120 research outputs found
Technisch werkdocument HBO-Monitor 1995: De arbeidsmarktpositie van afgestudeerden van het hoger beroepsonderwijs uit het studiejaar 1993/1994
Not availablelabour market entry and occupational careers;
Problems with latent class analysis to detect data-driven subtypes of depression
FSW – Publicaties zonder aanstelling Universiteit Leide
COvid MEdicaTion (COMET) study: protocol for a cohort study
Various theories about drugs such as ACE inhibitors or
angiotensin II receptor blockers (ARBs) in relation to
severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) and clinical outcomes of COVID-19 are circulating
in both mainstream media and medical literature.
These are based on the fact that ACE2 facilitates SARSCoV-2 cell invasion via binding of a viral spike protein
to ACE2. However, the effect of ACE inhibitors, ARBs
and other drugs on ACE2 is unclear and all theories
are based on conflicting evidence mainly from animal
studies. Therefore, clinical evidence is urgently needed.
The aim of this study is to investigate the relationship
between use of these drugs on clinical outcome of
patients with COVID-19. Patients will be included from
several hospitals in Europe. Data will be collected in a
user-friendly database (Digitalis) on an external server.
Analyses will be adjusted for sex, age and presence of
cardiovascular disease, hypertension and diabetes. These
results will enable more rational choices for randomised
controlled trials for preventive and therapeutic strategies
in COVID-19
Methicillin-Resistant Staphylococcus aureus in Meat Products, the Netherlands
A new methicillin-resistant Staphylococcus aureus (MRSA) clone related to pig and cattle farming was detected in the Netherlands. We investigated the extent of S. aureus presence in meat and found 36 S. aureus strains in 79 samples. Two strains were MRSA; 1 was multilocus sequence type 398, the clone related to farming
The value of ipsilateral breast tumor recurrence as a quality indicator:Hospital variation in the Netherlands
Sex dependent risk factors for mortality after myocardial infarction : individual patient data meta-analysis
Background. Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to accurate differentiation of patients with higher and lower risk for mortality. This study explored the effect of interactions of risk factors on all-cause mortality in patients with myocardial infarction based on individual patient data meta-analysis. Methods. Prospective data for 10,512 patients hospitalized for myocardial infarction were derived from 16 observational studies (MINDMAPS). Baseline measures included a broad set of risk factors for mortality such as age, sex, heart failure, diabetes, depression, and smoking. All two-way and three-way interactions of these risk factors were included in Lasso regression analyses to predict time-to-event related all-cause mortality. The effect of selected interactions was investigated with multilevel Cox regression models. Results. Lasso regression selected five two-way interactions, of which four included sex. The addition of these interactions to multilevel Cox models suggested differential risk patterns for males and females. Younger women (ag
Percentage of local recurrence following treatment for breast cancer is not a suitable performance indicator
Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence
A more virulent strain of the disease is emerging
ADHD Remission is linked to better neurophysiological error detection and attention-vigilance processes
Background: The processes underlying persistence and remission of attention-deficit/hyperactivity disorder (ADHD) are poorly understood. We aimed to examine whether cognitive and neurophysiological impairments on a performance monitoring task distinguish between ADHD persisters and remitters.
Methods: On average six years after initial assessment, 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched controls were compared on cognitive-performance measures and event-related potentials (ERPs) of conflict monitoring (N2) and error processing (ERN, Pe) from an arrow flanker task with low- and high-conflict conditions. ADHD outcome was examined with parent-reported symptoms and functional impairment measures using a categorical (DSM-IV) and a dimensional approach.
Results: ADHD persisters were impaired compared to controls on all cognitive-performance and ERP measures (all p<0.05). ADHD remitters differed from persisters, and were indistinguishable from controls, on the number of congruent (low-conflict) errors, reaction time variability (RTV), ERN and Pe (all p≤0.05). Remitters did not differ significantly from the other groups on incongruent (high-conflict) errors, mean reaction time and N2. In dimensional analyses on all participants with childhood ADHD, ADHD symptoms and functional impairment at follow up were significantly correlated with congruent errors, RTV and Pe (r=0.19-0.23, p≤0.05).
Conclusions: Cognitive and neurophysiological measures of attention-vigilance and error detection distinguished ADHD remitters from persisters. These results extend our previous findings with other tasks (Cheung et al. 2015), and indicate that such measures are markers of remission and candidates for the development of non-pharmacological interventions
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