Acousto-optic interaction in biconical tapered fibers: shaping of the stopbands

The effect of a gradual reduction of the fiber diameter on the acousto-optic (AO) interaction is reported. The experimental and theoretical study of the intermodal coupling induced by a flexural acoustic wave in a biconical tapered fiber shows that it is possible to shape the transmission spectrum, for example, substantially broadening the bandwidth of the resonant couplings. The geometry of the taper transitions can be regarded as an extra degree of freedom to design the AO devices. Optical bandwidths above 45 nm are reported in a tapered fiber with a gradual reduction of the fiber down to 70 μm diameter. The effect of including long taper transition is also reported in a double-tapered structure. A flat attenuation response is reported with 3-dB stopband bandwidth of 34 nm

COMPARACIÓN DE LAS PRINCIPALES MOSCAS NECRÓFAGAS ATRAÍDAS POR HÍGADOS HUMANOS EN ESTADO DE DESCOMPOSICIÓN, EXPUESTOS A DIFERENTES INTERVALOS DE TIEMPO, EN UN ÁREA URBANA DE LA PROVINCIA DE PANAMÁ.

Four samples of human´s livers of approximately 150 – 200 g. were obtained from the Judicial Mortuary of Panama. The livers were used at different interval from 12, 24, 48, 72 and 96 hours of decomposition. The flies were captured during 3 hours with intervals of 10, 15 and 20 min, until the 3 hours sampling was completed. A total amount of 1 003 flies were captured, distributed in 3 families: Calliphoridae, Sarcophagide y Muscidae. To capture 11 species, the more abundant species corresponded to Chrysomya megacephala, with 464 specimens, Lucila cuprina, with 117 specimens, Lucilia sericata, with 55 specimens and Lucilia eximia, with 47 specimens. The purpose of this research was knew the colonization of human liver, exposed at different time intervals in an urban area of the province of Panama.Se obtuvieron cuatro muestras de hígados humanos, de aproximadamente de 150 a 200 g. de la Morgue Judicial de Panamá. Los tejidos se expusieron a intervalos de tiempo que iban desde las primeras 12 horas, incluyendo las 24, 48, 72 y hasta 96 horas de descomposición. Las capturas de las moscas se realizaron durante tres horas continuas. En total se capturaron 1003 ejemplares, distribuidos en tres familias y 11 especies: Calliphoridae, Sarcophagidae y Muscida. La familia que mayormente atrapada en los tejidos fue la Calliphoridae seguida de la Sarcophagidae. Las especies más abundantes en el área correspondió a Chrysomya megacephala, con 464 ejemplares y Lucilia cuprina con 117 ejemplares, seguido de Lucilia sericata con 55 ejemplares y Lucilia eximia con 47 ejemplares. El objetivo de esta investigación fue conocer las principales especies de moscas necrófagas que arriban a los hígados humanos, expuestos a diferentes intervalos, en un área urbana de la provincia de Panamá

The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

86 pags., 49 figs., 24 tabs.NASA’s Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft.This work has been funded by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4-1-R (also -2-R, -3-R and -4-R) and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-1-R (also -2-R and -3-R), ESP2016-80320-C2-1-R, RTI2018-098728-B-C31 (also -C32 and -C33) and RTI2018-099825-B-C31; Instituto Nacional de Técnica Aeroespacial; Ministry of Science and Innovation’s Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant no 818602. The US co-authors performed their work under sponsorship from NASA’s Mars 2020 project, from the Game Changing Development program within the Space Technology Mission Directorate and from the Human Exploration and Operations Directorate

The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

86 pags, 49 figs, 24 tabsNASA's Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft.This work has been funded by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4-1-R (also -2-R, -3-R and -4-R) and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-1-R (also -2-R and -3-R), ESP2016-80320-C2-1-R, RTI2018-098728-B-C31 (also -C32 and -C33) and RTI2018-099825-B-C31; Instituto Nacional de Tecnica Aeroespacial; Ministry of Science and Innovation's Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant no 818602.Peer reviewe

An integrated expression atlas of miRNAs and their promoters in human and mouse

MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA (sRNA) libraries, with matching Cap Analysis Gene Expression (CAGE) data, from 396 human and 47 mouse RNA samples. Promoters were identified for 1,357 human and 804 mouse miRNAs and showed strong sequence conservation between species. We also found that primary and mature miRNA expression levels were correlated, allowing us to use the primary miRNA measurements as a proxy for mature miRNA levels in a total of 1,829 human and 1,029 mouse CAGE libraries. We thus provide a broad atlas of miRNA expression and promoters in primary mammalian cells, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions

Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted

High Sensitivity Refractive Index Sensor Based on Highly Overcoupled Tapered Fiber Optic Couplers

In this paper, a simple and compact fiber-optic sensor based on an overcoupled tapered fiber coupler is studied. The coupler is fabricated to be operated well beyond the initial coupling cycles, where the rapid exchange of energy between outputs ports enable the fabrication of a highly sensitive device. The suitability and sensitivity of the proposed scheme is demonstrated by measuring refractive index (RI) variations of sugar concentrations in water. The device presents a linear response in terms of power transmission or wavelength shift versus RI changes. The best achieved sensitivity is 0.442 units of normalized transmission per unit of sugar concentration, with a noise detection limit of 0.003 weight percentage of sugar concentration (wt %). From this result the minimum detectable RI change is estimated as 5 × 10-6 RI unit (RIU). The sensor can be also wavelength-encoded, exhibiting a sensitivity of 2171 nm/RIU, maintaining a linear response in a large range of RI. These experimental results are within the best results reported in the framework of fiber couplers and modal interferometer-based RI sensor