FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate

Infância e Escola: tempos e espaços de crianças

Resumo: A infância é abordada, neste artigo, como viés para pôr em discussão o tempo cronológico, demarcado por uma linearidade ordenada pelo progresso e pela racionalidade. Conjugando escritos poéticos de Mario Quintana com os diálogos e os mapas vivenciais das crianças em uma escola, este texto tem como objetivo discutir como tempos e espaços repercutem na construção da infância e nos processos educativos de crianças, no sentido de problematizar as dimensões calculadas e previsíveis que essas categorias assumem nesse contexto social. Buscamos, assim, dar visibilidade ao tempo do inusitado nas experiências das crianças, na escola, ao destacar como, nesse espaço, elas operam rupturas com a temporalidade contínua, progressiva e linear

The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications

Da janela lateral: Considerações sobre infância e territórios de brincar em tempos pandêmicos em um condomínio no subúrbio do Rio de Janeiro

Os playgrounds de condomínios residenciais costumam ser espaços pensados para uso prioritário do coletivo de crianças. Ainda que apresentem uma intencionalidade na disposição de seus equipamentos, são as crianças que na ocupação e uso destes espaços os reconfiguram segundo seus desejos, edificando seus territórios de brincar. A pandemia provocada pelo Covid19 tornou todos esses espaços inacessíveis. Durante quase dois anos as crianças e adultos estiveram confinados em seus apartamentos. Recentemente o distanciamento social tem sido abrandado e tais espaços voltam a ser ocupados. A inserção do pesquisador nesse universo permitiu a observação do fenômeno e a partir da tradição de pesquisa do Núcleo de Estudos de Infância e Cultura o presente trabalho se propõe tecer considerações sobre esse processo

Condição feminina de mulheres chefes de família em situação de vulnerabilidade social Feminine condition of women heads of family in situation of social vulnerability

O estudo efetuou uma aproximação com a história de mulheres residentes na região central de Santos para compreender sua condição de vida, estratégias de sobrevivência e representações sobre o papel feminino e a construção de sua identidade como mulher. Utilizou-se da história oral para captar os elementos mais significativos da trajetória vivida por nove mulheres por meio de entrevistas realizadas no domicílio. A história delas mostrou processos de rupturas e continuidades, a fragilidade da população sob o efeito dos processos de vulnerabilidade e exclusão, revelando a condição feminina de mulheres em situação de vulnerabilidade social.<br>The study approached the history of women who live in the central region of Santos to understand their life condition, their strategies to survive and their representations of the female role and of the construction of their identity as women. Nine women were interviewed in the places where they lived to get the most significant elements of their trajectory through their oral histories. Such histories showed processes of ruptures and continuities, as well as the fragility of the population under the effect of vulnerability and exclusion processes, and they disclosed the female condition of women in situation of social vulnerability

Mapping of the environmental contamination of Toxoplasma gondii by georeferencing isolates from chickens in an endemic area in Southeast Rio de Janeiro State, Brazil

Submitted by sandra infurna ([email protected]) on 2016-04-18T12:13:44Z No. of bitstreams: 1 joaocarlos_carreira_etal_IOC_2015.pdf: 725117 bytes, checksum: 241efb3adb9e062303ccb30b1e6f653c (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-04-18T12:31:17Z (GMT) No. of bitstreams: 1 joaocarlos_carreira_etal_IOC_2015.pdf: 725117 bytes, checksum: 241efb3adb9e062303ccb30b1e6f653c (MD5)Made available in DSpace on 2016-04-18T12:31:17Z (GMT). No. of bitstreams: 1 joaocarlos_carreira_etal_IOC_2015.pdf: 725117 bytes, checksum: 241efb3adb9e062303ccb30b1e6f653c (MD5) Previous issue date: 2015Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.The environmental contamination of Toxoplasma gondii in an endemic area in Brazil was mapped by georeferencing isolates from chickens in farms in the Southeast of the state of Rio de Janeiro. Tissue samples obtained from 153 adult chickens were analyzed by the mouse bioassay for T. gondii infection. These animals were reared free-range on 51 farms in the municipalities of Rio Bonito and Maricá. The ArcGIS kernel density estimator based on the frequency of T. gondii-positive chickens was used to map the environmental contamination with this parasite. A questionnaire was applied to obtain data on the presence and management of cats and the type of water consumed. Of the farms studied, 64.7% were found to be located in areas of low to medium presence of T. gondii, 27.5% in areas with a high or very high contamination level and 7.8% in non-contaminated areas. Additionally, 70.6% kept cats, 66.7% were near water sources and 45.0% were in or near dense vegetation. Humans used untreated water for drinking on 41.2% of the farms, while all animals were given untreated water. The intensity of environmental T. gondii contamination was significantly higher on farms situated at a distance >500 m from water sources (P=0.007) and near (≤500 m) dense vegetation (P=0.003). Taken together, the results indicate a high probability of T. gondii infection of humans and animals living on the farms studied. The kernel density estimator obtained based on the frequency of chickens testing positive for T. gondii in the mouse bioassay was useful to map environmental contamination with this parasit

Fatal Cronobacter sakazakii Sequence Type 494 Meningitis in a Newborn, Brazil

We describe a case of infection with Cronobacter sakazakii sequence type 494 causing bacteremia and meningitis in a hospitalized late premature infant in Brazil. We conducted microbiological analyses on samples of powdered infant formula from the same batch as formula ingested by the infant but could not identify the source of contamination