Nonlinear Optical Corneal Crosslinking, Mechanical Stiffening, and Corneal Flattening Using Amplified Femtosecond Pulses.

Purpose:We have shown that nonlinear optical corneal crosslinking (NLO CXL) and stiffening can be achieved in ex vivo rabbit corneas using an 80-MHz, 760-nm femtosecond (FS) laser, however the required power was beyond the American National Standard Institute limit. The purpose of this study was to test the efficacy of amplified FS pulses to perform CXL to reduce power by increasing pulse energy. Methods:A variable numerical aperture laser scanning delivery system was coupled to a 1030-nm laser with a noncollinear optical parametric amplifier to generate 760 nm, 50 to 150 kHz amplified FS pulses with 79.5-μm axial and 2.9-μm lateral two-photon focal volume. Ex vivo rabbit corneas received NLO CXL, and effectiveness was assessed by measuring collagen autofluorescence (CAF) and mechanical stiffening. NLO CXL was also performed in 14 live rabbits, and changes in corneal topography were measured using an Orbscan. Results:Amplified pulses (0.3 μJ) generated significant CAF that increased logarithmically with decreasing scan speed; achieving equivalent CAF to UVA CXL at 15.5 mm/s. Indentation testing detected a 62% increase in stiffness compared to control, and corneal topography measurements revealed a significant decrease of 1.0 ± 0.8 diopter by 1 month (P < 0.05). Conclusions:These results show that NLO CXL using amplified pulses can produce corneal collagen CXL comparable to UVA CXL. Translational Relevance:NLO CXL using amplified pulses can produce corneal CXL comparable to UVA CXL, suggesting a potential clinical application in which NLO CXL can be used to perform personalized crosslinking for treatment of refractive errors and keratoconus

Library-Based Data Curation, Management and Interdisciplinary Research at Florida International University: Reciprocal Use of Data through Collaboration

This paper shows the Florida International University (FIU) Libraries\u27 efforts in research data management, implementation, and practice. The FIU Library-based data team has led research projects that are directly built upon institutional and other data repositories, data hubs, and data visualization tools, through collaboration with the user community. We will present the technology setup and configuration of such a data framework, which includes Dataverse, ESRI’s ArcGIS Data Hub, and other data collection and visualization tools. We will also discuss the fiscal and organizational structure needed to support research data management initiatives. Using a couple of our applied research projects, we will demonstrate how users interact, collaborate, and contribute. We will discuss the challenges we encounter when it comes to data sharing, data curation, management, and most importantly, serving users at all levels of data literacy. In addition, we will present from a researcher’s perspective how he/she can manage his/her publications and associated research data and make them discoverable. We will showcase the websites of interdisciplinary research projects, such as the FIU Jack D. Gordon Institute for Public Policy’s (JGI) Security Research Hub (see also: https://srh.fiu.edu/home/) and the USAID-funded Global Water for Sustainability Program (see also: http://dpanther.fiu.edu/glows/). These project websites use FIU institutional repository and research data management platforms (see also: http://rdm.fiu.edu/dataverse/). We will demonstrate how we support a community-based research project using FIU’s research data repository and data hub, as well as community-based data repositories such as ESRI’s Living Atlas of the World

Impact of some herbicides on the growth and the yield of common vetch (Vicia sativa L.)

Received: January 23rd, 2023 ; Accepted: April 2nd, 2023 ; Published: April 27th, 2023 ; Correspondence: [email protected] production and use of common vetch has great potential, but the lack of approved pesticides makes the success of cultivation difficult and unpredictable. The research was carried out on sandy soil at the Nyíregyháza Research Institute of the University of Debrecen in Hungary in April 2022. Five different herbicides, pendimethalin, metolachlor, flumioxazin, bentazon in doses 5 L ha-1 , 1.4 L ha-1 , 0.06 kg ha-1 , 2 L ha-1 , respectively, and imazamox in four different doses (0.6, 0.8, 1.0, 1.2 L ha-1 ) were applied with the consideration of the ranges specified in the Hungarian legislation. The results showed that the highest NDVI (Normalized Difference Vegetation Index) values were obtained with flumioxazin compared to the other treatments. The maximum harvested seed yield (194.1 kg ha-1 ) was obtained with the application of flumioxazin compared to the control treatment (132.5 kg ha-1 ). Flumioxazin was also the best as it had the fewest weeds per plot and the lowest phytotoxicity score. Although pendimethalin approached the cleaned and harvested average seed yield of the control plots with 121.3 kg ha-1 , it did not feature prominently in the other indicators. With regard to plant trash after cleaning of vetch seed, the highest plant trash (179.4 kg ha-1 ) was obtained with bentazon. Pendimethalin had the highest percentage ratio between seed yield ha-1 and plant trash ha-1 (61.8%), followed by flumioxazin (60.7%). The results also showed that there was a positive correlation between NDVI values and seed yield and a positive correlation between NDVI values and plant trash, while there was a negative correlation at the 0.01 level between NDVI values and phytotoxicity

Testis-Specific Bb8 Is Essential in the Development of Spermatid Mitochondria.

Mitochondria are essential organelles of developing spermatids in Drosophila, which undergo dramatic changes in size and shape after meiotic division, where mitochondria localized in the cytoplasm, migrate near the nucleus, aggregate, fuse and create the Nebenkern. During spermatid elongation the two similar mitochondrial derivatives of the Nebenkern start to elongate parallel to the axoneme. One of the elongated mitochondrial derivatives starts to lose volume and becomes the minor mitochondrial derivative, while the other one accumulates paracrystalline and becomes the major mitochondrial derivative. Proteins and intracellular environment that are responsible for cyst elongation and paracrystalline formation in the major mitochondrial derivative need to be identified. In this work we investigate the function of the testis specific big bubble 8 (bb8) gene during spermatogenesis. We show that a Minos element insertion in bb8 gene, a predicted glutamate dehydrogenase, causes recessive male sterility. We demonstrate bb8 mRNA enrichment in spermatids and the mitochondrial localisation of Bb8 protein during spermatogenesis. We report that megamitochondria develop in the homozygous mutant testes, in elongating spermatids. Ultrastructural analysis of the cross section of elongated spermatids shows enlarged mitochondria and the production of paracrystalline in both major and minor mitochondrial derivatives. Our results suggest that the Bb8 protein and presumably glutamate metabolism has a crucial role in the normal development and establishment of the identity of the mitochondrial derivatives during spermatid elongation

Random elastic networks : strong disorder renormalization approach

For arbitrary networks of random masses connected by random springs, we define a general strong disorder real-space renormalization (RG) approach that generalizes the procedures introduced previously by Hastings [Phys. Rev. Lett. 90, 148702 (2003)] and by Amir, Oreg and Imry [Phys. Rev. Lett. 105, 070601 (2010)] respectively. The principle is to eliminate iteratively the elementary oscillating mode of highest frequency associated with either a mass or a spring constant. To explain the accuracy of the strong disorder RG rules, we compare with the Aoki RG rules that are exact at fixed frequency.Comment: 8 pages, v2=final versio

Phase diagram of two-lane driven diffusive systems

We consider a large class of two-lane driven diffusive systems in contact with reservoirs at their boundaries and develop a stability analysis as a method to derive the phase diagrams of such systems. We illustrate the method by deriving phase diagrams for the asymmetric exclusion process coupled to various second lanes: a diffusive lane; an asymmetric exclusion process with advection in the same direction as the first lane, and an asymmetric exclusion process with advection in the opposite direction. The competing currents on the two lanes naturally lead to a very rich phenomenology and we find a variety of phase diagrams. It is shown that the stability analysis is equivalent to an `extremal current principle' for the total current in the two lanes. We also point to classes of models where both the stability analysis and the extremal current principle fail

The Rapid Outbursting Star GM Cep: An EX-or in Tr 37?

We present optical, IR and millimeter observations of the solar-type star 13-277, also known as GM Cep, in the 4 Myr-old cluster Tr 37. GM Cep experiences rapid magnitude variations of more than 2 mag at optical wavelengths. We explore the causes of the variability, which seem to be dominated by strong increases in the accretion, being similar to EX-or episodes. The star shows high, variable accretion rates (up to ~10$^{-6}$ Msun/yr), signs of powerful winds, and it is a very fast rotator (Vsini~43 km/s). Its strong mid-IR excesses reveal a very flared disk and/or a remnant envelope, most likely out of hydrostatic equilibrium. The 1.3 millimeter fluxes suggest a relatively massive disk (Mdisk~0.1 Msun). Nevertheless, the millimeter mass is not enough to sustain increased accretion episodes over large timescales, unless the mass is underestimated due to significant grain growth. We finally explore the possibility of GM Cep having a binary companion, which could trigger disk instabilities producing the enhanced accretion episodes.Comment: 43 pages, including 10 figures, ApJ in pres

BRSMG 772 : cultivar de soja convencional com resistência à ferrugem.

Soja convencional com maior estabilidade de produção empresença de ferrugem asiática. Grupo de maturidade relativa. Regiões edafoclimáticas de adaptação. Reação a doenças. População de plantas e ciclo em solos férteis. Características médias. Informações adicionais.bitstream/item/81081/1/Folder-BRSMG-772.pdf1 folder