Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis

Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis. Autoimmune tubulointerstitial nephritis (TIN) was induced in Lewis (LEW) rats by immunization with homologous Brown–Norway (BN) rat renal basement membrane (RBM), complete Freund's adjuvant and Bordetella pertussis vaccine. The BN strain has a tubular basement membrane (TBM) antigen (Ag+) detectable by immunofluorescence which is lacking in unmodified LEW rat TBM. Development of TIN in LEW rats correlated with TBM Ag+ immunogens from homologous and heterologous RBM preparations. By day 14 after immunization TIN developed characterized by elevated serum creatinine levels and by tubular destruction with focal, circumscribed lesions containing epithelioid cells, giant cells and mononuclear cell infiltrates. Approximately 60% of the mononuclear cells bore T cell antigens with most cells expressing la markers. Immunofluorescence and elution studies revealed no selective IgG fixation to TBM at day 14 despite high titers of circulating alloantibody reactive with the immunizing TBM. Intravenous transfer of LNC and/or splenic cells (3.5 to 7 × 108) to naive LEW rats resulted in less severe but histologically identical TIN in seven days with T cell subpopulations similar to those seen in the active model. This model strongly suggests an initiating role for cell–mediated immunity in TIN in the rat and may provide a parallel to human TIN

A-CHAIM: Near-Real-Time Data Assimilation of the High Latitude Ionosphere With a Particle Filter

The Assimilative Canadian High Arctic Ionospheric Model (A-CHAIM) is an operational ionospheric data assimilation model that provides a 3D representation of the high latitude ionosphere in Near-Real-Time (NRT). A-CHAIM uses low-latency observations of slant Total Electron Content (sTEC) from ground-based Global Navigation Satellite System (GNSS) receivers, ionosondes, and vertical TEC from the JASON-3 altimeter satellite to produce an updated electron density model above 45° geomagnetic latitude. A-CHAIM is the first operational use of a particle filter data assimilation for space environment modeling, to account for the nonlinear nature of sTEC observations. The large number (>104 ) of simultaneous observations creates significant problems with particle weight degeneracy, which is addressed by combining measurements to form new composite observables. The performance of A-CHAIM is assessed by comparing the model outputs to unassimilated ionosonde observations, as well as to in-situ electron density observations from the SWARM and DMSP satellites. During moderately disturbed conditions from 21 September 2021 through 29 September 2021, A-CHAIM demonstrates a 40%–50% reduction in error relative to the background model in the F2-layer critical frequency (foF2) at midlatitude and auroral reference stations, and little change at higher latitudes. The height of the F2-layer (hmF2) shows a small 5%–15% improvement at all latitudes. In the topside, A-CHAIM demonstrates a 15%–20% reduction in error for the Swarm satellites, and a 23%–28% reduction in error for the DMSP satellites. The reduction in error is distributed evenly over the assimilation region, including in data-sparse regions

Long-term determination of energetic electron precipitation into the atmosphere from AARDDVARK subionospheric VLF observations

We analyze observations of subionospherically propagating very low frequency (VLF) radio waves to determine outer radiation belt energetic electron precipitation (EEP) flux magnitudes. The radio wave receiver in Sodankylä, Finland (Sodankylä Geophysical Observatory) observes signals from the transmitter with call sign NAA (Cutler, Maine). The receiver is part of the Antarctic-Arctic Radiation-belt Dynamic Deposition VLF Atmospheric Research Konsortia (AARDDVARK). We use a near-continuous data set spanning November 2004 until December 2013 to determine the long time period EEP variations. We determine quiet day curves over the entire period and use these to identify propagation disturbances caused by EEP. Long Wave Propagation Code radio wave propagation modeling is used to estimate the precipitating electron flux magnitudes from the observed amplitude disturbances, allowing for solar cycle changes in the ambient D region and dynamic variations in the EEP energy spectra. Our method performs well during the summer months when the daylit ionosphere is most stable but fails during the winter. From the summer observations, we have obtained 693 days worth of hourly EEP flux magnitudes over the 2004–2013 period. These AARDDVARK-based fluxes agree well with independent satellite precipitation measurements during high-intensity events. However, our method of EEP detection is 10–50 times more sensitive to low flux levels than the satellite measurements. Our EEP variations also show good agreement with the variation in lower band chorus wave powers, providing some confidence that chorus is the primary driver for the outer belt precipitation we are monitoring

All-sky interferometric riometry

The first implementation of a Fourier-based interferometric riometry technique for measuring electron density induced ionospheric opacity at VHF radio frequencies is presented. Unlike multibeam riometers, which form discrete beams on the sky, the interferometric technique permits all-sky sampling of incoming cosmic radio noise emissions resulting in a spatially-continuous radiogram of the entire sky. The map of the received power at each time may then be compared to the equivalent map from a “quiet day”, allowing the morphology of ionospheric absorption of cosmic radio noise to be ascertained. In this work, the high-latitude Kilpisjarvi Atmospheric Imaging Receiver Array (KAIRA) was used to carry out the first interferometric riometry measurements in late 2013, producing all-sky absorption maps of space weather related ionization in the D region

Exceptional middle latitude electron precipitation detected by balloon observations: implications for atmospheric composition

Energetic particle precipitation leads to ionization in the Earth\u27s atmosphere, initiating the formation of active chemical species which destroy ozone and have the potential to impact atmospheric composition and dynamics down to the troposphere. We report on one exceptionally strong high-energy electron precipitation event detected by balloon measurements in geomagnetic midlatitudes on 14 December 2009, with ionization rates locally comparable to strong solar proton events. This electron precipitation was possibly caused by wave–particle interactions in the slot region between the inner and outer radiation belts, connected with still poorly understood natural phenomena in the magnetosphere. Satellite observations of odd nitrogen and nitric acid are consistent with widespread electron precipitation into magnetic midlatitudes. Simulations with a 3D chemistry–climate model indicate the almost complete destruction of ozone in the upper mesosphere over the region where high-energy electron precipitation occurred. Such an extraordinary type of energetic particle precipitation can have major implications for the atmosphere, and their frequency and strength should be carefully studied

Mars Riometer System

A riometer (relative ionospheric opacity meter) measures the intensity of cosmic radio noise at the surface of a planet. When an electromagnetic wave passes through the ionosphere collisions between charged particles (usually electrons) and neutral gases remove energy from the wave. By measuring the received signal intensity at the planet's surface and comparing it to the expected value (the quietday curve) a riometer can deduce the absorption (attenuation) of the trans-ionospheric signal. Thus the absorption measurements provide an indication of ionisation changes occurring in the ionosphere. To avoid the need for orbiting sounders riometers use the cosmic noise background as a signal source. Earth-based systems are not subject to the challenging power, volume and mass restriction that would apply to a riometer for Mars. Some Earth-based riometers utilise phased-array antennas in order to provide an imaging capability

Rotational spectra of isotopic species of methyl cyanide, CH3_3CN, in their ground vibrational states up to terahertz frequencies

Methyl cyanide is an important trace molecule in star-forming regions. It is one of the more common molecules used to derive kinetic temperatures in such sources. As preparatory work for Herschel, SOFIA, and in particular ALMA we want to improve the rest frequencies of the main as well as minor isotopologs of methyl cyanide. The laboratory rotational spectrum of methyl cyanide in natural isotopic composition has been recorded up to 1.63 THz. Transitions with good signal-to-noise ratio could be identified for CH$_3$CN, $^{13}$CH$_3$CN, CH$_3^{13}$CN, CH$_3$C$^{15}$N, CH$_2$DCN, and $^{13}$CH$_3^{13}$CN in their ground vibrational states up to about 1.2 THz. The main isotopic species could be identified even in the highest frequency spectral recordings around 1.6 THz. The highest $J'$ quantum numbers included in the fit are 64 for $^{13}$CH$_3^{13}$CN and 89 for the main isotopic species. Greatly improved spectroscopic parameters have been obtained by fitting the present data together with previously reported transition frequencies. The present data will be helpful to identify isotopologs of methyl cyanide in the higher frequency bands of instruments such as the recently launched Herschel satellite, the upcoming airplane mission SOFIA or the radio telescope array ALMA.Comment: 13 pages, 2 figures, article appeared; CDMS links update

Ground-based estimates of outer radiation belt energetic electron precipitation fluxes into the atmosphere

AARDDVARK data from a radio wave receiver in Sodankyla, Finland have been used to monitor transmissions across the auroral oval and just into the polar cap from the very low frequency communications transmitter, call sign NAA (24.0 kHz, 44 degrees N, 67 degrees W, L = 2.9), in Maine, USA, since 2004. The transmissions are influenced by outer radiation belt (L = 3-7) energetic electron precipitation. In this study, we have been able to show that the observed transmission amplitude variations can be used to determine routinely the flux of energetic electrons entering the upper atmosphere along the total path and between 30 and 90 km. Our analysis of the NAA observations shows that electron precipitation fluxes can vary by 3 orders of magnitude during geomagnetic storms. Typically when averaging over L = 3-7 we find that the >100 keV POES "trapped" fluxes peak at about 10(6) el. cm(-2) s(-1) sr(-1) during geomagnetic storms, with the DEMETER >100 keV drift loss cone showing peak fluxes of 105 el. cm(-2) s(-1) sr(-1), and both the POES >100 keV "loss" fluxes and the NAA ground-based >100 keV precipitation fluxes showing peaks of similar to 10(4) el. cm(-2) s(-1) sr(-1). During a geomagnetic storm in July 2005, there were systematic MLT variations in the fluxes observed: electron precipitation flux in the midnight sector (22-06 MLT) exceeded the fluxes from the morning side (0330-1130 MLT) and also from the afternoon sector (1130-1930 MLT). The analysis of NAA amplitude variability has the potential of providing a detailed, near real-time, picture of energetic electron precipitation fluxes from the outer radiation belts

Multi-instrument observations of the Pajala fireball: Origin, characteristics, and atmospheric implications

Meteor observations provide information about Solar System constituents and their influx onto Earth, their interaction processes in the atmosphere, as well as the neutral dynamics of the upper atmosphere. This study presents optical, radar, and infrasound measurements of a daytime fireball that occurred on 4 December 2020 at 13:30 UTC over Northeast Sweden. The fireball was recorded with two video cameras, allowing a trajectory determination to be made. The orbital parameters are compatible with the Northern Taurid meteor shower. The dynamic mass estimate based on the optical trajectory was found to be 0.6–1.7 kg, but this estimate can greatly vary from the true entry mass significantly due to the assumptions made. The meteor trail plasma was observed with an ionosonde as a sporadic E-like ionogram trace that lasted for 30 min. Infrasound emissions were detected at two sites, having propagation times consistent with a source location at an altitude of 80–90 km. Two VHF specular meteor radars observed a 6 minute long non-specular range spread trail echo as well as a faint head echo. Combined interferometric range-Doppler analysis of the meteor trail echoes at the two radars, allowed estimation of the mesospheric horizontal wind altitude profile, as well as tracking of the gradual deformation of the trail over time due to a prevailing neutral wind shear. This combined analysis indicates that the radar measurements of long-lived non-specular range-spread meteor trails produced by larger meteoroids can be used to measure the meteor radiant by observing the line traveled by the meteor. Furthermore, a multistatic meteor radar observation of these types of events can be used to estimate mesospheric neutral wind altitude profiles

Separating Nightside Interplanetary And Ionospheric Scintillation With Lofar

Observation of interplanetary scintillation (IPS) beyond Earth-orbit can be challenging due to the necessity to use low radio frequencies at which scintillation due to the ionosphere could confuse the interplanetary contribution. A recent paper by Kaplan {\it et al} (2015) presenting observations using the Murchison Widefield Array (MWA) reports evidence of night-side IPS on two radio sources within their field of view. However, the low time cadence of 2\,s used might be expected to average out the IPS signal, resulting in the reasonable assumption that the scintillation is more likely to be ionospheric in origin. To verify or otherwise this assumption, this letter uses observations of IPS taken at a high time cadence using the Low Frequency Array (LOFAR). Averaging these to the same as the MWA observations, we demonstrate that the MWA result is consistent with IPS, although some contribution from the ionosphere cannot be ruled out. These LOFAR observations represent the first of night-side IPS using LOFAR, with solar wind speeds consistent with a slow solar wind stream in one observation and a CME expecting to be observed in another.Comment: Accepted for publication in Astrophysical Journal Letter