40 research outputs found
Frequency Dispersion of Sound Propagation in Rouse Polymer Melts via Generalized Dynamic Random Phase Approximation
An extended generalization of the dynamic random phase approximation (DRPA)
for L-component polymer systems is presented. Unlike the original version of
the DRPA, which relates the (LxL) matrices of the collective density-density
time correlation fumctions and the corresponding susceptibilities of polymer
concentrated systems to those of the tracer macromolecules and so-called broken
links system (BLS), our generalized DRPA solves this problem for (5xL)x(5xL)
matrices of the coupled susceptibilities and time correlation functions of the
component number, kinetic energy and flux densities. The presented technique is
used to study propagation of sound and dynamic form-factor in disentangled
(Rouse) monodisperse homopolymer melt. The calculated sound velocity and
absorption coefficient reveal substantial frequency dispersion. The relaxation
time is found to be N times less than the Rouse time (N is the degree of
polymerization), which evidences strong dynamic screening because of interchain
interaction. We discuss also some peculiarities of the Brillouin scattering in
polymer melts. Besides, a new convenient expression for the dynamic structural
function of the Rouse chain in (q,p)-representation is found.Comment: 37 pages, 2 appendices, 48 references, 1 figur
Only vulnerable adults show change in chronic low-grade inflammation after contemplative mental training: evidence from a randomized clinical trial.
Growing evidence suggests that chronic low-grade inflammation can be reduced through mindfulness-based mental training interventions. However, these results are inconsistent and based on patient populations with heterogeneous conditions. Similar research in healthy adults is lacking. Moreover, common intervention protocols involve varying combinations of different contemplative practices, such that it remains unclear which types of training most effectively influence biomarkers of inflammation. The present study investigated the effect of three distinct 3-month training modules cultivating a) interoception and present-moment focus (Presence), b) socio-affective skills (Affect), or c) socio-cognitive skills (Perspective) on the inflammatory biomarkers interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) in 298 healthy adults. We observed no group-level effect of training on either biomarker, but trend-level interactions of training type and participant sex. In additionally exploring the influence of participants' baseline inflammation, a selective training effect emerged: Following the Presence module, participants with relatively higher inflammatory load showed stronger reduction in IL-6 on average, and in hs-CRP if they were male. Mindfulness- and attention-based mental practice thus appears most effective when targeting chronic low-grade inflammation in healthy adults, particularly in men. Overall, our data point to a floor effect in the reduction of inflammatory markers through contemplative mental training, suggesting that mental training may be less effective in improving basal biological health outcomes in healthy, low-stressed adults than in vulnerable populations
Reproductive patterns among twins - a Swedish register study of men and women born 1973-1983
Meditation and cognitive ageing: The role of mindfulness meditation in building cognitive reserve
Mindfulness-related meditation practices engage various cognitive skills including the ability to focus and sustain attention, which in itself requires several interacting attentional sub-functions. There is increasing behavioural and neuroscientific evidence that mindfulness meditation improves these functions and associated neural processes. More so than other cognitive training programmes, the effects of meditation appear to generalise to other cognitive tasks, thus demonstrating far transfer effects. As these attentional functions have been linked to age-related cognitive decline, there is growing interest in the question whether meditation can slow-down or even prevent such decline. The cognitive reserve hypothesis builds on evidence that various lifestyle factors can lead to better cognitive performance in older age than would be predicted by the existing degree of brain pathology. We argue that mindfulness meditation, as a combination of brain network and brain state training, may increase cognitive reserve capacity and may mitigate age-related declines in cognitive functions. We consider available direct and indirect evidence from the perspective of cognitive reserve theory. The limited available evidence suggests that MM may enhance cognitive reserve capacity directly through the repeated activation of attentional functions and of the multiple demand system and indirectly through the improvement of physiological mechanisms associated with stress and immune function. The article concludes with outlining research strategies for addressing underlying empirical questions in more substantial ways
In Situ Dynamic Light Scattering Complementing Neutron Spin Echo Measurements on Protein Samples
Monitoring the state of the sample on the minute-time scale is crucial in case of sensitive soft matter or biological samples, given that neutron spin echo measurements take up to several days. Moreover, there is no method to interpret the normalized intermediate scattering function obtained by neutron spin echo measurements if relevant sample properties change during the measurement. Dynamic light scattering provides information on the diffusion constant of particles in solution (biological macromolecules like proteins, protein aggregates, polymer particles, etc.) with average hydrodynamic radii in a broad range from a few nanometers up to several microns. This information can be obtained within a few minutes and it offers a good overview of the current sample state. Details on the novel in situ dynamic light scattering set-up with one fixed scattering angle and first results obtained on a molten globule state of apo-myoglobin are presented
Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.
Monomer dynamics in single- and double-stranded DNA coils
In our paper (Tothova et al., Czech. J. Phys. 55, 221 (2005)), the first observation of the kinetics of individual polymer monomers using the fluorescence correlation technique (R. Shusterman et al., Phys. Rev. Lett. 92, 048303 (2004)) has been interpreted within the bead-spring theory. Optimizing the joint Rouse-Zimm model to the experimental data, the phenomenological parameters for the statistical-mechanical description of the universal behavior of double- and single-stranded DNA and the dominant types of their dynamics have been determined. Recently, these data have been corrected (R. Shusterman et al., Phys. Rev. Lett. 98, 029901 (2007)). In the present work, the fits of the theory to the new data are given. The main conclusions of our preceding paper remain unchanged but some of the polymer parameters have changed. The new data allow a significantly better agreement with the theory than the previous ones. Our calculations confirm that dsDNA follows mainly the classical Zimm-type kinetics rather than the Rouse one as it was proposed by Shusterman et al. Single-stranded DNA also behaves predominantly as the Zimm polymer. To support these conclusions, we analyze the draining effects on the monomer dynamics and the applicability of simple “universal” laws, according to which the monomer mean square displacement scales with the time as t
1/2 and t
2/3 for the Rouse and Zimm polymers, respectively