350 research outputs found
Consumer attitudes and preference exploration towards fresh-cut salads using bestâworst scaling and latent class analysis
This research explored the preferences and buying habits of a sample of 620 consumers of fresh-cut, ready-to-eat salads. A bestâworst scaling approach was used to measure the level of preference stated by individuals regarding 12 attributes for quality (intrinsic, extrinsic and credence) of fresh-cut salads. The experiment was carried out through direct interviews at several large-scale retail outlets in the Turin metropolitan area (north-west of Italy). Out of the total number of questioned consumers, 35% said they did not consume fresh-cut salads. On the contrary, the rest of the involved sample expressed the highest degree of preference towards the freshness/appearance attribute, followed by the expiration date and the brand. On the contrary, attributes such as price, organic certification and food safety did not emerge as discriminating factors in consumer choices. Additionally, five clusters of consumers were identified, whose preferences are related both to purchasing styles and socio-demographic variables. In conclusion, this research has highlighted the positive attitude of consumers towards quality products backed by a brand, providing ideas for companies to improve within this sector and implement strategies to answer the needs of a new segment of consumers, by determining market opportunities that aim to strengthen local brands
A Study on Perceptions towards Organic and Local Production, and Individualsâ Socio-Demographic and Geographical Affiliation Influencing Fruit and Vegetable Purchasing Preferences of EU Households
E-commerce e competitività del vino italiano in Cina: focus sui punti di forza del vino piemontese nel mercato internazionale.
Observations of radio pulses from CU Virginis
The magnetic chemically peculiar star CU Virginis is a unique astrophysical
laboratory for stellar magnetospheres and coherent emission processes. It is
the only known main sequence star to emit a radio pulse every rotation period.
Here we report on new observations of the CU Virginis pulse profile in the 13
and 20\,cm radio bands. The profile is known to be characterised by two peaks
of 100 circularly polarised emission that are thought to arise in an
electron-cyclotron maser mechanism. We find that the trailing peak is stable at
both 13 and 20\,cm, whereas the leading peak is intermittent at 13\,cm. Our
measured pulse arrival times confirm the discrepancy previously reported
between the putative stellar rotation rates measured with optical data and with
radio observations. We suggest that this period discrepancy might be caused by
an unknown companion or by instabilities in the emission region. Regular
long-term pulse timing and simultaneous multi-wavelength observations are
essential to clarify the behaviour of this emerging class of transient radio
source.Comment: Accepted by MNRAS Letters; 5 pages, 2 figures, 3 table
The CORALIE survey for southern extra-solar planets IX. A 1.3-day period brown dwarf disguised as a planet
In this article we present the case of HD 41004 AB, a system composed of a
K0V star and a 3.7-magnitude fainter M-dwarf companion separated by only 0.5
arcsec. An analysis of CORALIE radial-velocity measurements has revealed a
variation with an amplitude of about 50m/s and a periodicity of 1.3days. This
radial-velocity signal is consistent with the expected variation induced by the
presence a very low mass giant planetary companion to HD 41004 A, whose light
dominates the spectra. The radial-velocity measurements were then complemented
with a photometric campaign and with the analysis of the bisector of the
CORALIE Cross-Correlation Function (CCF). While the former revealed no
significant variations within the observational precision of 0.003-0.004 mag
(except for an observed flare event), the bisector analysis showed that the
line profiles are varying in phase with the radial-velocity. This latter
result, complemented with a series of simulations, has shown that we can
explain the observations by considering that HD 41004 B has a brown-dwarf
companion orbiting with the observed 1.3-day period. If confirmed, this
detection represents the first discovery of a brown dwarf in a very short
period (1.3-day) orbit around an M dwarf. Finally, this case should be taken as
a serious warning about the importance of analyzing the bisector when looking
for planets using radial-velocity techniques.Comment: 16 pages, 17 eps figures, A&A in press (Figure 11 not as in original
version due to size
Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G
Background:
The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse proteins of the MIC and ULBP/RAET families that are upregulated on the surface of virally infected cells and tumours. Two splicing variants of ULBP5/RAET1G have been cloned previously, but not extensively characterised.
Methodology/Principal Findings:
We pursue a number of approaches to characterise the expression, trafficking, and function of the two isoforms of ULBP5/RAET1G. We show that both transcripts are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. The full-length transcript, RAET1G1, is predicted to encode a molecule with transmembrane and cytoplasmic domains that are unique amongst NKG2D ligands. Using specific anti-RAET1G1 antiserum to stain tissue microarrays we show that RAET1G1 expression is highly restricted in normal tissues. RAET1G1 was expressed at a low level in normal gastrointestinal epithelial cells in a similar pattern to MICA. Both RAET1G1 and MICA showed increased expression in the gut of patients with celiac disease. In contrast to healthy tissues the RAET1G1 antiserum stained a wide variety or different primary tumour sections. Both endogenously expressed and transfected RAET1G1 was mainly found inside the cell, with a minority of the protein reaching the cell surface. Conversely the truncated splicing variant of RAET1G2 was shown to encode a soluble molecule that could be secreted from cells. Secreted RAET1G2 was shown to downregulate NKG2D receptor expression on NK cells and hence may represent a novel tumour immune evasion strategy.
Conclusions/Significance:
We demonstrate that the expression patterns of ULBP5RAET1G are very similar to the well-characterised NKG2D ligand, MICA. However the two isoforms of ULBP5/RAET1G have very different cellular localisations that are likely to reflect unique functionality
Validation of thoracic aortic dimensions on ECG-triggered SSFP as alternative to contrast-enhanced MRA
Objectives: Assessment of thoracic aortic dimensions with non-ECG-triggered contrast-enhanced magnetic resonance angiography (CE-MRA) is accompanied with motion artefacts and requires gadolinium. To avoid both motion artefacts and gadolinium administration, we evaluated the similarity and reproducibility of dimensions measured on ECG-triggered, balanced steady-state free precession (SSFP) MRA as alternative to CE-MRA. Methods: All patients, with varying medical conditions, referred for thoracic aortic examination between September 2016 and March 2018, who underwent non-ECG-triggered CE-MRA and SSFP-MRA (1.5 T) were retrospectively included (n = 30). Aortic dimensions were measured after double-oblique multiplanar reconstruction by two observers at nine landmarks predefined by literature guidelines. Image quality was scored at the sinus of Valsalva, mid-ascending aorta and mid-descending aorta by semi-automatically assessing the vessel sharpness. Results: Aortic dimensions showed high agreement between non-ECG-triggered CE-MRA and SSFP-MRA (r = 0.99, p < 0.05) without overestimation or underestimation of aortic dimensions in SSFP-MRA (mean difference, 0.1 mm; limits of agreement, â 1.9 mm and 1.9 mm). Intra- and inter-observer variabilities were significantly smaller with SSFP-MRA for the sinus of Valsalva and sinotubular junction. Image quality of the sinus of Valsalva was significantly better with SSFP-MRA, as fewer images were of impaired quality (3/30) than in CE-MRA (21/30). Reproducibility of dimensions was significantly better in images scored as good quality compared to impaired quality in both sequences. Conclusions: Thoracic aortic dimensions measured on SSFP-MRA and non-ECG-triggered CE-MRA were similar. As expected, SSFP-MRA showed better reproducibility close to the aortic root because of lesser motion artefacts, making it a feasible non-contrast imaging alternative. Key Points: âą SSFP-MRA provides similar dimensions as non-ECG-triggered CE-MRA. âą Intra- and inter-observer reproducibilities improve for the sinus of Valsalva and sinotubular junction with SSFP-MRA. âą ECG-triggered SSFP-MRA shows better image quality for landmarks close to the aortic root in the absence of cardiac motion
Spinal cord hypermetabolism extends to skeletal muscle in amyotrophic lateral sclerosis: a computational approach to [18F]-fluorodeoxyglucose PET/CT images
Purpose: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to neuromuscular palsy and death. We propose a computational approach to [18F]-fluorodeoxyglucose (FDG) PET/CT images to analyze the structure and metabolic pattern of skeletal muscle in ALS and its relationship with disease aggressiveness. Materials and methods: A computational 3D method was used to extract whole psoas muscle\u2019s volumes and average attenuation coefficient (AAC) from CT images obtained by FDG PET/CT performed in 62 ALS patients and healthy controls. Psoas average standardized uptake value (normalized on the liver, N-SUV) and its distribution heterogeneity (defined as N-SUV variation coefficient, VC-SUV) were also extracted. Spinal cord and brain motor cortex FDG uptake were also estimated. Results: As previously described, FDG uptake was significantly higher in the spinal cord and lower in the brain motor cortex, in ALS compared to controls. While psoas AAC was similar in patients and controls, in ALS a significant reduction in psoas volume (3.6 \ub1 1.02 vs 4.12 \ub1 1.33 mL/kg; p < 0.01) and increase in psoas N-SUV (0.45 \ub1 0.19 vs 0.29 \ub1 0.09; p < 0.001) were observed. Higher heterogeneity of psoas FDG uptake was also documented in ALS (VC-SUV 8 \ub1 4%, vs 5 \ub1 2%, respectively, p < 0.001) and significantly predicted overall survival at Kaplan\u2013Meier analysis. VC-SUV prognostic power was confirmed by univariate analysis, while the multivariate Cox regression model identified the spinal cord metabolic activation as the only independent prognostic biomarker. Conclusion: The present data suggest the existence of a common mechanism contributing to disease progression through the metabolic impairment of both second motor neuron and its effector
- âŠ