Necrosis del miembro superior tras administración de drogas vía arterial: caso clínico

La administración de drogas por vía parenteral puede causar complicaciones de variada intensidad que pueden llegar a comprometer la viabilidad no sólo de la extremidad, sino también la vida del paciente. Los mejores resultados terapéuticos se lograrían con un diagnóstico y tratamiento precoces. La amputación del miembro debe reservarse para necrosis establecidas y limitadas del mismo.The injection of drugs can cause complications of varying intensity which can compromise the viability of not only the limb but also the patient's life. The best therapeutic results can be achieved with early diagnosis and treatment. Amputation should be reserved for a demarcated gangrene

Instant messaging-based dialog system for device control in the Internet of things

La finalidad del proyecto im4Things es el desarrollo de una herramienta que proporcione una interfaz de comunicación entre humanos y dispositivos en la Internet de las cosas mediante diálogo en lenguaje natural escrito a través de servicios de mensajería instantánea. Esta comunicación puede ser de distintos tipos tales como el envío de órdenes, la consulta del estado e incluso se permite que sean los mismos dispositivos los encargados de alertar al usuario, si se ha producido un cambio del estado en los sensores de los dispositivos. Este proyecto está siendo desarrollado conjuntamente por la empresa Proasistech y el grupo TECNOMOD de la Universidad de Murcia y ha sido financiado por los fondos propios de la empresa Proasistech y con un contrato de I+D+i de asesoría tecnológica con el citado grupo de la Universidad de Murcia.The im4Things project aims to develop a communication interface to devices on the Internet of the Things (IoT) through intelligent dialogue based on written natural language over instant messaging services. This communication can be established in different ways such as order sending, status querying and even the devices themselves are responsible for alert users when a change has been produced in the devices sensors. This project is being developed by Proasistech company in cooperation with the TECNOMOD research group of the University of Murcia and it has been funded by equity capital of Proasistech company and by an R&D&i technology consulting contract with the aforementioned University of Murcia research group.Este trabajo ha sido financiado por la empresa Proasistech (http://www.proasistech.com/) a través de sus fondos propios

Effect of passage through the plant on virulence and endophytic behavioural adaptation in the entomopathogenic fungus Beauveria bassiana

Systemic crop protection using endophytic isolates of entomopathogenic fungi is at the forefront of IPM. Nonetheless, any potential trade-offs between virulence and endophytic behaviour must be elucidated if they are to be effectively used in pest management strategies. Here we investigated endophytic adaptation in an isolate of Beauveria bassiana following successive passage through melon, tomato and cotton tissues. Plants were sprayed with a suspension of B. bassiana endophytic isolate EABb 04/01-Tip to initiate endophytic colonization. Once colonization was established, the fungus was re-isolated from the plant, applied to another plant and re-isolated again; this was repeated to achieve three passages. After each passage, a conidial suspension of each isolate was used in bioassays to evaluate both virulence against 4th instar larvae of the model insect Galleria mellonella and to quantify the extent of endophytic activity in each respective host plant species. When sprayed leaves were inspected for fungal colonization, differences in percentage tissue colonization amongst the plant species were detected after the first re-isolation. Endophytic colonization rates in melon and tomato, which varied from 70 to 100%, were higher than those observed in cotton, which ranged from 40 to 50%; endophytic colonization in cotton increased to 75–100% after the third passage. This improvement in endophytic behaviour in cotton, an apparently suboptimal plant for fungal colonization, suggests an evolutionary adaptation to localized or transient endophytic colonization, while further assays are needed. Meanwhile, when endophytic colonization of non-sprayed leaves distant from the sprayed ones was investigated, endophytic activity was evident in all three crop species suggesting that movement within plants after successive passage increased the extent of endophytic colonization from transient to systemic. The present research highlights the potential for adaptation to endophytic behaviour in crops that are less suitable for endophytic colonization. Furthermore, we demonstrated stability in virulence after multiple passages through host plants. This is a key result for the development of IPM strategies based on endophytic entomopathogenic fungi

A discretization method for the characterization of a plate heat exchanger working as evaporator during transient conditions

In this work, a method for the characterization of a plate heat exchanger working as evaporator is presented. It is based on a one-dimensional discretization of the exchanger, which solves the heat transfer balance equations by means of an iterative methodology based on a heat transfer area converging method. The inputs of the method are the flow rates of the fluids, the inlet enthalpy of the refrigerant, the superheating, and the inlet temperature and pressure of the secondary fluid. Once the inlet pressure of the refrigerant is assumed, pressure drop is calculated in each cell and then enthalpy. The consideration of the proper heat transfer coefficient (HTC) correlations allows the calculation of the heat transfer area, which is after compared to the actual one. The method has been validated by means of a database of 366 experimental data obtained for eight plate heat exchangers working as evaporators by using six different refrigerants, namely R134a, R1234yf, R513A, R744, R290, and R507A. As the method requires suitable correlations for the calculation of the HTC and pressure drop, several correlations for the HTC and Δp found in the literature are studied and the results obtained by using them are presented in terms of the maximum absolute relative deviation (MARD). The results corresponding to the correlation which yields the best results are graphically represented. Finally, the method is used to predict the evaporator performance operating in transient conditions. The results obtained show an excellent agreement with the experimental results collected during the transient operation of a transcritical CO2 water heater coupled to a storage tank.The work in this paper has been financed by the Spanish Ministry of Science and Innovation under Project TED2021-131173B–I00 and the NextGenerationEU recovery plan

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

Green analytical chemistry principles aim to minimize the negative impact of analytical procedures in the environment, which can be considered both at close (to ensure the safety of the analysts) and global (to conserve our natural resources) levels. These principles suggest, among other guidelines, the reduction/minimization of the sample treatment and the use of renewable sources when possible. The first aspect is largely fulfilled by microextraction, which is considered to be among the greenest sample treatment techniques. The second consideration is attainable if natural products are used as raw materials for the preparation of new extraction phases. This strategy is in line with the change in our production system, which is being gradually moved from a linear model (take–make–dispose) to a circular one (including reusing and recycling as key terms). This article reviews the potential of natural products as sorbents in extraction and microextraction techniques from the synergic perspectives of two research groups working on the topic. The article covers the use of unmodified natural materials and the modified ones (although the latter has a less green character) to draw a general picture of the usefulness of the materials

Aplicación del Real Decreto 1311/2012 al ámbito de parques y jardines

[ES] La normativa Europea que regula el uso de productos fitosanitarios se ha transpuesto en España mediante dos Reales Decretos, el Real Decreto 1702/2011 que regula las inspecciones periódicas de los equipos de tratamiento con productos fitosanitarios, y el Real Decreto 1311/2012 que regula la mayor parte de los temas relacionados con el uso de productos fitosanitarios. Frente a esta Normativa y la necesidad de eliminar o reducir al máximo la utilización de productos fitosanitarios en el ámbito de Parques y Jardines, se han de crear Planes de Gestión Integrada de Plagas (GIP) para los Espacios Verdes Urbanos. Dada la escasez de productos registrados por normativas comunitarias para el ámbito de Parques y Jardines y la intolerancia de la ciudadanía a los daños como la melaza que producen pulgones y silas, que gotea sobre pavimentos y mobiliario urbano, se han de trasladar los Planes de Gestión Integrado de Plagas GIP en agricultura, que se llevan utilizando hace tiempo, a los Espacios Verdes Urbanos. La Gestión Integrada en Espacios Verdes a medio o largo plazo es la única alternativa porque hay muy pocos productos registrados disponibles para utilizar en este ámbito. Es también una técnica lenta que exige implicación de políticos, de técnicos de áreas verdes y de ciudadanos. Además es necesaria la observación y seguimiento por parte de técnicos especializados en Gestión Integrada de Plagas. Los motivos para realizar esta Gestión Integrada de las afecciones serían entre otros crear un entorno atractivo y saludable desde el punto de vista medioambiental, además del cumplimiento de la legislación actual, con el uso de nematodos, hongos, feromonas y bacterias entomopatógenas, dejando los productos fitosanitarios como último recurso, y empleando productos autorizados, selectivos y respetuosos con la fauna útil y en tratamientos lo más localizados posible.García Atienza, ME.; Laborda Cenjor, R.; Valverde, P. (2014). Aplicación del Real Decreto 1311/2012 al ámbito de parques y jardines. En XVI CONGRESO NACIONAL DE ARBORICULTURA. Editorial Universitat Politècnica de València. 198-203. https://doi.org/10.4995/XVI_CNA.2014.87OCS19820

Hiperplasia angiolinfoide con eosinofilia: a propósito de una localización atípica en músculo trapecio

La hiperplasia angiolinfoide con eosinofilia es una patología poco frecuente de presentación clínica inespecífica que lleva a que rara vez se diagnostique antes del estudio histológico. Habitualmente afecta a piel y tejido celular subcutáneo siendo rara la localización extracutánea. Presentamos un caso clínico de una tumoración en una mujer de 46 años localizada a nivel del músculo trapecio; y revisamos las características histopatológicas y de tratamiento de esta patología.Angiolymphoid hyperplasia with eosinophilia is an uncommon condition with non-specific clinical symptoms that needs a histological study to have the diagnosis. Usually this lesion occurs in the skin and the subcutaneous tissue, with extracutaneous affection being rare. We describe a tumour affecting the trapezius muscle in a 40- year-old woman; and we review the histopathologic findings and the treatment of this pathology

Comparación de ecuaciones para ajustar curvas de crecimiento de vacas Holstein, Jersey y Jersey x Holstein en pastoreo

The objective of the study was to compare the goodness of fit of four nonlinear equations to describe the growth curves of Jersey, Holstein, and Jersey x Holstein cows in grazing. The Brody, Gompertz, von Bertalanffy, and Logistic equations were fitted to the data (n= 2,315) on weight and age of Jersey (n= 54), Holstein (n= 6) and Jersey x Holstein (n= 30) cows. For each animal, genotype and equation, the parameters A, b and k that generated the best-fit growth curves were estimated. In each of the four equations compared, parameter A corresponds to the upper asymptote of the curve and estimates the ‘mature weight’ of the animal, parameters b and k represent the integration constant and the maturation rate. For the growth curves of Jersey cows and Jersey x Holstein crosses, the Gompertz and von Bertalanffy equations produced the best fit. In contrast, the Logistic equation had the best fit for the growth curves of Holstein, followed closely by the Gompertz and von Bertalanffy equations. Under the management and feeding conditions of the animals in this study, the growth curves of the females of the three genotypes studied can be fitted with the von Bertalanffy equation.El objetivo del estudio fue comparar la bondad de ajuste de cuatro ecuaciones no lineales para describir las curvas de crecimiento de vacas Jersey, Holstein, y Jersey x Holstein en pastoreo. Las ecuaciones de Brody, Gompertz, von Bertalanffy, y Logística se ajustaron a los datos (n= 2,315) de peso y edad de vacas Jersey (n= 54), Holstein (n= 6) y Jersey x Holstein (n= 30). Para cada animal, genotipo y ecuación, se estimaron los parámetros A, b y k que produjeron las curvas de crecimiento de mejor ajuste. En cada una de las cuatro ecuaciones comparadas, el parámetro A corresponde a la asíntota superior de la curva y estima el ‘peso maduro’ del animal, los parámetros b y k representan la constante de integración y la tasa de maduración. Para las curvas de crecimiento de las vacas Jersey y las cruzas de Jersey x Holstein, las ecuaciones de Gompertz y de von Bertalanffy produjeron el mejor ajuste. En contraste, la ecuación Logística tuvo el mejor ajuste para las curvas de crecimiento de Holstein, seguida muy de cerca por las ecuaciones de Gompertz y von Bertalanffy. En las condiciones de manejo y alimentación de los animales en este estudio, las curvas de crecimiento de las hembras de los tres genotipos estudiados pueden ajustarse con la ecuación de von Bertalanffy

Safety and Efficacy of a New Synthetic Material Based on Monetite, Silica Gel, PS-Wallastonite, and a Hydroxyapatite Calcium Deficient: A Randomized Comparative Clinic Trial

Background and Objectives: Maxillary bone defects related to post-extraction alveolar ridge resorption are usual. These defects may lead to failure in further surgical implant phases given the lack of bone volume to perform the dental implant. The objective of this clinical assay was to evaluate the safety and efficacy of an experimental synthetic bone substitute in the preservation of post-extraction maxillary alveoli. Materials and Methods: 33 voluntary patients who had at least one maxillary premolar tooth that was a candidate for exodontia (n = 39) and subsequent implant rehabilitation participated. The regenerated alveoli were monitored by means of periodic clinical examinations (days 9 ± 1, 21 ± 4, 42 ± 6, and 84 ± 6), measuring the height and width of the alveolar crest (days 0 and 180 ± 5), measurement of radiodensity using tomographic techniques (days 0–5 and 175 ± 5), and histological examination of biopsies collected at 180 ± 5 days. Results: No significant differences were observed during the entire follow-up period between the two groups with respect to the safety variables studied. A variation in width of −0.9 ± 1.3 mm and −0.6 ± 1.5 mm, and a variation in height of −0.1 ± 0.9 mm and −0.3 ± 0.7 mm was observed for experimental material Sil-Oss® and Bio-Oss®, respectively. The radiodensity of the alveoli regenerated with the experimental material was significantly lower than that corresponding to Bio-Oss®. However, the histological study showed greater osteoid matrix and replacement of the material with newformed bone in the implanted beds with the experimental material. Conclusions: Both materials can be used safely and proved equally effective in maintaining alveolar flange dimensions, they are also histologically biocompatible, bioactive and osteoconductive. The experimental material showed the advantage of being resorbable and replaced with newformed bone, in addition to promoting bone regeneration

KBS4FIA: Sistema inteligente basado en conocimiento para análisis de información financiera

Decision making takes place in an environment of uncertainty. Therefore, it is necessary to have information which is as accurate and complete as possible in order to minimize the risk that is inherent to the decision-making process. In the financial domain, the situation becomes even more critical due to the intrinsic complexity of the analytical tasks within this field. The main aim of the KBS4FIA project is to automate the processes associated with financial analysis by leveraging the technological advances in natural language processing, ontology learning and population, ontology evolution, opinion mining, the Semantic Web and Linked Data. This project is being developed by the TECNOMOD research group at the University of Murcia and has been funded by the Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund (ERDF) through the Spanish National Plan for Scientific and Technical Research and Innovation Aimed at the Challenges of Society.La toma de decisiones tiene lugar en un ambiente de incertidumbre, por lo tanto es necesario disponer de información lo más exacta y completa posible para minimizar el riesgo inherente al proceso de toma de decisiones. En el dominio de las finanzas la situación se hace, si cabe, aún más crítica debido a la complejidad intrínseca de las tareas analíticas dentro de este campo. La finalidad del proyecto KBS4FIA es la automatización de los procesos ligados al análisis financiero, utilizando para ello tecnologías asociadas con el procesamiento del lenguaje natural, el aprendizaje, la instanciación y la evolución de ontologías, la minería de opiniones, la Web Semántica y el Linked Data. Este proyecto está siendo desarrollado por el grupo TECNOMOD de la Universidad de Murcia y ha sido financiado por el Ministerio de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional (FEDER) a través del Programa Estatal de I+D+i Orientada a los Retos de la Sociedad.This project has been funded by the Spanish National Research Agency (AEI) and the European Regional Development Fund (FEDER / ERDF) through project KBS4FIA (TIN2016-76323-R)