Search for partial resistance to leaf rust in a collection of ancient Spanish wheats

A collection of 917 accessions of Spanish durum and bread wheat was screened for resistance to leaf rust (Puccinia triticina) under field conditions at three locations. Resistance levels ranged from very low to very high, high susceptibility being most frequent. Relative disease severity (referred to the most susceptible accession = 100 %) was lower than 20 % in about 6 % of the accessions in each location. In the collection most of the lines (84 %)displayed a susceptible infection type. A final selection of seven accessions (one of them durum) displaying low severity level in the field and high infection type in a growth chamber was chosen for further studies. High levels of partial resistant with longer latency period and high percentage of early aborted colonies without necrosis were found. They might be used in breeding programmes

Efectos derrame interestatales y transfronterizos de la red de carreteras: Un estudio para México

El objetivo de esta investigación es identificar la existencia de efectos derrame de la infraestructura carretera nacional y transfronteriza de Estados Unidos sobre la producción en México, a través de la implementación de un modelo de fronteras estocásticas. Para ello, se han elaborado indicadores espaciales que capturan estos efectos y que recogen la influencia de las entidades federativas contiguas a cada una de ellas. Los resultados muestran que tanto las carreteras nacionales como las transfronterizas generan un efecto favorable para la producción, reduciendo la ineficiencia técnica estatal, generando efectos derrame entre las entidades federativas contiguas

Eficiencia técnica de las entidades federativas de México

El interés por tener una medida de la eficiencia técnica parte de que se acepta la existencia de una brecha entre el supuesto teórico de eficiencia técnica total y la observada en la realidad empírica, por lo que se abre la posibilidad de mejorar el output únicamente optimizando los inputs. En este contexto, el objetivo de esta investigación es obtener un indicador de niveles de eficiencia técnica que permita identificar la posición relativa y la evolución temporal en las entidades federativas de México respecto a su frontera eficiente. En particular, se aproxima la frontera de producción mediante el análisis de fronteras estocásticas planteado por Battese y Coelli. El resultado general permite identificar que se puede ampliar la producción en aproximadamente 20%. Asimismo, se elabora un ranking de eficiencia técnica para las entidades federativas de México

Frontera tecnológica y productividad total de los factores de las regiones de México

El objetivo de esta investigación es determinar la frontera tecnológica y la productividad total de los factores de las regiones socioeconómicas de México, y también su composición en cuanto al cambio técnico y cambio en eficiencia, mediante el análisis envolvente de datos y el índice de Malmquist. Según los resultados, el primero de los cambios es el más importante en la composición de la productividad total de los factores de las regiones del país, y el segundo no contribuye significativamente, por lo que existe mayor posibilidad de mejorar en el uso de los factores productivos, para lograr un acercamiento de las regiones a la frontera tecnológica. Así mismo, el cambio en productividad intertemporal es oscilante y está influido, en mayor medida, por el cambio técnico

Indicador de infraestructuras productivas por entidad federativa en México, 1970-2003

El objetivo de este trabajo es llevar a cabo la cuantificación de un indicador de infraestructuras en unidades físicas, que engloba las principales categorías (transportes, telecomunicaciones, abastecimiento de agua, energía eléctrica y drenaje), agregadas mediante la utilización del análisis multivariante. Este indicador ha permitido comprobar el hecho de que las entidades federativas que poseen gran parte de las infraestructuras pertenecen a las zonas en las que se observa mayor actividad económica

Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) has a variable prognosis; left atrial size, presence of clinical signs and left ventricular systolic function have been shown to predict outcomes. Mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) assess longitudinal ventricular systolic function and are decreased in cats with HCM. The aim of the study was to ascertain whether MAPSE and TAPSE have prognostic value in HCM and if cats with pleural effusion have lower MAPSE and TAPSE than cats with pulmonary oedema

Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study

Breast cancer (BC) is the most common tumour in women and one of the most important causes of cancer death worldwide. Radiation therapy (RT) is widely used for BC treatment. Some proteins have been identified as prognostic factors for BC (Ki67, p53, E‐cadherin, HER2). In the last years, it has been shown that variations in the expression of MMPs and TIMPs may contribute to the development of BC. The aim of this pilot work was to study the effects of RT on different MMPs (‐1, ‐2, ‐3, ‐7, ‐8, ‐9, ‐10, ‐12 and ‐13) and TIMPs (‐1 to ‐4), as well as their relationship with other variables related to patient characteristics and tumour biology. A group of 20 BC patients treated with RT were recruited. MMP and TIMP serum levels were analysed by immunoassay before, during and after RT. Our pilot study showed a slight increase in the levels of most MMP and TIMP with RT. However, RT produced a significantly decrease in TIMP‐1 and TIMP‐3 levels. Significant correlations were found between MMP‐3 and TIMP‐4 levels, and some of the variables studied related to patient characteristics and tumour biology. Moreover, MMP‐9 and TIMP‐3 levels could be predictive of RT toxicity. For this reason, MMP‐3, MMP‐9, TIMP‐3 and TIMP‐4 could be used as potential prognostic and predictive biomarkers for BC patients treated with RT.FUNDACIÓN PROGRESO Y SALUD, Grant/Award Number: PI‐730; Instituto de Salud Carlos III, Grant/Award Number: PIE16‐00045; Oncología Básica y Clínica, Grant/Award Number: CTS‐20

Direct oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial fibrillation.

Background: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. Methods: Data from patients treated with NOACs (n=99) and VKA (n=433) at 9 inherited cardiac diseases units were retrospectively collected. Annual rates of embolic events, serious bleeding and death were analysed and compared. Quality of life and treatment satisfaction were evaluated with SF-36 and SAFUCA questionnaires in 80 NOAC-treated and 57 VKA-treated patients. Results: After median follow-up of 63 months (IQR:26–109), thromboembolic events (TIA/stroke and peripheral embolism) occurred in 10% of patients on oral anticoagulation. Major/clinically relevant bleeding occurred in 3.8% and the global mortality rate was 23.3%. Thromboembolic event rate was 0.62 per 100 patient-years in the NOAC group vs. 1.59 in the VKA group [subhazard ratio (SHR) 0.32;95%CI:0.04– 2.45;p=0.27]. Major/clinically relevant bleeding occurred in 0.62 per 100 person-years in the NOAC group vs. 0.60 in the VKA group (SHR 1.28;95%CI 0.18–9.30;p=0.85). Quality of life scores were similar in both groups; however, NOAC-treated patients achieved higher scores in the SAFUCA. Conclusions: HCM patients with AF on NOACs showed similar embolic and bleeding rates to those on VKA. Although quality of life was similar in both groups, the NOAC group reported higher treatment satisfaction.pre-print929 K