Evolution of the Velocity Ellipsoids in the Thin Disk of the Galaxy and the Radial Migration of Stars

Data from the revised Geneva--Copenhagen catalog are used to study the influence of radial migration of stars on the age dependences of parameters of the velocity ellipsoids for nearby stars in the thin disk of the Galaxy, assuming that the mean radii of the stellar orbits remain constant. It is demonstrated that precisely the radial migration of stars, together with the negative metallicity gradient in the thin disk,are responsible for the observed negative correlation between the metallicities and angular momenta of nearby stars, while the angular momenta of stars that were born at the same Galactocentric distances do not depend on either age or metallicity. (abridged)Comment: Astronomy Reports, Vol. 86 No. 9, P.1117-1126 (2009

Soliton-like Spin State in the A-like Phase of 3He in Anisotropic Aerogel

We have found a new stable spin state in the A-like phase of superfluid 3He confined to intrinsically anisotropic aerogel. The state can be formed by radiofrequency excitation applied while cooling through the superfluid transition temperature and its NMR properties are different from the standard A-like phase obtained in the limit of very small excitation. It is possible that this new state is formed by textural domain walls pinned by aerogel.Comment: 9 pages, 3 figures. Submitted to J. of Low Tem. Phys. (QFS2007 Proceedings

Disclosure of type 1 diabetes at work among Finnish workers

© 2016 Diabetes UK.Aims: To determine which self-management factors and psychosocial work factors were associated with disclosing diabetes to colleagues, line managers and occupational health personnel among workers with Type 1 diabetes. Methods: A total of 767 working-aged respondents with Type 1 diabetes completed a Finnish cross-sectional survey named 'People with Type 1 Diabetes in Worklife'. Factor analysis was carried out, followed by logistic regressions to estimate the associations between self-management factors, psychosocial work factors and the likelihood of disclosure separately to colleagues, line managers and occupational health personnel. The models were adjusted for sociodemographic, diabetes-related and work-related variables. Results: A total of 52% of the respondents had disclosed their diabetes to their colleagues, 45% to occupational health personnel and 28% to their line manager. Receiving social support and having good psychosocial work ability were significantly associated with disclosure to colleagues, line managers and occupational health personnel. Relations at work were associated with disclosure to colleagues and the line manager. Furthermore, opportunity to self-manage diabetes at work was associated with disclosure to colleagues. Conclusions: Line managers and colleagues have a remarkable role to play in providing workplace support to workers with Type 1 diabetes. Disclosure of Type 1 diabetes should be encouraged as line managers can provide workers with the right support, implement work adaptations and facilitate job retention. As only half of respondents disclosed their Type 1 diabetes at work, further research is required into the reasons for and consequences of not disclosing a diagnosis

Concealment of type 1 diabetes at work in Finland: a mixed-method study

Objectives To explore the possible reasons for concealing type 1 diabetes (T1D) at work. Methods The main set of data came from a cross-sectional survey (response rate 49.3%), the participants of which were 688 wage earners with T1D. Concealment of T1D was measured by asking respondents have they ever during their working career hidden their diabetes from their (A) colleagues and (B) line manager. Furthermore, semistructured interviews (n=20) were conducted to obtain deeper understanding. Questionnaire data were analysed using logistic regression analyses and qualitative interviews with inductive thematic analysis. Results About 30% of wage earners with T1D had concealed their condition during their working career from their colleagues and almost 20% from their line manager. Individuals aged 18–44 years age were more likely to conceal their T1D from their colleagues than older workers during their working career. Not disclosing T1D to the extended family (OR 5.24 (95% CI 2.06 to 13.35)), feeling an outsider at work (OR 2.47 (95% CI 1.58 to 3.84)), being embarrassed by receiving special attention at work (OR 1.99 (95% CI 1.33 to 2.96)) and neglecting treatment at work (OR 1.59 (95% CI 1.01 to 2.48)) were all associated with concealment of T1D from colleagues. The youngest age group of 18–24 years were more likely to conceal their T1D from their line managers than the older age groups during their working career. Not disclosing T1D to the extended family (OR 4.41 (95% CI 1.72 to 11.32)), feeling like an outsider at work (OR 2.51 (1.52 to 4.14)) and being embarrassed by receiving special attention at work (OR 1.81 (95% CI 1.13 to 2.91)) were associated with concealment of T1D from line managers. From the interviews, five main themes related to concealment emerged, expressing fears related to the consequences of telling: (1) being perceived as weak, (2) job discrimination, (3) unwanted attention, (4) being seen as a person who uses their T1D for seeking advantages and (5) losing privacy. Conclusions A considerable proportion of wage earners with T1D are concealing their diagnosis often because of feelings associated with stigma. Both overemphasis and underestimation of T1D at work by the colleagues or line manager may lead to concealing T1D and may thus be harmful to self-management of T1D. The obstacles in disclosing T1D might be diminished by giving adequate information at the workplace about the condition and its significance

Universal Behaviour of the Superfluid Fraction and Tc of He-3 in 99.5% Open Aerogel

We have investigated the superfluid transition of He-3 in a 99.5% porosity silica aerogel. This very dilute sample shows behaviour intermediary between bulk He-3 and He-3 confined to the denser aerogels previously studied. We present data on both the superfluid transition temperature and the superfluid density and compare our results with previous measurements. Finally, we show that the suppression of the superfluid transition temperature and suppression of the superfluid density of He-3 in aerogel follow a universal relation for a range of aerogel samples.Comment: 4 pages, 5 figures; 1 new figure, minor change

Relationship between the Velocity Ellipsoids of Galactic-Disk Stars and their Ages and Metallicities

The dependences of the velocity ellipsoids of F-G stars of the thin disk of the Galaxy on their ages and metallicities are analyzed based on the new version of the Geneva-Copenhagen Catalog. The age dependences of the major, middle, and minor axes of the ellipsoids, and also of the dispersion of the total residual veltocity, obey power laws with indices 0.25,0.29,0.32, and 0.27 (with uncertainties \pm 0.02). Due to the presence of thick-disk objects, the analogous indices for all nearby stars are about a factor of 1.5 larger. Attempts to explain such values are usually based on modeling relaxation processes in the Galactic disk. With increasing age, the velocity ellipsoid increases in size and becomes appreciably more spherical, turns toward the direction of the Galactic center, and loses angular momentum. The shape of the velocity ellipsoid remains far from equilibrium. With increasing metallicity, the velocity ellipsoid for stars of mixed age increases in size, displays a weak tendency to become more spherical, and turns toward the direction of the Galactic center (with these changes occurring substantially more rapidly in the transition through the metallicity [Fe/H]= -0.25). Thus, the ellipsoid changes similarly to the way it does with age; however, with decreasing metallicity, the rotational velocity about the Galactic center monotonically increases, rather than decreases(!). Moreover, the power-law indices for the age dependences of the axes depend on the metallicity, and display a maximum near [Fe/H]=-0.1. The age dependences of all the velocity-ellipsoid parameters for stars with equal metallicity are roughly the same. It is proposed that the appearance of a metallicity dependence of the velocity ellipsoids for thin-disk stars is most likely due to the radial migration of stars.Comment: 15 pages, 6 figures, accepted 2009, Astronomy Reports, Vol. 53 No. 9, P.785-80

Reconstructing ‘the Alcoholic’: Recovering from Alcohol Addiction and the Stigma this Entails

Public perception of alcohol addiction is frequently negative, whilst an important part of recovery is the construction of a positive sense of self. In order to explore how this might be achieved, we investigated how those who self-identify as in recovery from alcohol problems view themselves and their difficulties with alcohol and how they make sense of others’ responses to their addiction. Semi-structured interviews with six individuals who had been in recovery between 5 and 35 years and in contact with Alcoholics Anonymous were analysed using Interpretative Phenomenological Analysis. The participants were acutely aware of stigmatising images of ‘alcoholics’ and described having struggled with a considerable dilemma in accepting this identity themselves. However, to some extent they were able to resist stigma by conceiving of an ‘aware alcoholic self’ which was divorced from their previously unaware self and formed the basis for a new more knowing and valued identity

Intestinal Microbiota Shifts towards Elevated Commensal Escherichia coli Loads Abrogate Colonization Resistance against Campylobacter jejuni in Mice

Background: The zoonotic pathogen Campylobacter jejuni is a leading cause of bacterial foodborne enterocolitis in humans worldwide. The understanding of immunopathology underlying human campylobacteriosis is hampered by the fact that mice display strong colonization resistance against the pathogen due to their host specific gut microbiota composition. Methodology/Principal Findings: Since the microbiota composition changes significantly during intestinal inflammation we dissected factors contributing to colonization resistance against C. jejuni in murine ileitis, colitis and in infant mice. In contrast to healthy animals C. jejuni could stably colonize mice suffering from intestinal inflammation. Strikingly, in mice with Toxoplasma gondii-induced acute ileitis, C. jejuni disseminated to mesenteric lymphnodes, spleen, liver, kidney, and blood. In infant mice C. jejuni infection induced enterocolitis. Mice suffering from intestinal inflammation and C. jejuni susceptible infant mice displayed characteristical microbiota shifts dominated by increased numbers of commensal Escherichia coli. To further dissect the pivotal role of those distinct microbiota shifts in abrogating colonization resistance, we investigated C. jejuni infection in healthy adult mice in which the microbiota was artificially modified by feeding live commensal E. coli. Strikingly, in animals harboring supra-physiological intestinal E. coli loads, colonization resistance was significantly diminished and C. jejuni infection induced enterocolitis mimicking key features of human campylobacteriosis. Conclusion/Significance: Murine colonization resistance against C. jejuni is abrogated by changes in the microbiot

NGF Is an Essential Survival Factor for Bronchial Epithelial Cells during Respiratory Syncytial Virus Infection

Background: Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs. lower airways) and why, these changes occur. We analyzed systematically the expression of neurotrophic factors and receptors following RSV infection of human nasal, tracheal, and bronchial epithelial cells, and tested the hypothesis that neurotrophins work as innate survival factors for infected respiratory epithelia. Methodology: Expression of neurotrophic factors (nerve growth factor, NGF; brain-derived neurotrophic factor, BDNF) and receptors (trkA, trkB, p75) was analyzed at the protein level by immunofluorescence and flow cytometry and at the mRNA level by real-time PCR. Targeted siRNA was utilized to blunt NGF expression, and its effect on virus-induced apoptosis/ necrosis was evaluated by flow cytometry following annexin V/7-AAD staining. Principal Findings: RSV infection was more efficient in cells from more distal (bronchial) vs. more proximal origin. In bronchial cells, RSV infection induced transcript and protein overexpression of NGF and its high-affinity receptor trkA, with concomitant downregulation of the low-affinity p75 NTR. In contrast, tracheal cells exhibited an increase in BDNF, trkA and trkB, and nasal cells increased only trkA. RSV-infected bronchial cells transfected with NGF-specific siRNA exhibited decreased trkA and increased p75 NTR expression. Furthermore, the survival of bronchial epithelial cells was dramaticall