Statistical Study of Plasmoids associated with post-CME Current Sheet

We investigate the properties of plasmoids observed in the current sheet formed after an X-8.3 flare followed by a fast CME eruption on September 10, 2017 using Extreme Ultraviolet (EUV) and white-light coronagraph images. The main aim is to understand the evolution of plasmoids at different spatio-temporal scales using existing ground- and space-based instruments. We identified the plasmoids in current sheet observed in the successive images of {\it Atmospheric Imaging Assembly} (AIA) and white-light coronagraphs, K-Cor and LASCO/C2. We found that the current sheet is accompanied by several plasmoids moving upwards and downwards. Our analysis showed that the downward and upward moving plasmoids have average width of 5.92 Mm and 5.65 Mm, respectively in the AIA field of view (FOV). However, upward moving plasmoids have average width of 64 Mm in the K-Cor which evolves to a mean width of 510 Mm in the LASCO/C2 FOV. Upon tracking the plasmoids in successive images, we observe that downward and upward moving plasmoids have average speeds of $\sim$272 km s$^{-1}$ and $\sim$191 km s$^{-1}$ respectively in the EUV passbands. We note that the plasmoids become super-Alfv\'enic when they reach at LASCO FOV. Furthermore, we estimate that the null-point of the current sheet at $\approx$ 1.15 R$_\odot$ where bidirectional plasmoid motion is observed. We study the width distribution of plasmoids formed and notice that it is governed by a power law with a power index of -1.12. Unlike previous studies there is no difference in trend for small and large scale plasmoids. The presence of accelerating plasmoids near the neutral point indicates a longer diffusion region as predicted by MHD models.Comment: Accepted for the publication in Astronomy & Astrophysics (A&A). 10 pages, 11 figures. Animations can be found at https://www.dropbox.com/sh/g0wjq2awxai1hy4/AAClkTHPFkTa5JU-Zulf9a75a?dl=

First Results from MFOSC-P : Low Resolution Optical Spectroscopy of a Sample of M dwarfs within 100 parsecs

Mt. Abu Faint Object Spectrograph and Camera (MFOSC-P) is an in-house developed instrument for Physical Research Laboratory (PRL) 1.2m telescope at Mt. Abu India, commissioned in February 2019. Here we present the first science results derived from the low resolution spectroscopy program of a sample of M Dwarfs carried out during the commissioning run of MFOSC-P between February-June 2019. M dwarfs carry great significance for exoplanets searches in habitable zone and are among the promising candidates for the observatory's several ongoing observational campaigns. Determination of their accurate atmospheric properties and fundamental parameters is essential to constrain both their atmospheric and evolutionary models. In this study, we provide a low resolution (R$\sim$500) spectroscopic catalogue of 80 bright M dwarfs (J$<$10) and classify them using their optical spectra. We have also performed the spectral synthesis and $\chi^2$ minimisation techniques to determine their fundamental parameters viz. effective temperature and surface gravity by comparing the observed spectra with the most recent BT-Settl synthetic spectra. Spectral type of M dwarfs in our sample ranges from M0 to M5. The derived effective temperature and surface gravity are ranging from 4000 K to 3000 K and 4.5 to 5.5 dex, respectively. In most of the cases, the derived spectral types are in good agreement with previously assigned photometric classification.Comment: Accepted for Publication in MNRA

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity

Obesity is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; angiotensin (Ang)-converting enzyme 2 (ACE2) negatively regulates RAS by metabolizing Ang II into Ang 1-7. We studied the role of ACE2 in obesity-mediated cardiac dysfunction. ACE2 null (ACE2KO) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet and studied at 6 months of age. Loss of ACE2 resulted in decreased weight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polarization of macrophages into a proinflammatory phenotype in response to HFD. Similarly, human EAT in patients with obesity and heart failure displayed a proinflammatory macrophage phenotype. Exacerbated EAT inflammation in ACE2KO-HFD mice was associated with decreased myocardial adiponectin, decreased phosphorylation of AMPK, increased cardiac steatosis and lipotoxicity, and myocardial insulin resistance, which worsened heart function. Ang 1-7 (24 µg/kg/h) administered to ACE2KO-HFD mice resulted in ameliorated EAT inflammation and reduced cardiac steatosis and lipotoxicity, resulting in normalization of heart failure. In conclusion, ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced EAT inflammation and cardiac insulin resistance

Characterizing Spectral Channels of Visible Emission Line Coronagraph of Aditya-L1

Aditya-L1 is India’s first solar mission with the Visible Emission Line Coronagraph (VELC), which consists of three spectral channels taking high-resolution spectroscopic observations of the inner corona up to 1.5 Rʘ at 5,303, 7,892, and 10,747 Å. In this work, we present a strategy for the slit width optimization of the VELC using synthetic line profiles by taking into account the instrument characteristics and coronal conditions for log(T) varying from 6 to 6.5. The synthetic profiles are convolved with simulated instrumental scattered light and noise to estimate the signal-to-noise ratio (SNR), which will be crucial to designing the future observation plans. We find that the optimum slit width for VELC turns out to be 50 μm, providing sufficient SNR for observations in different solar conditions. We also analyzed the effect of plasma temperature on the SNR at different heights in the VELC field of view for the optimized slit width. We also studied the expected effect of the presence of a CME on the spectral channel observations. This analysis will help to plan the scientific observations of VELC in different solar conditions

Antagonism of angiotensin 1-7 prevents the therapeutic effects of recombinant human ACE2

Activation of the angiotensin 1-7/Mas receptor (MasR) axis counteracts angiotensin II (Ang II)-mediated cardiovascular disease. Recombinant human angiotensin-converting enzyme 2 (rhACE2) generates Ang 1-7 from Ang II. We hypothesized that the therapeutic effects of rhACE2 are dependent on Ang 1-7 action. Wild type male C57BL/6 mice (10-12 weeks old) were infused with Ang II (1.5 mg/kg/d) and treated with rhACE2 (2 mg/kg/d). The Ang 1-7 antagonist, A779 (200 ng/kg/min), was administered to a parallel group of mice. rhACE2 prevented Ang II-induced hypertrophy and diastolic dysfunction while A779 prevented these beneficial effects and precipitated systolic dysfunction. rhACE2 effectively antagonized Ang II-mediated myocardial fibrosis which was dependent on the action of Ang 1-7. Myocardial oxidative stress and matrix metalloproteinase 2 activity was further increased by Ang 1-7 inhibition even in the presence of rhACE2. Activation of Akt and endothelial nitric oxide synthase (eNOS) by rhACE2 were suppressed by the antagonism of Ang 1-7 while the activation of pathological signaling pathways was maintained. Blocking Ang 1-7 action prevents the therapeutic effects of rhACE2 in the setting of elevated Ang II culminating in systolic dysfunction. These results highlight a key cardioprotective role of Ang 1-7, and increased Ang 1-7 action represents a potential therapeutic strategy for cardiovascular diseases. KEY MESSAGES: Activation of the renin-angiotensin system (RAS) plays a key pathogenic role in cardiovascular disease. ACE2, a monocarboxypeptidase, negatively regulates pathological effects of Ang II. Antagonizing Ang 1-7 prevents the therapeutic effects of recombinant human ACE2. Our results highlight a key protective role of Ang 1-7 in cardiovascular disease

Impact of district mental health care plans on symptom severity and functioning of patients with priority mental health conditions: the Programme for Improving Mental Health Care (PRIME) cohort protocol

Background: The Programme for Improving Mental Health Care (PRIME) sought to implement mental health care plans (MHCP) for four priority mental disorders (depression, alcohol use disorder, psychosis and epilepsy) into routine primary care in five low- and middle-income country districts. The impact of the MHCPs on disability was evaluated through establishment of priority disorder treatment cohorts. This paper describes the methodology of these PRIME cohorts. Methods: One cohort for each disorder was recruited across some or all five districts: Sodo (Ethiopia), Sehore (India) , Chitwan (Nepal), Dr. Kenneth Kaunda (South Africa) and Kamuli (Uganda), comprising 17 treatment cohorts in total (N = 2182). Participants were adults residing in the districts who were eligible to receive mental health treatment according to primary health care staff, trained by PRIME facilitators as per the district MHCP. Patients who screened positive for depression or AUD and who were not given a diagnosis by their clinicians (N = 709) were also recruited into comparison cohorts in Ethiopia, India, Nepal and South Africa. Caregivers of patients with epilepsy or psychosis were also recruited (N = 953), together with or on behalf of the person with a mental disorder, depending on the district. The target sample size was 200 (depression and AUD), or 150 (psychosis and epilepsy) patients initiating treatment in each recruiting district. Data collection activities were conducted by PRIME research teams. Participants completed follow-up assessments after 3 months (AUD and depression) or 6 months (psychosis and epilepsy), and after 12 months. Primary outcomes were impaired functioning, using the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS), and symptom severity, assessed using the Patient Health Questionnaire (depression), the Alcohol Use Disorder Identification Test (AUD), and number of seizures (epilepsy). Discussion: Cohort recruitment was a function of the clinical detection rate by primary health care staff, and did not meet all planned targets. The cross-country methodology reflected the pragmatic nature of the PRIME cohorts: while the heterogeneity in methods of recruitment was a consequence of differences in health systems and MHCPs, the use of the WHODAS as primary outcome measure will allow for comparison of functioning recovery across sites and disorders