Cantos, voces y vocalidades: acervos etnomusicológicos y formación de cantantes

Partimos de las dimensiones social, histórica y cultural de la voz contenidas en el concepto de vocalidad, que busca profundizar la noción de oralidad dando anclaje fono-corporal a la producción de la voz en el tiempo-espacio (Zumthor, 1997). Las vocalidades tradicionales han sido estudiadas por la etnomusicología desde el inicio del siglo XX irrumpiendo en el campo musical con otros sonidos, produciendo una expansión del campo tímbrico y multiplicando las posibilidades de la polifonía vocal. Dichas vocalidades conformaron archivos vinculados a órganos públicos y/o a centros de investigación académicos, pero a partir de los años 1980 dichos archivos se digitalizan y, por otro lado, comienzan a circular en la industria fonográfica. Por tanto, a las reflexiones y debates sobre “memoria nacional” e “identidad” necesitamos incluir otras nociones como fetiche y mercadería, abriendo la discusión a cuestiones éticas surgidas de nuestro abordaje y repertorización de esas vocalidades.Facultad de Bellas Arte

Proferindo quilombo: cantos épicos latino-americanos de descolonização e liberdade

ResumoO artigo apresenta uma escuta de três obras – produções artístico-culturais brasileiras da segunda metade do século XX (Teatro Experimental do Negro fundado por Abdias do Nascimento, editor do jornal Quilombo na década de 1950; o filme Ôrí dirigido por Raquel Gerber com textos e locução da historiadora Beatriz Nascimento, nos finais dos 70; e a Missa dos Quilombos de Pedro Casaldáliga, Pedro Tierra e Milton Nascimento, de 1981), com o intuito de embasar uma dimensão filosófica e mitopoética da noção de Quilombo.Palavras-chaveQuilombo, Palavra-força, Quilombismo, Cultura afro-brasileira

Phenolic quantification and botanical origin of Portuguese propolis

The production of propolis by honeybees results from a selective collection of exudates from leaf buds and plants present in the hive neighborhood leading to a resin with many potentialities in the pharmaceutical industry. This study aims to quantify the phenolic content in propolis from different Portuguese regions and in the potential floral sources, Populus x Canadensis Moench buds and Cistus ladanifer L., in order to establish links with geographical and botanical origin. The Portuguese propolis revealed a phenolic profile with marked differences in concentrations: the richness in flavonoids is common in all regions, but more evident in propolis from central interior, south and Madeira. The composition of poplar type propolis common in temperate zones was observed in the north, central coast and Azores, while the central interior and south samples, with a composition rich in kaempferol derivatives, resemble the C. ladanifer exudates, a spontaneous bush widespread in the Mediterranean. The compound kaempferol-3,7-dimethyl-ether, absent in the poplar type propolis, can be regard as a possible marker for the discrimination of these two types of propolis

AVALIAÇÃO DA SATISFAÇÃO NO ENSINO REMOTO EMERGENCIAL SOB A PERSPECTIVA DISCENTE

Due to the SARS-CoV-2 pandemic, the Federal University of Minas Gerais (UFMG) established Emergency Remote Education (ERE) in July 2020, with the purpose of continuing the first semester of classes at the institution.  Considering the adaptive period, the goal was to evaluate the satisfaction of the students studying Pharmacy with ERE, focusing on the learning process.  Data collection was carried out through a virtual platform, with a questionnaire addressing sociodemographic data, lifestyle habits and the teaching-learning process. Data were analyzed using simple linear regression and the CART technique. The profile of the responding students was mainly characterized by women and students from the undergraduate professional cycle (above the 5th period). The average general satisfaction  with the teaching of students was 3.12 (on a scale that ranged from 1 to 5), showing an inverse correlation with learning in the professional cycle of the course (p<0.000).  Only 3.1% of students who indicated “none or little learning” rated having maximum satisfaction with the ERE. There was low satisfaction with the quality of practical classes (3.06), revealing the limitation of the ERE for the development of courses with content as practical as that of Pharmacy Finally, great satisfaction is observed for factors related to the didactics and methodology of the professor, showing their engagement and dedication with the ERE, despite the difficulties for its establishment.Debido a la pandemia del SARS-CoV-2, la Universidad Federal de Minas Gerais (UFMG) estableció la Enseñanza Remota de Emergencia (ERE), en julio de 2020, con el objetivo de continuar el primer semestre de clases. Teniendo en cuenta el periodo de adaptación, el objetivo fue evaluar la satisfacción de los estudiantes del curso de Farmacia con la ERE, enfocándose en el proceso de aprendizaje. Se realizó la recolección de datos a través de una plataforma virtual, con cuestionario acerca de datos sociodemográficos, hábitos de vida y el proceso de enseñanza-aprendizaje. Los datos fueron analizados por medio de regresión lineal simple y la técnica CART. El perfil de los estudiantes que respondieron se caracterizó principalmente por mujeres y estudiantes del ciclo profesional del curso de grado (después del quinto período). El promedio de satisfacción global con la docencia de los estudiantes fue de 3,12 (en una escala que osciló de 1 a 5), mostrando correlación inversa con el aprendizaje en el ciclo profesional del curso (p<0,000). Solo el 3,1% de los estudiantes que indicaron “poco o ningún aprendizaje" evaluaron tener la máxima satisfacción con el ERE. Hubo baja satisfacción con la calidad de las clases prácticas (3.06), revelando la limitación del ERE para el desarrollo de cursos con contenido tan práctico como el de Farmacia. Finalmente, se retrata una satisfacción por encima de la media por factores relacionados con la didáctica y metodologías del profesor, mostrando la dedicación de los profesores para adaptarse incluso con los obstáculos del ERE.Devido à pandemia do SARS-CoV-2, a Universidade Federal de Minas Gerais (UFMG) estabeleceu o Ensino Remoto Emergencial (ERE), em julho de 2020, com o objetivo de dar continuidade ao primeiro semestre letivo de aulas na instituição. Considerando o período adaptativo, objetivou-se avaliar a satisfação dos discentes do curso de Farmácia com o ERE, focando no processo de aprendizagem. Realizou-se coleta de dados por meio de plataforma virtual, com questionário sobre dados sociodemográficos, hábitos de vida e processo de ensino-aprendizagem. Os dados foram analisados por meio de regressão linear simples e da técnica CART. O perfil dos alunos respondentes foi caracterizado majoritariamente por mulheres e estudantes do ciclo profissionalizante da graduação (acima do 5º período). A média de satisfação geral com o ensino dos discentes foi de 3,12 (em uma escala que variou de 1 a 5), apresentando correlação inversa ao aprendizado no ciclo profissionalizante do curso (p<0,000). Apenas 3,1% dos alunos que indicaram “nenhum ou pouco aprendizado” atribuíram satisfação máxima com o ERE. Observou-se menor satisfação com a qualidade das aulas práticas (3,06), revelando a limitação do ERE para o desenvolvimento de cursos com conteúdos tão práticos como o de Farmácia. Por fim, é retratada uma satisfação acima da média para fatores relacionados à didática e metodologias dos docentes, mostrando o compromisso e dedicação dos professores ao ERE, apesar das dificuldades para o seu estabelecimento

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a decrease in in vivo BM infiltration. Characterization of gene regulatory networks using scRNA-seq identified regulons associated to activation and exhaustion up-regulated in CARHigh T cells, providing mechanistic insights behind differential functionality of these cells. Last, we demonstrate that patients treated with CAR T cell products enriched in CARHigh T cells show a significantly worse clinical response in several hematological malignancies. In summary, our work demonstrates that CAR density plays an important role in CAR T activity with notable impact on clinical response

Percepção sobre qualidade de vida dos idosos de Portugal e do Brasil

Este estudo objetivou avaliar a percepção sobre qualidade de vida dos idosos de Portugal e do Brasile identificar a faceta do instrumento Whoqol-Old com maior escore avaliativo.Método:O estudo foi realizado com 508 idosos de Portugal e 349 idosos do Brasil. Para avaliação da qualidade de vida utilizou-se o instrumentoWhoqol-Old da OMS. Resultados:Identificou-se que as facetas com melhores escores avaliativos foram Família/Vida Familiar(74,05) para os idosos de Portugal e Morte e Morrer (75,37) para os idosos do Brasil.Conclusão:Os idosos que participaram deste estudo, tanto em Portugal quanto no Brasil, percepcionaram positivamente a sua qualidade de vida.Objective:This study aimed to evaluate the perception of life quality of the elderly in Portugal and Brazil, and to identify the facet of the WHOQOL-Old instrument with a higher evaluation score. Method:The study was conducted with 508 elderly from Portugal and 349elderly from Brazil. To evaluate the quality of life it was used the WHOQOL-Old instrument of WHO. Results:It was found that the facets with the best evaluative scores were Family/ FamilyLife(74.05) for the elderly in Portugal and DeathandDying(75.37) for the elderly in Brazil. Conclusion:The elderly in this study, both in Portugal and in Brazil, positively perceived their quality of life.Objetivo:Este estudio ha objetivado evaluar la percepción sobre calidad de vida de los viejos de Portugal y Brasil e identificar la faceta del instrumento WHOQOL-OLD con mayor puntuación de evaluación. Método:El estudio ha sido realizado con 508 viejos en Portugal y 349 en Brasil. Para evaluación de calidad de vida se ha utilizado el instrumento WHOQOL-OLD. Resultados:Se ha identificado que las facetas con mejores puntuaciones de evaluación han sido Familia/Vida familiar (74,05) para los de Portugal y Muerte y Morir (75,37) para los de Brasil. Conclusión:Los que han participado de este estudio, tanto en Portugal cuanto en Brasil, han tenido una percepción positiva en su calidad de vida.info:eu-repo/semantics/publishedVersio

Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia.

Histone deacetylases (HDACs) have been identified as therapeutic targets due to their regulatory function in chromatin structure and organization. Here, we analyzed the therapeutic effect of LBH589, a class I-II HDAC inhibitor, in acute lymphoblastic leukemia (ALL). In vitro, LBH589 induced dose-dependent antiproliferative and apoptotic effects, which were associated with increased H3 and H4 histone acetylation. Intravenous administration of LBH589 in immunodeficient BALB/c-RAG2(-/-)γc(-/-) mice in which human-derived T and B-ALL cell lines were injected induced a significant reduction in tumor growth. Using primary ALL cells, a xenograft model of human leukemia in BALB/c-RAG2(-/-)γc(-/-) mice was established, allowing continuous passages of transplanted cells to several mouse generations. Treatment of mice engrafted with T or B-ALL cells with LBH589 induced an in vivo increase in the acetylation of H3 and H4, which was accompanied with prolonged survival of LBH589-treated mice in comparison with those receiving vincristine and dexamethasone. Notably, the therapeutic efficacy of LBH589 was significantly enhanced in combination with vincristine and dexamethasone. Our results show the therapeutic activity of LBH589 in combination with standard chemotherapy in pre-clinical models of ALL and suggest that this combination may be of clinical value in the treatment of patients with ALL