A Real-time Decision Support System Prototype for Management of a Power Block

This paper describes the basic tools for a real-time decision support system of a semiotic type on the example of the prototype for management and monitoring of a nuclear power block implemented on the basis of the tool complex G2+GDA using cognitive graphics and parallel processing. This work was supported by RFBR (project 02-07-90042)

Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps

Journal ArticleThe molecular-replacement method has been extended to locate molecules and their fragments in an electron-density map. The approach is based on a new spherically averaged phased translation function. The position of the centre of mass of a search model is found prior to determination of its orientation. The orientation is subsequently found by a phased rotation function. The technique also allows superposition of distantly related macromolecules. The method has been implemented in a computer program MOLREP and successfully tested using experimental data sets

Development and analysis of functional model of business process design of steam turbine plants on the example of the steam turbine department SBTt CJSC "The Ural Turbine Works"

Статья представляет собой анализ производственных и бизнес процессов ОПТ (отдела паровых турбин) ЗАО «Уральский турбинный завод». Целью анализа является создании функциональной модели типа «As-Is» и информационных связей системы проектирования паротурбинных установок.This article is an analysis of production and business processes of the DST (department of steam turbine), CJSC "The Ural Turbine Works". The purpose of the analysis is to create a functional model of the type "As-is" and information links system design of steam turbine plants

BALBES: a molecular-replacement pipeline

The fully automated pipeline, BALBES, integrates a redesigned hierarchical database of protein structures with their domains and multimeric organization, and solves molecular-replacement problems using only input X-ray and sequence data

JLigand: a graphical tool for the CCP4 template-restraint library

The CCP4 template-restraint library defines restraints for biopolymers, their modifications and ligands that are used in macromolecular structure refinement. JLigand is a graphical editor for generating descriptions of new ligands and covalent linkages

Linear theory of nonlocal transport in a magnetized plasma

A system of nonlocal electron-transport equations for small perturbations in a magnetized plasma is derived using the systematic closure procedure of V. Yu. Bychenkov et al., Phys. Rev. Lett. 75, 4405 (1995). Solution to the linearized kinetic equation with a Landau collision operator is obtained in the diffusive approximation. The Fourier components of the longitudinal, oblique, and transversal electron fluxes are found in an explicit form for quasistatic conditions in terms of the generalized forces: the gradients of density and temperature, and the electric field. The full set of nonlocal transport coefficients is given and discussed. Nonlocality of transport enhances electron fluxes across magnetic field above the values given by strongly collisional local theory. Dispersion and damping of magnetohydrodynamic waves in weakly collisional plasmas is discussed. Nonlocal transport theory is applied to the problem of temperature relaxation across the magnetic field in a laser hot spot.Comment: 27 pages, 13 figure

To the question of research on hoisting equipment hydraulic drive dynamics by using it means in educational process

The program "Mobile Mining Hoisting Units Dynamics" has been developed. The programme proposed can be applied while teaching discipline "Dynamics of Mining Machines" to students of a master degree course in the direction 151000.68, also to those studying in specialty 130400.65 whose major is "Mining machinery and Equipment", "Electrification and automation of mining operations" in doing coursework and diploma projects on disciplines "Hydropneumatic electric drive" and "Dynamic Strength"Разработана программа «Динамика мобильных проходческих подъемных установок». Предложенная программа применима при изучении дисциплины «Динамика горных машин» для магистрантов, обучающихся по направлению 151000.68 «Технологические машины и оборудование» и студентов специальности 130400.65 специализаций «Горные машины и оборудование», «Электрификация и автоматизация горного производства» для выполнения курсового и дипломного проектирования по дисциплинам «Гидро- пневмо- электропривод» и «Динамика и прочность

Laser in the axial electric field as a tool to search for P-, T- invariance violation

We consider rotation of polarization plane of the laser light when a gas laser is placed in a longitudinal electric field (10~kV/cm). It is shown that residual anisotropy of the laser cavity 10^{-6} and the sensitivity to the angle of polarization plane rotation about 10^{-11} -10^{-12} rad allows one to measure an electron EDM with the sensitivity about 10^{-30} e cm.Comment: 12 page

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties. One such regulatory mechanism is the presence of an autoinhibitory module, which in Ets-1 allosterically inhibits the DNA binding activity. This inhibition can be relieved by interaction with protein partners or cooperative binding to closely separated Ets binding sites in a palindromic arrangement. In this study we describe the 2.5 Å resolution crystal structure of a DNA complex of the Ets-2 Ets domain. The Ets domain crystallized with two distinct species in the asymmetric unit, which closely resemble the autoinhibited and DNA bound forms of Ets-1. This discovery prompted us to re-evaluate the current model for the autoinhibitory mechanism and the structural basis for cooperative DNA binding. In contrast to Ets-1, in which the autoinhibition is caused by a combination of allosteric and steric mechanisms, we were unable to find clear evidence for the allosteric mechanism in Ets-2. We also demonstrated two possibly distinct types of cooperative binding to substrates with Ets binding motifs separated by four and six base pairs and suggest possible molecular mechanisms for this behavior