- Noonan Matthew J.
- Norman C
- Novotny Petr
- Nunag Jose Lloyd
- Nwafor Lorenza
- Nwanguma Uchechi
- Nyaboko J
- O'Brien Caitlin
- O'Brien Linda
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- Odell Natasha
- Ogbole Godwin
- Ogg G.
- Olaosebikan Olaoluwa
- Oliver Catherine
- Omar Zohra
- Openshaw Peter J.M.
- Orriss-Dib Lorna
- Osborne Lynn
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- Ostermann Marlies
- Overton Charlotte
- Owen J.
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- Pack Jamie
- Pacpaco Edmund
- Paddick S.
- Painter Sharon
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- Palmer Sue
- Papineni Padmasayee
- Paques K
- Paradowski Kerry
- Pareek Manish
- Parekh Dhruv
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- Pariante C.
- Parker S
- Parkes M.
- Parmar J
- Patale Sheetal
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- Patel Manish
- Patel Suhani
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- Payne Sheila
- Pearce Lorraine
- Pearl John E
- Peckham D.
- Pendlebury Jessica
- Peng Yanchun
- Pennington Chris
- Peralta Ida
- Perkins Emma
- Peterkin Z
- Peto T.
- Petousi Nayia
- Petrie J
- Pfeffer Paul
- Phipps Janet
- Piechnik Stefan K
- Pimm John
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- Pius R
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- Plein Sven
- Plekhanova Tatiana
- Plowright Megan
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- Popescu Iulia
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- Porter Julie
- Portukhay Sofiya
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- Pratt James
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- Price Claire
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- Price L.
- Prickett A
- Prosper Sabrina
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- Quaid Sheena
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- Quint Jennifer
- Qureshi H
- Qureshi I N
- Radhakrishnan K.
- Rahman Najib M.
- Ralser M
- Raman Betty
- Ramos Albert
- Ramos Hazel
- Rangeley Jade
- Rangelov B
- Ratcliffe L
- Ravencroft Phillip
- Reddington A
- Reddy A
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- Redfearn H
- Redwood Dawn
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- Regan Karen
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- Ribeiro Carla
- Richards A.
- Richardson Emma
- Richardson Matthew
- Rivera-Ortega P.
- Roberts K.
- Robertson E.
- Robinson E
- Robinson Leanne
- Roche Lisa
- Roddis C
- Rodger J
- Rogers Natalie
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- Ross Gavin
- Rossdale J.
- Rostron A
- Rowe Anna
- Rowland A
- Rowland J.
- Rowland Matthew J.
- Rowland-Jones Sarah L
- Roy K
- Roy Maura
- Rudan I
- Russell Emily
- Russell Richard
- Saalmink Gwen
- Sabit Ramsey
- Sage E.K.
- Samakomva T
- Samani Nilesh
- Samat Azlan Helmy A
- Sampson Claire
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- Sanders Zeena-Britt
- Sanderson Amy
- Sapey E
- Saralaya Dinesh
- Sargant J
- Sarginson C
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- Saunders Kathryn
- Saunders Laura C
- Saunders Peter
- Saunders Ruth M
- Savill Heather
- Saxon W.
- Sayer A.
- Schronce J.
- Schwaeble W
- Scott Janet T.
- Scott Kathryn
- Selby N.
- Semple Malcolm G.
- Sereno Marco
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- Shah Ajay M
- Shah K.
- Shah P.
- Shankar-Hari M
- Sharma M
- Sharpe C.
- Sharpe M.
- Shashaa Sharlene
- Shaw Alison
- Shaw Karen
- Shaw V.
- Sheikh Aziz
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- Shenton Liz
- Shevket K.
- Shikotra Aarti
- Short J
- Siddique Sulman
- Siddiqui Salman
- Sidebottom J
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- Simpson J.
- Simpson Neil
- Singapuri Amisha
- Singh Claire
- Singh Sally J
- Singh Suver
- Sissons D
- Skeemer J
- Slack Katie
- Smith Andrew
- Smith D.
- Smith Jacqui
- Smith Laurie
- Smith Nikki
- Smith Stephen
- Smith Susan
- Soares M
- Solano Teresa S
- Solly Reanne
- Solstice A.R.
- Soulsby T
- Southern David
- Sowter D
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- Spencer L G
- Speranza Fabio
- Stadon Louise
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- Steeds Rick
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- Steiner Mike
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- Stephens G
- Stephenson Lorraine
- Stern M
- Stewart I
- Stimpson R
- Stockdale Sue
- Stockley J
- Stoker Wendy
- Stone Roisin
- Storrar Will
- Storrie Andrew
- Storton Kim
- Stringer E
- Strong-Sheldrake Sophia
- Stroud Natalie
- Subbe Christian
- Sudlow C L
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland Debbie
- Sykes D.L.
- Sykes R.
- Talbot Nick
- Tan Ai Lyn
- Tarusan Lawrence
- Tavoukjian Vera
- Taylor Abigail
- Taylor Chris
- Taylor Jessica
- Te Amelie
- Tedd H.
- Tee Caroline
- Teixeira J
- Tench Helen
- Terry Sarah
- Thackray-Nocera Susannah
- Thaivalappil Favas
- Thamu B
- Thickett D
- Thomas Andrew K.
- Thomas Caradog
- Thomas David C.
- Thomas S.
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- Thompson A A Roger
- Thompson T
- Thornton T
- Thorpe M
- Thwaites Ryan S.
- Tilley Jo
- Tinker N
- Tiongson Gerlynn F
- Tobin Martin
- Tomlinson Johanne
- Tong C
- Toshner Mark
- Touyz R.
- Treibel Thomas A
- Tripp K.A.
- Tunnicliffe Elizabeth M.
- Turnbull A
- Turner E
- Turner Kim
- Turner Sarah
- Turner Victoria
- Turney Sharon
- Turtle Lance
- Turton Helena
- Ugoji Jacinta
- Ugwuoke R
- Upthegrove R
- Valabhji J.
- Ventura M
- Vere Joanne
- Vickers Carinna
- Vinson B
- Wade Elaine
- Wade Phillip
- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Ribavirin Improves Early Responses to Peginterferon Through Improved Interferon Signaling
- Author
- Avidan U. Neumann
- Christopher Koh
- Claudia Meek
- Contreras
- Dahari
- Davis
- Diago
- Dixit
- Durante-Mangoni
- Feld
- Feld
- Glen A. Lutchman
- Herrmann
- Hezode
- Jay H. Hoofnagle
- Jessner
- Jordan J. Feld
- Julie K. Pfeiffer
- Koji Hara
- Lindh
- Liu
- Lutchman
- Maag
- Marc G. Ghany
- Maria Rivera
- McHutchison
- Myung Ko
- Neumann
- Padovan
- Pawlotsky
- Poynard
- Rahman
- Richard D. Leff
- Romero
- Sarasin-Filipowicz
- T. Jake Liang
- Tam
- Taylor
- Theo Heller
- Tsubota
- Vanessa Haynes–Williams
- Yaron Rotman
- Yurkovetsky
- Zhang
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Recommended from our members
Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype
- Author
- Afdhal Nezam
- Ayala Claudia
- Barritt A Sidney
- Bass Sheila
- Belle Steven H
- Betts Michael
- Cardona Danielle
- Cardona-Gonzalez Lupita
- Carithers Robert C
- Chang Kyong-Mi
- Chung Raymond T
- Cloonan Yona
- Cooper Stewart L
- Danielson Michelle
- Darling Jama M
- DeVole Nata
- Di Bisceglie Adrian M
- Do Son
- Evon Donna
- Feld Jordan
- Fontana Robert J
- French Samuel
- Fried Michael W
- Fryzek Nancy
- Ganova-Raeva Lilia Milkova
- Ghany Marc G
- Haller Tamara
- Han Johanna
- Han Steven-Huy B
- Hassan Mohamed
- Haynes-Williams Vanessa
- Heathcoate Jenny
- Hofmann Charlotte
- Huddleston Leslie
- Janssen Harry LA
- Javaid Asad
- Johnson Geoffrey
- Juan Joshua
- Kaza Sravanthi
- Keith James
- Kelley Stephanie
- Khalili Mandana
- Khudyakov Yury
- Kim W Ray
- King Debra L
- Kleiner David
- Kowdley Kris V
- La Danie
- Lau Daryl T-Y
- Lau Ivy
- Lee William M
- Levine Danielle
- Li Ruosha
- Liang T Jake
- Lisker-Melman Mauricio
- Liu Lucie
- Lok Anna Suk-Fong
- Luketic Velimir A
- Marsh Tiffany
- Mathisen Terri
- McKenna Barbara
- Metheny Vikki
- Minshall Stacey
- Montaner Luis J
- Mooney Jody
- Morris Nevitt
- Nagy Rosemary A
- Nasser Imad
- Network Hepatitis B Research
- Niu Jianghe
- Oberhelman Kelly
- Olson Emma
- Park Jang-June
- Patel Keyur
- Peacock Velma
- Perrillo Robert
- Podolskaya Veronika
- Poerzgen Peter
- Punkova Lili T
- Rivera Elenita
- Roberts Lewis R
- Rodd Cassandra
- Shuhart Margaret C
- Smith Coleman I
- Smith Paula G
- Stadheim Linda
- Stahler Alisha C
- Sterling Richard K
- Strom Susan
- Teo Chong-Gee
- Terrault Norah A
- Torrey Keith
- Tran Tram T
- Tsai Naoky
- Ungermann Ashley
- Valiga Mary E
- Wahed Abdus
- Wang Chia C
- Wong David K
- Yim Colina
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2015
- Field of study
Background & aimsChronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.MethodsThe HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America.ResultsHalf of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range.ConclusionsThe HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America
Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype
- Author
- A. Sidney Barritt
- Abdus Wahed
- Adrian M. Di Bisceglie
- Alisha C. Stahler
- Andrew Pelesko
- Anna Suk-Fong Lok
- Asad Javaid
- Ashley Ungermann
- Barbara McKenna
- Barbara Walters
- Cassandra Rodd
- Charlotte Hofmann
- Chia C. Wang
- Chong-Gee Teo
- Chu
- Claudia Ayala
- Coleman I. Smith
- Colina Yim
- Danie La
- Danielle Cardona
- Danielle Levine
- Daryl T.-Y. Lau
- David K. Wong
- David Kleiner
- Debra L. King
- Donna Evon
- Donna Stoliker
- Elenita Rivera
- Ella Zadorozny
- Emma Olson
- Funk
- Ganova-Raeva
- Geoffrey Johnson
- Hadziyannis
- Harry L.A. Janssen
- Imad Nasser
- Ivy Lau
- Jama M. Darling
- James Keith
- Jang-June Park
- Jenny Heathcoate
- Jianghe Niu
- Joan M. MacGregor
- Jody Mooney
- Johanna Han
- Jordan Feld
- Joshua Juan
- Keith Torrey
- Kelly Oberhelman
- Keyur Patel
- Kowdley
- Kris V. Kowdley
- Kyong-Mi Chang
- Lavanchy
- Leslie Huddleston
- Lewis R. Roberts
- Lili T. Punkova
- Lilia Milkova Ganova-Raeva
- Linda Stadheim
- Liu
- Lozano
- Lucie Liu
- Luis J. Montaner
- Lupita Cardona-Gonzalez
- Mandana Khalili
- Manuel Lombardero
- Marc G. Ghany
- Margaret C. Shuhart
- Mary E. Valiga
- Mauricio Lisker-Melman
- McQuillan
- Michael Betts
- Michael W. Fried
- Michelle Danielson
- Mitchell
- Mohamed Hassan
- Nancy Fryzek
- Naoky Tsai
- Nata DeVole
- Nevitt Morris
- Nezam Afdhal
- Norah A. Terrault
- Paula G. Smith
- Perz
- Peter Poerzgen
- Raymond T. Chung
- Richard K. Sterling
- Robert C. Carithers
- Robert J. Fontana
- Robert Perrillo
- Rosemary A. Nagy
- Rotermann
- Ruosha Li
- Ruosha Li
- Samuel French
- Schwarz
- Sharon Lawlor
- Sheila Bass
- Son Do
- Sravanthi Kaza
- Stacey Minshall
- Stephanie Kelley
- Steven H. Belle
- Steven-Huy B. Han
- Stewart L. Cooper
- Susan Strom
- T. Jake Liang
- Tamara Haller
- Terri Mathisen
- Tiffany Marsh
- Tram T. Tran
- Vanessa Haynes-Williams
- Velimir A. Luketic
- Velma Peacock
- Veronika Podolskaya
- Vikki Metheny
- W. Ray Kim
- Wang
- William M. Lee
- Yona Cloonan
- Yury Khudyakov
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network
Recommended from our members
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
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- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
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- Stephen R. Walsh
- Steve Clemons
- Steven E. Carsons
- Steven Palmer
- Steven Shinn
- Steven Shoptaw
- Steven Sperber
- Stuart H. Cohen
- Surisday Mederos
- Susan Jeanfreau
- Susan Kline
- Susan L. Koletar
- Susan Parker
- Susanne Doblecki-Lewis
- Suzanna Studdard
- Suzanne Fiorillo
- Suzanne Gharib
- Suzanne Swan
- Sybil G. Hosek
- Szheckera Fearon
- Tamara Richards
- Tambra Dora
- Tameika Scott
- Tami Wahlin
- Tammi L. Shlotzhauer
- Tana Bourgeois
- Tanya Hutchins
- Taryn Petty
- Tatiana Beresnev
- Tavane Harrison
- Taylor Nelson
- Teletha Gipson
- Teresa A. Batteiger
- Teresa Becker
- Teresa Deese
- Teresa S. Sligh
- Teri Thompson-Seim
- Terri Moye
- Terry D. Klein
- Terry L. Poling
- Terry Piedra
- Theresa Hegmann
- Thomas B. Campbell
- Thomas C. Klein
- Thomas C.S. Martin
- Thomas Mellman
- Thomas Patterson
- Thomas Weiss
- Tiffany Esinhart
- Tiffany Nemecek
- Tiffany Schwasinger-Schmidt
- Tilly Varughese
- Timothy J. Hatlen
- Timothy P. Vachris
- Timothy Shope
- Timothy W. Schacker
- Timothy Wilkin
- Tina Tong
- Tina Wang
- Toby Briskin
- Todd Simmons
- Tom Fiel
- Toni Robinson
- Toni White
- Tracy Okonya
- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
- Akane Yamamoto
- Akihiro Fujimoto
- Akihiro Katayama
- Akihito Tanaka
- Akiko Fujita
- Akiko Hashimoto
- Akiko Ishiguro
- Akiko Omata
- Akimasa Asai
- Akinwande Akinfolarin
- Akio Kanazawa
- Akiyo Nishiyama
- Akiyo Tanabe
- Alastair Rankin
- Alastair Woodman
- Albert Hing
- Albert Power
- Alberto Rosati
- Aldo P Maggioni
- Aldo Peixoto
- Aleksandra Murawska
- Alessandro D'Amelio
- Alex Aguilera
- Alex Baxter
- Alex Howson
- Alexa Wonnacott
- Alexander Hadley
- Alexander Hodakowski
- Alexander Paliege
- Alexis Africano
- Alexis Stevenson
- Alfio Giuffrida
- Alfred K Cheung
- Alia Hasan
- Alia Zubaidah Bahtar
- Alice Aitken
- Alice Guerini
- Aliseiya Garza
- Alison Cowley
- Alison Jenkins
- Alison Timadjer
- Allen Young
- Allison Leslie
- Amalia Caamano
- Amanda Aliu
- Amanda Axler
- Amanda Davis
- Amanda Scott
- Amanda Tyler
- Amar Ali
- Amber Avery
- Amber Hurst
- Amelia Te
- Ami Inamori
- Amin Oomatia
- Amir Kazory
- Amret Hawfield
- Amritanshu Pandey
- Amy Hudson
- Amy Hunter
- Amy Mottl
- Ana Moncada
- Anand Srivastava
- Anastassiya Reisler
- Anca Gherman
- Andre Valleteau
- Andrea Lorimer
- Andrea Schwab
- Andrea Webster
- Andrea Wilson
- Andreas Schneider
- Andrew Breach
- Andrew Connor
- Andrew Frankel
- Andrew Gordon
- Andrew Lewington
- Andrew Shepherd
- Andrew Steele
- Andy Burke
- Andy Measor
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- Angela Chamberlain
- Angela Field
- Angela Moon
- Angeline Mbuyisa
- Angharad Williams
- Anil George
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- Anju Oommen
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- Ankit Mehta
- Ann Bennett
- Ann Cooper
- Ann Vasseur
- Anna Brewer
- Anna Liew
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- Annalisa Aloisi
- Anne Froment
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- Annie Saillant
- Annika Küpper
- Anoushka Bhatt
- Anthony Lambert
- Anthony Torres
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- Aparna Padiyar
- Arash Rashidi
- Archie Maskill
- Arelis Madera
- Arif Khwaja
- Arihiro Kiyosue
- Asako Takesada
- Ashlee Morris
- Ashleigh Wheeler
- Ashley Lawson
- Ashwathy Varughese
- Ashwini Gore
- Asma Sabarai
- Astrid Maselli
- Atsuko Nakatsuka
- Atsuyuki Tokuyama
- Auguste Kutschat
- Autumn Wood
- Aya Kawase
- Aya Tanaka
- Aya Yamanaka
- Ayako Imai
- Ayana Tatsuzawa
- Aydin Er
- Ayesha Ali
- Ayesha Irtiza-Ali
- Aziee Sudin
- Bader Al-Zeer
- Baigent Colin
- Bak Leong Goh
- Balwinder Gill
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- Baochun Guo
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- Bhupinder Grewal
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- Gregory Greenwood
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- Martin Kachele
- Martin Radley
- Martina Brueckmann
- Martina Ceseri
- Martina Ruocco
- Mary Parrigon
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- Massey Dan
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- Maurie Tarlac
- Maurizio Caroppo
- Mauver Skipper
- Maximillian von-Eynatten
- Maya Joseph
- Maya Matsushita
- Maylin Garcia
- Mayne Kaitlin J
- Mayu Kiyota
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- Sendogan Aker
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- Severin Schricker
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- Sherry Brown
- Sherry Gasko
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- Shiho Iwagaitsu
- Shin Tsunekawa
- Shingo Iwasaki
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- Shinichi Nishi
- Shinji Kitamura
- Shinji Kume
- Shinjiro Kodama
- Shintaro Nunokawa
- Shintaro Yano
- Shinya Goto
- Shinya Yoshida
- Shiva Ugni
- Shivinder Jolly
- Shizuka Higashi
- Shogo Banno
- Shogo Kimura
- Shoichi Maruyama
- Shoji Saito
- Shoko Hayashi
- Shoko Otomo
- Shona Murray
- Shota Hashimoto
- Shraddha Shah
- Shuai Tang
- Shuang Xia
- Shuhan Zhou
- Shunichiro Asahara
- Shunsuke Goto
- Shweta Bansal
- Sian Griffin
- Sibylle J Hauske
- Silke Markau
- Simona Barberi
- Simona Bianco
- Simone Boedecker
- Simone Hagge
- Simone Streitenberger
- Simone Vettoretti
- Sina Rolfsmeier
- Sion Roy
- Siti Munirah Jaafar
- Siti Nabilah Mohamad Zaini
- Smeeta Sinha
- Smita Gunda
- Sodai Kubota
- Sofia Dayi
- Sonja Grotjahn
- Sonoka Yamamoto
- Soo Kun Lim
- Soon Yi Sor
- Sorcha Mulligan
- Sri Yarlagadda
- Sridhar Ramanaidu
- Srinivasan Beddhu
- Stacey-Ann Villaruel
- Stacie Hitchcock
- Stacy Gillham
- Staplin Natalie
- Stefan Degenhardt
- Stefan Haack
- Stefan Hantel
- Stefanie Jones
- Stefanie Kuhn
- Stephan Matthias
- Stephanie Bolton
- Stephanie Estcourt
- Stephanie Evans
- Stephanie Martinez
- Stephanie Rosenberg
- Stephanie Watson
- Stephanie Whittaker
- Stephany Topping
- Stephen Aronoff
- Steubl Dominik
- Steven Nagelberg
- Stevens Will
- Stewart Moffat
- Subash Somalanka
- Subha Clarke
- Subrata Debnath
- Sucharit Joshi
- Sue Ann Lee
- Sue Hewins
- SueAnn Squyres
- Sui Phin Kon
- Sunil Bhandari
- Sunita Bavanandan
- Suresh Ramadoss
- Suria Junus
- Susan Haskett
- Susan Hurley
- Susan McLaughlin
- Susannah Pajak
- Susanne Bodine
- Susanne Brenner
- Susumu Nakatani
- Suzannah Dorey
- Sybille Merscher
- Tabbatha Duck
- Tabinda Dugal
- Tadahiro Tomita
- Taeko Uchida
- Tai Meng Chen
- Takahiro Ishikawa
- Takahiro Kato
- Takahiro Matsunaga
- Takahiro Yamano
- Takako Kuramae
- Takako Ozawa
- Takanori Hyo
- Takashi Funayama
- Takashi Kadowaki
- Takashi Kobayashi
- Takashi Udagawa
- Takatoshi Otani
- Takayuki Katsuno
- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
- Tatyana Chavagnon
- Tejas Patel
- Teresa Kozlowski
- Teresa McKinley
- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
- Thomas Weinreich
- Tim Doulton
- Tim Williams
- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
- Tobias Bergler
- Toluleyi Sobande
- Tomoe Sato
- Tomohide Hayami
- Tomohito Gohda
- Tomohito Izumi
- Tomoka Nakamura
- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
- Tomoko Takahashi
- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
- Ashur-Fabian Osnat
- Atanasov Atanas G
- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H
- Baek Ahruem
- Baek Seung-Hoon
- Baek Sung Hee
- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xiyuan
- Bai Yidong
- Bairagi Nandadulal
- Baksi Shounak
- Balazadeh Salma
- Balbi Teresa
- Baldari Cosima T
- Balduini Walter
- Ballabio Andrea
- Ballester Maria
- Balzan Rena
- Bandopadhyay Rina
- Banerjee Sreeparna
- Banerjee Sulagna
- Bao Yan
- Baptista Mauricio S
- Baracca Alessandra
- Barbati Cristiana
- Bargiela Ariadna
- Barila Daniela
- Barlow Peter G
- Barmada Sami J
- Barreiro Esther
- Barrera Miguel Calvo-Rubio
- Barreto George E
- Bartek Jiri
- Bartel Bonnie
- Bartolome Alberto
- Barve Gaurav R
- Basagoudanavar Suresh H
- Bassham Diane C
- Basu Alakananda
- Batoko Henri
- Batten Isabella
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- Baumgarner Bradley L
- Bayry Jagadeesh
- Beale Rupert
- Beau Isabelle
- Beaumatin Florian
- Bechara Luiz RG
- Beck George R Jr
- Beers Michael F
- Begun Jakob
- Behl Christian
- Behrends Christian
- Behrens Georg MN
- Bei Roberto
- Bejarano Eloy
- Bel Shai
- Belaid Amine
- Belgareh-Touze Naima
- Bellarosa Cristina
- Belleudi Francesca
- Bello Perez Melissa
- Bello-Morales Raquel
- Beltran Sebastian
- Benbrook Doris Mangiaracina
- Bendorius Mykolas
- Benitez Bruno A
- Benito-Cuesta Irene
- Bensalem Julien
- Berchtold Martin W
- Berezowska Sabina
- Bergamaschi Daniele
- Bergami Matteo
- Bergmann Andreas
- Berliocchi Laura
- Berlioz-Torrent Clarisse
- Bernard Amelie
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- Beyaert Rudi
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- Bharath MM Srinivas
- Bhaskar Kiran
- Bhatia-Kissova Ingrid
- Bhattacharya Resham
- Bhattacharya Sujoy
- Bhattacharyya Shalmoli
- Bhuiyan Md Shenuarin
- Bhutia Sujit Kumar
- Bi Lanrong
- Bi Xiaolin
- Biden Trevor J
- Bijian Krikor
- Billes Viktor A
- Binart Nadine
- Bincoletto Claudia
- Birgisdottir Asa B
- Bjorkoy Geir
- Blanco Gonzalo
- Blas-Garcia Ana
- Blasiak Janusz
- Blomgran Robert
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- Blum Janice S
- Boada-Romero Emilio
- Boban Mirta
- BoeszeBattaglia Kathleen
- Boeuf Philippe
- Boland Barry
- Bomont Pascale
- Bonaldo Paolo
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- Strappazzon Flavie
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- Stupack Dwayne G
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- Subauste Carlos S
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- Tai Haoran
- Tait Stephen WG
- Takahashi Yoshinori
- Takats Szabolcs
- Talwar Priti
- Tam Chit
- Tam Shing Yau
- Tampellini Davide
- Tamura Atsushi
- Tan Chong Teik
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- Tan Ya-Qin
- Tanaka Masaki
- Tanaka Motomasa
- Tang Daolin
- Tang Jingfeng
- Tang Tie-Shan
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- Tao Zhipeng
- Taouis Mohammed
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- Van den Berghe Greet
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- Vandenberghe Wim
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- Vannier-Santos Marcos A
- Vannini Nicola
- Vanrell M Cristina
- Vantaggiato Chiara
- Varano Gabriele
- Varela-Nieto Isabel
- Varga Mate
- Vasconcelos M Helena
- Vats Somya
- Vavvas Demetrios G
- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
- Velazquez Ariadna P
- Vellai Tibor
- Vellenga Edo
- Velotti Francesca
- Verdier Mireille
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- Villalobo Antonio
- Villarejo-Zori Beatriz
- Villarroya Francesc
- Villarroya Joan
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- Visnjic Dora
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- Xie Min
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- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
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- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
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- Yang Ying
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- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field