6,986 research outputs found
Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity
San Martin, J (San Martin, Jose). Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, ChileThe extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectivel
Multiplicative processes and power laws
[Takayasu et al., Phys. Rev.Lett. 79, 966 (1997)] revisited the question of
stochastic processes with multiplicative noise, which have been studied in
several different contexts over the past decades. We focus on the regime, found
for a generic set of control parameters, in which stochastic processes with
multiplicative noise produce intermittency of a special kind, characterized by
a power law probability density distribution. We briefly explain the physical
mechanism leading to a power law pdf and provide a list of references for these
results dating back from a quarter of century. We explain how the formulation
in terms of the characteristic function developed by Takayasu et al. can be
extended to exponents , which explains the ``reason of the lucky
coincidence''. The multidimensional generalization of (\ref{eq1}) and the
available results are briefly summarized. The discovery of stretched
exponential tails in the presence of the cut-off introduced in \cite{Taka} is
explained theoretically. We end by briefly listing applications.Comment: Extended version (7 pages). Phys. Rev. E (to appear April 1998
The structure of a polyketide synthase bimodule core
Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules. Each module performs one round of precursor extension and optional modification, followed by directed transfer of the intermediate to the next module. While enzymatic domains and even modules of PKSs are well understood, the higher-order modular architecture of PKS assembly lines remains elusive. Here, we visualize a PKS bimodule core using cryo-electron microscopy and resolve a two-dimensional meshwork of the bimodule core formed by homotypic interactions between modules. The sheet-like organization provides the framework for efficient substrate transfer and for sequestration of trans-acting enzymes required for polyketide production
Dark Matter in a Constrained NMSSM
We explore the parameter space of a Constrained Next-to-Minimal
Supersymmetric Standard Model with GUT scale boundary conditions (CNMSSM) and
find regions where the relic density of the lightest neutralino is compatible
with the WMAP measurement. We emphasize differences with the MSSM: cases where
annihilation of the LSP occurs via a Higgs resonance at low values of tan\beta
and cases where the LSP has a large singlino component. The particle spectrum
as well as theoretical and collider constraints are calculated with NMSSMTools.
All neutralino annihilation and coannihilation processes are then computed with
micrOMEGAs, taking into account higher order corrections to the Higgs sector.Comment: 17 pages, 6 figures, references added, some comments added, version
to be published in JCA
From multiplicative noise to directed percolation in wetting transitions
A simple one-dimensional microscopic model of the depinning transition of an
interface from an attractive hard wall is introduced and investigated. Upon
varying a control parameter, the critical behaviour observed along the
transition line changes from a directed-percolation to a multiplicative-noise
type. Numerical simulations allow for a quantitative study of the multicritical
point separating the two regions, Mean-field arguments and the mapping on a yet
simpler model provide some further insight on the overall scenario.Comment: 4 pages, 3 figure
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