A benefit-oriented framework for the decision-making process on the application of KMS in SME

The result of the presented PhD project is an artifact providing the SME practitioner with the KinS conceptual framework including method support. Therefore concepts from KM and KMS are newly combined and validated applying the perceived benefit approach of the KMS Success Model. The KinS framework uses the demand for support as the starting point for the perceived benefit and analyzes it with regard to the support opportunities by knowledge services. With the help of the framework, the gap in the knowledge base can be addressed and benefit-orientation in the KMS support can be provided

Risks of pregnancy and birth in obese primiparous women: an analysis of German perinatal statistics

Purpose: To compare risks of pregnancy and birth in obese (body mass index, BMI≥30) and normal weight women (BMI 18.5-24.99) giving birth to their first child. Methods: We analysed data of 243,571 pregnancies in primiparous women from the German perinatal statistics of 1998-2000. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for selected pregnancy and birth risks. ORs were adjusted for the confounding factors age, smoking status, single mother status, and maternal education. Results: Obesity during pregnancy is common in primiparous women (n=19,130; 7.9% of all cases) and it is significantly associated with a number of risks of pregnancy and birth, including diabetes [OR 3.71 (95% CI 2.93; 4.71); p<0.001], hypertension [OR 8.44 (7.91; 9.00); p<0.001], preecalmpsia/eclampsia [OR 6.72 (6.30; 7.17); p<0.001], intraamniotic infection [OR 2.33 (2.05; 2.64); p<0.001], birth weight ≥4,000g [OR 2.16 (2.05; 2.28); p<0.001], and an increased rate of Caesarean section [OR 2.23 (2.15; 2.30); p<0.001]. Some risks were less frequent in the obese such as cervical incompetence [OR 0.55 (0.48; 0.63); p<0.001] and preterm labour [OR 0.47 (0.43; 0.51); p<0.001]. Conclusions: Obesity during pregnancy is an important clinical problem in primiparous women because it is common and it is associated with a number of risks of pregnancy and birth. Because of these increased risks, obese women need special attention clinically during the course of their first pregnancy. Weight reduction before the first pregnancy is generally indicated in obese women to prevent the above-mentioned complications of pregnancy and birt

Risks of pregnancy and birth in obese primiparous women: an analysis of German perinatal statistics

PURPOSE: To compare risks of pregnancy and birth in obese (body mass index, BMI ≥ 30) and normal weight women (BMI 18.5–24.99) giving birth to their first child. METHODS: We analysed data of 243,571 pregnancies in primiparous women from the German perinatal statistics of 1998–2000. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for selected pregnancy and birth risks. ORs were adjusted for the confounding factors age, smoking status, single mother status, and maternal education. RESULTS: Obesity during pregnancy is common in primiparous women (n = 19,130; 7.9% of all cases) and it is significantly associated with a number of risks of pregnancy and birth, including diabetes [OR 3.71 (95% CI 2.93; 4.71); p &lt; 0.001], hypertension [OR 8.44 (7.91; 9.00); p &lt; 0.001], preecalmpsia/eclampsia [OR 6.72 (6.30; 7.17); p &lt; 0.001], intraamniotic infection [OR 2.33 (2.05; 2.64); p &lt; 0.001], birth weight ≥4,000 g [OR 2.16 (2.05; 2.28); p &lt; 0.001], and an increased rate of Caesarean section [OR 2.23 (2.15; 2.30); p &lt; 0.001]. Some risks were less frequent in the obese such as cervical incompetence [OR 0.55 (0.48; 0.63); p &lt; 0.001] and preterm labour [OR 0.47 (0.43; 0.51); p &lt; 0.001]. CONCLUSIONS: Obesity during pregnancy is an important clinical problem in primiparous women because it is common and it is associated with a number of risks of pregnancy and birth. Because of these increased risks, obese women need special attention clinically during the course of their first pregnancy. Weight reduction before the first pregnancy is generally indicated in obese women to prevent the above-mentioned complications of pregnancy and birth

Investigation of the association of Apgar score with maternal socio-economic and biological factors: an analysis of German perinatal statistics

PURPOSE: To examine the relationship of 5-min Apgar score with maternal socio-economic and biological factors. METHODS: We analyzed data from 465,964 singleton pregnancies (37–41 weeks’ gestation) from the German perinatal statistics of 1998–2000. Using a logistic regression model we analyzed the incidence of low (0–6) 5-min Apgar scores in relation to these maternal factors: body mass index (BMI), age, previous live births, country of origin, occupation, single mother status, working during pregnancy, and smoking. RESULTS: A low Apgar score was more common in overweight [adjusted odds ratio (OR) 1.24; 95% confidence interval (CI) 1.10–1.40; P &lt; 0.001] and obese [OR 1.92 (95% CI 1.67–2.20); P &lt; 0.001] compared to normal weight women. A low Apgar score was also more common for women aged &gt;35 years compared to those aged 20–35 years [OR 1.35 (95% CI 1.16–1.58); P &lt; 0.001]. Furthermore, odds of a low Apgar score were higher for women with no previous live births compared to those with one or more previous live births [OR 1.52 (95% CI 1.37–1.70); P &lt; 0.001]. Socio-economic factors did not convincingly influence Apgar scores. CONCLUSIONS: There was an influence of the biological maternal factors age, BMI, and parity on the 5-min Apgar score. There was no convincing effect of socio-economic factors on Apgar score in our study population. Possible reasons for this are discussed

Entwicklung einer Balanced-Scorecard zur Nutzenbewertung eines Lehr-Lern-Portals für die wissenschaftliche Weiterbildung

Lehr-Lern-Portale können eingesetzt werden, um Lernende durch das Bereitstellen von relevanten Informationen an einem zentralen Ort sinnvoll zu unterstützen. Es stellt sich jedoch schnell die Frage, wie der intuitiv erwartete Mehrwert bezüglich des Nutzens eines solchen Portals objektiv gemessen werden kann? Ansätze zur Qualitätsbewertung von Software fokussieren sich häufig auf einzelne Teilaspekte wie den wahrgenommenen Nutzen. Diese Arbeit präsentiert als ganzheitlichen Ansatz zur Nutzenbewertung eines Lehr-Lern-Portals eine angepasste Balanced-Scorecard am Beispiel des Portals „myKosmos“. Diese Arbeit entstand im Rahmen des Projekts KOSMOS, das darauf abzielt, ein Konzept für das Lebenslange Lernen an Hochschulen zu entwickeln, um traditionellen und nicht-traditionellen Zielgruppen individuell angepasste Studienmöglichkeiten auf universitärem Niveau anzubieten

Konzeption und Realisierung eines Portals für nicht-traditionelle Studienformate einer Universität

Die in diesem Aufsatz dargestellten Arbeiten entstanden im Projekt KOSMOS, das sich zum Ziel gesetzt, ein Konzept für das Lebenslange Lernen zu implementieren, in dessen Rahmen traditionellen und nicht-traditionellen Zielgruppen maßgeschneiderte Studienmöglichkeiten auf universitärem Niveau angeboten werden. Neue Studienformate ermöglichen die Aufnahme eines Studiums in allen Lebensphasen. Der Aufsatz konzentriert sich im Umfeld von KOSMOS auf die Frage, wie eine geeignete IT-Unterstützung für neue Zielgruppen und Studienformate aussehen muss. Die zentrale Idee ist ein kontextorientiertes informationstechnisches Portal für das e-Learning. Das Ergebnis ist das „MeinKOSMOS“ Portal mit einer individualisierten und bedarfsgerechten Informationsversorgung für die Lernenden. Der Beitrag beschreibt das Konzept für das Portal und Erfahrungen aus dessen Realisierung. Ein wichtiger Bestandteil ist dabei ein Leitfaden zur Bewertung, ob MeinKOSMOS für ein Studienformat geeignet ist bzw. wie das Portal dafür anzupassen ist

Konzeption und Realisierung eines Portals für nicht-traditionelle Studienformate einer Universität

Die in diesem Aufsatz dargestellten Arbeiten entstanden im Projekt KOSMOS, das sich zum Ziel gesetzt, ein Konzept für das Lebenslange Lernen zu implementieren, in dessen Rahmen traditionellen und nicht-traditionellen Zielgruppen maßgeschneiderte Studienmöglichkeiten auf universitärem Niveau angeboten werden. Neue Studienformate ermöglichen die Aufnahme eines Studiums in allen Lebensphasen. Der Aufsatz konzentriert sich im Umfeld von KOSMOS auf die Frage, wie eine geeignete IT-Unterstützung für neue Zielgruppen und Studienformate aussehen muss. Die zentrale Idee ist ein kontextorientiertes informationstechnisches Portal für das e-Learning. Das Ergebnis ist das „MeinKOSMOS“ Portal mit einer individualisierten und bedarfsgerechten Informationsversorgung für die Lernenden. Der Beitrag beschreibt das Konzept für das Portal und Erfahrungen aus dessen Realisierung. Ein wichtiger Bestandteil ist dabei ein Leitfaden zur Bewertung, ob MeinKOSMOS für ein Studienformat geeignet ist bzw. wie das Portal dafür anzupassen ist

Therapeutic miR-506-3p Replacement in Pancreatic Carcinoma Leads to Multiple Effects including Autophagy, Apoptosis, Senescence, and Mitochondrial Alterations In Vitro and In Vivo

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality. Considering its very poor prognosis, novel treatment options are urgently needed. MicroRNAs (miRNAs) are involved in the regulation of various physiological and pathological processes. In tumors, aberrant downregulation of given miRNAs may result in pathological overexpression of oncogenes, rendering miRNA replacement as a promising therapeutic strategy. In different tumor entities, miRNA-506-3p (miR506-3p) has been ambivalently described as tumor suppressing or oncogenic. In PDAC, miR-506 is mainly considered as a tumor-suppressing miRNA. In this study, we extensively analyze the cellular and molecular effects of miRNA-506-3p replacement in different PDAC cell lines. Beyond profound antiproliferation and induction of cell death and autophagy, we describe new cellular miR506-3p effects, i.e., induction of senescence and reactive oxygen species (ROS), as well as alterations in mitochondrial potential and structure, and identify multiple underlying molecular effects. In a preclinical therapy study, PDAC xenograft-bearing mice were treated with nanoparticle-formulated miRNA-506 mimics. Profound tumor inhibition upon systemic miRNA-506 administration was associated with multiple cellular and molecular effects. This demonstrates miRNA replacement as a potential therapeutic option for PDAC patients. Due to its broad mechanisms of action on multiple relevant target genes, miR506-3p is identified as a particularly powerful tumor-inhibitory miRNA