Aclaración de los términos implicados en el proceso de evaluación educativa

p. 70-91El presente capítulo intenta proporcionar algo de luz a la falta de coherencia entre la terminología de evaluación empleada en el contexto universitario y la utilizada en el ámbito no universitari

Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection

Background: The role of vitamin D status in COVID-19 patients is a matter of debate. Objectives: To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients with COVID-19 and to analyze the possible influence of vitamin D status on disease severity. Methods: Retrospective case-control study of 216 COVID-19 patients and 197 population-based controls. Serum 25OHD levels were measured in both groups. The association of serum 25OHD levels with COVID-19 severity (admission to the intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated. Results: Of the 216 patients, 19 were on vitamin D supplements and were analyzed separately. In COVID-19 patients, mean ± standard deviation 25OHD levels were 13.8 ± 7.2 ng/mL, compared with 20.9 ± 7.4 ng/mL in controls (P < .0001). 25OHD values were lower in men than in women. Vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population-based controls (P < .0001). 25OHD inversely correlates with serum ferritin (P = .013) and D-dimer levels (P = .027). Vitamin D-deficient COVID-19 patients had a greater prevalence of hypertension and cardiovascular diseases, raised serum ferritin and troponin levels, as well as a longer length of hospital stay than those with serum 25OHD levels ?20 ng/mL. No causal relationship was found between vitamin D deficiency and COVID-19 severity as a combined endpoint or as its separate components. Conclusions: 25OHD levels are lower in hospitalized COVID-19 patients than in population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease.The Camargo Cohort Study was supported by grants from the Instituto de Salud Carlos III (PI18/00762), Ministerio de Economía y Competitividad, Spain, which included FEDER funds from the EU

Cellulose production in Pseudomonas syringae pv. syringae: a compromise between epiphytic and pathogenic lifestyles.

Política de acceso abierto tomada de: https://v2.sherpa.ac.uk/id/publication/882Genome sequencing and annotation have revealed a putative cellulose biosynthetic operon in the strain Pseudomonas syringae pv. syringae UMAF0158, the causal agent of bacterial apical necrosis. Bioinformatics analyses and experimental methods were used to confirm the functionality of the cellulose biosynthetic operon. In addition, the results showed the contribution of the cellulose operon to important aspects of P. syringae pv. syringae biology, such as the formation of biofilms and adhesion to the leaf surface of mango, suggesting that this operon increases epiphytic fitness. However, based on the incidence and severity of the symptoms observed in tomato leaflets, cellulose expression reduces virulence, as cellulose-deficient mutants increased the area of necrosis, whereas the cellulose-overproducing strain decreased the area of necrosis compared with the wild type. In conclusion, the results of this study show that the epiphytic and pathogenic stages of the P. syringae pv. syringae UMAF0158 lifestyle are intimately affected by cellulose production.This study was supported by funding from Consejería de Innovación, Ciencia y Empresa, Secretaría General de Universidades, Investigación y Tecnología, Junta de Andalucía, Spain (Incentivos a Proyectos de Excelencia P07-AGR-2471 and P12- AGR-1473), and co-financed by FEDER funds (EU)

Criterios de ordenación temporal de las intervenciones quirúrgicas en patología cardiovascular y endovascular adquirida. Versión 2022

Waiting list management of cardiac surgical procedures is a main concern for all the Spanish autonomic health systems and for our scientific Society. The first statement for optimal timing of patients waiting for cardiac surgery was published in 2000. Since then, after significant changes in the management of some pathologies, new normative frameworks and the current healthcare situation, a review of the timing criteria to offer an adequate and updated standard of care is needed. In this document we aim to review the available literature in the field and stablish a consensus within a working group of the Spanish Society of Cardiovascular and Endovascular Surgery to optimize the priority recommendations in cardiac surgical waiting lists in our country. (c) 2022 Sociedad Espanola de Cirugia Cardiovascular y Endovascular. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ riccuses/by-nc-nri/4.0/)

High-Dimensional Analysis of Single-Cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukaemia

B-cell Acute Lymphoblastic Leukaemia is one of the most common cancers in childhood, with 20% of patients eventually relapsing. Flow cytometry is routinely used for diagnosis and follow-up, but it currently does not provide prognostic value at diagnosis. The volume and the high-dimensional character of this data makes it ideal for its exploitation by means of Artificial Intelligence methods. We collected flow cytometry data from 56 patients from two hospitals. We analysed differences in intensity of marker expression in order to predict relapse at the moment of diagnosis. We finally correlated this data with biomolecular information, constructing a classifier based on CD38 expression. Artificial intelligence methods may help in unveiling information that is hidden in high-dimensional oncological data. Flow cytometry studies of haematological malignancies provide quantitative data with the potential to be used for the construction of response biomarkers. Many computational methods from the bioinformatics toolbox can be applied to these data, but they have not been exploited in their full potential in leukaemias, specifically for the case of childhood B-cell Acute Lymphoblastic Leukaemia. In this paper, we analysed flow cytometry data that were obtained at diagnosis from 56 paediatric B-cell Acute Lymphoblastic Leukaemia patients from two local institutions. Our aim was to assess the prognostic potential of immunophenotypical marker expression intensity. We constructed classifiers that are based on the Fisher's Ratio to quantify differences between patients with relapsing and non-relapsing disease. We also correlated this with genetic information. The main result that arises from the data was the association between subexpression of marker CD38 and the probability of relapse

Webinars 360: Una Experiencia Formativa Transnacional de la Red Universitaria de Tecnología Educativa

In this work we present “360  Webinar Series” a transnational professional development online initiative promoted and developed by Red Universitaria de Tecnolog a Educativa (RUTE). Since March 2019, a cycle of monthly webinars led by experts from eight countries (France; USA; Australia; Germany; Czech Republic; Portugal; Chile, and Russia) has been implemented with the aim of analyzing the initial training of pre-service teachers, as well as professional development practices of in-service ones in regards to the promotion and use of Educational Technology. The cross-sectional analysis of the content of this initiative has allowed us to obtain conclusions related to: a) the defining characteristics of initial training in educational technology for teachers in the participating countries; b) the common and differentiating characteristics that define educational technology training for teachers in the participating countries, and; c) the challenges that training in educational technology is experiencing from a transnational perspective.En este trabajo presentamos la experiencia “Webinars 360º series” una iniciativa de formación online promovida y desarrollada por la Red Universitaria de Tecnología Educativa (RUTE). Desde Marzo de 2019 se ha venido desarrollando un ciclo de webinars mensuales liderados por expertos provenientes de ocho países (EEUU; Australia; Alemania; República Checa; Portugal; Chile, y Rusia), con el objetivo de analizar tanto la formación inicial como la formación permanente del profesorado en Tecnología Educativa a nivel internacional. El análisis transversal del contenido de esta iniciativa transnacional nos ha permitido obtener conclusiones relacionadas con: a) las características definitorias de la formación inicial permanente en tecnología educativa del profesorado en los países participantes; b) las características comunes y diferenciadoras que definen la formación en tecnología educativa en los países participantes, y; c) los desafíos y retos que la formación en tecnología educativa está experimentando desde una perspectiva transnacional

El plan del estado de Veracruz (México) ante el cambio climático. Parte II: guía metodológica

Ponencia presentada en: VI Congreso Internacional de la Asociación Española de Climatología celebrado en Tarragona del 8 al 11 de octubre de 2008.[ES]México está conformado por 31 estados y un Distrito Federal. Éste, seguido del estado de Veracruz -al oriente del país, en la costa del Golfo de México- son las primeras entidades en elaborar un Plan Estatal ante el Cambio Climático (PEACC). Como resultado secundario del Plan Estatal de Cambio Climático de Veracruz, se generó una Guía Metodológica para la elaboración de este tipo de programas estatales. En el tema del cambio climático, es necesario facilitar la obtención de aproximaciones a la realidad local o regional presentes y de escenarios futuros, que favorezcan acciones en esas mismas escalas. En esta comunicación se presenta un extracto de esta Guía Metodología que será utilizada para la elaboración de diez estudios estatales que iniciarán en 2008.[EN]Mexico is a federal republic constituted of thirty-one states and a Federal District. This one and the state of Veracruz – situated in the southwest part of the country, in the cost of the Gulf of Mexico – became the two first states that designed a State Plan for Climate Change (PEACC, for its initials in Spanish). One of the secondary results of the Veracruz PEACC was the creation of a Methodological Guide for the elaboration of comparable plans.When addressing the matter of climate change it is necessary to have a wide perspective on this issue, thus one should include local o regional research which might help to future actions that operate in the same scale. The following is an extract of this Methodological Guide that will be used for the elaboration of 10 state studies which will begin in 2008