Angle-of-Arrival based localization using polynomial chaos expansions

International audienceIn this paper, polynomial chaos expansions are applied to angle-of-arrival based localization. By using a polynomial chaos expansion on a least squares estimator, a new positioning method is designed. Simulation results show that the proposed method returns precise information about the statistical distribution of the position

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis

During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis. Furthermore, we investigated the role of lymphatics in atherosclerosis progression. Dissection of plaque draining lymph node and lymphatic vessel in atherosclerotic ApoE(-/-)mice aggravated plaque formation, which was accompanied by increased intimal and adventitial CD3(+) T cell numbers. Likewise, inhibition of VEGF-C/D dependent lymphangiogenesis by AAV aided gene transfer of hVEGFR3-Ig fusion protein resulted in CD3(+) T cell enrichment in plaque intima and adventitia. hVEGFR3-Ig gene transfer did not compromise adventitial lymphatic density, pointing to VEGF-C/D independent lymphangiogenesis. We were able to identify the CXCL12/CXCR4 axis, which has previously been shown to indirectly activate VEGFR3, as a likely pathway, in that its focal silencing attenuated lymphangiogenesis and augmented T cell presence. Taken together, our study not only shows profound, partly CXCL12/CXCR4 mediated, expansion of lymph capillaries in the adventitia of atherosclerotic plaque in humans and mice, but also is the first to attribute an important role of lymphatics in plaque T cell accumulation and development.Peer reviewe

Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression

Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial for tissue development and homeostasis, it has been implicated in various inflammatory diseases by regulating processes like immune cell recruitment and activation. ADAM8 expression has been associated with human atherosclerosis development and myocardial infarction, however a causal role of ADAM8 in atherosclerosis has not been investigated thus far. In this study, we examined the expression of ADAM8 in early and progressed human atherosclerotic lesions, in which ADAM8 was significantly upregulated in vulnerable lesions. In addition, ADAM8 expression was most prominent in the shoulder region of human atherosclerotic lesions, characterized by the abundance of foam cells. In mice, Adam8 was highly expressed in circulating neutrophils and in macrophages. Moreover, ADAM8 deficient mouse macrophages displayed reduced secretion of inflammatory mediators. Remarkably, however, neither hematopoietic nor whole-body ADAM8 deficiency in mice affected atherosclerotic lesion size. Additionally, except for an increase in granulocyte content in plaques of ADAM8 deficient mice, lesion morphology was unaffected. Taken together, whole body and hematopoietic ADAM8 does not contribute to advanced atherosclerotic plaque development, at least in female mice, although its expression might still be valuable as a diagnostic/ prognostic biomarker to distinguish between stable and unstable lesions

Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model

Bioluminescence imaging (BLI) has shown its appeal as a sensitive technique for in vivo whole body optical imaging. However, the development of injectable tumor-specific near-infrared fluorescent (NIRF) probes makes fluorescence imaging (FLI) a promising alternative to BLI in situations where BLI cannot be used or is unwanted (e.g., spontaneous transgenic tumor models, or syngeneic mice to study immune effects)

ToA-based iterative localization in rich multipath channels

Iterative localization is arising as a promising solution to determine the position of a mobile station in a cellular network. We recently showed that in a perfect line-of-sight environment, iterating between the conventional delay estimation and multi-lateration steps allows to approach the performance of the direct localization based on the observation of the received signals. In this paper we extend our iterative localization method to operate in rich multipath environments. Simulation results prove that given some prior knowledge on the power delay profile of the channel, the proposed iterative algorithm is robust to harsh propagation environments and performs very close to the direct localization approachinfo:eu-repo/semantics/publishe

Evolution of 5G networks: communications and positioning interplay

Invited talkinfo:eu-repo/semantics/nonPublishe

Low complexity iterative localization of time-misaligned terminals in cellular networks

Recently, iterative localization has arisen as a promising approach to localize a Mobile Station (MS) in a cellular system. The conventional geo-location is obtained in a two-step approach: propagation delays are estimated and then the multi-lateration is responsible for the determination of the user position, based on the estimated delays. Iterative localization iterates between the two conventional steps to progressively refine delay estimates based on the position estimate available from the previous iterations. This localization scheme was seen to provide appealing performances compared to the two-step approach. It also seems to be computationally attractive with respect to direct localization that estimates the position using the digitized received signals directly. However, the iterative localization solution developed in literature relies on a strict time synchronization between MS and Base Stations (BSs). Moreover,the computational complexity of the iterative approach is not thoroughly compared to two-step and optimal solutions. This paper therefore proposes a new iterative localization method able to operate in a cellular system with time-misaligned terminals.We show by means of a detailed complexity analysis that the iterative positioning algorithm is one order of magnitude less complex than direct localization. Simulation results prove that the achievable performance after a few iterations approaches the performance of the direct localization solution.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Iterative ToA-based terminal positioning in emerging cellular systems

Emerging cellular networks integrate the user terminal geo-localization function besides the communication function. The conventional positioning approach is to estimate the terminal location in two-steps: first the distance to all connected base stations is assessed based on signal time-of-flight measurements, then the location is deduced from the distances by multilateration. The two-step approach incurs a performance degradation because information is lost from the received signal when the multi-lateration is performed. In this paper, we propose to iterate between the two conventional steps to progressively refine the distance estimates based on the knowledge of the position estimate obtained from the previous iterations. The information exchanged between the two-steps not only consists in the mean of the estimates (distance or position) but also of their variance that convey information about the reliability of the estimates. Simulation results show that the achievable performance after a few iterations is close to the performance of the optimal approach that directly estimates the position based on the observation of the received signal.info:eu-repo/semantics/publishe