A Political Method of Evaluating the Education for All Handicapped Children Act of 1975 and the Several Gaps of Gap Analysis

This project can be seen as a collection of architectural explorations that originate from the concept of misunderstanding. The misunderstanding involves an unconscious transformation that can create something new and unexpected and is therefore an important element both in history and in an individual design process. Five examples of misunderstanding from the history of architecture are described in short texts. From each text a drawing is selected that becomes the starting point for a process where translation between alternating digital and analog representation techniques transform the original object, in multiple steps. For each transformation, a text follows, in which the story is reinterpreted and distorted. The last step in this process is a larger physical object that no longer resembles the original drawing, and which, by its ambiguity begins to live its own life. One theme that emerged during the process has been the relationship between architecture and figures or bodies.Detta projekt kan ses som en samling arkitektoniska betraktelser som tar sin utgångspunkt ur begreppet missförstånd. Missförståndet innebär en omedveten transformation som kan skapa något nytt och oväntat och är därför ett viktigt inslag både i historien och i en individuell designprocess. Fem exempel på missförstånd ur arkitekturhistorien beskrivs i korta texter. Utifrån dessa väljs ett antal ritningar som blir utgångspunkt för en process där översättningen mellan omväxlande digitala och analoga representationstekniker förvandlar det ursprungliga objektet i flera steg. För varje transformation följer en text där berättelsen omtolkas och förvrids. Det sista steget i denna process är ett fysiskt objekt i större skala vars gestalt är svår att härleda till den ursprungliga ritningen och som genom sin tvetydighet börjar leva sitt eget eget liv. Ett tema som utkristalliserat sig under processen har varit relationen mellan arkitektur och figurer eller kroppar

A digital controller using multirate sampling for gain control

Digital controller using multirate sampling for gain contro

Hotspot Zuidplaspolder: Climate adaptation in the Zuidplaspolder

Building at the lowest point in the Netherlands, in the Zuidplaspolder, is viewed as a challenge and not something that is impossible. The Xplorelab approach in the Hotspot Zuidplaspolder project is a combination of research, implementation of ideas into inspiring examples and evaluation

“I Wish I Had AIDS”: A qualitative study on access to health care services for HIV/AIDS and diabetic patients in Cambodia

Financially stricken Cambodian patients with diabetes and HIV/AIDS typically encounter multiple, serious barriers to effective care. This process may extend over many years and involve numerous rounds of diagnosis and treatment as the disease progresses from initial symptoms to longer term complications. Living with both the impact of the disease and this ongoing struggle for care can severely disrupt the everyday life of both sufferers and their families. Our retrospective study adopted qualitative research methods to collect data from HIV/AIDS and diabetic patients enrolled and not enrolled in treatment programs at varying institutions in urban and rural settings. Using purposive sampling techniques, a total of 25 HIV/AIDS and 45 diabetic patients were recruited. Semi-structured and open-ended interviews were used to collect information on patient experiences of different phases in the on-going process of seeking care and treatment. The findings indicate that both HIV/AIDS and diabetic patients encounter multiple supply- and demand-side barriers to care at different stages of their illness. More strikingly, our research findings suggest that supply-side barriers, for example rationing systems or targeting strategies that limit access to free treatment or social assistance, are substantially higher for diabetic patients. This perceived inequity had a profound impact on diabetic patients to the extent that some “wished they had HIV/AIDS”. These findings suggest that there is an urgent need to widen the focus of health care to address the substantial and increasing burden of disease resulting from diabetes and other serious chronic disorders in Cambodia and many other low/middle income countries.

Библиотековедение как фундаментальная наука

The Netherlands saw an unexplained increase in campylobacteriosis incidence between 2003 and 2011, following a period of continuous decrease. We conducted an ecological study and found a statistical association between campylobacteriosis incidence and the annual number of prescriptions for proton pump inhibitors (PPIs), controlling for the patient's age, fresh and frozen chicken purchases (with or without correction for campylobacter prevalence in fresh poultry meat). The effect of PPIs was larger in the young than in the elderly. However, the counterfactual population-attributable fraction for PPIs was largest for the elderly (ca 45% in 2011) and increased at population level from 8% in 2004 to 27% in 2011. Using the regression model and updated covariate values, we predicted a trend break for 2012, largely due to a decreased number of PPI prescriptions, that was subsequently confirmed by surveillance data. Although causality was not shown, the biological mechanism, age effect and trend-break prediction suggest a substantial impact of PPI use on campylobacteriosis incidence in the Netherlands. We chose the ecological study design to pilot whether it is worthwhile to further pursue the effect of PPI on campylobacteriosis and other gastrointestinal pathogens in prospective cohort studies. We now provide strong arguments to do so

Tethered atmospheric/ionospheric research satellite (AIRSAT)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76917/1/AIAA-1993-4767-104.pd

Proliferative Activity In Vitro and DNA Repair Indicate that Adult Mouse and Human Sertoli Cells Are Not Terminally Differentiated, Quiescent Cells

Sertoli cells isolated from the adult mouse and human testis resume proliferation in culture. After 20 days of culture in Dulbecco modified Eagle medium/Ham F12 (DMEM/F12) medium containing 5% fetal calf serum, about 36% of the mouse Sertoli cells, identified by their immunohistochemical staining for the Sertoli cell marker vimentin, incorporated bromodeoxyuridine (BrdU). The renewed proliferation was associated with a 70% decrease in expression of the cell cycle inhibitor CDKN1B (P27(kip1)) and a 2-fold increase in the levels of the proliferation inducer ID2. In vivo, the balance between cell cycle inhibitors and inducers probably is such that the cells remain quiescent, whereas in culture the balance is disturbed such that Sertoli cells start to proliferate again. The renewed proliferative activity of Sertoli cells in culture was further confirmed by double staining for BrdU and the Sertoli cell marker clusterin (CLU), showing about 25% of the CLU-positive Sertoli cells to be also positive for BrdU after 13 days of culture. Radiobiologically, Sertoli cells are also different from other quiescent somatic cells in the testis because they express several DNA repair proteins (XRCC1, PARP1, and others). Indeed, a comet assay on irradiated Sertoli cells revealed a 70% reduction in tail length and tail moment at 20 h after irradiation. Hence, Sertoli cells repair DNA damage, whereas other quiescent somatic testicular cells do not. This repair may be accomplished by nonhomologous end joining via XRCC1 and PARP1. In conclusion, cell kinetic and radiobiological data indicate that Sertoli cells more resemble arrested proliferating cells than the classic postmitotic and terminally differentiated somatic cells that they have always been assumed to b