Energiaa ryhmästä – Plusfactor-hyvinvointivalmennus auttoi lisäämään työelämän voimavaroja

Artikkeli kuvaa Plusfactor-hyvinvointivalmennuksen tuloksia ja kokemuksia osallistujien näkökulmasta. Osallistujat ovat asiantuntija- ja yrittäjänaisia ja he ovat osallistuneet prosessiin 7 kuukauden ajan vuonna 2016

Vanhempien kokemuksia tukea tarvitsevan lapsen siirtymästä esiopetuksesta peruskouluun

Tiivistelmä. Tämän tutkimuksen tavoitteena on selvittää, millaisia kokemuksia vanhemmilla on tukea tarvitsevan lapsen siirtymästä esiopetuksesta peruskouluun ja kuinka he ovat kokeneet tuen jatkuvuuden toteutuneen siirtymävaiheessa. Aiheesta tekee ajankohtaisen tukea tarvitsevien lasten vuosittain lisääntynyt määrä, sillä sen vuoksi yhä useampi perhe kokee koulun aloituksen tukea tarvitsevan lapsen kanssa. Tutkimuksemme teoreettisessa viitekehyksessä määrittelemme laajasti siirtymää, avaamme tukea tarvitsevan lapsen koulun aloitukseen liittyviä tekijöitä sekä kirjoitamme vanhempien roolista siirtymäprosessissa. Tutkielma on laadullinen tutkimus ja sen lähestymistapana toimii fenomenologia. Tutkimusaineisto koostuu kahdeksan tukea tarvitsevan lapsen vanhemman etänä toteutetusta haastattelusta. Vanhemmista kuudella oli erityistä tukea saava lapsi ja kahdella tehostettua tukea saava lapsi. Tutkimukseen osallistujien tavoittamiseen hyödynnettiin vanhemmille suunnattuja järjestöjä sekä sosiaalista mediaa. Tutkimusaineisto analysoitiin fenomenologisella metodilla. Tutkimustulokset osoittavat, että vanhempien kokemukset tukea tarvitsevan lapsen siirtymästä esiopetuksesta peruskouluun ovat moninaisia. Siirtymään liittyvät käytänteet ja tapahtumat erosivat vanhempien kokemuksissa, mikä osaltaan vaikuttaa vanhempien näkemykseen tukea tarvitsevan lapsensa siirtymän onnistumisesta. Samat tekijät näyttäytyvät vanhemmille joko siirtymää edesauttaneena tai haastavana tekijänä riippuen toteutuksen tavoista. Vanhemmat liittävät siirtymään usein jännityksen ja jopa pelon tunteita. Huolta aiheuttavat tulevaan siirtymään liittyvien muutosten vaikutukset lapsen arkeen ja siinä pärjäämiseen. Vanhemmat pitävät siirtymässä tärkeänä yhteistyötä, tiedottamista ja tiedonsiirtoa esiopetuksesta koululle. Lapsen saaman tuen koettiin muuttuneen kouluun siirtymisen jälkeen ja tuen jatkuvuuden kokemuksissa oli vaihtelua. Osa vanhemmista ilmaisi tyytymättömyyttä koulupaikasta ja tuen resurssoinnista vastaavia päättäjiä kohtaan. Tutkimustulosten perusteella yhteistyön toimivuus ja kokemus kuulluksi tulemisesta määrittelevät siirtymän onnistumista. Vanhemmat haluavat olla aktiivisesti mukana lapsensa siirtymässä sekä toivovat, että heitä kuultaisiin siihen liittyvässä päätöksenteossa. Opettajat ovat merkityksellisessä roolissa siirtymän toteuttamisessa ja toimivan vuorovaikutussuhteen rakentamisessa vanhempiin. Tutkimuksen tulokset osoittavat, että tukea tarvitsevan lapsen siirtymä koskee kokonaisvaltaisesti koko perhettä ja vanhemmat kokevat kouluun siirtymän hyvin merkittävänä tapahtumana.Parents’ experiences of the transition from preschool to primary school for a child with special needs. Abstract. The aim of this study is to examine what kind of experiences parents of children with special needs have about their child’s transition from preschool to primary school and how they have experienced the continuity of support in transition phase. This is a topical issue because the amount of children with special needs has increased every year and therefore more and more families experience starting school with a child with special needs. In our study’s theoretical framework we define transition extensively, explain factors related to starting school as a child with special needs and write about the parents’ role in transition process. This thesis is a qualitative research and the approach to the topic is phenomenological. The research material consist of remotely conducted interviews of eight parents of children with special needs. Six parents’ children were receiving special support and two parents’ children were receiving intensified support. Reaching the participants for this study we used organizations directed to parents and social media. The data was analyzed by the phenomenological method. The results of this study show that parents had various experiences of the transition from preschool to primary school for their child with special needs. Transition practices differed in parents’ experiences which affected on the parents’ view of success of transition. The same factors appear to parents either helping or challenging the transition depending on how they were implemented. Parents often associate transition with feelings of nervousness or even fear. Worry is caused by the changes related to transition and their impacts on child’s daily life and coping in it. Parents consider cooperation, informing and transfer of information from preschool to primary school to be important in transition. Parents experienced that the support received by the child changed after transition and the experiences of continuity of support varied. Some of the parents expressed dissatisfaction with decision-makers responsible for the school placements and the resource allocation of support. Based on this study a functioning collaboration and experience of being heard define how transition will succeed. Parents want to be active participants in their child’s transition and they wish that they could be heard in transition related decision-making. Teachers have a significant role in implementing the transition and building a functional relationship to parents. The results of this study show that the transition of a child with special needs concerns comprehensively the whole family and parents experience the transition to primary school as a significant event

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Retinal pigment epithelial (RPE) cells are continually exposed to oxidative stress that contributes to protein misfolding, aggregation and functional abnormalities during aging. The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retrograde trafficking to a juxtanuclear location. We demonstrate that Hsp90 inhibition by geldanamycin can effectively suppress proteasome inhibitor, MG-132-induced protein aggregation in a way that is independent of HDAC inhibition or the tubulin acetylation levels in ARPE-19 cells. However, the tubulin acetylation and polymerization state affects the localization of the proteasome-inhibitor-induced aggregation. These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration

Quantitative criteria for choosing targets and indicators for sustainable use of ecosystems

The authors thank Simon Greenstreet, Cristina Herbon, Simon Jennings, Tiziana Luisetti, Lucille Paltriguera, and Christian Wilson for comments on previous versions of this paper. This work has resulted from the DEVOTES (DEVelopment Of innovative Tools for understanding marine biodiversity and assessing Good Environmental Status) project funded by the EU under the 7th Framework Programme, ‘The Ocean of Tomorrow’ Theme (No. 308392), www.devotes-project.eu. Further, A.G.R. was partially funded by the Natural Environment Research Council and the UK Department for Food, Environment and Rural Affairs (Defra) within the Marine Ecosystems Research Program (MERP), C.P.L. by Defra (M1228), A.Z. by BIOsingle bondC3 within the joint Baltic Sea Research and Development Programme (EU 7th and Research Council of Lithuania, BONUS-1/2014), and M.C.U. by the Spanish Programme for talent and employability in I + D + i ‘Torres Quevedo’

Characterisation of the RNA Virome of Nine Ochlerotatus Species in Finland

RNA viromes of nine commonly encountered Ochlerotatus mosquito species collected around Finland in 2015 and 2017 were studied using next-generation sequencing. Mosquito homogenates were sequenced from 91 pools comprising 16–60 morphologically identified adult females of Oc. cantans, Oc. caspius, Oc. communis, Oc. diantaeus, Oc. excrucians, Oc. hexodontus, Oc. intrudens, Oc. pullatus and Oc. punctor/punctodes. In total 514 viral Reverse dependent RNA polymerase (RdRp) sequences of 159 virus species were recovered, belonging to 25 families or equivalent rank, as follows: Aliusviridae, Aspiviridae, Botybirnavirus, Chrysoviridae, Chuviridae, Endornaviridae, Flaviviridae, Iflaviridae, Negevirus, Partitiviridae, Permutotetraviridae, Phasmaviridae, Phenuiviridae, Picornaviridae, Qinviridae, Quenyavirus, Rhabdoviridae, Sedoreoviridae, Solemoviridae, Spinareoviridae, Togaviridae, Totiviridae, Virgaviridae, Xinmoviridae and Yueviridae. Of these, 147 are tentatively novel viruses. One sequence of Sindbis virus, which causes Pogosta disease in humans, was detected from Oc. communis from Pohjois-Karjala. This study greatly increases the number of mosquito-associated viruses known from Finland and presents the northern-most mosquito-associated viruses in Europe to date

Characterisation of the RNA Virome of Nine Ochlerotatus Species in Finland

RNA viromes of nine commonly encountered Ochlerotatus mosquito species collected around Finland in 2015 and 2017 were studied using next-generation sequencing. Mosquito homogenates were sequenced from 91 pools comprising 16–60 morphologically identified adult females of Oc. cantans, Oc. caspius, Oc. communis, Oc. diantaeus, Oc. excrucians, Oc. hexodontus, Oc. intrudens, Oc. pullatus and Oc. punctor/punctodes. In total 514 viral Reverse dependent RNA polymerase (RdRp) sequences of 159 virus species were recovered, belonging to 25 families or equivalent rank, as follows: Aliusviridae, Aspiviridae, Botybirnavirus, Chrysoviridae, Chuviridae, Endornaviridae, Flaviviridae, Iflaviridae, Negevirus, Partitiviridae, Permutotetraviridae, Phasmaviridae, Phenuiviridae, Picornaviridae, Qinviridae, Quenyavirus, Rhabdoviridae, Sedoreoviridae, Solemoviridae, Spinareoviridae, Togaviridae, Totiviridae, Virgaviridae, Xinmoviridae and Yueviridae. Of these, 147 are tentatively novel viruses. One sequence of Sindbis virus, which causes Pogosta disease in humans, was detected from Oc. communis from Pohjois-Karjala. This study greatly increases the number of mosquito-associated viruses known from Finland and presents the northern-most mosquito-associated viruses in Europe to date

Sindbis Virus Strains of Divergent Origin Isolated from Humans and Mosquitoes During a Recent Outbreak in Finland

Sindbis virus (SINV) is a mosquito-borne avian hosted virus that is widely distributed in Europe, Africa, Asia, and Oceania. Disease in humans is documented mainly from Northern Europe and South Africa and associated with genotype I. In 2018 under extremely warm climatic conditions, a small outbreak of 71 diagnosed SINV infections was recorded in Finland. We screened 52 mosquito pools (570 mosquitoes) and 223 human sera for SINV with real-time RT-PCR and the positive samples with virus isolation. One SINV strain was isolated from a pool (n = 13) of genusOchlerotatusmosquitoes and three strains from patient serum samples. Complete genome analysis suggested all the isolates to be divergent from one another and related to previous Finnish, Swedish, and German strains. The study provides evidence of SINV strain transfer within Europe across regions with different epidemiological characteristics. Whether these are influenced by different mosquito genera involved in the transmission remains to be studied.Peer reviewe

A novel negevirus isolated from Aedes vexans mosquitoes in Finland

Negeviruses are insect-specific enveloped RNA viruses that have been detected in mosquitoes and sandflies from various geographical locations. Here, we describe a new negevirus from Northern Europe, isolated from pool ofAedes vexansmosquitoes collected in Finland, designated as Mekrijarvi negevirus (MEJNV). MEJNV had a typical negevirus genome organization, is 9,740 nucleotides in length, and has a GC content of 47.53%. The MEJNV genome contains three ORFs, each containing the following identified conserved domains: ORF1 (7,068 nt) encodes a viral methyltransferase, an FtsJ-like methyltransferase, a viral RNA helicase, and an RNA-dependent RNA polymerase, ORF2 (1,242 nt) encodes a putative virion glycoprotein, and ORF3 (660 nt) encodes a putative virion membrane protein. A distinctive feature relative to other currently known negeviruses is a 7-nucleotide-long overlap between ORF1 and ORF2. MEJNV shares the highest sequence identity with Ying Kou virus from China, with 67.71% nucleotide and 75.19% and 59.00% amino acid sequence identity in ORF 1 and ORF 2, respectively. ORF3 had the highest amino acid sequence similarity to Daeseongdong virus 1 and negevirus Nona 1, both with 77.61% identity, and to Ying Kou virus, with 71.22% identity. MEJNV is currently the northernmost negevirus described. Our report supports the view that negeviruses are a globally distributed, diverse group of viruses that can be found from mosquitoes in a wide range of terrestrial biomes from tropical to boreal forests.Peer reviewe

High-Power 1180-nm GaInNAs DBR Laser Diodes

We report high-power 1180-nm GaInNAs distributed Bragg reflector laser diodes with and without a tapered amplifying section. The untapered and tapered components reached room temperature output powers of 655 mW and 4.04 W, respectively. The diodes exhibited narrow linewidth emission with side-mode suppression ratios in the range of 50 dB for a broad range of operating current, extending up to 2 A for the untapered component and 10 A for the tapered component. The high output power is rendered possible by the use of a high quality GaInNAs-based quantum well gain region, which allows for lower strain and better carrier confinement compared with traditional GaInAs quantum wells. The development opens new opportunities for the power scaling of frequency-doubled lasers with emission at yellow–orange wavelengths.publishedVersionPeer reviewe