666 research outputs found
Melanin-concentrating hormone in peripheral circulation in the human
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a well-characterised role in energy homeostasis and emergent roles in diverse physiologic functions such as arousal, mood and reproduction. Work to date has predominantly focused on its hypothalamic functions using animal models; however, little attention has been paid to its role in circulation in humans. The aims of this study were to (a) develop a radioimmunoassay for the detection of MCH in human plasma; (b) establish reference ranges for circulating MCH and (c) characterise the pattern of expression of circulating MCH in humans. A sensitive and specific RIA was developed and cross-validated by RP-HPLC and MS. The effective range was 19.5–1248 pg MCH/mL. Blood samples from 231 subjects were taken to establish a reference range of 19.5–55.4 pg/mL for fasting MCH concentrations. There were no significant differences between male and female fasting MCH concentrations; however, there were correlations between MCH concentrations and BMI in males and females with excess fat (P < 0.001 and P = 0.020) and between MCH concentrations and fat mass in females with excess fat (P = 0.038). Plasma MCH concentrations rose significantly after feeding in a group of older individuals (n = 50, males P = 0.006, females P = 0.023). There were no robust significant correlations between fasting or post-prandial MCH and resting metabolic rate, plasma glucose, insulin or leptin concentrations although there were correlations between circulating MCH and leptin concentrations in older individuals (P = 0.029). These results indicate that the role of circulating MCH may not be reflective of its regulatory hypothalamic role
Vector-meson contributions do not explain the rate and spectrum in K_L -> pi0 gamma gamma
We analyze the recent NA48 data for the reaction K_L -> pi0 gamma gamma with
and without the assumption of vector meson dominance (VMD). We find that the
data is well described by a three-parameter expression inspired by O(p^6)
chiral perturbation theory. We also find that it is impossible to fit the shape
of the decay distribution and the overall rate simultaneously if one imposes
the VMD constraints on the three parameters. We comment on the different fits
and their implications for the CP-conserving component of the decay K_L -> pi0
e+ e-.Comment: Version accepted for publication on Phys. Rev. D. 19 pages, LaTeX, 8
figures, uses epsf.st
Rare Decays with a Light CP-Odd Higgs Boson in the NMSSM
We have previously proposed a light pseudoscalar Higgs boson in the
next-to-minimal supersymmetric standard model (NMSSM), the A_1^0, as a
candidate to explain the HyperCP observations in Sigma^+ -> p mu^+ mu^-. In
this paper we calculate the rates for several other rare decay modes that can
help confirm or refute this hypothesis. The first modes we evaluate are K_L ->
pi pi A_1^0, which are interesting because they are under study by the KTeV
Collaboration. We next turn to eta -> pi pi A_1^0, which are interesting
because they are independent of the details of the flavor-changing sector of
the NMSSM and may be accessible at DAPhNE. For completeness, we also evaluate
Omega^- -> Xi^- A_1^0.Comment: 17 pages, 11 figure
Modeling the Effect of Propofol and Remifentanil Combinations for Sedation-Analgesia in Endoscopic Procedures Using an Adaptive Neuro Fuzzy Inference System (ANFIS)
BACKGROUND:
The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase in the methods to provide and control sedation and analgesia for these patients. In this study, we evaluated different combinations of propofol and remifentanil, administered through a target-controlled infusion system, to estimate the optimal concentrations as well as the best way to control the sedative effects induced by the combinations of drugs in patients undergoing ultrasonographic endoscopy.
METHODS:
One hundred twenty patients undergoing ultrasonographic endoscopy were randomized to receive, by means of a target-controlled infusion system, a fixed effect-site concentration of either propofol or remifentanil of 8 different possible concentrations, allowing adjustment of the concentrations of the other drug. Predicted effect-site propofol (C(e)pro) and remifentanil (C(e)remi) concentrations, parameters derived from auditory evoked potential, autoregressive auditory evoked potential index (AAI/2) and electroencephalogram (bispectral index [BIS] and index of consciousness [IoC]) signals, as well as categorical scores of sedation (Ramsay Sedation Scale [RSS] score) in the presence or absence of nociceptive stimulation, were collected, recorded, and analyzed using an Adaptive Neuro Fuzzy Inference System. The models described for the relationship between C(e)pro and C(e)remi versus AAI/2, BIS, and IoC were diagnosed for inaccuracy using median absolute performance error (MDAPE) and median root mean squared error (MDRMSE), and for bias using median performance error (MDPE). The models were validated in a prospective group of 68 new patients receiving different combinations of propofol and remifentanil. The predictive ability (P(k)) of AAI/2, BIS, and IoC with respect to the sedation level, RSS score, was also explored.
RESULTS:
Data from 110 patients were analyzed in the training group. The resulting estimated models had an MDAPE of 32.87, 12.89, and 8.77; an MDRMSE of 17.01, 12.81, and 9.40; and an MDPE of -1.86, 3.97, and 2.21 for AAI/2, BIS, and IoC, respectively, in the absence of stimulation and similar values under stimulation. P(k) values were 0.82, 0.81, and 0.85 for AAI/2, BIS, and IoC, respectively. The model predicted the prospective validation data with an MDAPE of 34.81, 14.78, and 10.25; an MDRMSE of 16.81, 15.91, and 11.81; an MDPE of -8.37, 5.65, and -1.43; and P(k) values of 0.81, 0.8, and 0.8 for AAI/2, BIS, and IoC, respectively.
CONCLUSION:
A model relating C(e)pro and C(e)remi to AAI/2, BIS, and IoC has been developed and prospectively validated. Based on these models, the (C(e)pro, C(e)remi) concentration pairs that provide an RSS score of 4 range from (1.8 μg·mL(-1), 1.5 ng·mL(-1)) to (2.7 μg·mL(-1), 0 ng·mL(-1)). These concentrations are associated with AAI/2 values of 25 to 30, BIS of 71 to 75, and IoC of 72 to 76. The presence of noxious stimulation increases the requirements of C(e)pro and C(e)remi to achieve the same degree of sedative effects
CP asymmetry in the Higgs decay into the top pair due to the stop mixing
We investigate a potentially large CP violating asymmetry in the decay of a
neutral scalar or pseudoscalar Higgs boson into the top-anti-top pair. The
source of the CP nonconservation is the complex mixing in the (left-right) stop
sector. One of the interesting consequence is the different rates of the Higgs
boson decays into CP conjugate polarized states.Comment: 14 pages, 8 figures include
Rare Kaon Decays
The current status of rare kaon decay experiments is reviewed. New limits in
the search for Lepton Flavor Violation are discussed, as are new measurements
of the CKM matrix.Comment: 8 pages, 3 figures, LaTeX, presented at the 3rd International
Conference on B Phyiscs and CP Violation, Taipei December 3-7, 199
CP Violation in Hyperon Nonleptonic Decays within the Standard Model
We calculate the CP-violating asymmetries A(Lambda_-^0) and A(Xi_-^-) in
nonleptonic hyperon decay within the Standard Model using the framework of
heavy-baryon chiral perturbation theory (chiPT). We identify those terms that
correspond to previous calculations and discover several errors in the existing
literature. We present a new result for the lowest-order (in chiPT)
contribution of the penguin operator to these asymmetries, as well as an
estimate for the uncertainty of our result that is based on the calculation of
the leading nonanalytic corrections.Comment: 21 pages, 2 figures; discussion clarified, results & conclusions
unchanged, to appear in Phys. Rev.
CP--odd Correlation in the Decay of Neutral Higgs Boson into , , or
We investigate the possibility of detecting CP--odd angular correlations in
the various decay modes of the neutral Higgs boson including the modes of a
pair, a pair, or a heavy quark pair. It is a natural way to probe
the CP character of the Higgs boson once it is identified. Final state
interactions (i.e. the absorptive decay amplitude) is not required in such
correlations. As an illustrative example we take the fundamental source of the
CP nonconservation to be in the Yukawa couplings of the Higgs boson to the
heavy fermions. A similar correlation in the process is
also proposed. Our analysis of these correlations will be useful for
experiments in future colliders such as LEP II, SSC, LHC or NLC.Comment: 16 pages, plus 8 postscript graphs not posted befor
Hadron Collider Signatures for New Interactions of Top and Bottom Quarks
One of the main goals for hadron colliders is the study of the properties of
the third generation quarks. We study the signatures for new TeV resonances
that couple to top or bottom quarks both at the Tevatron Run II and at the LHC.
We find that in the simplest production processes of Drell-Yan type at the
Tevatron, the signals are overwhelmed by QCD backgrounds. We also find that it
is possible to study these resonances when they are produced in association
with a pair of heavy quarks or in association with a single top at the LHC.In
particular, with an integrated luminosity of 300 fb at the LHC, it is
possible to probe resonance masses up to around 2 TeV.Comment: 24 pages, 15 figures, Minor corrections, version to appear in Phys.
Rev.
Could we identify hot Ocean-Planets with CoRoT, Kepler and Doppler velocimetry?
Planets less massive than about 10 MEarth are expected to have no massive
H-He atmosphere and a cometary composition (50% rocks, 50% water, by mass)
provided they formed beyond the snowline of protoplanetary disks. Due to inward
migration, such planets could be found at any distance between their formation
site and the star. If migration stops within the habitable zone, this will
produce a new kind of planets, called Ocean-Planets. Ocean-planets typically
consist in a silicate core, surrounded by a thick ice mantle, itself covered by
a 100 km deep ocean. The existence of ocean-planets raises important
astrobiological questions: Can life originate on such body, in the absence of
continent and ocean-silicate interfaces? What would be the nature of the
atmosphere and the geochemical cycles ?
In this work, we address the fate of Hot Ocean-Planets produced when
migration ends at a closer distance. In this case the liquid/gas interface can
disappear, and the hot H2O envelope is made of a supercritical fluid. Although
we do not expect these bodies to harbor life, their detection and
identification as water-rich planets would give us insight as to the abundance
of hot and, by extrapolation, cool Ocean-Planets.Comment: 47 pages, 6 Fugures, regular paper. Submitted to Icaru
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