124 research outputs found
Forster energy transfer signatures in optically driven quantum dot molecules
The Forster resonant energy transfer mechanism (FRET) is investigated in
optically driven and electrically gated tunnel coupled quantum dot molecules.
Two novel FRET induced optical signatures are found in the dressed excitonic
spectrum. This is constructed from exciton level occupation as function of pump
laser energy and applied bias, resembling a level anticrossing spectroscopy
measurement. We observe a redistribution of spectral weight and splitting of
the exciton spectral lines. FRET among single excitons induces a splitting in
the spatially-direct exciton lines, away from the anticrossing due to charge
tunneling in the molecule. However, near the anticrossing, a novel signature
appears as a weak satellite line following an indirect exciton line. FRET
signatures may also occur among indirect excitons, appearing as split indirect
lines. In that case, the signatures appear also in the direct biexciton states,
as the indirect satellite mixes in near the tunneling anticrossing region
Coherent control of indirect excitonic qubits in optically driven quantum dot molecules
We propose an optoelectronic scheme to define and manipulate an indirect
neutral exciton qubit within a quantum dot molecule. We demonstrate coherent
dynamics of indirect excitons resilient against decoherence effects, including
direct exciton spontaneous recombination. For molecules with large interdot
separation, the exciton dressed spectrum yields an often overlooked avoided
crossing between spatially indirect exciton states. Effective two level system
Hamiltonians are extracted by Feshbach projection over the multilevel exciton
configurations. An adiabatic manipulation of the qubit states is devised using
time dependent electric field sweeps. The exciton dynamics yields the necessary
conditions for qubit initialization and near unitary rotations in the
picosecond time scale, driven by the system internal dynamics. Despite the
strong influence of laser excitation, charge tunneling, and interdot
dipole-dipole interactions, the effective relaxation time of indirect excitons
is much longer than the direct exciton spontaneous recombination time,
rendering indirect excitons as potential elemental qubits in more complex
schemes.Comment: Submitted to PRB, 11 pages and 6 figure
Aspectos generales de la metodología para el cálculo del Margen Bruto Estándar 2000
El objetivo de este documento de trabajo es presentar la metodología para el cálculo
del Margen Bruto Estándar con periodo de referencia 1999, 2000 y 2001 (MBE 2000) y
para el conjunto de categorías agrícolas definidas en el anexo de la Decisión de la Comisión
2003/369/CE. En este documento, dichas categorías vienen recogidas en el cuadro 2 del
anexo.
Este documento de trabajo se divide en tres secciones. En la sección 1 se presenta
el marco metodológico general recogido en la legislación comunitaria, prestando especial
interés a la definición de MBE. Las secciones 2 y 3 presentan, de forma resumida, la
metodología seguida para el cálculo de los coeficientes MBE 2000 de las categorías de
cultivos y ganados respectivamente
Serologic Evidence of West Nile Virus Infection in Horses, Coahuila State, Mexico
Serum samples were obtained from 24 horses in the State of Coahuila, Mexico, in December 2002. Antibodies to West Nile virus were detected by epitope-blocking enzyme-linked immunosorbent assay and confirmed by plaque reduction neutralization test in 15 (62.5%) horses. We report the first West Nile virus activity in northern Mexico
Planeación y estrategia de Ferris en el simulador de negocios capstone
En este documento se presenta el trabajo realizado en el simulador de negocios Capstone, en donde se dirigió una empresa de sensores llamada Ferris. Se presenta la planeación estratégica que se aplicó, su desarrollo y los resultados.ITESO, A.C
Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers
Many G-protein-coupled receptors, including the α1b-adrenoceptor, form homo-dimers or oligomers. Mutation of hydrophobic residues in transmembrane domains I and IV alters the organization of the α1b-adrenoceptor oligomer, with transmembrane domain IV playing a critical role. These mutations also result in endoplasmic reticulum trapping of the receptor. Following stable expression of this α1b-adrenoceptor mutant, cell surface delivery, receptor function and structural organization were recovered by treatment with a range of α1b-adrenoceptor antagonists that acted at the level of the endoplasmic reticulum. This was accompanied by maturation of the mutant receptor to a terminally N-glycosylated form, and only this mature form was trafficked to the cell surface. Co-expression of the mutant receptor with an otherwise wild-type form of the α1b-adrenoceptor that is unable to bind ligands resulted in this wild-type variant also being retained in the endoplasmic reticulum. Ligand-induced cell surface delivery of the mutant α1b-adrenoceptor now allowed co-recovery to the plasma membrane of the ligand-binding-deficient mutant. These results demonstrate that interactions between α1b-adrenoceptor monomers occur at an early stage in protein synthesis, that ligands of the α1b-adrenoceptor can act as pharmacological chaperones to allow a structurally compromised form of the receptor to pass cellular quality control, that the mutated receptor is not inherently deficient in function and that an oligomeric assembly of ligand-binding-competent and -incompetent forms of the α1b-adrenoceptor can be trafficked to the cell surface by binding of a ligand to only one component of the receptor oligomer
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
[Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular model of transmitochondrial cybrids.
Methods: Three prospective cohorts contributed participants. The osteoarthritis initiative (OAI) included 1095 subjects, the Cohort Hip and Cohort Knee included 373 and 326 came from the PROspective Cohort of Osteoarthritis from A Coruña. mtDNA variants were screened in an initial subset of 450 subjects from the OAI by in-depth sequencing of mtDNA. A meta-analysis of the three cohorts was performed. A model of cybrids was constructed to study the functional consequences of harbouring the risk mtDNA variant by assessing: mtDNA copy number, mitochondrial biosynthesis, mitochondrial fission and fusion, mitochondrial reactive oxygen species (ROS), oxidative stress, autophagy and a whole transcriptome analysis by RNA-sequencing.
Results: mtDNA variant m.16519C is over-represented in rapid progressors (combined OR 1.546; 95% CI 1.163 to 2.054; p=0.0027). Cybrids with this variant show increased mtDNA copy number and decreased mitochondrial biosynthesis; they produce higher amounts of mitochondrial ROS, are less resistant to oxidative stress, show a lower expression of the mitochondrial fission-related gene fission mitochondrial 1 and an impairment of autophagic flux. In addition, its presence modulates the transcriptome of cybrids, especially in terms of inflammation, where interleukin 6 emerges as one of the most differentially expressed genes.
Conclusions: The presence of the mtDNA variant m.16519C increases the risk of rapid progression of knee OA. Among the most modulated biological processes associated with this variant, inflammation and negative regulation of cellular process stand out. The design of therapies based on the maintenance of mitochondrial function is recommended
Self-assembled MgxZn1−xO quantum dots (0 ≤ x ≤ 1) on different substrates using spray pyrolysis methodology
By using the spray pyrolysis methodology in its classical configuration we have grown self-assembled MgxZn1−xO quantum dots (size [similar]4–6 nm) in the overall range of compositions 0 ≤ x ≤ 1 on c-sapphire, Si (100) and quartz substrates. Composition of the quantum dots was determined by means of transmission electron microscopy-energy dispersive X-ray analysis (TEM-EDAX) and X-ray photoelectron spectroscopy. Selected area electron diffraction reveals the growth of single phase hexagonal MgxZn1−xO quantum dots with composition 0 ≤ x ≤ 0.32 by using a nominal concentration of Mg in the range 0 to 45%. Onset of Mg concentration about 50% (nominal) forces the hexagonal lattice to undergo a phase transition from hexagonal to a cubic structure which resulted in the growth of hexagonal and cubic phases of MgxZn1−xO in the intermediate range of Mg concentrations 50 to 85% (0.39 ≤ x ≤ 0.77), whereas higher nominal concentration of Mg ≥ 90% (0.81 ≤ x ≤ 1) leads to the growth of single phase cubic MgxZn1−xO quantum dots. High resolution transmission electron microscopy and fast Fourier transform confirm the results and show clearly distinguishable hexagonal and cubic crystal structures of the respective quantum dots. A difference of 0.24 eV was detected between the core levels (Zn 2p and Mg 1s) measured in quantum dots with hexagonal and cubic structures by X-ray photoemission. The shift of these core levels can be explained in the frame of the different coordination of cations in the hexagonal and cubic configurations. Finally, the optical absorption measurements performed on single phase hexagonal MgxZn1−xO QDs exhibited a clear shift in optical energy gap on increasing the Mg concentration from 0 to 40%, which is explained as an effect of substitution of Zn2+ by Mg2+ in the ZnO lattice
West Nile Virus Isolation in Human and Mosquitoes, Mexico
West Nile virus has been isolated for the first time in Mexico, from a sick person and from mosquitoes (Culex quinquefasciatus). Partial sequencing and analysis of the 2 isolates indicate that they are genetically similar to other recent isolates from northern Mexico and the western United States
Robótica agrícola: proyecto Sureveg sobre agricultura ecológica en cultivos en franjas
The Sureveg project is a international consortium funded by CORE Organic Cofund devoted to foster biodiversity (above and below ground) by using new agricultural practices related to crop association in a strip-crop scheme, and applitying digital technologies (robotics, sensorics)for a organic sustainable production
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