Институционализация памяти: научно-организационные формы и практики изучения Великой Отечественной войны в советской и постсоветской историографии

Статья подготовлена в рамках проекта «Великая Отечественная война в пространстве исторической памяти Юга России» Подпрограммы фундаментальных исследований «Проблемы социально-экономического и этнополитического развития южного макрорегиона» Программы Президиума РАН «Фундаментальные проблемы пространственного развития Российской Федерации: междисциплинарный синтез» на 2009–2011 гг

Health-related quality of life and mental health problems after a disaster: Are chronically ill survivors more vulnerable to health problems?

Studies have shown that the chronically ill are at higher risk for reduced health-related quality of life (HRQL) and for mental health problems. A combination with traumatic events might increase this risk. This longitudinal study among 1216 survivors of a disaster examines whether chronically ill survivors had a different course of HRQL and mental health problems compared to survivors without chronic diseases. HRQL and mental health problems were measured 3 weeks, 18 months and 4 years post-disaster. Data on pre-disaster chronic diseases was obtained from the electronic medical records of general practitioners. Random coefficient analyses showed significant interaction effects for social functioning, bodily pain and emotional role limitations at T2 only. Chronically ill survivors did not consistently have a different course of general health, physical role limitations, and mental health problems. In conclusion, chronic diseases were not an important risk factor for impaired HRQL and mental health problems among survivors

Kalman-filter-based EEG source localization

This thesis uses the Kalman filter (KF) to solve the electroencephalographic (EEG) inverse problem to image its neuronal sources. Chapter 1 introduces EEG source localization and the KF and discusses how it can solve the inverse problem. Chapter 2 introduces an EEG inverse solution using a spatially whitened KF (SWKF) to reduce the computational burden. Likelihood maximization is used to fit spatially uniform neural model parameters to simulated and clinical EEGs. The SWKF accurately reconstructs source dynamics. Filter performance is analyzed by computing the innovations’ statistical properties and identifying spatial variations in performance that could be improved by use of spatially varying parameters. Chapter 3 investigates the SWKF via one-dimensional (1D) simulations. Motivated by Chapter 2, two model parameters are given Gaussian spatial profiles to better reflect brain dynamics. Constrained optimization ensures estimated parameters have clear biophysical interpretations. Inverse solutions are also computed using the optimal linear KF. Both filters produce accurate state estimates. Spatially varying parameters are correctly identified from datasets with transient dynamics, but estimates for driven datasets are degraded by the unmodeled drive term. Chapter 4 treats the whole-brain EEG inverse problem and applies features of the 1D simulations to the SWKF of Chapter 2. Spatially varying parameters are used to model spatial variation of the alpha rhythm. The simulated EEG here exhibits wave-like patterns and spatially varying dynamics. As in Chapter 3, optimization constrains model parameters to appropriate ranges. State estimation is again reliable for simulated and clinical EEG, although spatially varying parameters do not improve accuracy and parameter estimation is unreliable, with wave velocity underestimated. Contributing factors are identified and approaches to overcome them are discussed. Chapter 5 summarizes the main findings and outlines future work

Prediction of length and diameter of hamstring tendon autografts for knee ligament surgery in Caucasians

Purpose: Prediction of hamstring tendon autograft size facilitates preoperative planning of knee ligament surgery and may reduce the need for a

Lifting the Shroud: Government, Investment Banks and Power in Post Financial Crisis United Kingdom - A critical deconstruction of the relationship between government and investment banks in the United Kingdom post global financial crisis (2007 – 2011)

The late 2000s Global Financial Crisis swept the advanced world and spilled into the developing, creating chaos in its wake. At the crux of the crisis were the high-risk activities of investment banks in the developed world – and especially United Kingdom. Since then, academic and public discussion has revolved around the questionable relationship between investment banks and government that resulted in subpar regulation and the costly bank ‘bailouts’ of 2008 and 2009. What this thesis will to do is holistically assess how the power relationship between British investment banks and the United Kingdom government has evolved since the crisis, utilising Doris Fuchs’ Three Dimensional Approach to Business Power and Governance and a wide array of research to address those structural, instrumental and discursive elements of business power

Towards an individualized management strategy for patients with chronic venous disease: Results of a Delphi consensus

Objective: To obtain consensus on management criteria for symptomatic patients with chronic venous disease (CVD; C2–C6) and superficial venous reflux. Method: We used a Delphi method by means of 36 statements sent by email to experts in the field of phlebology across the world over the course of three rounds. The statements addressed criteria for different venous treatments in patients with different characteristics (e.g. extensive comorbidities, morbid obesity and peripheral arterial disease). If at least 70% of the ratings for a specific statement were between 6 and 9 (agreement) or between 1 and 3 (disagreement), experts’ consensus was reached. Results: Twenty-five experts were invited to participate, of whom 24 accepted and completed all three rounds. Consensus was reached in 25/32 statements (78%). However, several statements addressing UGFS, single phlebectomies, patients with extensive comorbidities and morbid obesity remained equivocal. Conclusion: Considerable consensus was reached within a group of experts but also some gaps in available research were highlighted

Macrofauna in de verontreinigde waterbodem van de Rijn/Maas-delta

Door middel van monsternemingen en statistische analyses is onderzoek gedaan naar de correlaties tussen fysische variabelen en verontreinigingen (zware metalen, organochloorpesticiden, PCB's, PAK's) in het sediment, de sedimenttoxiciteit bepaald door bioassays, en de variantie in soortensamenstelling van de bodembewonende macrofauna in Brabantsche Biesbosch, Dordtsche Biesbosch, Hollands Diep, Nieuwe Merwede en Haringvlie

Eculizumab Dosing Regimen in Atypical HUS: Possibilities for Individualized Treatment

Contains fulltext : 177003.pdf (publisher's version ) (Closed access) Contains fulltext : 177003pos.pdf (postprint version ) (Open Access)Recent studies indicate that eculizumab is often given in excess to atypical hemolytic uremic syndrome (aHUS) patients. Individualization of treatment is thus highly requested; however, data on the pharmacokinetics and pharmacodynamics of eculizumab remain limited. We analyzed 11 patients during induction (weekly), maintenance (2-weekly), and tapering (every 3-8 weeks) phases of treatment. The trough eculizumab levels increased with each additional dose during the induction phase (depending on body weight). During maintenance, high eculizumab concentrations of up to 772 mug/mL were observed. The levels decreased with each following dose during tapering (3- and 4-week intervals); however, three patients maintained target eculizumab levels over long time periods (30-48 weeks). At intervals of 6-8 weeks, target eculizumab levels were no longer attained. Serum samples with eculizumab concentrations >/=50 mug/mL showed adequate complement blockade. Our data provide essential insight for optimization of eculizumab dosing schemes and lessening of therapy burden for the patients and cost of the treatment

GDPR in research - what does it mean for research institutions?

Collection of materials from the event "GDPR in research - what does it mean for research institutions?" which was hosted by TU Delft Library on 30 August 2018. The collection includes the following materials: The programme of the event The welcome slide All presentations from the event All authors and event organisers are listed in alphabetical order. Any questions about these materials should be addressed to [email protected]