50 research outputs found
VISIONES DE LA EDUCACION FINANCIERA: Analisis y perspectivas.
- Author
- BRISEÑO FREGOSO LUIS CARLOS
- CASTILLO SANCHEZ MARTIN DARIO
- CASTORENA LABASTIDA NORMA
- CHAVEZ MAZA LUIS AUGUSTO
- ESTRADA RODRIGUEZ JOSE LUIS
- FLORES GARCIA ISAAC
- HERNANDEZ RIVERA ARADNA
- HERNANDEZ RIVERA ARIADNA
- HERNANDEZ RIVERA ARIADNA
- LOPEZ TOACHE VANIA DEL CARMEN
- MORENO PERALTA SAMUEL ALBERTO
- OLIVERA PEREZ EMMANUEL
- PEREZ MUNGUIA SORAYA
- RENDON ROJAS LILIANA
- REYES HERNANDEZ MARLEN ROCIO
- SANCHEZ BARCENAS HORACIO
- SANCHEZ ZAMORA ROMAN
- SILVA VAZQUEZ JULIO CESAR
- TRUJILLO MAZORRA MANUEL IGNACIO
- VALAZQUEZ VAZQUEZ MARIA DE JESUS
- VALENZUELA DIAZ ROGELIO
- VARGAS HERNANDEZ LARRY ALFREDO
- VERGARA CONTRERAS ABRAHAM ISAAC
- Publication venue
- 'Universidad Autonoma del Estado de Mexico'
- Publication date
- 06/04/2019
- Field of study
Este libro es el resultado de un trabajo de investigación por parte de todos
los autores quienes integraron los capítulos, por lo que agradecemos su
confianza e interés para ser parte de este gran proyecto académico.
Gracias a los enlaces de cada una de las Instituciones que aceptaron
respaldar este libro: Marlen Rocío Reyes Hernández, Profesora-Investigadora
de la Universidad Autónoma del Estado de México; Rogelio Valenzuela
Díaz, Decano de la Facultad de Economía de la Universidad de Panamá;
Samuel Alberto Moreno Peralta, Presidente del Colegio de Economistas de
Panamá, a los miembros de la Asociación Mexicana de Especialistas en
Educación Financiera, Asociación Valor México y la Federación de Economistas
de la República Mexicana.
Asimismo, hacemos una deferencia a los jóvenes talentosos que acompañaron
en la coordinación del documento final, entrañables alumnos,
becarios y amigos: Julio César Silva Vázquez y Alfredo Larry Vargas Hernández,
que estamos convencidas que alcanzarán todas sus metas que se
propongan en la vida.
También es necesario reconocer a nuestras amadas familias que compartieron
el tiempo de convivencia, para que lográramos la realización de
este libroVisiones de la educación financiera: análisis y perspectivas es una obra
que enmarca la importancia de la educación financiera en la sociedad
en el contexto actual. Las decisiones que en este tema realiza un individuo
pueden impactar positiva o negativamente su estabilidad económica
por un periodo indeterminado, es aquí cuando la educación financiera
actúa como una herramienta trascendental en su bienestar personal.
Además de tener la función de armadura ante las batallas que se libran
en los mercados —como la crisis financiera de 2008— funge como dinamizador
de las economías al potenciar los proyectos de inversión con el
aumento del emprendedurismo, impactando así en las variables macroeconómicas.
Esta área del conocimiento ha adquirido importancia y popularidad a
nivel internacional a raíz de las crisis económicas de los últimos años, sin
embargo, aún existen, entre otras, brechas sociodemográficas, culturales,
económicas, que no permiten el acceso a estas enseñanzas, excluyendo
parte de la población del proceso del bienestar económico. Para ejemplificar
esta desigualdad, en los capítulos se plasma un panorama internacional
de la educación financiera, considerando las implicaciones y retos
que han tenido las estrategias nacionales de educación financiera a nivel
mundial
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
- Author
- Abaterusso Cataldo
- Abdul Kadir Khalid
- Abrahamovych Orest
- Acharya Shamasunder
- Acosta Idalia
- Adam Noor
- Adams Luthando
- Adawi Faiad
- Adolphe Allen
- Ahmad Ghazali
- Ahmed Azazuddin
- Ahmed Ziauddin
- Ahn Kyu Jeung
- Alcantara-Gonzalez Altagracia Aurora
- Aldrete Jorge
- Ali Norhaliza Mohd
- Almirall Jaume
- Alscher Mark
- Alvarado Odilon
- Alvarez German
- Alvarisqueta Andres
- Amin Mohammad
- Amodeo Celso
- Andress Dennis L
- Annand Andrew
- Antunes Ferreira Manuel Anibal
- Anzai Jiichi
- Apostolou Theofanis
- Arauz-Pacheco Carlos
- Arciszewska Malgorzata
- Argoud Georges
- Arif Ahmed
- Aronson Ronnie
- Arrieta Lezama Javier
- Assefi Ali
- Ato Keita
- Atray Naveen
- Awua-Larbi Stella
- Aziz Nor Azizah
- Azuma Nobuyuki
- Bai Liqun
- Bailey Gordon
- Bajaj Harpreet Singh
- Bakdash Wa'El
- Baker John
- Baker Penelope
- Bako Gabriel
- Bakris George
- Bakris George
- Bansal Shweta
- Bar-Dayan Yosefa
- Bardymova Tatiana
- Barendregt Jnm
- Barengolts Elena
- Bartaskova Dagmar
- Bau Cho-Tsan
- Bayliss George
- Beddhu Srinivasan
- Bedros Fadi
- Belledonne Mario
- Belo Diogo
- Bentsianov Marie
- Bhargava Anuj
- Bhorat Qasim
- Bieler Tasso
- Birne Rita
- Blagoveshchenskaya Olga
- Bloom Scott
- Blumenthal Samuel
- Bochicchio-Ricardelli Tomasso
- Bock Andreas
- Bohm Guillermo
- Boiskin Mark
- Bonet Sol Josep
- Borges Joao Lindolfo
- Bowman-Stroud Cynthia
- Brantley Roman
- Bressler Peter
- Brown Eric
- Brunati Chiara
- Brusco Osvaldo
- Bucek Petr
- Budde Klemens
- Burga Nunez Jose
- Burgos-Calderon Rafael
- Busch Robert
- Butt Salman
- Cabrita Antonio
- Calderon Ortiz Ricardo
- Calderon Ticona Jorge
- Calero Gonzalez Francesca
- Cangiano Jose
- Capasso Giovambattista
- Carranza-Madrigal Jaime
- Castillo Alvaro
- Castro-Alonso Cristina
- Cathcart Harold
- Cercato Cintia
- Cha Dae-Ryong
- Chan Doris
- Chatha Rupi
- Chen Ching-Chu
- Chen Jung-Fu
- Chen Nan
- Cheung Siu Fai
- Chevaile-Ramos Jose
- Chew Wong Alfredo
- Chmelickova Hana
- Cho Ho Chan
- Cho Yong-Wook
- Choi Kyung Mook
- Choi Moon-Gi
- Chow Stephen
- Christofides Elena
- Chu Chih-Hsun
- Chuang Peale
- Chung Choon Hee
- Ciechanowski Kazimierz
- Cigarran Guldris Secundino
- Coetzee Kathleen
- Cohen Josef
- Combe Christian
- Comulada-Rivera Angel
- Conte Giuseppe
- Cooke Duncan
- Correa-Rotter Ricardo
- Costa e Forti Adriana
- Cournoyer Serge
- Cruz Lucita
- Cusumano Ana
- D'Avila Domingos
- Dahl Neera
- Danin Vargas Alfredo
- Daoud Deeb
- Davis Tim
- de Arteaga Javier
- De Cosmo Salvatore
- De la Calle Gilda
- de Lourdes Noronha Irene
- de Zeeuw Dick
- Deboni Luciane
- Delgado-Butron Cesar
- Dellanna Frank
- Desai Sachin
- Dextre Espinoza Augusto
- Ding Guohua
- Ding Xiaoqiang
- Distiller Larry
- Dixon Brad
- Doo-Man Kim
- Doshi Ankur
- Draibe Sergio
- Dudar Iryna
- Dulude Emily
- Duma Livia
- Dussol Bertrand
- Egido Jesus
- Egstrup Kenneth
- El-Shahawy Mohamed
- Elbert Alicia
- Elder John
- Eliaschewitz Freddy
- Ellis Graham
- Endre Zoltan
- Esnault Vincent
- Esposito Ciro
- Essaian Ashot
- Eustace Joseph
- Fang Michael
- Farfan-Aspilcueta Julio
- Farias Eduardo
- Fekete Jozef
- Felicio Joao
- Fellstrom Bengt
- Fernandez Fresnedo Gema
- Fernandez Giraldez Elvira
- Fernando Ronald
- Fitz-Patrick David
- Flores Jose
- Foo Marjorie Wai Yin
- Fraenkel Margaret
- Fraige Filho Fadlo
- Frajewicki Victor
- Frias Juan
- Fried Linda
- Fu Ping
- Fu Shuxia
- Fujii Shinya
- Fujita Akira
- Fulopova Alla
- Fung Samuel
- Fung Yin Khet
- Furuya Ryuichi
- Fushtey Ivan
- Galan Antonio
- Galfre Andrea
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- Gallagher Martin
- Galphin Claude
- Galushchak Olga
- Gansevoort Ronald
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- Garcia Mendez Isabel
- Gesualdo Loreto
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- Gnudi Luigi
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- Goh Bak Leong
- Goldfarb David
- Golestaneh Laden
- Goluch Richard
- Gonzalez Gonzalez Jose
- Gonzalez Fernando
- Gonzalez-Galvez Guillermo
- Goto Daisuke
- Gouge Steven
- Goumenos Dimitrios
- Graf Ronald
- Greenwood Gregory
- Greloni Gustavo
- Guadiz Ramon
- Guasch Antonio
- Gundroo Aijaz
- Guo Xiaohui
- Gutierrez Vicente
- Halimi Jean-Michel
- Hall Karen
- Hames Melanie
- Hancu Nicolae
- Hanson Lenita
- Hao Chuanming
- Harada Hiroyuki
- Hashiguchi Yasuhiro
- Hassan Wan Hasnul Halimi Wan
- Hasslacher Christoph
- Heerspink Hiddo J L
- Hellberg Olof
- Herman Lee
- Hernandez-Jaras Julio
- Herrada Orue Benjamin
- Herrero Calvo Jose
- Hershon Kenneth
- Hirano Fuminori
- Honova Vaclava
- Horwitz Edward
- Hou Fan-Fan
- Hou Fanfan
- Hougardy Jean
- Huang Chien-Ning
- Hugo Christian
- Hussein Zanariah
- Iehara Noriyuki
- Iitsuka Tadashi
- Ijaz Adeel
- Ikeda Naoko
- Imura Mitsuo
- Inoue Toshihiko
- Ionutiu Lavinia
- Ishikawa Kazuo
- Ishiko Tamayo
- Israel Ezra
- Itabashi Naoki
- Ivanova Svetlana
- Iwaoka Hideaki
- Jabbour Serge
- Jadoul Michel
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- Ji Linong
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- Joshi Sucharit
- Joshi Sudhir
- Juncos Luis
- Kalender Betul
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- Kanai Hidetoshi
- Kaneko Shizuka
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- Kantor Samuel
- Karim Shahana
- Karonova Tatiana
- Karpova Irina
- Kashihara Naoki
- Kashine Susumu
- Kayali Zeid
- Keitel Elizete
- Kenis Irina
- Khandwala Hasnain
- Kim Beom Seok
- Kim Byung-Joon
- Kim In-Joo
- Kim Min Seon
- Kim Sang Yong
- Kim Sin-Gon
- Kishimoto Rui
- Kitzman Dalane W
- Kiyosue Arihiro
- Klimontov Vadim
- Klodawska Katarzyna
- Knobler Hilla
- Kobayashi Kunihisa
- Kohan Donald
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- Kumar Jayant
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- Marasaev Vyacheslav
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- Markell Mariana
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- Matsuda Hirofumi
- Matsuhisa Munehide
- Matsutani Akira
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- Mayer Gert
- Mazur Stanislaw
- Mcfadden Christopher
- Mcmurray John J V
- Medina-Santander Boris
- Melish John
- Melnick Joel Z
- Menefee Judson
- Merican Nor Shaffinaz Yusuf Azmi
- Mersey James
- Milagres Rosangela
- Miller Alan
- Miller Michael G
- Miller Steven
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- Minguela Pesquera Jose Ignacio
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- Pergola Pablo E
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- Seo Ji A
- Seron Daniel
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- Shamkhalova Minara
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- Sheu Wayne
- Shi Bingyin
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- Shin Mijung
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- Stack Austin
- Stanislavchuk Mykola
- Stefanidis Ioannis
- Stoica George
- Strand Jorma
- Stranks Stephen
- Stryzhak Vasyl
- Su Benli
- Suh Sung Hwan
- Sukor Norlela
- Sun Shiren
- Suranyi Michael
- Suzuki Katsunori
- Szerlip Harold
- Tadika Takenobu
- Takeda Tetsuro
- Taliercio John
- Tam Paul
- Tan Kathryn
- Tanaka Tsuyoshi
- Tanaka Yukio
- Tang Sydney
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- Thakar Charuhas
- Thomson Stephen
- Tien Kai-Jen
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- Timar Romulus
- Tindall Hilary
- Tkac Ivan
- Tkach Sergii
- Tobe Sheldon
- Tobe Sheldon
- Tokui Mikiya
- Tomilina Natalia
- Topchii Ivan
- Toussaint Nigel
- Trokis Julien
- Tseng Shih-Ting
- Tsuchida Kenichi
- Tsujimoto Tetsuro
- Tsutsui Masahiro
- Tulloch Brian
- Tuta Liliana
- Tutescu Adriana
- Ueda Shinichiro
- Ujihara Makoto
- Umayahara Yutaka
- Urena Torres Pablo
- Vaithilingam Indralingam
- Valera Cortes Ildefonso
- Vallejos Augusto
- Van Vlem Bruno
- Van Zyl Louis
- Vargas-Gonzales Rolando
- Varghese Freemu
- Vazquez-Tanus Jose
- Vengadasalam V Paranthaman P
- Vercammen Chris
- Vicks Steven
- Vielhauer Volker
- Vijayasingham Shalini
- Villevalde Svetlana
- Vogel Daniel
- Vogt Liffert
- Wainstein Julio
- Wang Song
- Wanner Christoph
- Warling Xavier
- Watanabe Shuichi
- Weinstein Debra
- Weinstein Talia
- Weiss Robert
- Weng Jian
- Whaley-Connell Adam
- Wiecek Andrzej
- Wigderson Melissa
- Wise Jonathan
- Wong Hin Seng
- Woo Jeong-Taek
- Wruk Michal
- Wu Du-An
- Wu Mai-Szu
- Xiao Guanqing
- Xing Changying
- Xu Gang
- Xu Yan
- Yagil Yoram
- Yalcin Murat
- Yamada Daishiro
- Yamaguchi Yukinari
- Yamamoto Masahiro
- Yamauchi Akira
- Yambe Yuko
- Yang Jinkui
- Yavdosyuk Andrey
- Yeoh Lee Ying
- Yeung Vincent
- Yi Joo Hark
- Yi Tingting
- Yildiz Alaattin
- Yoo Soon-Jib
- Yoon Kun Ho
- Yoon Sun Ae
- Youmbissi Joseph
- Yu Shengqiang
- Yu Tae Yang
- Zahumensky Emil
- Zanella Maria
- Zaoui Philippe
- Zapata-Rincon Luis
- Zea-Nunez Carlos Antonio
- Zeig Steven
- Zhao Hongwen
- Zhao Jiajun
- Zhao Minghui
- Zieve Franklin
- Zolotaikina Viktoriia
- Zrazhevskiy Konstantin
- Zucchini Alfredo
- Zuo Li
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
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- D'Agostino Ralph B.
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- Granger Christopher B.
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- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
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- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
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- Leiter Lawrence A.
- Lentz John
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- Sigal Helena
- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
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- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
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- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
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- Stuebler Petra
- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
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- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
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- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- de Almeida Roberto Simões
- de Brito Claudia Moreira
- De Cosmo Salvatore
- De Nicola Luca
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- de Souza Pedro
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- de Zeeuw Dick
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- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
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- Flores Fernando Jimenez
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- Heerspink Hiddo J. L.
- Heerspink Hiddo J. L.
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- Keightley Gerald
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- Keresztesi Sandor
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- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
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- Kim Sin Gon
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- Klein Alexandre
- Klokocnikova Vera
- Klyver Maria Isabel
- Kodera Takamoto
- Kohara Suely Keiko
- Kolesnyk Inna
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- Komisarenko Iuliia
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- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Kopyt Nelson
- Koroleva Tatiana
- Korzh Oleksii
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- Kovar Richard
- Kovesdy Csaba
- Koyama Kazunori
- Kozloviene Dalia
- Kraft Florencia
- Krane Vera
- Kravchun Nonna
- Krishna Gopal
- Krishnan Singhan
- Kropp Jeffrey (Jay)
- Krynski Fernando
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- Lane Wendy
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- Li Nicole
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- Lin Chih-Ching
- Lin Hongli
- Lisboa Hugo Roberto Kurtz
- Liss Kenneth
- Liu Jian
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- Lombard Landman
- Lopez Marta Dominguez
- Lozano Fernando Flores
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- Lu Weiping
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- Luna Ceballos Rosa Isela
- MacDougall Iain
- Maddux Andreas
- Madej Andrzej
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- Mah Peak Mann
- Mahaffey Kenneth W.
- Mahaffey Kenneth W.
- Maheshwari Hiralal
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- Malaver Natalia
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- Mazur Stanislaw
- McMahon Alan
- Mehta Bhasker
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- Mendoza Jose Luis Accini
- Mendoza Manuel Lopez
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- Mesa Juan Villagordoa
- Middleton John
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- Mileder Margit
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Mkrtumyan Ashot
- Mlodawska-Choluj Dorota
- Molina Hugo Laviada
- Molnar Marta
- Montenegro María Alicia Fernández
- Mookadam Mohamed
- Mordujovich Jorge
- Moreda Ramon
- Moreira Diaz Juan Pablo
- Moreno Loza Oscar Tarsicio
- Morugova Tatiana
- Mostovoy Yuriy
- Moustafa Moustafa
- Mucsi Janos
- Muirhead Norman
- Munar Vila Maria Antonia
- Munteanu Mircea
- Nagibovich Galina
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- Nam Moon-Suk
- Narayanan Mohanram
- Narvarte Javier
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- Quesada-Suarez Luis
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- Rangelov Rangel
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- Raskina Tatiana
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- Robinson Michael
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- Takai Masahiko
- Tamayo y Orozco Juan Alfredo
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- Tinahones Madueno Francisco Jose
- Toarba Cristina
- Tolentino Marsha
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- Topchii Ivan
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- Torshizi Ali
- Trenche Samuel Mujica
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- Trevisan Roberto
- Triana Eric Hernandez
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turatti Luiz Alberto Andreotti
- Turner Wayne
- Twahirwa Marcel
- Ulla Maria Rosa
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Vargas Alonso Ruben Dario
- Varghese Freemu
- Vasas Szilard
- Vazelov Evgueniy
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vera Gregorio Obrador
- Vera Merce Perez
- Veronelli Anna Maria
- Vêncio Sérgio Alberto Cunha
- Villarino Adriana
- Villegas Ivan
- Visco Virginia Esther
- Vizir Vadym
- Vlasenko Maryna
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
- Williams Michael
- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
Highly-parallelized simulation of a pixelated LArTPC on a GPU
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Adriano Cris
- Aduszkiewicz Antoni
- Aguilar Jessica
- Ahmad Zubayer
- Ahmed Jhanzeb
- Aimard Benjamin
- Akbar Faiza
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alt Christoph
- Alton Andrew
- Alvarez Rodrigo
- Amedo Pablo
- Anderson John
- Andrade Aldana Diego
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P.
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Anicézio Campanelli Wallison Luiz
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Ashkenazi Adi
- Asquith Lily
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Bagaturia Iuri
- Bagby Linda
- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baldini Wander
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barham Alzás Pablo
- Barker Gary
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Adilson
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Battat James
- Battisti Federico
- Bay Fatih
- Bazetto Maria
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior Ewerton
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Montiel Carlos
- Benjamin Douglas
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Bersani Andrea
- Bertolucci Sergio
- Betancourt Minerba
- Betancur Rodríguez Amalia
- Bevan Adrian
- Bezawada Yashwanth
- Bezerra Anibal
- Bezerra Thiago
- Bhambure Jay
- Bhardwaj Akhil
- Bhatnagar Vipin
- Bhattacharjee Maharnab
- Bhattacharya Meghna
- Bhattarai Devesh
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bisignani Valeria
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor
- Blazey Gerald
- Blend Dylan
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bonilla-Diaz Cesar
- Bonini Filiberto
- Booth Alexander
- Boran Fatma
- Bordoni Stefania
- Borkum Aran
- Bostan Nilay
- Bour Petr
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Branca Antonio
- Brandt Andrew
- Bravo-Moreno Marina
- Bremer Johan
- Brew Christopher
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Buergi Jonas
- Caceres Vera Gian
- Cagnoli Irene
- Cai Tejin
- Caiulo Davide
- Calabrese Roberto
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calivers Livio
- Calvez Steven
- Calvo Enrique
- Caminata Alessio
- Caratelli David
- Carber Daniel
- Carceller Juan
- Carini Gabriella
- Carlus Bruno
- Carneiro Mateus
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Carrara Nicholas
- Carroll Lauren
- Carroll Thomas
- Carter Alex
- Castaño Forero Javier
- Castillo Andrés
- Catano-Mur Erika
- Cattadori Carla
- Cavalier Fabien
- Cavallaro Giuseppe
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chakraborty Kaustav
- Chalifour Michel
- Chappell Andrew
- Chardonnet Etienne
- Charitonidis Nikolas
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
- Chen Zheyang
- Chen-Wishart Zachary
- Cheon Yoolim
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Chirco Robert
- Chiriacescu Ana
- Chitirasreemadam Namitha
- Cho Kihyeon
- Choate Sarah
- Chokheli David
- Chong Pooi
- Chowdhury Barnali
- Christensen Anne
- Christian David
- Christodoulou Georgios
- Chukanov Artem
- Chung Moses
- Church Eric
- Cicero Valentina
- Clapa Daniel
- Clarke Peter
- Cline Gordon
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Cohen Ariel
- Collot Johann
- Conley Erin
- Conrad Janet M.
- Convery Mark
- Copello Simone
- Cova Paolo
- Cox Callum
- Cremaldi Lucien
- Cremonesi Linda
- Crespo-Anadón José
- Crisler Michael
- Cristaldo Esteban
- Crnkovic Jason
- Crone Gordon
- Cross Ryan
- Cudd Andrew
- Cuesta Clara
- Cui Yanou
- Cussans David
- da Motta Helio
- da Silva Peres Leonardo
- Dai Joel
- Dalager Olivia
- Dallavalle Ricardo
- Dar Zubair
- Darby Robert
- David Claire
- David Quentin
- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Aguiar Renan
- de Almeida Patricia
- de Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- de Jong Paul
- de la Torre Andres
- de Leo Veronica
- de Lurgio Patrick
- de Mello Neto Joao
- de Roeck Albert
- de Romeri Valentina
- de Souza Greg
- De Kaushik
- De Shruti
- Debbins Paul
- Decowski M. Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- Delmonte Nicola
- Demuth David
- Dennis Steve
- Densham Chris
- Denton Peter
- Deptuch Grzegorz
- Detje Jan
- Devi Ritu
- Dharmapalan Ranjan
- Di Capua Francesco
- Di Domenico Antonio
- Di Domizio Sergio
- Di Falco Stefano
- Di Giulio Letizia
- Di Noto Lea
- Dias Marco
- Diaz Jorge S.
- Ding Pengfei
- Diociaiuti Eleonora
- Distefano Carla
- Diurba Richard
- Diwan Milind
- Djurcic Zelimir
- Doering Dionisio
- Dolan Stephen
- Dolek Furkan
- Dolinski Michelle J.
- Domenici Danilo
- Domine Laura
- Donati Simone
- Donon Yann
- Doran Steven
- Douglas Daniel
- Dragone Angelo
- Drielsma Francois
- Duarte Laura Cristina
- Duchesneau Dominique
- Duffy Kirsty
- Dugas Katherine
- Dunne Patrick
- Dutta Bhaskar
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A.
- Dyshkant Alexandre S.
- Díaz Felix
- Eads Michael
- Earle Antony
- Edmunds Daniel
- Eisch Jonathan
- Emberger Lorenz
- Englezos Panagiotis
- Ereditato Antonio
- Erjavec Tyler
- Escobar Carlos O.
- Evans Justin
- Ewart Erin
- Ezeribe Anthony
- Fahey Kevin
- Fajt Lukas
- Falcone Andrea
- Fani Mattia
- Farnese Christian
- Farzan Yasaman
- Fedoseev Dmitry
- Felix Julian
- Feng Yue
- Fernandez-Martinez Enrique
- Ferraro Federico
- Fields Laura
- Filip Peter
- Filkins Amy
- Filthaut Frank
- Fine Robert
- Fiorillo Giuliana
- Fiorini Massimiliano
- Fischer Vincent
- Fitzpatrick Rory
- Flanagan Will
- Fleming Bonnie
- Flight Robert
- Fogarty Sam
- Foreman Will
- Fowler Jack
- Franc Jiri
- Franco Domenico
- Freeman John
- Fried Jack
- Friedland Alex
- Fuess Stu
- Furic Ivan
- Furman Krzysztof
- Furmanski Andrew
- Gabrielli Alessandro
- Gago A.M.
- Gallagher Hugh
- Gallas Alexandre
- Gallego-Ros Ana
- Gallice Niccolo
- Galymov Vyacheslav
- Gamberini Enrico
- Gamble Trevor
- Ganacim Francisco
- Gandhi Raj
- Ganguly Sudeshna
- Gao Fan
- Gao Shanshan
- Garcia-Gamez Diego
- García-Peris Miguel
- Gardiner Steven
- Gastler Dan
- Gauch Anja
- Gauvreau Jean-Luc
- Gauzzi Paolo
- Ge Guanqun
- Geffroy Nicolas
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Gerlach Lino
- Ghorbani-Moghaddam Zahra
- Giammaria Paola
- Giammaria Tommaso
- Giangiacomi Nico
- Gibin Daniele
- Gil-Botella Ines
- Gilligan Sean
- Gioiosa Antonio
- Giovannella Simona
- Girerd Claude
- Giri Anjan Kumar
- Gnani Dario
- Gogota Olga
- Gold Michael
- Gollapinni Sowjanya
- Gollwitzer Keith
- Gomes Ricardo
- Gomez Bermeo Laura Vanessa
- Gomez Fajardo Luz
- Gonnella Francesco
- Gonzalez-Diaz Diego
- Gonzalez-Lopez Manuel
- Goodman Maury
- Goodwin Owen
- Goswami Srubabati
- Gotti Claudio
- Goudeau Jacob
- Goudzovski Evgueni
- Grace Carl
- Gran Rik
- Granados Everardo
- Granger Pierre
- Grant Christopher
- Gratieri Diego
- Green Patrick
- Greenberg Stephen
- Greenler Leland
- Greer Joel
- Grenard Jean-Louis
- Griffith Clark
- Groetschla Florian
- Groh Micah
- Grzelak Katarzyna
- Gu Wenqiang
- Guarino Victor
- Guarise Marco
- Guenette Roxanne
- Guerard Eric
- Guerzoni Marco
- Guffanti Daniele
- Guglielmi Alberto
- Guo Bing
- Gupta Aseem
- Gupta Vikas
- Guthikonda K.K.
- Guzowski Pawel
- Guzzo Marcelo
- Gwon Sunwoo
- Ha Chang Hyon
- Haaf Kevin
- Habig Alec
- Hadavand Haleh
- Hadef Asma
- Haenni Roger
- Hagaman Lee
- Hahn Alan
- Haiston James
- Hamacher-Baumann Philip
- Hamernik Thomas
- Hamilton Philip
- Han Jiyeon
- Hancock Jonathan
- Happacher Fabio
- Harris Deborah
- Hartnell Jeffrey
- Hartnett Trevor
- Harton John
- Hasegawa Takyua
- Hasnip Ciaran
- Hatcher Robert
- Hatfield Kaleb
- Hatzikoutelis Athanasios
- Hayes Christopher
- Hayrapetyan Karen
- Hays Jonathan
- Hazen Eric
- He Muyuan
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Henry Sarah
- Hernandez Morquecho Miguel Angel
- Herner Kenneth
- Hewes V.
- Hilgenberg Christopher
- Hill Tony
- Hillier Stephen
- Himmel Alexander
- Hinkle Elise
- Hirsch Luciana
- Ho Jason
- Hoff James
- Holin Anna
- Holvey Thomas
- Hoppe Eric
- Horton-Smith Glenn
- Hostert Matheus
- Houdy Thibaut
- Hourlier Adrien
- Howard Bruce
- Howell Ryan
- Hoyos Barrios Jaime
- Hristova Ivana
- Hronek Maxine
- Huang Junying
- Huang Roger
- Hulcher Zachary
- Iles Gregory
- Ilic Nikolina
- Iliescu Antoniu
- Illingworth Robert
- Ingratta Gianfranco
- Ioannisian Ara
- Irwin Burke
- Isenhower Larry
- Ismerio Oliveira Marcelo
- Itay Ran
- Jackson Christopher
- Jain Vivek
- James Eric
- Jang Wooyoung
- Jargowsky Benjamin
- Jediny Filip
- Jena Deepika
- Jeong Yu Seon
- Jesús-Valls César
- Ji Xiangpan
- Jiang Junjie
- Jiang Libo
- Jipa Alexandru
- Jo Jay Hyun
- Joaquim Filipe
- Johnson Walker
- Jones Benjamin
- Jones Rhiannon
- Jovancevic Nikola
- Judah Matthew
- Jung Chang Kee
- Junk Thomas
- Jwa Yeon-Jae
- Kabirnezhad Monireh
- Kaboth Asher
- Kadenko Igor
- Kakorin Igor
- Kalitkina Anastasia
- Kalra Daisy
- Kamer Koseyan Ohannes
- Kamiya Felipe
- Kaplan Daniel
- Karagiorgi Georgia
- Karaman Gurkan
- Karcher Armin
- Karyotakis Yannis
- Kasai Seiji
- Kasetti Siva
- Kashur Lane
- Katsioulas Ioannis
- Kazaryan Narine
- Kearns Edward
- Keener Paul
- Kelly Kevin
- Kemp Ernesto
- Kemularia Otari
- Kermaidic Yoann
- Ketchum Wes
- Kettell Steve
- Khabibullin Marat
- Khotjantsev Alexei
- Khvedelidze Arsen
- Kim Doojin
- King Bonnie
- Kirby Brian
- Kirby Mike
- Klein Joshua
- Kleykamp Jeffrey
- Klustova Anezka
- Kobilarcik Thomas
- Koehler Kevin
- Koerner Lisa
- Koh Dae
- Kohn Sam
- Koller Patrick
- Kolupaeva Liudmila
- Korablev Denis
- Kordosky Mike
- Kosc Thomas
- Kose Umut
- Kostelecky V. Alan
- Kothekar Kunal
- Kotler Ian
- Kozhukalov Vladimir
- Kralik Robert
- Kreczko Luke
- Krennrich Frank
- Kreslo Igor
- Kropp William
- Kroupova Tereza
- Kubu Miroslav
- Kudenko Yury
- Kudryavtsev Vitaly
- Kuhlmann Stephen
- Kulagin Sergey
- Kumar Jason
- Kumar Praveen
- Kunze Pablo
- Kuravi Ramachandra
- Kurita Nadine
- Kuruppu Chatura
- Kus Vaclav
- Kutter Thomas
- Kvasnicka Jiri
- Kwak Donghyun
- Lambert Andrew
- Land Benjamin
- Lane Charles
- Lang Karol
- Langford Thomas
- Langstaff Mark
- Lanni Francesco
- Lantwin Oliver
- Larkin Jacob
- Lasorak Pierre
- Last David
- Laundrie Andy
- Laurenti Giuliano
- Lawrence Andrew
- Laycock Paul
- Lazanu Ionel
- Lazzaroni Massimo
- Le Trung
- Leardini Sara
- Learned John
- Lebrun Patrice
- Lecompte Thomas
- Lee Claire
- Legin Vladyslav
- Lehmann Miotto Giovanna
- Lehnert Ralf
- Leigui de Oliveira M.A.
- Leitner Matthaeus
- Lepin Luis
- Li Shirley W.
- Li Yichen
- Liao Heng-Ye
- Lin Cheng-Ju Stephen
- Lin Shih-Kai
- Lindebaum Dennis
- Lineros Roberto
- Ling Jiajie
- Lister Adam
- Littlejohn Bryce
- Liu Junze
- Liu Yinrui
- Lockwitz Sarah
- Loew Timothy
- Lokajicek Milos
- Lomidze Irakli
- Long Ken
- Lord Tom
- Losecco John M.
- Louis William
- Lu Xianguo
- Luk Kam-Biu
- Lunday Benjamin
- Luo Xiao
- Luppi Eleonora
- Lux Thorsten
- Luzio Vitor
- Maalmi Jihane
- Macfarlane David
- Machado Ana Amelia
- Machado Pedro
- Macias Christopher Thomas
- Macier Jolie R.
- Macmahon Margot
- Maddalena Antonello
- Madera Alfonso
- Madigan Peter
- Magill Steve
- Mahn Kendall
- Maio Amélia
- Major Adryanna
- Majumdar Krishanu
- Maloney James
- Man Matthew
- Mandrioli Gianni
- Mandujano Roberto
- Maneira José
- Manenti Laura
- Manly Steve
- Mann Anthony
- Manolopoulos Konstantinos
- Manrique Plata Maria
- Manyam Venkata
- Marchan Miquel
- Marchionni Alberto
- Marciano William
- Marfatia Danny
- Mariani Camillo
- Maricic Jelena
- Marinho Franciole
- Marino Alysia
- Markiewicz Thomas
- Marsden David
- Marshak Marvin
- Marshall Chris
- Marshall John
- Marteau Jacques
- Martinez Caicedo David
- Martinez Norman
- Martynenko Sergey
- Martín-Albo Justo
- Martínez López Francisco
- Martínez Miravé Pablo
- Mascagna Valerio
- Mason Katie
- Mastbaum Andrew
- Matichard Fabrice
- Matsuno Shigenobu
- Matthews James
- Mauger Christopher
- Mauri Nicoletta
- Mavrokoridis Konstantinos
- Mawby Isobel
- Mazza Roberto
- Mazzacane Anna
- Mcaskill Tracy
- Mccluskey Elaine
- Mcconkey Nicola
- Mcfarland Kevin
- Mcgrew Clark
- Mcnab Andrew
- Mefodiev Alexander
- Mehta Poonam
- Melas Pantelis
- Mena Olga
- Mendez Hector
- Mendez Patricia
- Menegolli A.
- Meng Guang
- Messier Mark
- Metcalf William
- Mewes Matthew
- Meyer Holger
- Miao Ting
- Michna Gregory
- Mikola Veera
- Milincic Radovan
- Miller Graham
- Miller William
- Mills Joshua
- Mineev Oleg
- Minotti Alessandro
- Miranda Omar
- Miryala Sandeep
- Miscetti Stefano
- Mishra C. Shekhar
- Mishra Sanjib R.
- Mislivec Aaron
- Mitchell Mote
- Mladenov Dimitar
- Mocioiu Irina
- Moffat Kristian
- Mogan Andrew
- Moggi Niccolo
- Mohanta Rukmani
- Mohayai Tanaz
- Mokhov Nikolai
- Molina Bueno Laura
- Molina Jorge
- Montagna Elisabetta
- Montanari Alessandro
- Montanari Claudio
- Montanari David
- Montanino Daniele
- Montaño Zetina Luis
- Moon Seok Ho
- Mooney Michael
- Moor Alexandra
- Moreno Deywis
- Morescalchi Luca
- Moretti Davide
- Morris Casandra
- Mossey Chris
- Motuk Erdem
- Moura Célio
- Mousseau Joel
- Mouster Gwenn
- Mu Wei
- Mualem Leon
- Mueller Justin
- Muether Mathew
- Muheim Franz
- Muir Alan
- Mulhearn Mike
- Munford Donnie
- Munteanu Laura
- Muramatsu Hajime
- Muraz Jean-Francois
- Murphy Matt
- Murphy Sebastien
- Musser Jim
- Méndez Diana
- Nachtman Jane
- Nagai Yoshikazu
- Nagu Srishti
- Nalbandyan Mikayel
- Nandakumar Raja
- Naples Donna
- Narita Shinya
- Nath Atanu
- Navrer-Agasson Anyssa
- Nayak Nitish
- Nebot-Guinot Miquel
- Negishi Kentaro
- Nelson Jeff
- Nelson Matthew
- Nesbit Jake
- Nessi Marzio
- Newbold David
- Newcomer Mitch
- Newton Hannah
- Nichol Ryan
- Nicolas-Arnaldos Francisco
- Nikolica Adrian
- Nikolov Jovana
- Niner Evan
- Nishimura Kurtis
- Norman Andrew
- Norrick Anne
- Novella Pau
- Nowak Jaroslaw
- Oberling Michael
- Ochoa-Ricoux Juan Pedro
- Olivier Andrew
- Olshevskiy Alexander
- Onel Yasar
- Onishchuk Yuriy
- Ott Jordan
- Pagani Luca
- Palacio Guillermo
- Palamara Ornella
- Palestini Sandro
- Paley Jonathan
- Pallavicini Marco
- Palomares Carmen
- Pan Supriya
- Panduro Vazquez William
- Pantic Emilija
- Paolone Vittorio
- Papadimitriou Vaia
- Papaleo Riccardo
- Papanestis Antonis
- Paramesvaran Sudarshan
- Parke Stephen
- Parozzi Elisabetta
- Parsa Saba
- Parsa Zohreh
- Parveen Sabila
- Parvu Mihaela
- Pasciuto Daniele
- Pascoli Silvia
- Pasqualini Laura
- Pasternak Jaroslaw
- Pater Joleen
- Patrick Cheryl
- Patrizii Laura
- Patterson Ryan
- Patton Simon John
- Patzak Thomas
- Paudel Ajib
- Paulucci Laura
- Pavlovic Zarko
- Pawloski Greg
- Payne David
- Pec Viktor
- Peeters Simon
- Pena Perez Aldo
- Pennacchio Elisabetta
- Penzo Aldo
- Peres Orlando
- Perez Gonzalez Yuber Ferney
- Pernas Carlos
- Perry James
- Pershey Daniel
- Pessina Gianluigi
- Petrillo Gianluca
- Petta Catia
- Petti Roberto
- Piastra Francesco
- Pickering Luke
- Pietropaolo Francesco
- Pimentel Vinicius
- Pinaroli Giovanni
- Plows Komninos-John
- Plunkett Robert
- Pollman Tina
- Pompa Federica
- Pons Xavier
- Poonthottathil Navaneeth
- Poppi Francesco
- Pordes Stephen
- Porter Joshua
- Potekhin Maxim
- Potenza Renato
- Potukuchi Baba
- Pozimski Juergen
- Pozzato Michele
- Prakash Suprabh
- Prakash Tarun
- Pratt Christian
- Prest Michela
- Psihas Fernanda
- Pugnere Denis
- Pérez-Molina Laura
- Qian Xin
- Raaf Jennifer L.
- Radeka Veljko
- Rademacker Jonas
- Radev Radi
- Radics Balint
- Rafique Aleena
- Raguzin Eric
- Rai Mousam
- Rajaoalisoa Miriama
- Rakhno Igor
- Rakotonandrasana Andrianjafy Michaël
- Rakotondravohitra Laza
- Rameika Regina
- Ramirez Delgado Manuel Alejandro
- Ramson Bryan
- Rappoldi A.
- Raselli G.L.
- Ratoff Peter
- Raut Sanil
- Razafinime Herilala
- Razakamiandra Rado Fanantenana
- Rea Eran
- Real Jean-Sebastien
- Rebel Brian
- Rechenmacher Ronald
- Reggiani-Guzzo Marina
- Reichenbacher Juergen
- Reitzner S.
- Rejeb Sfar Haifa
- Renshaw Andrew
- Rescia Sergio
- Resnati Filippo
- Ribas Marlos
- Riboldi Stefano
- Riccio Ciro
- Riccobene Giorgio
- Rice Logan
- Ricol Jean-Stephane
- Rigamonti Alberto
- Rigaut Yann-Axel
- Rincón Edgar
- Ritchie-Yates Asher
- Rivera David
- Rivera Ryan
- Robert Arnaud
- Rocabado Rocha Jose Luis
- Rochester Leon
- Roda Marco
- Rodrigues Philip
- Rodriguez Alonso Manuel
- Rodriguez Rondon Jairo
- Romeo Emanuele
- Rosauro-Alcaraz Salvador
- Rosier Philippe
- Ross-Lonergan Mark
- Rossella Massimo
- Rossi Marco
- Rout Jogesh
- Roy Palash
- Rubbia Andre
- Rubbia Carlo
- Ruiz Ferreira Guilherme
- Russell Brooke
- Ruterbories Daniel
- Rybnikov Arseniy
- Saa-Hernandez Angela
- Saakyan Ruben
- Sacerdoti Sabrina
- Sahu Narendra
- Sala Paola
- Samios Nicholas
- Samoylov Oleg
- Sanchez Mayly
- Sandberg Vern
- Sanders David
- Sankey David
- Santoro Danilo
- Saoulidou Niki
- Sapienza Piera
- Sarasty Carlos
- Sarcevic Ina
- Sarra Ivano
- Savage Geoffrey
- Savinov Vladimir
- Scanavini Giacomo
- Scaramelli Alberto
- Scarff Andrew
- Scarpelli Andrea
- Schefke Tristan
- Schellman Heidi
- Schifano Sebastiano
- Schlabach Philip
- Schmitz David
- Schneider Austin
- Scholberg Kate
- Schukraft Anne
- Segreto Ettore
- Selyunin Alexander
- Senise Carlos
- Sensenig Jon
- Sgalaberna Davide
- Shaevitz Michael H.
- Shafaq Sheeba
- Shaker Fady
- Shamma Michael
- Shanahan Peter
- Sharankova Ralitsa
- Sharma Hans
- Sharma Rahul
- Sharma Rajeev
- Shaw Kate
- Shaw Terri
- Shchablo Konstantin
- Shepherd-Themistocleous Claire
- Sheshukov Andrey
- Shi Wei
- Shin Seodong
- Shoemaker Ian
- Shooltz Dean
- Shrock Robert
- Silber Joseph
- Simard Laurent
- Sinclair James
- Sinev Gleb
- Singh Chauhan Sushil
- Singh Jaydip
- Singh Jyotsna
- Singh Lakwinder
- Singh Prabhjot
- Singh Venktesh
- Sipos Roland
- Sirri Gabriele
- Sitraka Andriaseta
- Siyeon Kim
- Skarpaas Knut
- Smith Erica
- Smith Paul
- Smolik Jan
- Smy Michael
- Snider E.L.
- Snopok Pavel
- Snowden-Ifft Daniel
- Soares Nunes Mônica
- Sobel Henry
- Soderberg Mitch
- Sokolov Sergei
- Solano Salinas Carlos
- Soleti Stefano Roberto
- Solomey Nicholas
- Solovov Vladimir
- Sondheim Walter
- Sorel Michel
- Sotnikov Albert
- Soto-Oton Jose
- Sousa Alexandre
- Soustruznik Karel
- Spagliardi Fabio
- Spanu Maura
- Spitz Joshua
- Spooner Neil
- Spurgeon Kyle
- Stalder Deigo
- Stancari Michelle
- Stanco Luca
- Steenis Jacob
- Stein Raul
- Steiner Herbert M.
- Steklain Lisbôa André
- Stepanova Anna
- Stewart James
- Stillwell Ben
- Stock Jason
- Stocker Francesca
- Stokes Tyler
- Strait Matthew
- Strauss Thomas
- Strigari Louis
- Stuart Alexander
- Suarez Juan
- Subash Joeal
- Surdo Antonio
- Susic Vasja
- Suter Louise
- Sutera Concetta Maria
- Sutton Kathryn
- Suvorov Yury
- Svoboda Robert
- Swain Sanjay
- Szczerbinska Barbara
- Szelc Andrzej
- Söldner-Rembold Stefan
- Taffara Alessandra
- Talukdar Nibir
- Tamara Jose
- Tanaka Hirohisa
- Tang Shaochun
- Taniuchi Natsumi
- Tapia Oregui Beatriz
- Tapper Alexander
- Tariq Salman
- Tarpara Eaglekumar
- Tata Neeraj
- Tayloe Rex
- Teklu Abraham Meles
- Tennessen Peter
- Tenti Matteo
- Terao Kazuhiro
- Terranova Francesco
- Testera Gemma
- Thakore Tarak
- Thea Alessandro
- Thompson Adrian
- Thorn Craig
- Timm Steven C.
- Tishchenko Vladimir
- Todorović Nataša
- Tomassetti Luca
- Tonazzo Alessandra
- Torbunov Dmitri
- Torti Marta
- Tortola Mariam
- Tortorici Francesco
- Tosi Nicolo
- Totani Dante
- Toups Matthew
- Touramanis Christos
- Travaglini Riccardo
- Trevor Jason
- Trilov Stoyan
- Trzaska Wladyslaw
- Tsai Yu-Dai
- Tsai Yun-Tse
- Tsamalaidze Zviadi
- Tsang Ka Vang
- Tsverava Nikolozi
- Tu Shuang
- Tufanli Serhan
- Tull Craig
- Turner Jessica
- Tuzi Mirald
- Tyler Jennifer
- Tzanov Martin
- Uboldi Lorenzo
- Uchida Melissa
- Urheim Jon
- Usher Tracy
- Utaegbulam Hilary
- Uzunyan Sergey
- Vagins Mark
- Vahle Patricia
- Valder Sammy
- Valdiviesso Gustavo
- Valencia Edgar
- Valentim Rodolfo
- Vallari Zoya
- Vallazza Erik
- Valle Jose
- Vallecorsa Sofia
- van Berg Rick
- van de Water Richard
- Vanegas Forero David
- Vannerom David
- Varanini Filippo
- Vargas Oliva Danaisis
- Varner Gary
- Vasina Svetlana
- Vaughan Noah
- Vaziri Kamran
- Vega Juan
- Ventura Sandro
- Verdugo Antonio
- Vergani Stefano
- Vermeulen Milo
- Verzocchi Marco
- Vicenzi Matteo
- Vieira de Souza Henrique
- Vignoli Chiara
- Vilela Cristovao
- Viren Brett
- Vizcaya-Hernandez Ana
- Vrba Tomas
- Vuong Quynh
- Wachala Tomasz
- Waldron Abigail
- Wallbank Michael
- Walton Tammy
- Wang Hanguo
- Wang Jingbo
- Wang Li
- Wang Michael
- Wang Xiaoran
- Wang Yi
- Wang Yue
- Warburton Karl
- Warner David
- Wascko Morgan
- Waters David
- Watson Alan
- Wawrowska Klaudia
- Weatherly Pierce
- Weber Alfons
- Weber Michele
- Wei Hanyu
- Weinstein Amanda
- Wenman Dan
- Wetstein Matthew
- Whilhelmi James
- White Andy
- White Angela
- Whitehead Leigh
- Whittington Denver
- Wilking Michael
- Wilkinson Alexander
- Wilkinson Callum
- Williams Zachary
- Wilson Fergus
- Wilson Robert
- Wisniewski William
- Wolcott Jeremy
- Wolfs Jean
- Wongjirad Taritree
- Wood Anthony
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Wospakrik Marianette
- Wresilo Karolina
- Wret Clarence
- Wu Shaowei
- Wu Wanwei
- Wu Wenjie
- Wurm Michael
- Wyenberg Jason
- Xiao Yiwen
- Xiotidis Ioannis
- Yaeggy Barbara
- Yahlali Nadia
- Yandel Erin
- Yang Guang
- Yang Kang
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Yoon Young Soo
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Hongzhao
- Yu Jae
- Yu Yiding
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhang Yuze
- Zhao Manhong
- Zhivun Elena
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- HAL CCSD
- Publication date
- 19/12/2022
- Field of study
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 103 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype
The DUNE Far Detector Vertical Drift Technology, Technical Design Report
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Adriano Cris
- Aduszkiewicz Antoni
- Aguilar Jessica
- Aimard Benjamin
- Akbar Faiza
- Aldana Diego Andrade
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alton Andrew
- Alvarez Rodrigo
- Amar Hamza
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arrieta Diaz Enrique
- Arroyave Manuel
- Asaadi Jonathan
- Ashkenazi Adi
- Asquith Lily
- Atkin Edward
- Auguste Didier
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Azfar Farrukh
- Back Ashley
- Back Henning
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- Bagby Linda
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- Turner Jessica
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- Tyley E
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- Waldron Abigail
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- Weber Michele
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- White Andy
- White Angela
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- Wilking Michael
- Wilkinson Alexander
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- Wilson Fergus
- Wilson Robert
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- Wisniewski William
- Wolcott Jeremy
- Wolfs Jean
- Wongjirad Taritree
- Wood Anthony
- Wood Kevin
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- Worcester Matthew
- Wospakrik Marianette
- Wresilo Karolina
- Wret Clarence
- Wu Shaowei
- Wu Wanwei
- Wu Wenjie
- Wurm Michael
- Wyenberg Jason
- Xiao Yiwen
- Xiotidis Ioannis
- Yaeggy Barbara
- Yahlali Nadia
- Yandel Erin
- Yang Kang
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Jae
- Yu Yiding
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zapata Noreña Oscar
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhao Manhong
- Zhivun Elena
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- HAL CCSD
- Publication date
- 09/01/2024
- Field of study
International audienceDUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals
The DUNE Far Detector Vertical Drift Technology, Technical Design Report
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Adriano Cris
- Aduszkiewicz Antoni
- Aguilar Jessica
- Aimard Benjamin
- Akbar Faiza
- Aldana Diego Andrade
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alton Andrew
- Alvarez Rodrigo
- Amar Hamza
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arrieta Diaz Enrique
- Arroyave Manuel
- Asaadi Jonathan
- Ashkenazi Adi
- Asquith Lily
- Atkin Edward
- Auguste Didier
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Bagaturia Iuri
- Bagby Linda
- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baldini Wander
- Baller Bruce
- Bambah Bindu
- Banerjee Rituparna
- Barao Fernando
- Barenboim Gabriela
- Barham Alzás Pablo
- Barker Gary
- Barkhouse Wayne
- Barr Giles
- Barros Adilson
- Barros Nuno
- Barrow Daniel
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Bathe-Peters Lars
- Battat James
- Battisti Federico
- Bay Fatih
- Bazetto Maria
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior Ewerton
- Bell Gerard
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Axel Campos
- Benjamin Douglas
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bermeo Laura Vanessa Gomez
- Bernardini Paolo
- Bersani Andrea
- Bertolucci Sergio
- Betancourt Minerba
- Bevan Adrian
- Bezawada Yashwanth
- Bezerra Anibal
- Bezerra Thiago
- Bhat Avinay
- Bhatnagar Vipin
- Bhatt Jayesh
- Bhattacharjee Maharnab
- Bhattacharya Meghna
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor
- Blazey Gerald
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bonilla-Diaz Cesar
- Bonini Filiberto
- Booth Alexander
- Boran Fatma
- Bordoni Stefania
- Borkum Aran
- Bostan Nilay
- Bracinik Juraj
- Braga Davide
- Brahma Barnali
- Brailsford Dominic
- Bramati Filippo
- Branca Antonio
- Brandt Andrew
- Bravo Alberto Sánchez
- Bremer Johan
- Brew Christopher
- Brice Stephen
- Brio Vanessa
- Brizzolari Claudia
- Bromberg Carl
- Brooke Jim
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- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Bueno Laura Molina
- Buergi Jonas
- Burgardt Dustin
- Butchart Sophie
- Caceres Vera Gian
- Cagnoli Irene
- Cai Tejin
- Calabrese Roberto
- Calcutt Jacob
- Calin Marius
- Calivers Livio
- Calvo Enrique
- Caminata Alessio
- Campanelli Wallison
- Canci Nicola
- Capó Jordi
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- Caratelli David
- Carber Daniel
- Carceller Juan
- Carini Gabriella
- Carlus Bruno
- Carneiro Mateus
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Carrara Nicholas
- Carroll Lauren
- Carroll Thomas
- Carter Alex
- Casazza Denise
- Castaño Forero Javier
- Castaño F.A
- Castillo Andrés
- Castromonte Cesar
- Catano-Mur Erika
- Cattadori Carla
- Cavalier Fabien
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Chakraborty Kaustav
- Chalifour Michel
- Chappell Andrew
- Charitonidis Nikolas
- Chatterjee Animesh
- Chauhan Sushil Singh
- Chen Hucheng
- Chen Mu-Chun
- Chen Wen Chao
- Chen Yifan
- Chen-Wishart Zachary
- Cherdack Daniel
- Chi Cheng-Yi
- Chirco Robert
- Chitirasreemadam Namitha
- Cho Kihyeon
- Choate Sarah
- Chokheli David
- Chong Pooi
- Chowdhury Barnali
- Christian David
- Chukanov Artem
- Chung Moses
- Church Eric
- Cicala Maria Flavia
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- Cicero Valentina
- Ciolini Riccardo
- Clair Judicael
- Clarke Peter
- Cline Gordon
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- Cohen Ariel
- Collot Johann
- Conley Erin
- Conrad Janet M
- Convery Mark
- Cooke Peter
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- Cremonesi Linda
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- Crisler Michael
- Cristaldo Esteban
- Crnkovic Jason
- Crone Gordon
- Cross Ryan
- Cudd Andrew
- Cuesta Clara
- Cui Yanou
- Cussans David
- da Motta H
- Dai Joel
- Dalager Olivia
- Dallavalle Ricardo
- Dar Zubair
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- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Aguiar Renan
- de Almeida Patricia
- de Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- de Jong Paul
- de la Torre Andres
- de Lurgio Patrick
- de Mello Neto Joao
- de Oliveira M.A. Leigui
- de Rego Ignacio López
- de Roeck Albert
- de Romeri Valentina
- de Souza Henrique Vieira
- Debbins Paul
- Decowski M.Patrick
- Delbart Alain
- Delepine David
- Delgado Manuel Alejandro Ramirez
- Delgado Maritza
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- Demuth David
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- Di Capua Francesco
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- Ding Pengfei
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- Duarte Laura Cristina
- Duchesneau Dominique
- Duffy Kirsty
- Dugas Katherine
- Dunne Patrick
- Dutta Bhaskar
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A
- Dyshkant Alexandre S
- Dytman Steven
- Díaz Felix
- Eads Michael
- Earle Antony
- Edayath Sijith
- Edmunds Daniel
- Eisch Jonathan
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- Ereditato Antonio
- Erjavec Tyler
- Escobar Carlos O
- Evans Justin
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- Furman Krzysztof
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- Gabrielli Alessandro
- Gago A.M
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- Gallagher Hugh
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- Gauzzi Paolo
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- Gilligan Sean
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- Happacher Fabio
- Harris Deborah
- Hartnell Jeffrey
- Hartnett Trevor
- Harton John
- Hasegawa Takyua
- Hasnip Ciaran
- Hatcher Robert
- Hayrapetyan Karen
- Hays Jonathan
- Hazen Eric
- He Muyuan
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Henry Sarah
- Hernandez Morquecho Miguel Angel
- Herner Kenneth
- Hewes V
- Higuera Pichardo Aaron
- Hilgenberg Christopher
- Hillier Stephen
- Himmel Alexander
- Hinkle Elise
- Hirsch Luciana
- Ho Jason
- Hoff James
- Holin Anna
- Holvey Thomas
- Hoppe Eric
- Horton-Smith Glenn
- Hostert Matheus
- Houdy Thibaut
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- Huang Roger
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- Ibrahim Mahmoud
- Iles Gregory
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- Li Shirley W
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- Macier Jolie R
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- Mendez Patricia
- Menegolli A
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- Mishra C.Shekhar
- Mishra Sanjib R
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- Warsame Liban
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- Weber Michele
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- Westerdale Shawn
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- Whilhelmi James
- White Andy
- White Angela
- Whitehead Leigh
- Whittington Denver
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- Wilkinson Alexander
- Wilkinson Callum
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- Wisniewski William
- Wolcott Jeremy
- Wolfs Jean
- Wongjirad Taritree
- Wood Anthony
- Wood Kevin
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- Worcester Matthew
- Wospakrik Marianette
- Wresilo Karolina
- Wret Clarence
- Wu Shaowei
- Wu Wanwei
- Wu Wenjie
- Wurm Michael
- Wyenberg Jason
- Xiao Yiwen
- Xiotidis Ioannis
- Yaeggy Barbara
- Yahlali Nadia
- Yandel Erin
- Yang Kang
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Jae
- Yu Yiding
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zapata Noreña Oscar
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhao Manhong
- Zhivun Elena
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- HAL CCSD
- Publication date
- 09/01/2024
- Field of study
International audienceDUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals
Highly-parallelized simulation of a pixelated LArTPC on a GPU
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Adriano Cris
- Aduszkiewicz Antoni
- Aguilar Jessica
- Ahmad Zubayer
- Ahmed Jhanzeb
- Aimard Benjamin
- Akbar Faiza
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alt Christoph
- Alton Andrew
- Alvarez Rodrigo
- Amedo Pablo
- Anderson John
- Andrade Aldana Diego
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P.
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Anicézio Campanelli Wallison Luiz
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Antusch Stefan
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arnold Lukas
- Arroyave Manuel
- Asaadi Jonathan
- Ashkenazi Adi
- Asquith Lily
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Ayala-Torres Marco Alberto
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Bagaturia Iuri
- Bagby Linda
- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baldini Wander
- Baller Bruce
- Bambah Bindu
- Barao Fernando
- Barenboim Gabriela
- Barham Alzás Pablo
- Barker Gary
- Barkhouse Wayne
- Barnes Christopher
- Barr Giles
- Barranco Monarca Juan
- Barros Adilson
- Barros Nuno
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Battat J.B.R.
- Battisti Federico
- Bay Fatih
- Bazetto M.C.Q.
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior Ewerton
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Montiel Carlos
- Benjamin Douglas
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bernardini Paolo
- Berner Roman
- Bersani Andrea
- Bertolucci Sergio
- Betancourt Minerba
- Betancur Rodríguez Amalia
- Bevan Adrian
- Bezawada Yashwanth
- Bezerra Anibal
- Bezerra Thiago
- Bhambure Jay
- Bhardwaj Akhil
- Bhatnagar Vipin
- Bhattacharjee Maharnab
- Bhattacharya Meghna
- Bhattarai Devesh
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biassoni Matteo
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bisignani Valeria
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor
- Blazey Gerald
- Blend Dylan
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bonilla-Diaz Cesar
- Bonini Filiberto
- Booth Alexander
- Boran Fatma
- Bordoni Stefania
- Borkum Aran
- Bostan Nilay
- Bour Petr
- Boyden Daniel
- Bracinik Juraj
- Braga Davide
- Brailsford Dominic
- Branca Antonio
- Brandt Andrew
- Bravo-Moreno Marina
- Bremer Johan
- Brew Christopher
- Brice Stephen
- Brizzolari Claudia
- Bromberg Carl
- Brooke Jim
- Bross Alan
- Brunetti Giulia
- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Buergi Jonas
- Caceres Vera Gian
- Cagnoli Irene
- Cai Tejin
- Caiulo Davide
- Calabrese Roberto
- Calafiura Paolo
- Calcutt Jacob
- Calin Marius
- Calivers Livio
- Calvez Steven
- Calvo Enrique
- Caminata Alessio
- Caratelli David
- Carber Daniel
- Carceller Juan
- Carini Gabriella
- Carlus Bruno
- Carneiro Mateus
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Carrara Nicholas
- Carroll Lauren
- Carroll Thomas
- Carter Alex
- Castaño Forero Javier
- Castillo Andrés
- Catano-Mur Erika
- Cattadori Carla
- Cavalier Fabien
- Cavallaro Giuseppe
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Cervera Villanueva Anselmo
- Chakraborty Kaustav
- Chalifour Michel
- Chappell Andrew
- Chardonnet Etienne
- Charitonidis Nikolas
- Chatterjee Animesh
- Chattopadhyay Subhasish
- Chen Hucheng
- Chen Mu-Chun
- Chen Yifan
- Chen Zheyang
- Chen-Wishart Zachary
- Cheon Yoolim
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Chirco Robert
- Chiriacescu Ana
- Chitirasreemadam Namitha
- Cho Kihyeon
- Choate Sarah
- Chokheli David
- Chong Pooi
- Chowdhury Barnali
- Christensen Anne
- Christian David
- Christodoulou Georgios
- Chukanov Artem
- Chung Moses
- Church Eric
- Cicero Valentina
- Clapa Daniel
- Clarke Peter
- Cline Gordon
- Coan Thomas
- Cocco Alfredo
- Coelho J.A.B.
- Cohen Ariel
- Collot Johann
- Conley Erin
- Conrad Janet M.
- Convery Mark
- Copello Simone
- Cova Paolo
- Cox Callum
- Cremaldi Lucien
- Cremonesi Linda
- Crespo-Anadón José
- Crisler Michael
- Cristaldo Esteban
- Crnkovic Jason
- Crone Gordon
- Cross Ryan
- Cudd Andrew
- Cuesta Clara
- Cui Yanou
- Cussans David
- da Motta Helio
- da Silva Peres Leonardo
- Dai Joel
- Dalager Olivia
- Dallavalle Ricardo
- Dar Zubair
- Darby Robert
- David Claire
- David Quentin
- Davies Gavin
- Davini Stefano
- Dawson Jaime
- de Aguiar Renan
- De Almeida Patricia
- De Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
- De Jong Paul
- De la Torre Andres
- De Leo Veronica
- De Lurgio Patrick
- de Mello Neto J.R.T.
- De Roeck Albert
- De Romeri Valentina
- de Souza Greg
- De Kaushik
- De Shruti
- Debbins Paul
- Decowski M. Patrick
- Deisting Alexander
- Delbart Alain
- Delepine David
- Delgado Maritza
- Dell'Acqua Andrea
- Delmonte Nicola
- DeMuth David
- Dennis Steve
- Densham Chris
- Denton Peter
- Deptuch Grzegorz
- Detje J.P.
- Devi Ritu
- Dharmapalan Ranjan
- Di Capua Francesco
- Di Domenico Antonio
- Di Domizio Sergio
- Di Falco Stefano
- Di Giulio Letizia
- Di Noto Lea
- Dias Marco
- Diaz Jorge S.
- Ding Pengfei
- Diociaiuti Eleonora
- Distefano Carla
- Diurba Richard
- Diwan Milind
- Djurcic Zelimir
- Doering Dionisio
- Dolan Stephen
- Dolek Furkan
- Dolinski Michelle J.
- Domenici Danilo
- Domine Laura
- Donati Simone
- Donon Yann
- Doran Steven
- Douglas Daniel
- Dragone Angelo
- Drielsma Francois
- Duarte Laura Cristina
- Duchesneau Dominique
- Duffy Kirsty
- Dugas Katherine
- Dunne Patrick
- Dutta Bhaskar
- Duyang Hongyue
- Dvornikov Olexiy
- Dwyer Daniel A.
- Dyshkant Alexandre S.
- Díaz Felix
- Eads Michael
- Earle Antony
- Edmunds Daniel
- Eisch Jonathan
- Emberger Lorenz
- Englezos Panagiotis
- Ereditato Antonio
- Erjavec Tyler
- Escobar Carlos O.
- Evans Justin
- Ewart Erin
- Ezeribe Anthony
- Fahey Kevin
- Fajt Lukas
- Falcone Andrea
- Fani' Mattia
- Farnese Christian
- Farzan Yasaman
- Fedoseev Dmitry
- Felix Julian
- Feng Yue
- Fernandez-Martinez Enrique
- Ferraro Federico
- Fields Laura
- Filip Peter
- Filkins Amy
- Filthaut Frank
- Fine Robert
- Fiorillo Giuliana
- Fiorini Massimiliano
- Fischer Vincent
- Fitzpatrick Rory
- Flanagan Will
- Fleming Bonnie
- Flight Robert
- Fogarty Sam
- Foreman Will
- Fowler Jack
- Franc Jiri
- Franco Domenico
- Freeman John
- Fried Jack
- Friedland Alex
- Fuess Stu
- Furic Ivan
- Furman Krzysztof
- Furmanski Andrew
- Gabrielli Alessandro
- Gago A.M.
- Gallagher Hugh
- Gallas Alexandre
- Gallego-Ros Ana
- Gallice Niccolo
- Galymov Vyacheslav
- Gamberini Enrico
- Gamble Trevor
- Ganacim Francisco
- Gandhi Raj
- Ganguly Sudeshna
- Gao Fan
- Gao Shanshan
- Garcia-Gamez Diego
- García-Peris Miguel
- Gardiner Steven
- Gastler Dan
- Gauch Anja
- Gauvreau Jean-Luc
- Gauzzi Paolo
- Ge Guanqun
- Geffroy Nicolas
- Gelli Bruno
- Gendotti Adamo
- Gent Stephen
- Gerlach Lino
- Ghorbani-Moghaddam Zahra
- Giammaria Paola
- Giammaria Tommaso
- Giangiacomi Nico
- Gibin Daniele
- Gil-Botella Ines
- Gilligan Sean
- Gioiosa Antonio
- Giovannella Simona
- Girerd Claude
- Giri Anjan Kumar
- Gnani Dario
- Gogota Olga
- Gold Michael
- Gollapinni Sowjanya
- Gollwitzer Keith
- Gomes Ricardo
- Gomez Bermeo Laura Vanessa
- Gomez Fajardo L.S.
- Gonnella Francesco
- Gonzalez-Diaz Diego
- Gonzalez-Lopez Manuel
- Goodman Maury
- Goodwin Owen
- Goswami Srubabati
- Gotti Claudio
- Goudeau Jacob
- Goudzovski Evgueni
- Grace Carl
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- Granger Pierre
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- Gratieri Diego
- Green Patrick
- Greenberg Stephen
- Greenler Leland
- Greer Joel
- Grenard Jean-Louis
- Griffith Clark
- Groetschla Florian
- Groh Micah
- Grzelak Katarzyna
- Gu Wenqiang
- Guarino Victor
- Guarise Marco
- Guenette Roxanne
- Guerard Eric
- Guerzoni Marco
- Guffanti Daniele
- Guglielmi Alberto
- Guo Bing
- Gupta Aseem
- Gupta Vikas
- Guthikonda K.K.
- Guzowski Pawel
- Guzzo Marcelo
- Gwon Sunwoo
- Ha Chang Hyon
- Haaf Kevin
- Habig Alec
- Hadavand Haleh
- Hadef Asma
- Haenni Roger
- Hagaman Lee
- Hahn Alan
- Haiston James
- Hamacher-Baumann Philip
- Hamernik Thomas
- Hamilton Philip
- Han Jiyeon
- Hancock Jonathan
- Happacher Fabio
- Harris Deborah
- Hartnell Jeffrey
- Hartnett Trevor
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- Weber Michele
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- White Angela
- Whitehead Leigh
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- Wilking Michael
- Wilkinson Alexander
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- Wood Kevin
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- Worcester Matthew
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- Wresilo Karolina
- Wret Clarence
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- Wu Wanwei
- Wu Wenjie
- Wurm Michael
- Wyenberg Jason
- Xiao Yiwen
- Xiotidis Ioannis
- Yaeggy Barbara
- Yahlali Nadia
- Yandel Erin
- Yang Guang
- Yang Kang
- Yang Tingjun
- Yankelevich Alejandro
- Yershov Nikolai
- Yonehara Katsuya
- Yoon Young Soo
- Young Tim
- Yu Bo
- Yu Haiwang
- Yu Hongzhao
- Yu Jae
- Yu Yiding
- Yuan Wenlong
- Zaki Rowan
- Zalesak Jaroslav
- Zambelli Laura
- Zamorano Bruno
- Zani Andrea
- Zazueta Luis
- Zeller Geralyn
- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhang Yuze
- Zhao Manhong
- Zhivun Elena
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- HAL CCSD
- Publication date
- 19/12/2022
- Field of study
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 103 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype
The DUNE Far Detector Vertical Drift Technology, Technical Design Report
- Author
- Abed Abud Adam
- Abi Babak
- Acciarri Roberto
- Acero Mario
- Adames Marcio
- Adamov George
- Adamowski Mark
- Adams David
- Adinolfi Marco
- Adriano Cris
- Aduszkiewicz Antoni
- Aguilar Jessica
- Aimard Benjamin
- Akbar Faiza
- Aldana Diego Andrade
- Allison Kyle
- Alonso Monsalve Saul
- Alrashed Munera
- Alton Andrew
- Alvarez Rodrigo
- Amar Hamza
- Amedo Pablo
- Anderson John
- Andreopoulos Costas
- Andreotti Mirco
- Andrews Michael P.
- Andrianala Fenompanirina
- Andringa Sofia
- Anfimov Nikolay
- Ankowski Artur
- Antoniassi Marcelo
- Antonova Maria
- Antoshkin Alexander
- Aranda-Fernandez Alfredo
- Arellano Luciano
- Arrieta Diaz Enrique
- Arroyave Manuel
- Asaadi Jonathan
- Ashkenazi Adi
- Asquith Lily
- Atkin Edward
- Auguste Didier
- Aurisano Adam
- Aushev Vladimir
- Autiero Dario
- Azfar Farrukh
- Back Ashley
- Back Henning
- Back John
- Bagaturia Iuri
- Bagby Linda
- Balashov Nikita
- Balasubramanian Supraja
- Baldi Pierre
- Baldini Wander
- Baller Bruce
- Bambah Bindu
- Banerjee Rituparna
- Barao Fernando
- Barenboim Gabriela
- Barham Alzás Pablo
- Barker Gary
- Barkhouse Wayne
- Barr Giles
- Barros Adilson
- Barros Nuno
- Barrow Daniel
- Barrow Joshua
- Basharina-Freshville Anastasia
- Bashyal Amit
- Basque Vincent
- Batchelor Charlie
- Bathe-Peters Lars
- Battat James
- Battisti Federico
- Bay Fatih
- Bazetto Maria
- Bazo Alba José Luis
- Beacom John
- Bechetoille Edouard
- Behera Biswaranjan
- Belchior Ewerton
- Bell Gerard
- Bellantoni Leo
- Bellettini Giorgio
- Bellini Vincenzo
- Beltramello Olga
- Benekos Nektarios
- Benitez Axel Campos
- Benjamin Douglas
- Bento Neves Francisco
- Berger Joshua
- Berkman Sophie
- Bermeo Laura Vanessa Gomez
- Bernardini Paolo
- Bersani Andrea
- Bertolucci Sergio
- Betancourt Minerba
- Bevan Adrian
- Bezawada Yashwanth
- Bezerra Anibal
- Bezerra Thiago
- Bhat Avinay
- Bhatnagar Vipin
- Bhatt Jayesh
- Bhattacharjee Maharnab
- Bhattacharya Meghna
- Bhuller Shyam
- Bhuyan Bipul
- Biagi Simone
- Bian Jianming
- Biery Kurt
- Bilki Burak
- Bishai Mary
- Bitadze Alexander
- Blake Andrew
- Blaszczyk Flor
- Blazey Gerald
- Blucher Edward
- Boissevain Jan
- Bolognesi Sara
- Bolton Timothy
- Bomben Luca
- Bonesini Maurizio
- Bonilla-Diaz Cesar
- Bonini Filiberto
- Booth Alexander
- Boran Fatma
- Bordoni Stefania
- Borkum Aran
- Bostan Nilay
- Bracinik Juraj
- Braga Davide
- Brahma Barnali
- Brailsford Dominic
- Bramati Filippo
- Branca Antonio
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- Bremer Johan
- Brew Christopher
- Brice Stephen
- Brio Vanessa
- Brizzolari Claudia
- Bromberg Carl
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- Brunetti Maria
- Buchanan Norman
- Budd Howard
- Bueno Laura Molina
- Buergi Jonas
- Burgardt Dustin
- Butchart Sophie
- Caceres Vera Gian
- Cagnoli Irene
- Cai Tejin
- Calabrese Roberto
- Calcutt Jacob
- Calin Marius
- Calivers Livio
- Calvo Enrique
- Caminata Alessio
- Campanelli Wallison
- Canci Nicola
- Capó Jordi
- Caracas Ioana
- Caratelli David
- Carber Daniel
- Carceller Juan
- Carini Gabriella
- Carlus Bruno
- Carneiro Mateus
- Carniti Paolo
- Caro Terrazas Ivan
- Carranza Hector
- Carrara Nicholas
- Carroll Lauren
- Carroll Thomas
- Carter Alex
- Casazza Denise
- Castaño Forero Javier
- Castaño F.A.
- Castillo Andrés
- Castromonte Cesar
- Catano-Mur Erika
- Cattadori Carla
- Cavalier Fabien
- Cavanna Flavio
- Centro Sandro
- Cerati Giuseppe
- Cervelli Alberto
- Chakraborty Kaustav
- Chalifour Michel
- Chappell Andrew
- Charitonidis Nikolas
- Chatterjee Animesh
- Chauhan Sushil Singh
- Chen Hucheng
- Chen Mu-Chun
- Chen Wen Chao
- Chen Yifan
- Chen-Wishart Zachary
- Cherdack Daniel
- Chi Cheng-Yi
- Chirco Robert
- Chitirasreemadam Namitha
- Cho Kihyeon
- Choate Sarah
- Chokheli David
- Chong Pooi
- Chowdhury Barnali
- Christian David
- Chukanov Artem
- Chung Moses
- Church Eric
- Cicala Maria Flavia
- Cicerchia Magda
- Cicero Valentina
- Ciolini Riccardo
- Clair Judicael
- Clarke Peter
- Cline Gordon
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Cohen Ariel
- Collot Johann
- Conley Erin
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- Convery Mark
- Cooke Peter
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- da Motta H.
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- Dalager Olivia
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- de Aguiar Renan
- De Almeida Patricia
- De Bonis Isabelle
- de Gouvea Andre
- de Holanda Pedro
- de Icaza Astiz Iker
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- De Lurgio Patrick
- de Mello Neto Joao
- de Oliveira M.A. Leigui
- de Rego Ignacio López
- De Roeck Albert
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- de Souza Henrique Vieira
- Debbins Paul
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- Delbart Alain
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- Delgado Manuel Alejandro Ramirez
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- Ding Pengfei
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- Dwyer Daniel A.
- Dyshkant Alexandre S.
- Dytman Steven
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- Escobar Carlos O.
- Evans Justin
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- Fahey Kevin
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- Qian Xin
- Raaf Jennifer L.
- Radeka Veljko
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- Rappoldi A.
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- Ratoff Peter
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- Sensenig Jon
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- Steiner Herbert M.
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- Tapia Casanova Alex
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- Thompson Adrian
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- Timm Steven C.
- Tiras Emrah
- Tishchenko Vladimir
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- Turner Jessica
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- Tyler Jennifer
- Tyley E.
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- Uchida Melissa
- Urheim Jon
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- Verge Lluis Miralles
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- Vrba Tomas
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- Waldron Abigail
- Wallbank Michael
- Walsh Joseph
- Walton Tammy
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- Warsame Liban
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- Zennamo Joseph
- Zeug Kyle
- Zhang Chao
- Zhang Shuaixiang
- Zhao Manhong
- Zhivun Elena
- Zimmerman Eric
- Zucchelli Stefano
- Zuklin Josef
- Zutshi Vishnu
- Zwaska Robert
- Publication venue
- Publication date
- 05/12/2023
- Field of study
DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals