Ciudadanos del mundo. ¿Compartimos los mismos valores comunes?

En esta comunicación expondremos las experiencias adquiridas en las diferentes actividades formativas realizadas en varios centros cívicos de la ciudad de Huelva. La principal finalidad era la sensibilización y la formación de mujeres y hombres onubenses, en torno a la interculturalidad utilizando una colección de cómics de valores comunes. Con el objetivo de tomar conciencia de la importancia en la convivencia entre las personas de diferentes culturas, etnias, religiones... Se llevó a cabo con una metodología activa y participativa en la que todos eran protagonistas del desarrollo de dichos talleres.In this communication we will set out the experiences gained in the different training activities carried out in several community centers in the city of Huelva. The main purpose was to raise awareness and training of women and men from Huelva, around an intercultural environment using a collection of comics that share similar values. The aim is to become aware of the importance of living in harmony with other people from different cultures, ethnic groups, religions, and so on. It was carried out with an active and participatory methodology in which all the participants led the development of the different workshops

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons

The cyclic AMP response element binding protein (CREB) is a primary hub of a activity-driven genetic programs in neurons controlling plasticity, neurogenesis and survival. By contrast, the gene networks coordinated by CREB in astrocytes are Unknown despite the fact that the astrocytic CREB is a also activity-driven and neuroprotective. Herein we identified the transcriptional programs regulated by CREB in astrocytes as compared to neurons using, as study materials, transcriptome databases of astrocyte exposed to weII-known activators of CREB-dependent transcription as well as publidy available transcriptomes of neuronal cultures. Functional CREB signatures were extracted from the transcriptomes using Gene Ontology, adult-brain gene lists generated by Translating Ribosome Affinity Purification (TRAP) and CREB-target gene repositories. We found minimal overlap between CREB signatures in astrocytes and neurons. In astrocytes, the top triad of functions regulated by CREB consists of'Gene expression', 'Mitochondria', and 'Signa Iling', while in neurons it is 'Neurotransmission', 'Signalling' and 'Gene expression', the latter being represented by different genes from those in astrocytes. The newly gene rated data bases Will provide a tool to explore novel means whereby CREB impinges on brain functions requiring adaptive, long-lasting changes by coordinating transcriptionaI cascades in astrocytes

Projecte d’entrenament del procés d’administració de medicació mitjançant la simulació d’alta fidelitat en el Grau d’Infermeria

Projecte: 2020PID-UB/020L’Organització Mundial de la Salut va posar en marxa la campanya “Coneix, Comprova i Pregunta” amb la finalitat de motivar als pacients, cuidadors i professionals de la salut (infermeres, metges i farmacèutics) a assumir un rol actiu en la seguretat del procés d’administració de la medicació (PAM). Una de las responsabilitats de les infermeres es l’administració segura i efectiva de medicació. Adquirir aquesta competència implica integrar coneixements teòrics, pràctics i de presa de decisions. Sense substituir hores de pràctica clínica amb el pacient real, es van programar sessions de simulació d'alta fidelitat per entrenar el PAM, de manera transversal a 3er i 4rt curs del Grau en Infermeria. Els i les estudiants van participar de forma individual en casos clínics en els que, primer van estudiar online (fase prebriefing) les habilitats cognitives del PAM (fàrmac correcte i dosi correcta) i posteriorment van participar en l'escenari simulat, amb un maniquí d'alta fidelitat, per entrenar les habilitats pràctiques del PAM (ítems nuclears del procés, vigilància, seguretat i prevenció). Es va utilitzar per guiar i avaluar el PAM l'instrument MEDICORRECT, creat i validat pel grup d'investigació SGR 2017 GRISimula amb finançament del REDICE (18-2020). Es van dur a terme 48 sessions de simulació a 3er curs i 4rt curs, implicant un total de 320 i 280 estudiants/tes respectivament

International consensus recommendations on the diagnostic work-up for malformations of cortical development

Malformations of cortical development (MCDs) are neurodevelopmental disorders that result from abnormal development of the cerebral cortex in utero. MCDs place a substantial burden on affected individuals, their families and societies worldwide, as these individuals can experience lifelong drug-resistant epilepsy, cerebral palsy, feeding difficulties, intellectual disability and other neurological and behavioural anomalies. The diagnostic pathway for MCDs is complex owing to wide variations in presentation and aetiology, thereby hampering timely and adequate management. In this article, the international MCD network Neuro-MIG provides consensus recommendations to aid both expert and non-expert clinicians in the diagnostic work-up of MCDs with the aim of improving patient management worldwide. We reviewed the literature on clinical presentation, aetiology and diagnostic approaches for the main MCD subtypes and collected data on current practices and recommendations from clinicians and diagnostic laboratories within Neuro-MIG. We reached consensus by 42 professionals from 20 countries, using expert discussions and a Delphi consensus process. We present a diagnostic workflow that can be applied to any individual with MCD and a comprehensive list of MCD-related genes with their associated phenotypes. The workflow is designed to maximize the diagnostic yield and increase the number of patients receiving personalized care and counselling on prognosis and recurrence risk

Temporal effects of prescribed burning on terpene production in Mediterranean pines

International audiencePrescribed burning is used to reduce fuel hazard but underburning can damage standing trees. The effect of burning on needle terpene storage, a proxy for secondary metabolism, in fire-damaged pines is poorly understood despite the protection terpenes confer against biotic and abiotic stressors. We investigated variation in needle terpene storage after burning in three Mediterranean pine species featuring different adaptations to fire regimes. In two pure-stands of Pinus halepensis Mill. and two mixed-stands of Pinus sylvestris L. and Pinus nigra ssp. salzmanni (Dunal) Franco, we compared 24 h and 1 year post-burning concentrations with pre-burning concentrations in 20 trees per species, and evaluated the relative contribution of tree fire severity and physiological condition (δ 13 C and N concentration) on temporal terpene dynamics (for mono-sesqui-and diterpenes). Twenty-four hours post-burning, monoterpene concentrations were slightly higher in P. halepensis than at pre-burning, while values were similar in P. sylvestris. Differently, in the more fire-resistant P. nigra monoterpene concentrations were lower at 24 h, compared with pre-burning. One year post-burning, concentrations were always lower compared with pre-or 24 h post-burning, regardless of the terpene group. Mono-and sesquiterpene variations were negatively related to pre-burning δ 13 C, while diter-pene variations were associated with fire-induced changes in needle δ 13 C and N concentration. At both post-burning times, mono-and diterpene concentrations increased significantly with crown scorch volume in all species. Differences in post-burning terpene contents as a function of the pine species' sensitivity to fire suggest that terpenic metabolites could have adaptive importance in fire-prone ecosystems in terms of flammability or defence against biotic agents post-burning. One year post-burning, our results suggest that in a context of fire-induced resource availability, pines likely prioritize primary rather than secondary metabolism. Overall, this study contributes to the assessment of the direct and indirect effects of fire on pine terpene storage, providing valuable information about their vulnerability to biotic and abiotic stressors throughout time

Projecte d’entrenament del procés d’administració de medicació mitjançant la simulació d’alta fidelitat en el Grau d’Infermeria

Projecte: 2020PID-UB/020L’Organització Mundial de la Salut va posar en marxa la campanya “Coneix, Comprova i Pregunta” amb la finalitat de motivar als pacients, cuidadors i professionals de la salut (infermeres, metges i farmacèutics) a assumir un rol actiu en la seguretat del procés d’administració de la medicació (PAM). Una de las responsabilitats de les infermeres es l’administració segura i efectiva de medicació. Adquirir aquesta competència implica integrar coneixements teòrics, pràctics i de presa de decisions. Sense substituir hores de pràctica clínica amb el pacient real, es van programar sessions de simulació d'alta fidelitat per entrenar el PAM, de manera transversal a 3er i 4rt curs del Grau en Infermeria. Els i les estudiants van participar de forma individual en casos clínics en els que, primer van estudiar online (fase prebriefing) les habilitats cognitives del PAM (fàrmac correcte i dosi correcta) i posteriorment van participar en l'escenari simulat, amb un maniquí d'alta fidelitat, per entrenar les habilitats pràctiques del PAM (ítems nuclears del procés, vigilància, seguretat i prevenció). Es va utilitzar per guiar i avaluar el PAM l'instrument MEDICORRECT, creat i validat pel grup d'investigació SGR 2017 GRISimula amb finançament del REDICE (18-2020). Es van dur a terme 48 sessions de simulació a 3er curs i 4rt curs, implicant un total de 320 i 280 estudiants/tes respectivament

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons

The cyclic AMP response element binding protein (CREB) is a primary hub of a activity-driven genetic programs in neurons controlling plasticity, neurogenesis and survival. By contrast, the gene networks coordinated by CREB in astrocytes are Unknown despite the fact that the astrocytic CREB is a also activity-driven and neuroprotective. Herein we identified the transcriptional programs regulated by CREB in astrocytes as compared to neurons using, as study materials, transcriptome databases of astrocyte exposed to weII-known activators of CREB-dependent transcription as well as publidy available transcriptomes of neuronal cultures. Functional CREB signatures were extracted from the transcriptomes using Gene Ontology, adult-brain gene lists generated by Translating Ribosome Affinity Purification (TRAP) and CREB-target gene repositories. We found minimal overlap between CREB signatures in astrocytes and neurons. In astrocytes, the top triad of functions regulated by CREB consists of'Gene expression', 'Mitochondria', and 'Signa Iling', while in neurons it is 'Neurotransmission', 'Signalling' and 'Gene expression', the latter being represented by different genes from those in astrocytes. The newly gene rated data bases Will provide a tool to explore novel means whereby CREB impinges on brain functions requiring adaptive, long-lasting changes by coordinating transcriptionaI cascades in astrocytes

Programa de Doctorat Projectes Arquitectònics. Jornada de Difusió

Jornada oberta a tots els docents, estudiants de Grau, Màster Habilitant, Màster Universitari i Doctorat de les Escoles d'Arquitectura de Barcelona i el Vallé