332 research outputs found
Effect of Cognitive Behavioral Therapy on Clinical Disease Course in Adolescents and Young Adults With Inflammatory Bowel Disease and Subclinical Anxiety and/or Depression:Results of a Randomized Trial
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach
Die Tosefta. Text. Seder I: Zeraim. In Zusammenarbeit mit Peter FREIMARK, Wolfgang E. GERBER, Wolfgang Friedrich KRÄMER, Gerhard LISOWSKY, Eduard LOHSE, Günter MAYER und Günther SCHLICHTING herausgegeben von Karl Heinrich RENGSTORF (Rabbinische Texte. Erste Reihe), Verlag W. Kohlhammer, Stuttgart-Berlin-Köln-Mainz 1983, XXIII und 341 S. (Text und Apparat), geb. DM 348,-
Igor R. TANTLEVSKIJ, The Two Wicked Priests in the Qumran Commentary on Habakkuk (The Qumran Cronicle. Appendix C), The Enigma Press [ul. Borsucza 3/58, 30-408 Kraków, Poland], Kraków-St. Petersburg 1995, 39 pp., paper $ 10,__. ISBN 83 86110 14 7
Doron MENDELS, The Land of Israel as a Political Concept in Hasmonean Literature (Texte und Studien zum Antiken Judentum 15), J.C.B. Mohr (Paul Siebeck), Tübingen 1987, x und 181 S., geb. DM 78
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