11 research outputs found
Aulas virtuales paralelas: un espacio para la flexibilización, una experiencia de virtualización
- Publication venue
- 'Universidad La Gran Colombia'
- Publication date
- 01/01/2006
- Field of study
El presente artículo recoge la experiencia que sobre los procesos devirtualización viene desarrollando la Universidad La Gran Colombia SeccionalArmenia. Se presenta una metodología denominada Aulas Virtuales paralelasAVP, encaminada a implementar procesos educativos virtuales articulados anuevas formas de flexibilización curricular y el desarrollo del sistema de créditosacadémicos en la educación superior, partiendo de un proceso reflexivo quelleva al docente a repensar sus prácticas desde los escenarios del trabajopresencial y el trabajo independiente articulados al Modelo Educativo Virtualuniversitario llamado SEA-Virtual
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
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- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
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- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
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- Ballardin G.
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- Yeh S. -W.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
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- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
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- Banerjee Biswajit
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- Barone Fabrizio
- Barr Bryan
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- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
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- Bassiri Riccardo
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- Bayley Joseph
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- Bedakihale V. M.
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- Bejger Michał
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- Benoit William
- Bentley Joe
- Bera Sayantani
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- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
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- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
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- Bhaumik Shubhagata
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- Bécsy Bence
- C. Utina Andrei
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- Cabras Giuseppe
- Cabrita Ricardo
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- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
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- Bagui E.
- Baier Jeremy
- Baiotti Luca
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- Ballardin G.
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- Banerjee Biswajit
- Bankar Deepak
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- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
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- Bartoletti A. M.
- Barton Mark Andrew
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- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
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- Bayley Joseph
- Baylor Amanda
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- Bejger Michał
- Belardinelli Daniele
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- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
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- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
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- Boldrini Mattia
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- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chattopadhyay Debatri
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- Chaty Sylvain
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- Chen A.
- Chen A. H. -Y.
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- Christensen Nelson
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- Chun Lung Chan Juno
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- Ciecieląg Paweł
- Cieślar Marek
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- Ciolfi Riccardo
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- Clearwater P.
- Clesse S.
- Coccia E.
- Codazzo Elena
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- Colpi Monica
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- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
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- Couineaux A.
- Coulon J. -P.
- Countryman Stefan
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- Cremonese Paolo
- Criswell Alexander
- Crockett-Gray J. C. G.
- Crook S.
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- Cullen Torrey
- Cumming Alan
- Cuoco E.
- Cusinato Marco
- Cáceres-Barbosa V.
- César Martins Julio
- D'Angelo Beatrice
- D'Antonio Sabrina
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
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- Danilishin Stefan
- Danzmann K.
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- De Bolle Jorden
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- de Lluc Planas Maria
- De Marco F.
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- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo Walter
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
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- Depasse Antoine
- DePergola N.
- DeSalvo Riccardo
- Dhani A.
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- Di Giovanni Matteo
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- Di Palma Irene
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- Diab R.
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- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Aulas virtuales paralelas: un espacio para la flexibilización, una experiencia de virtualización
- Publication venue
- Publication date
- 01/01/2006
- Field of study
El presente artículo recoge la experiencia que sobre los procesos devirtualización viene desarrollando la Universidad La Gran Colombia SeccionalArmenia. Se presenta una metodología denominada Aulas Virtuales paralelasAVP, encaminada a implementar procesos educativos virtuales articulados anuevas formas de flexibilización curricular y el desarrollo del sistema de créditosacadémicos en la educación superior, partiendo de un proceso reflexivo quelleva al docente a repensar sus prácticas desde los escenarios del trabajopresencial y el trabajo independiente articulados al Modelo Educativo Virtualuniversitario llamado SEA-Virtual
Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2) : results of a randomised, double-blind, placebo-controlled, phase 3 trial
- Author
- Accini Mendoza Jose Luis
- Achtyes Eric
- Ahsan Habibul
- Albertson Timothy E.
- Alhatemi Azhar
- Allen Nancy
- Arribas Jose R.
- Backenroth Daniel
- Bahrami Ghazaleh
- Bailon Lucia
- Bajwa Ali
- Baker Jonathan
- Baron Mira
- Benet Susana
- Berdaï Driss
- Berger Patrick
- Bertoch Todd
- Bethune Claire
- Bevilacqua Sybille
- Bhushanan Jisha
- Biagioni Santos Maria Silvia
- Binnian Ian
- Bisnauthsing Karen
- Boivin Jean-Marc
- Bollen Hilde
- Bonnet Sandrine
- Borobia Alberto M.
- Botelho-Nevers Elisabeth
- Brandenburg Börries
- Bright Phil
- Britten Vianne
- Brown Claire
- Buadi Amanda
- Buntinx Erik
- Burgess Lesley
- Bush Larry
- Capeding Maria Rosario
- Carr Quito Osuna
- Carrasco Mas Amparo
- Catala Hélène
- Cathie Katrina
- Caudill T. Shawn
- Cereto Castro Fernando
- Chau Kénora
- Chavoustie Steven
- Chen Bohang
- Chen Fei
- Chetty Polan
- Chowdhury Marie
- Chronos Nicolas
- Chu Pei-Ling
- Cicconi Paola
- Cifuentes Liliana
- Cobo Sara Maria
- Collins Helen
- Colton Hayley
- Cooper Kimberly
- Cuaño Carlos Rolando G.
- Custers Jerome
- Cárdenas Vicky
- D'Onofrio Valentino
- Dargan Paul
- Darton Thomas
- Deane Peter
- Del Pozo Jose Luis
- Delanghe Hilde
- Derdelinckx Inge
- Desai Amisha
- Dever Michael
- DiBuono Mark
- Douoguih Macaya
- Doust Matthew
- Duca Anna
- Duncan Christopher
- Díaz-Pollán Beatriz
- Echave-Sustaeta Jose Maria
- Eder Frank
- Ellis Kimberly
- Elzi Stanton
- Emmett Stevan
- Engelbrecht Johannes
- Evans Mim
- Farah Theo
- Faust Saul N
- Felton Timothy
- Ferreira João Pedro
- Floutier Catherine
- Flume Patrick
- Ford Stacy
- Fragoso Veronica
- Freedman Andrew
- Frentiu Emilia
- Galloway Christopher
- Galtier Florence
- Garcia Diaz Julia
- Garcia Alcaide
- García García Irene
- Gardener Zoe
- Garibaldi Brian T.
- Gauteul Pascale
- Geller Steven
- Gibson Andrew
- Gillet Claudia
- Girerd Nicolas
- Girodet Pierre-Olivier
- Gler Maria Tarcela
- Glover Richard
- Go Herschel Don D.
- Goecker Erin A.
- Gokani Karishma
- Gonthier Damien
- Green Christopher
- Greenberg Richard
- Greninger Alexander L.
- Griffin Carl
- Grobbelaar Coert
- Guancia Adonis
- Hakkarainen Gloria
- Hardt Karin
- Harris James
- Hassman Michael
- Heimer Deirdre
- Hellstrom-Louw Elizabeth
- Henrick Tracy
- Herades Yoan
- Holroyd Christopher
- Hussen Nazreen
- Isidro Marie Grace Dawn
- Jackson Yvonne
- Jain Manish
- Jerome Keith R.
- Johnson Daniel
- Jones Ben
- Joseph Natasha
- João Filho Esaú Custódio
- Jumeras Analyn
- Junquera Patricia
- Juraszek Jarek
- Kamphuis Tobias
- Kellett-Wright Johanna
- Kennedy Patrick
- Kilgore Paul E.
- Kim Kenneth
- Kimmel Murray
- Konis George
- Kutner Mark
- Lacombe Karine
- Launay Odile
- Lazarus Rajeka
- Le Gars Mathieu
- Lederman Samuel
- Lee Janet S.
- Lefebvre Gigi
- Lennon Collins Katrina
- Leroux-Roels Isabel
- Lim Kenneth Wilson O.
- Lins Muriel
- Liu Edward
- Llewelyn Martin
- Looney Mark R.
- Lowson David
- Mahomed Akbar
- Maia Bernardo Porto
- Martinot Jean Benoit
- Martínez-Gómez Xavier
- Marín-Candon Alícia
- Mazzella Andrea
- McCaughan Frank
- McCormack Louise
- McGettigan John
- Mehra Purvi
- Mejeur Rhonda
- Miller Vicki
- Mills Anthony
- Molto Marhuenda Jose
- Moodley Prebashan
- Mora-Rillo Marta
- Mothe Beatriz
- Mullan Daniel
- Munro Alasdair
- Myers Paul
- Nalpas Catherine
- Nell Jeremy
- Newman Lobato Souza Tamara
- O'Halloran Jane A.
- Ochoa Mazarro Maria Dolores
- Oliver Abigail
- Onate Gutierrez Jose Millan
- Ortega Jessica
- Oshita Masaru
- Otero Romero Susana
- Overcash Jeffrey Scott
- Owens Daniel
- Packham Alice
- Pacurar Mihaela
- Paiva de Sousa Leonardo
- Palfreeman Adrian
- Pallares Christian José
- Patel Rahul
- Patel Suchet
- Peeters Monika
- Pelkey Leslie
- Peluso Denise
- Penciu Florentina
- Pinheiro Jose
- Pinto S. Jerry
- Pounds Kevin
- Pouzar Joe
- Pragalos Antoinette
- Presti Rachel
- Price David
- Qureshi Ehsaan
- Ramalho Madruga José Valdez
- Ramesh Mayur
- Rankin Bruce
- Razat Béatrice
- Riegel Santos Breno
- Riesenberg Robert
- Riffer Ernie
- Roche Siobhan
- Roels Sanne
- Rose Katie
- Rosellini Pietro
- Rossignol Patrick
- Roychoudhury Pavitra
- Ruiz-Guiñazú Javier
- Ryser Martin F.
- Sadoff Jerald
- Safirstein Beth
- Salas Jose
- Salazar Hernan
- Sanchez Vallejo Gregorio
- Sandrock Christian
- Santhosh Smrithi
- Santoro Matias Samantha
- Scheper Gert
- Scheys Ilse
- Schuitemaker Hanneke
- Seco-Meseguer Enrique
- Seep Michael
- Sherry Emma
- Shetty Pallavi
- Short Philip
- Shukarev Georgi
- Soentjens Patrick
- Solis Joel
- Soriano Viladomiu Alejandro
- Sorli Caroline
- Spangenthal Selwyn
- Spence Niamh
- Spinner Christoph D
- Stephenson Elaine
- Stoddard Jeffrey
- Strout Cynthia
- Struyf Frank
- Surowitz Ronald
- Takuva Simbarashe G.
- Taladua Kristy Michelle
- Talloen Willem
- Tapson Victor F.
- Tellalian David
- Thalamas Claire
- Thiriphoo Nang
- Thomas Judith
- Thomas Nicholas
- Tran NamPhuong
- Trout Guillermo
- Truyers Carla
- Urroz Mikel
- Vaissiere Nathalie
- Van Dromme Ilse
- Van Hoof Johan
- van Son-Palmen Elisabeth
- Vandebosch An
- Veekmans Bernard
- Veekmans Laurent
- Velarde Luis Humberto Anaya
- Villalobos Ralph Elvi M.
- Vingerhoets Johan
- Warren Sarah
- Webster Brian
- White Alexander
- Williams Gail
- Williams Hayes
- Wilson Barbara
- Winston Alan
- Wiselka Martin
- Wiysonge Charles Shey
- Xu Jiajun
- Zervos Marcus
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Despite the availability of effective vaccines against COVID-19, booster vaccinations are needed to maintain vaccine-induced protection against variant strains and breakthrough infections. This study aimed to investigate the efficacy, safety, and immunogenicity of the Ad26.COV2.S vaccine (Janssen) as primary vaccination plus a booster dose.
Methods ENSEMBLE2 is a randomised, double-blind, placebo-controlled, phase 3 trial including crossover vaccination after emergency authorisation of COVID-19 vaccines. Adults aged at least 18 years without previous COVID-19 vaccination at public and private medical practices and hospitals in Belgium, Brazil, Colombia, France, Germany, the Philippines, South Africa, Spain, the UK, and the USA were randomly assigned 1:1 via a computer algorithm to receive intramuscularly administered Ad26.COV2.S as a primary dose plus a booster dose at 2 months or two placebo injections 2 months apart. The primary endpoint was vaccine efficacy against the first occurrence of molecularly confirmed moderate to severe-critical COVID-19 with onset at least 14 days after booster vaccination, which was assessed in participants who received two doses of vaccine or placebo, were negative for SARS-CoV-2 by PCR at baseline and on serology at baseline and day 71, had no major protocol deviations, and were at risk of COVID-19 (ie, had no PCR-positive result or discontinued the study before day 71). Safety was assessed in all participants; reactogenicity, in terms of solicited local and systemic adverse events, was assessed as a secondary endpoint in a safety subset (approximately 6000 randomly selected participants). The trial is registered with ClinicalTrials.gov, NCT04614948, and is ongoing.
Findings Enrolment began on Nov 16, 2020, and the primary analysis data cutoff was June 25, 2021. From 34 571 participants screened, the double-blind phase enrolled 31 300 participants, 14 492 of whom received two doses (7484 in the Ad26.COV2.S group and 7008 in the placebo group) and 11 639 of whom were eligible for inclusion in the assessment of the primary endpoint (6024 in the Ad26.COV2.S group and 5615 in the placebo group). The median (IQR) follow-up post-booster vaccination was 36 center dot 0 (15 center dot 0-62 center dot 0) days. Vaccine efficacy was 75 center dot 2% (adjusted 95% CI 54 center dot 6-87 center dot 3) against moderate to severe-critical COVID-19 (14 cases in the Ad26.COV2.S group and 52 cases in the placebo group). Most cases were due to the variants alpha (B.1.1.7) and mu (B.1.621); endpoints for the primary analysis accrued from Nov 16, 2020, to June 25, 2021, before the global dominance of delta (B.1.617.2) or omicron (B.1.1.529). The booster vaccine exhibited an acceptable safety profile. The overall frequencies of solicited local and systemic adverse events (evaluated in the safety subset, n=6067) were higher among vaccine recipients than placebo recipients after the primary and booster doses. The frequency of solicited adverse events in the Ad26.COV2.S group were similar following the primary and booster vaccinations (local adverse events, 1676 [55 center dot 6%] of 3015 vs 896 [57 center dot 5%] of 1559, respectively; systemic adverse events, 1764 [58 center dot 5%] of 3015 vs 821 [52 center dot 7%] of 1559, respectively). Solicited adverse events were transient and mostly grade 1-2 in severity.
Interpretation A homologous Ad26.COV2.S booster administered 2 months after primary single-dose vaccination in adults had an acceptable safety profile and was efficacious against moderate to severe-critical COVID-19. Studies assessing efficacy against newer variants and with longer follow-up are needed. Funding Janssen Research & Development.
Copyright (c) 2022 The Author(s). Published by Elsevier Ltd
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
- Bennett James
- Berg-Johansen Jan
- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
- Borisov Borislav
- Bortnick Anna
- Bos Robert
- Botelho Roberto
- Botero Rodrigo
- Botero Rodrigo
- Bott Jochen
- Bouza Manuel
- Boyrazian Hagop
- Brabham David
- Braganza Denise
- Brath Helmut
- Brockmyre Andrew
- Broker Robert
- Brown Christopher
- Buchbinder Maurice
- Bueno Héctor
- Bugan Viliam
- Bula Larysa
- Burgess Lesley
- Busak Ladislav
- Busch Robert
- Busz-Papiez Benita
- Butman Samuel
- Buysschaert Ian
- Byanov Kolyo
- Cabrera Walter
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- Cantu Elias G
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- Carda Jiri
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- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
- Cheung Stephen
- Chhabra Anil
- Chiang Chern
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- de la Torre Hernández José M
- de Labriolle Axel
- de los Ríos Ibarra Manuel
- de Luca Leonardo
- de Maeseneire Stefan
- de Melker Edwin
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- Debs-Perez Giselle
- Decoulx Eric
- Dedek Vratislav
- Deering Joseph
- DeGregorio Michele
- Dehghani Payam
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- Delforge Marc
- Demchenko Elena
- Desai Pratik
- Deyoung Michael
- Di Pasquale Giuseppe
- Diaz Rafael
- Diaz Rafael
- Dickert Jim
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- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah Mouhamad
- Abdullakutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Agergaard Jensen Steen
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alexopoulos Dimitrios
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Orcajo Norberto
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Andrzej Lipko Jan
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E.
- Ayoub José Carlos Aidar
- Azizad Masoud M
- Babić Zdravko
- Baccara-Dinet Marie
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
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- Benov Haralambi O
- Benčić Martina Lovrić
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
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- Berman Brett
- Bernan Alisa
- Bernardez-Pereira Sabrina
- Berthou Christelle
- Berti Sergio
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- Binde Ronald
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- Blok Thomas
- Blonder Ronald
- Blumberg Eduardo DS
- Boccara Franck
- Bodanese Luiz C
- Bodí Peris Vicente
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- Bokarev Igor
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- Bos Robert J
- Botas Rodriguez Javier
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- Botelho Roberto V
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- Bouancheau Cecile
- Bougon Nathalie
- Bourgeois Ronald
- Brabham David
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- Braun-Dullaeus Rüdiger
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- Breedveld Robert W
- Brennan J. Matthew
- Brigui Imane
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- Camsari Ahmet
- Car Siniša
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- Citron Bernard
- Civeira Murillo Fernando
- Claeys Marc
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- Ding Chunhua
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- Do Rose
- Dodds III George
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- Sakalyte Gintare
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- Salomone Oscar
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- Schellenberg Detlev
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- Schifferdecker Branislav
- Schmalfuss Carsten
- Schmedtje John F
- Schmidberg Jorge M.
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- Schmitt Susanne
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- Schuyler Jones William
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- Shaburishvili Tamaz
- Shah Anil V
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- Shalaev Sergey
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- Sharman David
- Shaw James
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- Sheldon William
- Sheller Jennifer
- Sherwood Matthew W.
- Shetty Sanjay
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- Shimizu Masatoshi
- Shinde Rituparna
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- Sundram P. Sandy
- Suryapranata Harry
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- Tasic Nebojsa
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- Tespili Maurizio
- Teufel Edward
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- Thanvi Sunil
- Thew Stephen
- Timothy Eichenlaub
- Tirador Louie
- Tissera Nirmali
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- Todorov Georgi V
- Toledo Pablo
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- Treasure II Charles
- Tretyakova Tatyana V
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- Tricoci Pierluigi
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- Tse Hung-Fat
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- Tumbev Haralin S
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- Tyrenko Vadim V
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- Uematsu Masaaki
- Ueng Kwo-Chang
- Ungi Imre
- Ural Ertan
- Urina Triana Miguel A
- Ushakov Olexiy
- Utsu Noriaki
- Vahula Veiko
- Vakaluyk Ihor
- Vakili Babak
- Valdivielso Pedro
- Valgimigli Marco
- Valiris Janine
- Vallejos Julio A.
- Van Aswegen Dina
- Van Der Wal Ruud MA
- Van Der Zwaan Coenraad C
- Van Diepen Sean
- Van Haelst Paulus
- Van Kesteren Henricus
- Van Zyl Louis J
- Vardas Panagiotis
- Vardi Gil
- Vargas Gonzales Rolando J
- Varleta Paola
- Vatutin Mykola
- Vedere Amarnath
- Vedin Ola
- Vejar Margarita
- Velcheva Elena S
- Velicka Zdenek
- Verdel Gerardus JE
- Vered Zvi
- Verrier Melanie
- Vervoort Geert
- Vetrovec George
- Vico Marisa L.
- Vida Manuel
- Videbaek Lars
- Vidotti Maria H
- Vidovich Mladen
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- Viigimaa Margus
- Vijay Nampalli
- Vijayaraghavan Ram
- Vikman Saila
- Viktorova Inna
- Vincendet Marion
- Violini Roberto
- Vishnevsky Alexander Y
- Vizel Saul
- Vo Anthony
- Voevoda Mikhail I
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias CM
- Vulic Dusko
- Vuurmans Tycho
- Vázquez de Prada José Antonio
- Vöhringer Hans Friedrich
- Völler Heinz
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D
- Waites Jonathon H
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wan Mohamed Wan Mohd Izani
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
- Weißbrodt Matthias
- Welka Stephen
- Welker James
- Welker James
- Wells Terry
- Wells Terry
- Werner Christian
- Werner Nikos
- Westbrook Melissa
- Westerhausen Donald
- Whitaker Jack
- White Harvey D
- White Harvey D.
- White Harvey D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J
- Wijeyasingam Santharaj
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F
- Wilson Matthew D.
- Wilson Samuel
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wolfovitz Efrat
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew T.
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Édes István
- Černič Šuligoj Nataša
- Šikić Jozica
- Štambuk Kresimir
- Žuran Ivan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1.4-1.8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes
Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry
- Author
- Abban Dzifa Wosornu
- Abdul Nasser
- Abud Atilio Marcelo
- Adams Fran
- Addala Srinivas
- Adragão Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Agostoni Piergiuseppe
- Aguilar Francisco
- Aguinaga Luis
- Ahmed Jameel
- Aiello Allessandro
- Ainsworth Paul
- Aiub Jorge Roberto
- Al-Dallow Raed
- Alderson Lisa
- Alexopoulos Dimitrios
- Aliyar Pareed
- Almeida Luísa Fonseca
- Alonso David
- Alvaro Feliz
- Amado José
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrade Marianna
- Andrawis Nabil
- Annoni Giorgio
- Ansalone Gerardo
- Ariani M. Kevin
- Arias Juan Carlos
- Armero Sébastien
- Arora Chander
- Asensi Joaquín Osca
- Aslam Muhammad Shakil
- Asselman M.
- Audouin Philippe
- Augenbraun Charles
- Ayala Carlos Antero Chavez
- Aydin S.
- Ayryanova Ivaneta
- Aziz Emad
- Backes Luciano Marcelo
- Badings E.
- Bagni Ermentina
- Baker Seth
- Bala Richard
- Baldi Antonio
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Barr Craig
- Bartlett Maria
- Basic Kes Vanja
- Baula Giovanni
- Behrens Steffen
- Bell Alan
- Benedetti Raffaella
- Benhalima Bouziane
- Berg J.
- Bergler-Klein Jutta
- Berneau Jean-Baptiste
- Bernstein Richard
- Berrospi Percy
- Berti Sergio
- Berz Andrea
- Best Elizabeth
- Bettencourt Paulo
- Betzu Robert
- Bhagwat Ravi
- Bhatta Luna
- Biscione Francesco
- Bisignani Giovanni
- Black Toby
- Bloch Michael
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bodes Rafael Salguero
- Bollmann Andreas
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Boswijk D.
- Bott Jochen
- Bottacchi Edo
- Bradman Drew
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers P.
- Browne Kevin
- Bruni A.
- Brunschwig Claude
- Buathier Hervé
- Buenostro Gabriel Contreras
- Buhl Aurélie
- Bullinga John
- Bøhmer Ellen
- Cabrera Jose Walter
- Caccavo Alberto
- Cai Shanglang
- Caine Sarah
- Calvi Valeria
- Calò Leonardo
- Campos Rodrigo Noronha
- Candeias Rui
- Capuano Vincenzo
- Capucci Alessandro
- Caputo Ronald
- Cardona Francisco
- Carolei Antonio
- Carreño Susana
- Carvalho Paula
- Cary Susanna
- Casu Gavino
- Cavallini Claudio
- Cayla Guillaume
- Celentano Aldo
- Cha Kwang Soo
- Cha Tae-Joon
- Chae Jei Keon
- Chalamidas Kathrine
- Challappa Krishnan
- Chand Sunil Prakash
- Chandrashekar Harinath
- Chartier Ludovic
- Chatterjee Kausik
- Cheema Aamir
- Cheema Amjad
- Chen Jyh Hong
- Chen Lin
- Chen Shih-Ann
- Chiang Fu-Tien
- Chiarella Francesco
- Chih-Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Choi Jong-Il
- Chouinard Guy
- Chow Danny Hoi-Fan
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cislowski David
- Clay Anthony
- Clifford Piers
- Cohen Andrew
- Cohen Michael
- Cohen Serge
- Colivicchi Furio
- Collins Ronan
- Colonna Paolo
- Compton Steve
- Connolly Derek
- Conti Alberto
- Coodley Gregg
- Cooper Martin
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/05/2022
- Field of study
International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected
Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
- Author
- Abban Dzifa Wosornu
- Abdul Nasser
- Abud Atilio Marcelo
- Adams Fran
- Addala Srinivas
- Adragão Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Agostoni Piergiuseppe
- Aguilar Francisco
- Aguinaga Luis
- Ahmed Jameel
- Aiello Allessandro
- Ainsworth Paul
- Aiub Jorge Roberto
- Al-Dallow Raed
- Alderson Lisa
- Aldrete Velasco Jorge Antonio
- Alexopoulos Dimitrios
- Aliyar Pareed
- Almeida Luísa Fonseca
- Alonso David
- Alves da Costa Fernando Augusto
- Amado José
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrade Marianna
- Andrawis Nabil
- Angela Koh Su Mei
- Annoni Giorgio
- Ansalone Gerardo
- Ariani M Kevin
- Arias Juan Carlos
- Armero Sébastien
- Arora Chander
- Asensi Joaquín Osca
- Aslam Muhammad Shakil
- Asselman M
- Audouin Philippe
- Augenbraun Charles
- Aydin S
- Ayryanova Ivaneta
- Aziz Emad
- Backes Luciano Marcelo
- Badings E
- Bagni Ermentina
- Baker Seth H
- Bala Richard
- Baldi Antonio
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Barr Craig
- Bartlett Maria
- Baula Giovanni
- Behrens Steffen
- Bell Alan
- Benedetti Raffaella
- Benhalima Bouziane
- Berg JM ten
- Bergler-Klein Jutta
- Berneau Jean-Baptiste
- Bernstein Richard A
- Berrospi Percy
- Berti Sergio
- Berz Andrea
- Best Elizabeth
- Bettencourt Paulo
- Betzu Robert
- Bhagwat Ravi
- Bhatta Luna
- Biscione Francesco
- Bisignani Giovanni
- Bisson Arnaud
- Black Toby
- Bloch Michael J
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bodes Rafael Salguero
- Bollmann Andreas
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Boriani Giuseppe
- Boswijk DJ
- Bott Jochen
- Bottacchi Edo
- Bradman Drew
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- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers PJAM
- Browne Kevin
- Bruni A
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Hervé
- Buenostro Gabriel Contreras
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- Duygun A
- Dziewas Rainer
- Eaton Charles B
- Eaves William
- Ebels-Tuinbeek
- Eichinger-Hasenauer Sabine
- Eisenberg Steven J
- El Jabali Adnan
- El Shahawy Mahfouz
- Esperon Guillermo Llamas
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- Gartenlaub Olivier
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- Giedrimas Evaldas
- Gierba Mariusz
- Gillespie Eve
- Giniger Alberto
- Giudici Michael C
- Gkotsis Alexandros
- Glotzer Taya V
- Gmehling Joachim
- Gniot Jacek
- Goethals Peter
- Goldbarg Seth
- Goldberg Ronald
- Goldmann Britta
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- Gomes Ferreira Luis Gustavo
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- Gornick Charles
- Gorog Diana
- Gottipaty Venkat
- Goube Pascal
- Goudevenos Ioannis
- Graham Brett
- Greer G Stephen
- Gremmler Uwe
- Grena Paul G
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- Gronda Edoardo
- Grönefeld Gerian
- Gu Xiang
- Guardigli Gabriele
- Guevara Carolina
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- Ha Andrew
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- Han Bing
- Han Seongwook
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- Harris Kenneth B
- Haruna Tetsuya
- Hayek Emil
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- Heggelund Geir
- Heijmeriks JA
- Hemels Maarten
- Hendriks I
- Henein Sam
- Her Sung-Ho
- Hermany Paul
- Hernandes Mauro Esteves
- Hernandez Norberto Matadamas
- Hernández Del Río Jorge Eduardo
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
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- Hoghton Matthew
- Hoi-Fan Chow Danny
- Hong Kui
- Hong Suk keun
- Horbach Stevie
- Horiuchi Masataka
- Hou Yinglong
- Hsing Jeff
- Huang Chi-Hung
- Huckins David
- Hughes kathy
- Huisman Menno V
- Huizinga A
- Hulsman EL
- Hung Kuo-Chun
- Hwang Gyo-Seung
- Ikpoh Margaret
- Imberti Davide
- Ince Hüseyin
- Indolfi Ciro
- Inoue Shujiro
- Irles Didier
- Iseki Harukazu
- Israel C Noah
- Iteld Bruce
- Iyer Venkat
- Izal Ana Etxeberria
- Jackson-Voyzey Ewart
- Jaffrani Naseem
- James Martin
- Jang Sung-Won
- Jaramillo Nicolas
- Jarmukli Nabil
- Jattin Fernando Manzur
- Jeanfreau Robert J
- Jenkins Ronald D
- Jimenez Javier
- Jimenez Ricardo Pavón
- Jobe Robert
- Joen-Jakobsen Tomas
- Jones Nicholas
- Jose eena Padayattil
- José Roberto Eduardo Julián
- Jouve Bernard
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- Jäger Frank
- Kachkovskiy Mikhail
- Kafkala Krystallenia
- Kalan Marica Bracic
- Kalinina Larisa
- Kallmünzer Bernd
- Kamali Farzan
- Kamo Takehiro
- Kampus Priit
- Karla Kurrelmeyer
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John F
- Keeling P
- Kerr Saraiva José Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit Singh
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo-Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kmetzo James J
- Kneller G Larsen
- Knezevic Aleksandar
- Koide Shunichi
- Kollias Anastasios
- Kooistra JA
- Koons Jay
- Koschutnik Martin
- Kostis William J
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kraft Peter
- Kragten Johannes A
- Krantz Mori
- Krause Lars
- Krenning BJ
- Krikke F
- Kromhout Z
- Krysiak Waldemar
- Kumar Priya
- Kuniss Malte
- Kuo Jen-Yuan
- Kwak Choong Hwan
- Kümler Thomas
- Küppers Achim
- Laboulle Bénédicte
- Labovitz Arthur
- Lai Wen Ter
- Lam Andy
- Lam Yat Yin
- Landau Charles
- Landini Giancarlo
- Larsen Torben
- Lavandier Karine
- Lawrence Wong Ka Sing
- LeBlanc Jessica
- Lee Chang-Hoon
- Lee Moon Hyoung
- Lehman John
- Leitão Ana
- Lellouche Nicolas
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Lenderink T
- Leong-Sit Peter
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Xiaoming
- Li Zhanquan
- Lichy Christhoh
- Lieber Ira
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Linares Julio Aguilar
- Lip Gregory YH
- Lip Gregory YH
- Liu Feng
- Liu Hengliang
- Lo Eric
- Lokshyn Sergiy
- Lorga Filho Adalberto Menezes
- Lorraine Richard S
- Luengas Carlos Alberto
- Luke Robert
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- López Amador
- López-Sendón José Luís
- Ma Changsheng
- Ma Genshan
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Maid Gustavo
- Mainigi Sumeet K
- Makaritsis Konstantinos
- Malhotra Rohit
- Manning Rickey
- Manolis Athanasios
- Manrique Hurtado Helard Andres
- Mantas Ioannis
- Manterola Fernando Alfonso
- Maqueda Vicky
- Marchionni Niccolo
- Martinez Jorge
- Maskova Petra
- Matsuda Katsuhiro
- Maurer Tillmann
- Mauro Ciro
- May Erik
- Mayer Nolan
- Mazuecos Juan Benezet
- McClure John
- McCormack Terry
- McGarity William
- McIntyre Hugh
- McLaurin Brent
- Medina Palomino Feliz Alvaro
- Mei Davide Antonio
- Melandri Francesco
- Meno Hiroshi
- Menzies Dhananjai
- Mercader Marco
- Mesa Juan Gomez
- Meyer Beat J
- Meyer Christian
- Miarka Jacek
- Mibach Frank
- Michalski Dominik
- Michel Patrik
- Miguel Ricardo Nicolás
- Mikdadi Ghiath
- Mikus Milan
- Milicic Davor
- Militaru Constantin
- Minaie Sedi
- Minescu Bogdan
- Mintale Iveta
- Mirault Tristan
- Mirro Michael J
- Mistry Dinesh
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Miño
- Moccetti Tiziano
- Mohammed Akber
- Mollerus Michael
- Molon Giulio
- Mondillo Sergio
- Moniz Patrícia
- Mont Lluis
- Montagud Vicente
- Montaña Oscar
- Monti Cristina
- Moretti Luciano
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschini Luigi
- Moschos Nikitas
- Moura Jorge Jose Carlos
- Mulhearn Thomas J
- Muresan Carmen
- Muriago Michela
- Musial Wlodzimierz
- Musser Carl W
- Musumeci Francesco
- Mügge Andreas
- Nageh Thuraia
- Nakagawa Hidemitsu
- Nakamura Yuichiro
- Nakayama Toru
- Nam Gi-Byoung
- Nanna Michele
- Natarajan Indira
- Navarro Nassip Llerena
- Nayak Hemal M
- Naydenov Stefan
- Nazlić Jurica
- Nechvatal Libor
- Negron Sandra Adela
- Neiman James
- Neuenschwander Fernando Carvalho
- Neves David
- Neykova Anna
- Nica Nicoleta Cindea
- Nijmeh George
- Nizov Alexey
- Nor Azlisham Mohd
- Nossan Janko
- Novikova Tatiana
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- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nurgalieva Svetlana
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- O'Donnell Philip
- O'Hara Gilles
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- Ortega Ignacio Gil
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- Paparella Gaetano
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- Park Hyung Wook
- Park Jong Sung
- Parthenakis Fragkiskos
- Pascual Carlos Rodríguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Mehool
- Patel Rajesh J
- Patrick Janice
- Paz Analía
- Pengo Vittorio
- Pentz William
- Perlman Richard
- Persic Viktor
- Perticone Francesco
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- Petkar Sanjiv
- Pezo Luis Felipe
- Pflücke Christian
- Pham David N
- Phillips Roland T
- Phlaum Stephen
- Pieters Denis
- Pineau Julien
- Pinter Arnold
- Pinto Fausto
- Pisters R
- Pivac Nediljko
- Pocanic Darko
- Podoleanu Cristian
- Politano Alessandro
- Poljakovic Zdravka
- Pollock Stewart
- Poppert Holger
- Porcu Maurizio
- Prasad Neeraj
- Prelle Alessandro
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- Proietti Marco
- Protasov Konstantin
- Précoma Dalton Bertolim
- Pye Maurice
- Pérez Ríos Alma Minerva
- Pérez Beatriz
- Pérez-Cabezas Alejandro
- Qiu Zhaohui
- Quedillac Jean-Michel
- Quintana Antonio Garcia
- Raev Dimitar
- Raffo Grado Carlos Antonio
- Rahimi Sidiqullah
- Raisaro Arturo
- Rama Bhola
- Ramos Ricardo
- Ranieri Maria
- Raposo Nuno
- Rashba Eric
- Rauch-Kroehnert Ursula
- Reddy Ramakota
- Reino Antonio Pose
- Renda Giulia
- Reza Shabbir
- Ria Luigi
- Richter Dimitrios
- Rickli Hans
- Rieker Werner
- Rios Victoria Padilla
- Ritt Luiz Eduardo
- Rizo Tatiana Cárdenas
- Roberts Douglas
- Rodriguez Escudero Aldo Edwin
- Roman Mark
- Romeo Francesco
- Romiti Giulio Francesco
- Ronner E
- Rossi dos Santos Fabio
- Roux Jean-Francois
- Rozkova Nadezda
- Rubacek Miroslav
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- Ruiz Rafael Olvera
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- Rutgers Matthieu Pierre
- Rybak Karin
- Said Samir
- Sakamoto Tamotsu
- Salacata Abraham
- Salem Adrien
- Sales Juan Cosín
- Saltzman Marco A
- Salvioni Alessandro
- Santana Antonio Martín
- Saporito Wladmir Faustino
- Sarikonda Kesari
- Sasaoka Taishi
- Sati Hamdi
- Savelieva Irina
- Scala Pierre-Jean
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl-Heinz
- Schmitz Lisa
- Schnabel Teresa
- Schnupp Steffen
- Schoeniger Peter
- Schwimmbeck Peter
- Schön Norbert
- Seamark Clare
- Searles Greg
- Seidl Karl-Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Serrati Carlo
- Shah Anil
- Shah Neerav
- Shah Shujahat
- Shah Vinay
- Sharma Vijay Kumar
- Shaw Louise
- Sheikh Khalid H
- Shimizu Naruhito
- Shimomura Hideki
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- Smadja Didier
- Smith David W
- Snitman Marcelo
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- Sofley Carl
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex C
- Stakos Dimitrios
- Steinwender Clemens
- Stergiou Georgios
- Stiell Ian
- Stoddard Marcus
- Stoikov Anastas
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Sudnik Wanda
- Sukles Kai
- Sun Xiaofei
- Swart H
- Szavits-Nossan Janko
- Sánchez Carlos Jerjes
- Sánchez Mauricio Camarillo
- Taggeselle Jens
- Takagi Yuichiro
- Tamm Angelika
- Tanaka Katsumi
- Tanawuttiwat Tanyanan
- Tang Aylmer
- Tang Sherman
- Tarsi Giovanni
- Tassinari Tiziana
- Tayal Ashis
- Tayebjee Muzahir
- Tesloianu Dan
- The Salem HK
- Thomas Dierk
- Timsit Serge
- Tobaru Tetsuya
- Tomasik Andrzej R
- Topete Gilberto de la Pena
- Torosoff Mikhail
- Torres Torres Ivett Guadalupe
- Touze Emmanuel
- Trendafilova Elina
- Tsai W Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tu Tian Ming
- Tuininga Ype
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Tytus Richard
- Valadão C
- Valenzuela Chuquiure
- Vallejo Gregorio Sanchez
- van Bergen PFMM
- van de Borne Philippe
- van den Berg BJ
- van der Zwaan C
- Van Eck M
- Vanacker Peter
- Vasilev Dimo
- Vasilikos Vasileios
- Vasilyev Maxim
- Veerareddy Srikar
- Vera Tomas Ripolil
- Verdecchia Paolo
- Versaci Francesco
- Vester Ernst Günter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Victory Jason
- Villamil Alejandro
- Vincent Marc
- Vlastaris Anthony
- Vora Kishor
- Vranian Robert B
- Wakefield Paul
- Wang Feng
- Wang Mingsheng
- Wang Ningfu
- Wang Tian
- Wang Xinhua
- Warner Alberta L
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weiner Stanislav
- Weinrich Renate
- Wen Ming-Shien
- Wiemer Marcus
- Wiggers Preben
- Wilke Andreas
- Williams David
- Williams Marcus L
- Witzenbichler Bernhard
- Wong Brian
- Wozakowska-Kaplon Beata
- Wu Richard C
- Wu Shulin
- Wunderlich Silke
- Wyatt Nell
- Wylie John Jack
- Xu Xiangdong
- Xu Yong
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yao Jing
- Yeh Kuo-Ho
- Yin Wei Hsian
- Yotov Yoto
- Zahn Ralf
- Zanetti Fernando Lanas
- Zarich Stuart
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Donghui
- Zhang Huanyi
- Zhang Jun
- Zhang Ping
- Zhang Xingwei
- Zhao Shui Ping
- Zhao Yujie
- Zhao Zhichen
- Zheng Yang
- Zhou Jing
- Zimmermann Sergio
- Zini Andrea
- Zizzo Steven
- Zong Wenxia
- Zukerman L Steven
- Publication venue
- Elsevier BV
- Publication date
- 01/01/2023
- Field of study
Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH