27 research outputs found

    Impact of Internet of Things on Urban Mobility

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    The urban population is predicted to increase to 66% by 2050. The rapid growth of urbanization and increasing congestion are significant challenges faced by the world today. Innovative solutions in urban mobility are key for a successful development and a sustainable future. The new paradigm, Internet of Things (IoT), facilitates the need for new approaches in urban transportation, leading to a modern concept: Smart Mobility. The boom of technology and innovation from recent years allowed a great expansion of IoT. Furthermore, the number of smart devices that communicate, cooperate and complement each other, grows rapidly in every domain broadening the scope of IoT applications. This paper sets to discuss the impact that IoT might have on urban mobility, mentioning its implications, challenges and technical solutions. It further reviews the advancements made in the transport infrastructure along the years that support the emergence of Smart Mobility. Three main research questions stay at the forefront of this paper which are drafted in pursuit of the solutions for the problems and challenges currently faced by urban transportation. Which leads to a sustainable future with efficient and effective urban transportation system. The paper uses a mix-method approach, using on one hand qualitative research for literature review (State of the field) and on the other hand quantitative research to assess public opinion on the research topic, through an online questionnaire. To answer the research questions with proper arguments, both research methods were necessary, which lead to optimal results. The results of the questionnaire were interpreted based on Spearman's correlation and descriptive statistical analysis. They brought an in-depth view on the public opinion regarding IoT and the developments enabled by this paradigm within the urban mobility sphere. The output of the questionnaire highlights the eagerness of participants usually stuck in traffic to see innovation within urban mobility. Over all the results based on the opinions suggest that the public strongly believes in the Internet of Thing's applications and its adaptation will benefit the urban transportation system. Furthermore, new developments in the urban mobility sphere will be largely embraced

    DETERMINAN PEMBIAYAAN MURABAHAH (Studi Kasus Pada PT. Bank Muamalat Indonesia, Tbk.)

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    Penelitian ini bertujuan untuk menguji pengaruh Dana Pihak Ketiga (DPK), menguji pengaruh Non Performing Financing (NPF), menguji pengaruh Return on Asset (ROA) terhadap pembiayaan murabahah. Teknik pengambilan sampel yang digunakan adalah Purposive sampling. Penelitian ini menggunakan sampel PT. Bank Muamalat Indonesia dengan periode penelitian tahun 2007-2014. Teknik analisis data dilakukan menggunakan regresi linier berganda. Hasil penelitian ini menunjukkan bahwa Dana Pihak Ketiga berpengaruh positif karena bank cenderung untuk menyalurkan dananya semaksimal mungkin guna memperoleh keuntungan yang maksimal pula. Non Performing Financing berpengaruh negatif karena semakin sedikit dana pinjaman yang kembali ke bank, akan menyebabkan dana bank yang tersedia untuk disalurkan semakin berkurang. Sedangkan Return on Assets berpengaruh positif karena Semakin besar tingkat keuntungan yang didapat oleh bank, maka semakin besar pula upaya manajemen menginvestasikan keuntungan tersebut dengan berbagai kegiatan yang menguntungkan manajemen, terutama dengan penyaluran pembiayaa

    Chagas' disease and AIDS

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    Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly manifested by meningoencephalitis. A reactivation myocarditis is the second most common manifestation. These presentations may be difficult to distinguish from toxoplasmosis in individuals with HIV/AIDS. The overlap of HIV and Trypanosoma cruzi infection occurs not only in endemic areas but also in non-endemic areas of North America and Europe where the diagnosis may be even more difficult. The pathological features, diagnosis and the role of cytokines in the pathogenesis of the disease are discussed

    Perspectives on the Trypanosoma cruzi-host cell receptor interaction

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    Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets

    Chagas' disease: an update on immune mechanisms and therapeutic strategies

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    The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Nacional de Biologia Estrutural e QuImica Medicinal em Doencas Infecciosas (INBEQMeDI)Univ São Paulo, Inst Biomed Sci, Dept Parasitol, São Paulo, BrazilMackenzie Presbeterian Univ, Ctr Biomol Sci & Hlth, São Paulo, BrazilNatl Univ Rosario, Sch Med Sci, Inst Immunol, Rosario, Santa Fe, ArgentinaCSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, SpainUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilFAPESP: 08/57596-4FAPESP: 07/08648-9CNPq: 473906/2008-2Web of Scienc
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