Radiation pattern of the isolated pulsar PSR B1828-11

Based on the free precession model of the isolated pulsar PSR B1828-11, Link & Epstein 2001) showed that the observed pulse durations require the radio beam to have a non-standard shape: the beam duration is larger for beam sweeps farthest from the dipole axis. In their analysis they assumed that the actual precession period is ~ 500 d. Recent theoretical studies suggested that the actual precession period might be ~ 1000 d as seen in observations (Rezania 2002, Wasserman 2002). In this paper, in a good agreement with the observed data (Stairs et al. 2000), we model the changes of the pulse shape in a precession cycle with period ~ 1000 d and find that the variation of the pulse duration follows from a {\it standard} beam pattern in each cycle.Comment: 9 pages, 3 figures, Accepted for publication in A&

Vorticity affects the stability of neutron stars

The spin rate Omega of neutron stars at a given temperature T is constrained by the interplay between gravitational-radiation instabilities and viscous damping. Navier-Stokes theory has been used to calculate the viscous damping timescales and produce a stability curve for r-modes in the (Omega,T) plane. In Navier-Stokes theory, viscosity is independent of vorticity, but kinetic theory predicts a coupling of vorticity to the shear viscosity. We calculate this coupling and show that it can in principle significantly modify the stability diagram at lower temperatures. As a result, colder stars can remain stable at higher spin rates

Kinetic Theory of Collisionless Self-Gravitating Gases: Post-Newtonian Polytropes

In this paper we study the kinetic theory of many-particle astrophysical systems and we present a consistent version of the collisionless Boltzmann equation in the 1PN approximation. We argue that the equation presented by Rezania and Sobouti in A&A 354 1110 (2000) is not the correct expression to describe the evolution of a collisionless self-gravitating gas. One of the reasons that account for the previous statement is that the energy of a free-falling test particle, obeying the 1PN equations of motion for static gravitational fields, is not a static solution of the mentioned equation. The same statement holds for the angular momentum, in the case of spherical systems. We provide the necessary corrections and obtain an equation that is consistent with the corresponding equations of motion and the 1PN conserved quantities. We suggest some potential relevance for the study of high density astrophysical systems and as an application we construct the corrected version of the post-Newtonian polytropes.Comment: 23 pages, 24 figures. Accepted for publication in PR

The r-modes of rotating fluids

An analysis of the toroidal modes of a rotating fluid, by means of the differential equations of motion is not readily tractable. A matrix representation of the equations in a suitable basis, however, simplifies the problem considerably and reveals many of its intricacies.Comment: 12 pages, 4 fiures, revised version to appear in A&

Large frequency drifts during Type I X-ray bursts

We study the spin-down of a neutron star atmosphere during the Type I X-ray burst in low mass X-ray binaries. Using polar cap acceleration models, we show that the resulting stellar ``wind'' torque on the burning shell due to the flowing charged particles (electrons, protons and ions) from the star's polar caps may change the shell's angular momentum during the burst. We conclude that the net change in the angular momentum of the star's atmosphere can account for rather large frequency drifts observed during Type I X-ray burst.Comment: 8 pages, more discussion adde

RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis

A major cause of implant failure in skeletal tissues is failure of osseointegration, often due to lack of adhesion of cells to the titanium (Ti) alloy interface. Since arginine- glycine-aspartic acid (RGD)-containing peptides have been shown to regulate osteoblast adhesion, we tested the hypothesis that, bound to a Ti surface, these peptides would promote osteoblasts differentiation, while at the same time inhibit apoptosis. RGDS and RGES (control) peptides were covalently linked to Ti discs using an APTS linker. While the grafting of both RGDS and RGES significantly increased Ti surface roughness, contact angle analysis showed that APTS significantly increased the surface hydrophobicity; when the peptides were tethered to Ti, this was reduced. To evaluate attachment, MC3T3-E1 osteoblast cells were grown on these discs. Significantly more cells attached to the Ti-grafted RGDS then the Ti-grafted RGES control. Furthermore, expression of the osteoblasts phenotype was significantly enhanced on the Ti-grafted RGDS surface. When cells attached to the Ti-grafted RGDS were challenged with staurosporine, an apoptogen, there was significant inhibition of apoptosis; in contrast, osteoblasts adherent to the Ti-grafted RGES were killed. It is concluded that RGD-containing peptides covalently bonded to Ti promotes osteoblasts attachment and survival with minimal changes to the surface of the alloy. Therefore, such modifications to Ti would have the potential to promote osseointegration in vivo

Structural and functional characterization of endothelial microparticles released by cigarette smoke

Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but their mechanism of release and function remain unknown. We assessed biochemical and functional characteristics of EMPs and circulating microparticles (cMPs) released by CS. CS exposure was sufficient to increase microparticle levels in plasma of humans and mice, and in supernatants of primary human lung microvascular endothelial cells. CS-released EMPs contained predominantly exosomes that were significantly enriched in let-7d, miR-191; miR-126; and miR125a, microRNAs that reciprocally decreased intracellular in CS-exposed endothelium. CS-released EMPs and cMPs were ceramide-rich and required the ceramide-synthesis enzyme acid sphingomyelinase (aSMase) for their release, an enzyme which was found to exhibit significantly higher activity in plasma of COPD patients or of CS-exposed mice. The ex vivo or in vivo engulfment of EMPs or cMPs by peripheral blood monocytes-derived macrophages was associated with significant inhibition of efferocytosis. Our results indicate that CS, via aSMase, releases circulating EMPs with distinct microRNA cargo and that EMPs affect the clearance of apoptotic cells by specialized macrophages. These targetable effects may be important in the pathogenesis of diseases linked to endothelial injury and inflammation in smokers