A Realistic Radar Ray Tracing Simulator for Hand Pose Imaging

With the increasing popularity of human-computer interaction applications, there is also growing interest in generating sufficiently large and diverse data sets for automatic radar-based recognition of hand poses and gestures. Radar simulations are a vital approach to generating training data (e.g., for machine learning). Therefore, this work applies a ray tracing method to radar imaging of the hand. The performance of the proposed simulation approach is verified by a comparison of simulation and measurement data based on an imaging radar with a high lateral resolution. In addition, the surface material model incorporated into the ray tracer is highlighted in more detail and parameterized for radar hand imaging. Measurements and simulations show a very high similarity between synthetic and real radar image captures. The presented results demonstrate that it is possible to generate very realistic simulations of radar measurement data even for complex radar hand pose imaging systems.Comment: 4 pages, 5 figures, accepted at European Microwave Week (EuMW 2023) to the topic "R28 Human Activity Monitoring, including Gesture Recognition

Bone Loss after Allogeneic Haematopoietic Stem Cell Transplantation: A Pilot Study on the Use of Zoledronic Acid

Purpose. Bone loss is a common phenomenon following allogeneic haematopoietic stem cell transplantation (allo-HSCT). The study aimed on tolerance and efficacy of zoledronic acid (ZA) in patients after allo-HSCT. Methods. 40 patients' with osteoporosis or osteopenia were recruited on this phase II study. ZA was given at a dose of 4 mg IV every 3 months for 2 years (yrs). BMD was determined by dual-energy X-ray absorptiometry (LS lumbar spine, FH femur hip). Patients were evaluated for deoxypyridinoline (Dpd) and calcium excretion by longitudinal measurements. Results. 36 patients who had received at least 3 doses of ZA were evaluable. 26 patients had at least two BMD measurements since baseline (BMD group). Among these patients, BMD increased from 0.97 ± 0.15 to 1.10 ± 0.18 g/cm² (LS baseline—2 yrs, Δ+11.6 ± 6.0%, P < 0.001) and from 0.82 ± 0.10 to 0.91 ± 0.10 g/cm² (FH baseline—2 yrs, Δ+7.5 ± 7.0%, P < 0.001). Factors associated with an increase in BMD were younger age, female donor sex, and immunosuppression with CSA/MTX. Conclusion. ZA was generally well tolerated; it increases BMD and reduces Dpd excretion significantly in patients with bone loss after allo-HSCT

Gestación, puesta a punto y ejecución de una propuesta de abordaje vivencial y multidisciplinar para las ciencias naturales en la educación primaria

En este trabajo se describirá la gestación, puesta a punto e inicio de ejecución de un abordaje de tipo vivencial y multidisciplinar de las Ciencias Naturales a lo largo de la etapa de formación primaria. La experiencia descripta es el resultado de un ejercicio de interacción continua de más de cuatro años entre los directivos y la totalidad del cuerpo docente de nivel primario del Colegio Victoria Ocampo de la ciudad de Bahía Blanca con docentes e investigadores de la Universidad Nacional del Sur y el CONICET.Facultad de Humanidades y Ciencias de la Educació

Gestación, puesta a punto y ejecución de una propuesta de abordaje vivencial y multidisciplinar para las ciencias naturales en la educación primaria

En este trabajo se describirá la gestación, puesta a punto e inicio de ejecución de un abordaje de tipo vivencial y multidisciplinar de las Ciencias Naturales a lo largo de la etapa de formación primaria. La experiencia descripta es el resultado de un ejercicio de interacción continua de más de cuatro años entre los directivos y la totalidad del cuerpo docente de nivel primario del Colegio Victoria Ocampo de la ciudad de Bahía Blanca con docentes e investigadores de la Universidad Nacional del Sur y el CONICET.Facultad de Humanidades y Ciencias de la Educació

Gestación, puesta a punto y ejecución de una propuesta de abordaje vivencial y multidisciplinar para las ciencias naturales en la educación primaria

En este trabajo se describirá la gestación, puesta a punto e inicio de ejecución de un abordaje de tipo vivencial y multidisciplinar de las Ciencias Naturales a lo largo de la etapa de formación primaria. La experiencia descripta es el resultado de un ejercicio de interacción continua de más de cuatro años entre los directivos y la totalidad del cuerpo docente de nivel primario del Colegio Victoria Ocampo de la ciudad de Bahía Blanca con docentes e investigadores de la Universidad Nacional del Sur y el CONICET.Facultad de Humanidades y Ciencias de la Educació

Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model

Until recently, morpholino oligonucleotides have been widely employed in zebrafish as an acute and efficient loss-of-function assay. However, off-target effects and reproducibility issues when compared to stable knockout lines have compromised their further use. Here we employed an acute CRISPR/Cas approach using multiple single guide RNAs targeting simultaneously different positions in two exemplar genes (osgep or tprkb) to increase the likelihood of generating mutations on both alleles in the injected F0 generation and to achieve a similar effect as morpholinos but with the reproducibility of stable lines. This multi single guide RNA approach resulted in median likelihoods for at least one mutation on each allele of >99% and sgRNA specific insertion/deletion profiles as revealed by deep-sequencing. Immunoblot showed a significant reduction for Osgep and Tprkb proteins. For both genes, the acute multi-sgRNA knockout recapitulated the microcephaly phenotype and reduction in survival that we observed previously in stable knockout lines, though milder in the acute multi-sgRNA knockout. Finally, we quantify the degree of mutagenesis by deep sequencing, and provide a mathematical model to quantitate the chance for a biallelic loss-of-function mutation. Our findings can be generalized to acute and stable CRISPR/Cas targeting for any zebrafish gene of interest

Screening and contact precautions - A survey on infection control measures for multidrug-resistant bacteria in German university hospitals

To assess the scope of infection control measures for multidrug-resistant bacteria in high-risk settings, a survey among university hospitals was conducted. Fourteen professionals from 8 sites participated. Reported policies varied largely with respect to the types of wards conducting screening, sample types used for screening and implementation of contact precautions. This variability among sites highlights the need for an evidence-based consensus of current infection control policies

The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN

Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core. Applications from European PCD sites interested in participating in the PCD-CTN were requested. Inclusion criteria consisted of patient numbers, membership of ERN-LUNG PCD Core, use of associated standards of care, experience in PCD and/or CF clinical research, resources to run clinical trials, good clinical practice (GCP) certifications and institutional support. So far, applications from 22 trial sites in 18 European countries have been approved, including >1400 adult and >1600 paediatric individuals with PCD. The PCD-CTN is headed by a coordinating centre and consists of a steering and executive committee, a data safety monitoring board and committees for protocol review, training and standardisation. A strong association with patient organisations and industrial companies are further cornerstones. All participating trial sites agreed on a code of conduct. As CTNs from other diseases have demonstrated successfully, this newly formed PCD-CTN operates to establish evidence-based treatments for this orphan disease and to bring new personalised treatment approaches to patients

Mutations in KEOPS-Complex Genes Cause Nephrotic Syndrome with Primary Microcephaly

Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced apoptosis. Knockdown of OSGEP or TP53RK induced defects in the actin cytoskeleton and decreased the migration rate of human podocytes, an established intermediate phenotype of SRNS. We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms