Observation of spin-transfer switching in deep submicron-sized and low-resistance magnetic tunnel junctions

The spin-transfer effect has been studied in magnetic tunnel junctions (PtMn/CoFe/Ru/CoFe/Al2O3/CoFe/NiFe) with dimensions down to 0.1x0.2 um2 and resistance-area product RA in the range of 0.5-10 Ohm m2 (dR/R=1-20%). Current-induced magnetization switching is observed with a critical current density of about 8e6 A/cm2. The attribution of the switching to the spin-transfer effect is supported by a current-induced dR/R value identical to the one obtained from the R versus H measurements. Furthermore, the critical switching current density has clear dependence on the applied magnetic field, consistent with what has been observed previously in the case of spin-transfer induced switching in metallic multilayer systems

Targeting IL-17A in Multiple Myeloma: A Potential Novel Therapeutic Approach in Myeloma

We have previously demonstrated that interleukin-17A (IL-17) producing Th17 cells are significantly elevated in blood and bone marrow (BM) in multiple myeloma (MM) and IL-17A promotes MM cell growth via the expression of IL-17 receptor. In this study, we evaluated anti-human IL-17A human monoclonal antibody (mAb), AIN457 in MM. We observe significant inhibition of MM cell growth by AIN457 both in the presence and absence of BM stromal cells (BMSC). While IL-17A induces IL-6 production, AIN457 significantly down-regulated IL-6 production and MM cell-adhesion in MM-BMSC co-culture. AIN-457 also significantly inhibited osteoclast cell–differentiation. More importantly, in the SCIDhu model of human myeloma administration of AIN-457 weekly for 4 weeks after the first detection of tumor in mice led to a significant inhibition of tumor growth and reduced bone damage compared to isotype control mice. To understand the mechanism of action of anti-IL-17A mAb, we report here, that MM cells express IL-17A. We also observed that IL-17A knock-down inhibited MM cell growth and their ability to induce IL-6 production in co-cultures with BMSC. These pre-clinical observations suggest efficacy of AIN 457 in myeloma and provide the rationale for its clinical evaluation for anti-myeloma effects and for improvement of bone disease

La parole qui me porte / Paul Valet

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Table rase / Paul Valet

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Lacunes / Paul Valet

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Cation exchange isotherms applied to the study of salt affected-irrigated soils

The sodium adsorption ratio (SAR) is usefull to predict the status of waters and soils. It depends on the understanding of ion exchange. This paper shows that the practicle use of isotherm systems on square diagrams makes ion exchange study easier. The experimental curves obtained are expressed with the mathematical model proposed by Laï and Jurinak. It is pointed out that these experimental curves allow a correct representation of parameters involved in exchange process. They also give a theoritical basis to predict cation exchange isotherm at different intermediate concentration. This theory was applied to a "soil-irrigated water" system from Niger. The evolution of SAR could be proceeded when irrigation water was evaporated. (Résumé d'auteur