Associations plasmodiales P, Falciparum +P,Vivax au centre de santé de St Georges de l'Oyapock; Conséquences pour la stratégie diagnostique et thérapeutique anti-palustre en Guyanne Française (étude préliminaire)

ANGERS-BU Médecine-Pharmacie (490072105) / SudocSudocFranceF

Interest of laboratory database analysis for assessing the total number of bacterial meningitis managed in a French hospital

International audienc

Les premières occupations du Néolithique ancien dans le Nord-Ouest de la France

International audienceRecently, several sites dating from the Early Neolithic were discovered in the extreme North of France, in a region where this period had been unknown up until now. The ten sites presented here all date from the Blicquy/Villeneuve-Saint-Germain (BVSG) chrono-cultural horizon, in a geographic sector located between the Oise valley to the east, the Somme valley to the south and the shores of the Channel/North Sea to the northwest. These sites are rather late for an Early Neolithic, compared to the more imposing Linear Pottery Culture settlements in Belgian Hainaut or the Paris basin, which are several centuries older. The synopsis of these studies defines the typo-chronological framework of these settlements, in parallel with the radiocarbon results and a techno-functional approach to the different objects. Comparisons with Early Neolithic sites from the Paris basin and Belgium contribute to the discussion on the links between the different regions and the broader question of regional axes of Linear Pottery Culture and BVSG.La découverte récente de plusieurs gisements datés du Néolithique ancien dans l’extrême Nord de la France s’est faite dans une région où cette période n’était pas attestée. Les dix sites présentés ici, sont tous datés de l’horizon chrono-culturel Blicquy/Villeneuve-Saint-Germain (BVSG) et sont implantés dans un secteur géographique compris entre les vallées de l’Oise à l’est, de la Somme au sud et des rivages de la Manche/Mer du Nord au nord-ouest. Cet effectif faible est aussi tardif pour un premier néolithique comparé aux occupations rubanées reconnues, dans le Hainaut belge ou le Bassin parisien, plus importantes mais aussi plus anciennes de quelques siècles. La synthèse des études a permis de préciser le cadre typo-chronologique de ces occupations à l’aide d’approches techno-fonctionnelles sur les différents mobiliers en les mettant en parallèle avec les mesures radiocarbone. Les comparaisons avec les sites du Néolithique ancien du Bassin parisien et de Belgique viendront alimenter la discussion sur les liens entretenus entre les différentes régions et permettront finalement de revenir sur les apports de ces sites dans l'étude plus générale des axes régionaux de colonisation néolithique rubanés et BVSG

The first Early Neolithic settlements in northwest France

Recently, several sites dating from the Early Neolithic were discovered in the extreme North of France, in a region where this period had been unknown up until now. The ten sites presented here all date from the Blicquy/Villeneuve-Saint-Germain (BVSG) chrono-cultural horizon, in a geographic sector located between the Oise valley to the east, the Somme valley to the south and the shores of the Channel/North Sea to the northwest. These sites are rather late for an Early Neolithic, compared to the more imposing Linear Pottery Culture settlements in Belgian Hainaut or the Paris basin, which are several centuries older. The synopsis of these studies defines the typo-chronological framework of these settlements, in parallel with the radiocarbon results and a techno-functional approach to the different objects. Comparisons with Early Neolithic sites from the Paris basin and Belgium contribute to the discussion on the links between the different regions and the broader question of regional axes of Linear Pottery Culture and BVSG.La découverte récente de plusieurs gisements datés du Néolithique ancien dans l’extrême Nord de la France s’est faite dans une région où cette période n’était pas attestée. Les dix sites présentés ici, sont tous datés de l’horizon chrono-culturel Blicquy/Villeneuve-Saint-Germain (BVSG) et sont implantés dans un secteur géographique compris entre les vallées de l’Oise à l’est, de la Somme au sud et des rivages de la Manche/Mer du Nord au nord-ouest. Cet effectif faible est aussi tardif pour un premier néolithique comparé aux occupations rubanées reconnues, dans le Hainaut belge ou le Bassin parisien, plus importantes mais aussi plus anciennes de quelques siècles. La synthèse des études a permis de préciser le cadre typo-chronologique de ces occupations à l’aide d’approches techno-fonctionnelles sur les différents mobiliers en les mettant en parallèle avec les mesures radiocarbone. Les comparaisons avec les sites du Néolithique ancien du Bassin parisien et de Belgique viendront alimenter la discussion sur les liens entretenus entre les différentes régions et permettront finalement de revenir sur les apports de ces sites dans l’étude plus générale des axes régionaux de colonisation néolithique rubanés et BVSG

Coxiella burnetii endocarditis as a possible cause of ANCA-associated vasculitis

International audienc

Outpatient management or hospitalization of patients with proven or suspected SARS-CoV-2 infection: the HOME-CoV rule

International audienceIn the context of the COVID-19 pandemic and overloaded hospitals, a central issue is the need to define reliable and consensual criteria for hospitalization or outpatient management in mild cases of COVID-19. Our aim was to define an easy-to-use clinical rule aiming to help emergency physicians in hospitalization or outpatient management decision-making for patients with suspected or confirmed SARS-CoV-2 infection (the HOME-CoV rule). The Delphi method was used to reach a consensus of a large panel of 51 experts: emergency physicians, geriatricians, infectious disease specialists, and ethical consultants. A preliminary list of eligible criteria was compiled based on a literature review. Four rounds of anonymized expert consultations were performed. The experts were asked to score each item as relevant, possibly relevant and non-relevant, as major or minor, and to choose the cut-off. They were also able make suggestions and remarks. Eight criteria constituting the HOME-CoV were selected: six correspond to the severity of clinical signs, one to the clinical course (clinically significant worsening within the last 24 h), and the last corresponds to the association of a severe comorbidity and an inadequate living context. Hospitalization is deemed necessary if a patient meets one or more of the criteria. In the end, 94.4% of the experts agreed with the defined rule. Thanks to the Delphi method, an absolute consensus was obtained of a large panel of experts on the HOME-CoV rule, a decision-making support mechanism for clinicians to target patients with suspected or confirmed COVID-19 requiring hospitalization. Trial registration: NCT04338841

No antibody response in acral cutaneous manifestations associated with COVID-19 ?

International audienceSkins symptoms during COVID‐19 have been recently described but their relation to SARS‐CoV‐2 is unclear while results for real‐time reverse transcriptase polymerase chain reaction (rRT‐PCR) testing were variable. Recalcati et al. reported 14 cases of patients with skin symptoms consistent with previous described COVID‐19 lesions but all the patients were tested negative. They asked for a serology to validate the hypothesis that these lesions are related to COVID‐19

Air contamination for predicting wound contamination in clean surgery: A large multicenter study

International audienceThe best method to quantify air contamination in the operating room (OR) is debated, and studies in the field are controversial. We assessed the correlation between 2 types of air sampling and wound contaminations before closing and the factors affecting air contamination. This multicenter observational study included 13 ORs of cardiac and orthopedic surgery in 10 health care facilities. For each surgical procedure, 3 microbiologic air counts, 3 particles counts of 0.3, 0.5, and 5 μm particles, and 1 bacteriologic sample of the wound before skin closure were performed. We collected data on surgical procedures and environmental characteristics. Of 180 particle counts during 60 procedures, the median log10 of 0.3, 0.5, and 5 μm particles was 7 (interquartile range [IQR], 6.2-7.9), 6.1 (IQR, 5.4-7), and 4.6 (IQR, 0-5.2), respectively. Of 180 air samples, 50 (28%) were sterile, 90 (50%) had 1-10 colony forming units (CFU)/m(3) and 40 (22%) >10 CFU/m(3). In orthopedic and cardiac surgery, wound cultures at closure were sterile for 24 and 9 patients, 10 and 11 had 1-10 CFU/100 cm(2), and 0 and 6 had >10 CFU/100 cm(2), respectively (P < .01). Particle sizes and a turbulent ventilation system were associated with an increased number of air microbial counts (P < .001), but they were not associated with wound contamination (P = .22). This study suggests that particle counting is a good surrogate of airborne microbiologic contamination in the OR

Outpatient management or hospitalization of patients with proven or suspected SARS-CoV-2 infection: the HOME-CoV rule.

In the context of the COVID-19 pandemic and overloaded hospitals, a central issue is the need to define reliable and consensual criteria for hospitalization or outpatient management in mild cases of COVID-19. Our aim was to define an easy-to-use clinical rule aiming to help emergency physicians in hospitalization or outpatient management decision-making for patients with suspected or confirmed SARS-CoV-2 infection (the HOME-CoV rule). The Delphi method was used to reach a consensus of a large panel of 51 experts: emergency physicians, geriatricians, infectious disease specialists, and ethical consultants. A preliminary list of eligible criteria was compiled based on a literature review. Four rounds of anonymized expert consultations were performed. The experts were asked to score each item as relevant, possibly relevant and non-relevant, as major or minor, and to choose the cut-off. They were also able make suggestions and remarks. Eight criteria constituting the HOME-CoV were selected: six correspond to the severity of clinical signs, one to the clinical course (clinically significant worsening within the last 24 h), and the last corresponds to the association of a severe comorbidity and an inadequate living context. Hospitalization is deemed necessary if a patient meets one or more of the criteria. In the end, 94.4% of the experts agreed with the defined rule. Thanks to the Delphi method, an absolute consensus was obtained of a large panel of experts on the HOME-CoV rule, a decision-making support mechanism for clinicians to target patients with suspected or confirmed COVID-19 requiring hospitalization.Trial registration: NCT04338841

Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer

Preventing untoward immune responses against a specific antigen is a major challenge in different clinical settings such as gene therapy, transplantation, or autoimmunity. Following intramuscular delivery of recombinant adeno-associated virus (rAAV)-derived vectors, transgene rejection can be a roadblock to successful clinical translation. Specific immunomodulation strategies potentially leading to sustained transgene expression while minimizing pharmacological immunosuppression are desirable. Tolerogenic dendritic cells (TolDC) are potential candidates but have not yet been evaluated in the context of gene therapy, to our knowledge. Following intramuscular delivery of rAAV-derived vectors expressing an immunogenic protein in the nonhuman primate model, we assessed the immunomodulating potential of autologous bone marrow-derived TolDC generated in the presence of IL10 and pulsed with the transgene product. TolDC administered either intradermally or intravenously were safe and well tolerated. While the intravenous route showed a modest ability to modulate host immunity against the transgene product, intradermally delivery resulted in a robust vaccination of the macaques when associated to intramuscular rAAV-derived vectors-based gene transfer. These findings demonstrate the critical role of TolDC mode of injection in modulating host immunity. This study also provides the first evidence of the potential of TolDC-based immunomodulation in gene therapy