Plio-Pleistocene transpressional reactivation of Paleozoic and Paleogene structures in the Rhine-Bresse transform zone (northern Switzerland and eastern France)

Pliocene to recent uplift and shortening in the southern Rhinegraben is documented by deformation of Pliocene fluvial gravels, deposited on a nearly planar surface, as well as by progressive deflection and capture of rivers. This deformation is suggested to result from thick-skinned tectonic movements as evidenced by observations on seismic records, which demonstrate a spatial coincidence between en-échelon anticlines at the surface and faults located in the crystalline basement. These findings contradict the often invoked thin-skinned tectonism in the recent tectonic history of the Rhinegraben. In particular the transfer zone between the Rhinegraben and the Bressegraben is very suitable for reactivation under the present day stress field. Thick-skinned reactivation of faults in the basement is also expressed by focal plane mechanisms of recent earthquakes showing strike-slip- rather than reverse faulting characteristics. This is of importance for the densely populated and industrialised southern Rhinegraben, previously affected by large earthquakes in historical times (e.g. Basel 1356

Relative timing of uplift along the Zagros Mountain Front Flexure (Kurdistan Region of Iraq): Constrained by geomorphic indices and landscape evolution modeling

The Mountain Front Flexure marks a dominant topographic step in the frontal part of the Zagros Fold–Thrust Belt. It is characterized by numerous active anticlines atop of a basement fault. So far, little is known about the relative activity of the anticlines, about their evolution, or about how crustal deformation migrates over time. We assessed the relative landscape maturity of three along-strike anticlines (from SE to NW: Harir, Perat, and Akre) located on the hanging wall of the Mountain Front Flexure in the Kurdistan Region of Iraq to identify the most active structures and to gain insights into the evolution of the fold–thrust belt. Landscape maturity was evaluated using geomorphic indices such as hypsometric curves, hypsometric integral, surface roughness, and surface index. Subsequently, numerical landscape evolution models were run to estimate the relative time difference between the onset of growth of the anticlines, using the present-day topography of the Harir Anticline as a base model. A stream power equation was used to introduce fluvial erosion, and a hillslope diffusion equation was applied to account for colluvial sediment transport. For different time steps of model evolution, we calculated the geomorphic indices generated from the base model. While Akre Anticline shows deeply incised valleys and advanced erosion, Harir and Perat anticlines have relatively smoother surfaces and are supposedly younger than the Akre Anticline. The landscape maturity level decreases from NW to SE. A comparison of the geomorphic indices of the model output to those of the present-day topography of Perat and Akre anticlines revealed that it would take the Harir Anticline about 80–100 and 160–200&thinsp;kyr to reach the maturity level of the Perat and Akre anticlines, respectively, assuming erosion under constant conditions and constant rock uplift rates along the three anticlines. Since the factors controlling geomorphology (lithology, structural setting, and climate) are similar for all three anticlines, and under the assumption of constant growth and erosion conditions, we infer that uplift of the Akre Anticline started 160–200&thinsp;kyr before that of the Harir Anticline, with the Perat Anticline showing an intermediate age. A NW-ward propagation of the Harir Anticline itself implies that the uplift has been independent within different segments. Our method of estimating the relative age difference can be applied to many other anticlines in the Mountain Front Flexure region to construct a model of temporal evolution of this belt.</p

The Alpine-Carpathian-Dinaridic orogenic system: correlation and evolution of tectonic units

A correlation of tectonic units of the Alpine-Carpathian-Dinaridic system of orogens, including the substrate of the Pannonian and Transylvanian basins, is presented in the form of a map. Combined with a series of crustal-scale cross sections this correlation of tectonic units yields a clearer picture of the threedimensional architecture of this system of orogens that owes its considerable complexity to multiple overprinting of earlier by younger deformations. The synthesis advanced here indicates that none of the branches of the Alpine Tethys and Neotethys extended eastward into the Dobrogea Orogen. Instead, the main branch of the Alpine Tethys linked up with the Meliata- Maliac-Vardar branch of the Neotethys into the area of the present-day Inner Dinarides. More easterly and subsidiary branches of the Alpine Tethys separated Tisza completely, and Dacia partially, from the European continent. Remnants of the Triassic parts of Neotethys (Meliata-Maliac) are preserved only as ophiolitic mélanges present below obducted Jurassic Neotethyan (Vardar) ophiolites. The opening of the Alpine Tethys was largely contemporaneous with the Latest Jurassic to Early Cretaceous obduction of parts of the Jurassic Vardar ophiolites. Closure of the Meliata-Maliac Ocean in the Alps and West Carpathians led to Cretaceous-age orogeny associated with an eclogitic overprint of the adjacent continental margin. The Triassic Meliata- Maliac and Jurassic Western and Eastern Vardar ophiolites were derived from one single branch of Neotethys: the Meliata-Maliac-Vardar Ocean. Complex geometries resulting from out-of-sequence thrusting during Cretaceous and Cenozoic orogenic phases underlay a variety of multi-ocean hypotheses, that were advanced in the literature and that we regard as incompatible with the field evidence. The present-day configuration of tectonic units suggests that a former connection between ophiolitic units in West Carpathians and Dinarides was disrupted by substantial Miocene-age dislocations along the Mid-Hungarian Fault Zone, hiding a former lateral change in subduction polarity between West Carpathians and Dinarides. The SW-facing Dinaridic Orogen, mainly structured in Cretaceous and Palaeogene times, was juxtaposed with the Tisza and Dacia Mega-Units along a NW-dipping suture (Sava Zone) in latest Cretaceous to Palaeogene times. The Dacia Mega-Unit (East and South Carpathian Orogen, including the Carpatho-Balkan Orogen and the Biharia nappe system of the Apuseni Mountains), was essentially consolidated by E-facing nappe stacking during an Early Cretaceous orogeny, while the adjacent Tisza Mega-Unit formed by NW-directed thrusting (in present-day coordinates) in Late Cretaceous times. The polyphase and multi-directional Cretaceous to Neogene deformation history of the Dinarides was preceded by the obduction of Vardar ophiolites onto to the Adriatic margin (Western Vardar Ophiolitic Unit) and parts of the European margin (Eastern Vardar Ophiolitic Unit) during Late Jurassic to Early Cretaceous times

ADRIA LITHOSPHERE INVESTIGATION ALPHA - Cruise No. M86/3, January 20 - February 04, 2012, Brindisi (Italy) - Dubrovnik (Croatia)

The Adriatic Sea and underlying lithosphere remains the least investigated part of the Mediterranean Sea. To shed light on the plate tectonic setting in this central part of southern Europe, R/V METEOR cruise M86/3 set out to acquire deep penetrating seismic data in the Adriatic Sea. M86/3 formed the core of an amphibious investigation crossing Adria from the Italian Peninsula into Montenegro/Albania. A total of 111 OBS/OBH deployments were successfully carried out, in addition to 47 landstations both in Italy and Montenegro/Albania, which recorded the offshore airgun shots. In the scope of this shoreline-crossing study, the aim is to quantify the shallow geometry, deep boundaries and the architecture of the southern Adriatic crust and lithosphere and to provide insights on a possible decoupling zone between the northern and southern Adriatic domains. Investigating the structure of the Adriatic crust and lithospheric mantle and analyzing the tectonic activity are essential for understanding the mountain-building processes that underlie the neotectonics and earthquake hazard of the Periadriatic region, especially in the vicinity of local decoupling zones

Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma

Cellular processes like differentiation, mitotic cycle, and cell growth are regulated by tyrosine kinases with known oncogenic potential and tyrosine phosphatases that downmodulate the first. Therefore, tyrosine phosphatases are recurrent targets of gene alterations in human carcinomas. We and others suggested recently a tumor suppressor function of the PTPRD tyrosine phosphatase and reported homozygous deletions of the PTPRD locus in laryngeal squamous cell carcinoma. In this study, we investigated other gene-inactivating mechanisms potentially targeting PTPRD, including loss-of-function mutations and also epigenetic alterations like promoter DNA hypermethylation. We sequenced the PTPRD gene in eight laryngeal squamous cell carcinoma cell lines but did not identify any inactivating mutations. In contrast, by bisulfite pyrosequencing of the gene promoter region, we identified significantly higher levels of methylation (p = 0.001 and p = 0.0002, respectively) in 9/14 (64%) laryngeal squamous cell carcinoma cell lines and 37/79 (47%) of primary laryngeal squamous cell carcinoma tumors as compared to normal epithelium of the upper aerodigestive tract. There was also a strong correlation (p = 0.0001) between methylation and transcriptional silencing for the PTPRD gene observed in a cohort of 497 head and neck tumors from The Cancer Genome Atlas dataset suggesting that DNA methylation is the main mechanism of PTPRD silencing in these tumors. In summary, our data provide further evidence of the high incidence of PTPRD inactivation in laryngeal squamous cell carcinoma. We suggest that deletions and loss-of-function mutations are responsible for PTPRD loss only in a fraction of cases, whereas DNA methylation is the dominating mechanism of PTPRD inactivation.</p

Linking the northern Alps with their foreland: The latest exhumation history resolved by low-temperature thermochronology

The evolution of the Central Alpine deformation front (Subalpine Molasse) and its undeformed foreland is recently debated because of their role for deciphering the late orogenic evolution of the Alps. Its latest exhumation history is poorly understood due to the lack of late Miocene to Pliocene sediments. We constrain the late Miocene to Pliocene history of this transitional zone with apatite fission track and (U-Th)/He data. We used laser ablation inductively coupled mass spectrometry for apatite fission track dating and compare this method with previously published and unpublished external detector method fission track data. Two investigated sections across tectonic slices show that the Subalpine Molasse was tectonically active after the onset of folding of the Jura Mountains. This is much younger than hitherto assumed. Thrusting occurred at 10, 8, 6–5 Ma and potentially thereafter. This is contemporaneous with reported exhumation of the External Crystalline Massifs in the central Alps. The Jura Mountains and the Subalpine Molasse used the same detachments as the External Crystalline Massifs and are therefore kinematically coupled. Estimates on the amount of shortening and thrust displacement corroborate this idea. We argue that the tectonic signal is related to active shortening during the late stage of orogenesis

Ecological divergence of Chaetopteryx rugulosa species complex (Insecta, Trichoptera) linked to climatic niche diversification

Climate is often considered to be an important, but indirect driver of speciation. Indeed, environmental factors may contribute to the formation of biodiversity, but to date this crucial relationship remains largely unexplored. Here we investigate the possible role of climate, geological factors, and biogeographical processes in the formation of a freshwater insect species group, the Chaetopteryx rugulosa species complex (Trichoptera) in the Western Balkans. We used multi-locus DNA sequence data to establish a dated phylogenetic hypothesis for the group. The comparison of the dated phylogeny with the geological history of the Western Balkans shows that lineage formation coincided with major past Earth surface and climatic events in the region. By reconstructing present-day habitat conditions (climate, bedrock geology), we show that the lineages of C. rugulosa species complex have distinct climatic but not bedrock geological niches. Without exception, all splits associated with Pliocene/Pleistocene transition led to independent, parallel split into ‘warm’ and ‘cold’ sister lineages. This indicates a non-random diversification on the C. rugulosa species complex associated with late Pliocene climate in the region. We interpreted the results as the diversification of the species complex were mainly driven by ecological diversification linked to past climate change, along with geographical isolation

Graben width controlling syn-rift sedimentation : the Palaeogene southern Upper Rhine Graben as an example

Eocene to Early Oligocene syn-rift deposits of the southern Upper Rhine Graben (URG) accumulated in restricted environments. Sedimentation was controlled by local clastic supply from the graben flanks, as well as by strong intra-basinal variations in accommodation space due to differential tectonic subsidence, that in turn led to pronounced lateral variations in depositional environment. Three large-scale cycles of intensified evaporite sedimentation were interrupted by temporary changes towards brackish or freshwater conditions. They form three major base level cycles that can be traced throughout the basin, each of them representing a stratigraphic sub-unit. A relatively constant amount of horizontal extension (DL) in the range of 4-5 km has been estimated for the URG from numerous cross-sections. The width of the rift (Lf), however, varies between 35 and more than 60 km, resulting in a variable crustal stretching factor between the bounding masterfaults. Apart from block tilting, tectonic subsidence was, therefore, largely controlled by changes in the initial rift width (L0). The along-strike variations of the graben width are responsible for the development of a deep, trough-like evaporite basin (Potash Basin) in the narrowest part of the southern URG, adjacent to shallow areas in the wider parts of the rift such as the Colmar Swell in the north and the Rhine Bresse Transfer Zone that delimits the URG to the south. Under a constant amount of extension, the along-strike variation in rift width is the principal factor controlling depo-centre development in extensional basins