Montluçon – Les Hauts de Buffon

Identifiant de l'opération archéologique : 2005/304 - 2006/126 et 133 Date de l'opération : 2006 (EX) Le diagnostic réalisé en juin 2006 sur l’emprise du projet de lotissement « Les Hauts de Buffon » a révélé, dans un contexte sédimentaire peu dilaté, la présence de deux phases d’occupation, l’une datée du Magdalénien et l’autre de l’époque gallo-romaine. Un dépôt isolé d’une céramique se rapporte quant à lui à l’âge du Bronze. Le premier site, conservé s..

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

The intestine-specific caudal-related homeobox gene-2 (CDX2) homeobox gene, while being a tumor suppressor in the gut, is ectopically expressed in a large proportion of acute leukemia and is associated with poor prognosis. Here, we report that turning on human CDX2 expression in the hematopoietic lineage of mice induces acute monoblastic leukemia, characterized by the decrease in erythroid and lymphoid cells at the benefit of immature monocytic and granulocytic cells. One of the highly stimulated genes in leukemic bone marrow cells was BMP and activin membrane-bound inhibitor (Bambi), an inhibitor of transforming growth factor-β (TGF-β) signaling. The CDX2 protein was shown to bind to and activate the transcription of the human BAMBI promoter. Moreover, in a leukemic cell line established from CDX2-expressing mice, reducing the levels of CDX2 or Bambi stimulated the TGF-β-dependent expression of Cd11b, a marker of monocyte maturation. Taken together, this work demonstrates the strong oncogenic potential of the homeobox gene CDX2 in the hematopoietic lineage, in contrast with its physiological tumor suppressor activity exerted in the gut. It also reveals, through BAMBI and TGF-β signaling, the involvement of CDX2 in the perturbation of the interactions between leukemia cells and their microenvironment

Mass-loading, pile-up, and mirror-mode waves at comet 67P/Churyumov-Gerasimenko

International audienceThe data from all Rosetta plasma consortium instruments and from the ROSINA COPS instrument are used to study the interaction of the solar wind with the outgassing cometary nucleus of 67P/Churyumov-Gerasimenko. During 6 and 7 June 2015, the interaction was first dominated by an increase in the solar wind dynamic pressure, caused by a higher solar wind ion density. This pressure compressed the draped magnetic field around the comet, and the increase in solar wind electrons enhanced the ionization of the outflow gas through collisional ionization. The new ions are picked up by the solar wind magnetic field, and create a ring/ring-beam distribution, which, in a high-β plasma, is unstable for mirror mode wave generation. Two different kinds of mirror modes are observed: one of small size generated by locally ionized water and one of large size generated by ionization and pickup farther away from the comet

Stéphane Bourdin, Julien Dubouloz & Emmanuelle Rosso (Ed.), Peupler et habiter l’Italie et le monde romain : études d’histoire et d’archéologie offertes à Xavier Lafon. Aix-en-Provence, Presses universitaires de Provence, 2014

Vallat Jean-Pierre. Stéphane Bourdin, Julien Dubouloz & Emmanuelle Rosso (Ed.), Peupler et habiter l’Italie et le monde romain : études d’histoire et d’archéologie offertes à Xavier Lafon. Aix-en-Provence, Presses universitaires de Provence, 2014. In: L'antiquité classique, Tome 85, 2016. pp. 486-489

Alastair M. Small et Robert J. Buck, The Excavations of San Giovanni di Ruoti, 1. 1. : The Villas and their Environment, Toronto-Buffalo-Londres, Toronto University Press, 1994

Vallat Jean-Pierre. Alastair M. Small et Robert J. Buck, The Excavations of San Giovanni di Ruoti, 1. 1. : The Villas and their Environment, Toronto-Buffalo-Londres, Toronto University Press, 1994. In: Histoire & Sociétés Rurales, n°6, 2ème semestre 1996. pp. 168-170

Franca Parise Badoni et Maria Ruggeri Giove, Alfedena. La necropoli di Campo Consolino, Scavi 1974-1979

Vallat Jean-Pierre. Franca Parise Badoni et Maria Ruggeri Giove, Alfedena. La necropoli di Campo Consolino, Scavi 1974-1979. In: Annales. Économies, Sociétés, Civilisations. 38ᵉ année, N. 4, 1983. pp. 955-957