5,893 research outputs found
Integrated systems analysis reveals a molecular network underlying autism spectrum disorders.
Autism is a complex disease whose etiology remains elusive. We integrated previously and newly generated data and developed a systems framework involving the interactome, gene expression and genome sequencing to identify a protein interaction module with members strongly enriched for autism candidate genes. Sequencing of 25 patients confirmed the involvement of this module in autism, which was subsequently validated using an independent cohort of over 500 patients. Expression of this module was dichotomized with a ubiquitously expressed subcomponent and another subcomponent preferentially expressed in the corpus callosum, which was significantly affected by our identified mutations in the network center. RNA-sequencing of the corpus callosum from patients with autism exhibited extensive gene mis-expression in this module, and our immunochemical analysis showed that the human corpus callosum is predominantly populated by oligodendrocyte cells. Analysis of functional genomic data further revealed a significant involvement of this module in the development of oligodendrocyte cells in mouse brain. Our analysis delineates a natural network involved in autism, helps uncover novel candidate genes for this disease and improves our understanding of its molecular pathology
Non equilibrium anisotropic excitons in atomically thin ReS
We present a systematic investigation of the electronic properties of bulk
and few layer ReS van der Waals crystals using low temperature optical
spectroscopy. Weak photoluminescence emission is observed from two
non-degenerate band edge excitonic transitions separated by 20 meV. The
comparable emission intensity of both excitonic transitions is incompatible
with a fully thermalized (Boltzmann) distribution of excitons, indicating the
hot nature of the emission. While DFT calculations predict bilayer ReS to
have a direct fundamental band gap, our optical data suggests that the
fundamental gap is indirect in all cases
A Computational Approach for Designing Tiger Corridors in India
Wildlife corridors are components of landscapes, which facilitate the
movement of organisms and processes between intact habitat areas, and thus
provide connectivity between the habitats within the landscapes. Corridors are
thus regions within a given landscape that connect fragmented habitat patches
within the landscape. The major concern of designing corridors as a
conservation strategy is primarily to counter, and to the extent possible,
mitigate the effects of habitat fragmentation and loss on the biodiversity of
the landscape, as well as support continuance of land use for essential local
and global economic activities in the region of reference. In this paper, we
use game theory, graph theory, membership functions and chain code algorithm to
model and design a set of wildlife corridors with tiger (Panthera tigris
tigris) as the focal species. We identify the parameters which would affect the
tiger population in a landscape complex and using the presence of these
identified parameters construct a graph using the habitat patches supporting
tiger presence in the landscape complex as vertices and the possible paths
between them as edges. The passage of tigers through the possible paths have
been modelled as an Assurance game, with tigers as an individual player. The
game is played recursively as the tiger passes through each grid considered for
the model. The iteration causes the tiger to choose the most suitable path
signifying the emergence of adaptability. As a formal explanation of the game,
we model this interaction of tiger with the parameters as deterministic finite
automata, whose transition function is obtained by the game payoff.Comment: 12 pages, 5 figures, 6 tables, NGCT conference 201
Global behavior of cosmological dynamics with interacting Veneziano ghost
In this paper, we shall study the dynamical behavior of the universe
accelerated by the so called Veneziano ghost dark energy component locally and
globally by using the linearization and nullcline method developed in this
paper. The energy density is generalized to be proportional to the Hawking
temperature defined on the trapping horizon instead of Hubble horizon of the
Friedmann-Robertson-Walker (FRW) universe. We also give a prediction of the
fate of the universe and present the bifurcation phenomenon of the dynamical
system of the universe. It seems that the universe could be dominated by dark
energy at present in some region of the parameter space.Comment: 8 pages, 7 figures, accepted for publication in JHE
Unexpected features of branched flow through high-mobility two-dimensional electron gases
GaAs-based two-dimensional electron gases (2DEGs) show a wealth of remarkable
electronic states, and serve as the basis for fast transistors, research on
electrons in nanostructures, and prototypes of quantum-computing schemes. All
these uses depend on the extremely low levels of disorder in GaAs 2DEGs, with
low-temperature mean free paths ranging from microns to hundreds of microns.
Here we study how disorder affects the spatial structure of electron transport
by imaging electron flow in three different GaAs/AlGaAs 2DEGs, whose mobilities
range over an order of magnitude. As expected, electrons flow along narrow
branches that we find remain straight over a distance roughly proportional to
the mean free path. We also observe two unanticipated phenomena in
high-mobility samples. In our highest-mobility sample we observe an almost
complete absence of sharp impurity or defect scattering, indicated by the
complete suppression of quantum coherent interference fringes. Also, branched
flow through the chaotic potential of a high-mobility sample remains stable to
significant changes to the initial conditions of injected electrons.Comment: 22 pages, 4 figures, 1 tabl
Design Rules for Self-Assembly of 2D Nanocrystal/Metal-Organic Framework Superstructures.
We demonstrate the guiding principles behind simple two dimensional self-assembly of MOF nanoparticles (NPs) and oleic acid capped iron oxide (Fe3 O4 ) NCs into a uniform two-dimensional bi-layered superstructure. This self-assembly process can be controlled by the energy of ligand-ligand interactions between surface ligands on Fe3 O4 NCs and Zr6 O4 (OH)4 (fumarate)6 MOF NPs. Scanning transmission electron microscopy (TEM)/energy-dispersive X-ray spectroscopy and TEM tomography confirm the hierarchical co-assembly of Fe3 O4 NCs with MOF NPs as ligand energies are manipulated to promote facile diffusion of the smaller NCs. First-principles calculations and event-driven molecular dynamics simulations indicate that the observed patterns are dictated by combination of ligand-surface and ligand-ligand interactions. This study opens a new avenue for design and self-assembly of MOFs and NCs into high surface area assemblies, mimicking the structure of supported catalyst architectures, and provides a thorough fundamental understanding of the self-assembly process, which could be a guide for designing functional materials with desired structure
The SuperCOSMOS Sky Survey. Paper III: Astrometry
In this, the third in a series of three papers concerning the SuperCOSMOS Sky
Survey, we describe the astrometric properties of the database. We describe the
algorithms employed in the derivation of the astrometric parameters of the
data, and demonstrate their accuracies by comparison with external datasets
using the first release of data, the South Galactic Cap survey. We show that
the celestial coordinates, which are tied to the International Celestial
Reference Frame via the Tycho-2 reference catalogue, are accurate to better
than +/- 0.2 arcsec at J,R=19,18 rising to +/- 0.3 arcsec at J,R=22,21 with
positional dependent systematic effects from bright to faint magnitudes at the
+/- 0.1 arcsec level. The proper motion measurements are shown to be accurate
to typically +/- 10 mas/yr at J,R=19,18 rising to +/- 50 mas/yr at J,R=22,21
and are tied to zero using the extragalactic reference frame. We show that the
zeropoint errors in the proper motions are 17 and are no
larger than 10 mas/yr for R < 17 mas/yr.Comment: 15 pages, 12 figures; accepted for publication in MNRA
Systematic decay studies of even-even ^Nd, ^Gd, ^Hg and ^Pb isotopes
The alpha and cluster decay properties of the ^Nd, ^Gd,
^Hg and ^Pb even-even isotopes in the two mass regions A =
130-158 and A = 180-198 are analysed using the Coulomb and Proximity Potential
Model. On examining the clusters at corresponding points in the cold valleys
(points with same A_2) of the various isotopes of a particular nucleus we find
that at certain mass numbers of the parent nuclei, the clusters emitted are
getting shifted to the next lower atomic number. It is interesting to see that
the change in clusters appears at those isotopes where a change in shape is
occurring correspondingly. Such a change of clusters with shape change is
studied for the first time in cluster decay. The alpha decay half lives of
these nuclei are computed and these are compared with the available
experimental alpha decay data. It is seen that the two are in good agreement.
On making a comparison of the alpha half lives of the normal deformed and super
deformed nuclei, it can be seen that the normal deformed ^Nd, ^Hg
and ^Pb nuclei are found to be better alpha emitters than the super
deformed (in excited state) ^Nd, ^Hg and ^Pb nuclei. The
cluster decay studies reveal that as the atomic number of the parent nuclei
increases the N \neq Z cluster emissions become equally or more probable than
the N=Z emissions. On the whole the alpha and cluster emissions are more
probable from the parents in the heavier mass region (A=180-198) than from the
parents in the lighter mass region (A= 130-158). The effect of quadrupole
({\beta}_2) and hexadecapole ({\beta}_4) deformations of parent and fragments
on half life times are also studied.Comment: 42 pages,19 figure
Congenital isolated right radial club hand
Congenital radial club hand (RCH) is an uncommon congenital anomaly characterized by various degrees of deficiency along the preaxial or radial side of the extremity. We present one such case of Type 4 congenital isolated RCH who presented to a tertiary care center in the Middle East
Non-polynomial Worst-Case Analysis of Recursive Programs
We study the problem of developing efficient approaches for proving
worst-case bounds of non-deterministic recursive programs. Ranking functions
are sound and complete for proving termination and worst-case bounds of
nonrecursive programs. First, we apply ranking functions to recursion,
resulting in measure functions. We show that measure functions provide a sound
and complete approach to prove worst-case bounds of non-deterministic recursive
programs. Our second contribution is the synthesis of measure functions in
nonpolynomial forms. We show that non-polynomial measure functions with
logarithm and exponentiation can be synthesized through abstraction of
logarithmic or exponentiation terms, Farkas' Lemma, and Handelman's Theorem
using linear programming. While previous methods obtain worst-case polynomial
bounds, our approach can synthesize bounds of the form
as well as where is not an integer. We present
experimental results to demonstrate that our approach can obtain efficiently
worst-case bounds of classical recursive algorithms such as (i) Merge-Sort, the
divide-and-conquer algorithm for the Closest-Pair problem, where we obtain
worst-case bound, and (ii) Karatsuba's algorithm for
polynomial multiplication and Strassen's algorithm for matrix multiplication,
where we obtain bound such that is not an integer and
close to the best-known bounds for the respective algorithms.Comment: 54 Pages, Full Version to CAV 201
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