Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity

San Martin, J (San Martin, Jose). Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, ChileThe extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectivel

Multiplicative processes and power laws

[Takayasu et al., Phys. Rev.Lett. 79, 966 (1997)] revisited the question of stochastic processes with multiplicative noise, which have been studied in several different contexts over the past decades. We focus on the regime, found for a generic set of control parameters, in which stochastic processes with multiplicative noise produce intermittency of a special kind, characterized by a power law probability density distribution. We briefly explain the physical mechanism leading to a power law pdf and provide a list of references for these results dating back from a quarter of century. We explain how the formulation in terms of the characteristic function developed by Takayasu et al. can be extended to exponents $\mu >2$, which explains the ``reason of the lucky coincidence''. The multidimensional generalization of (\ref{eq1}) and the available results are briefly summarized. The discovery of stretched exponential tails in the presence of the cut-off introduced in \cite{Taka} is explained theoretically. We end by briefly listing applications.Comment: Extended version (7 pages). Phys. Rev. E (to appear April 1998

The structure of a polyketide synthase bimodule core

Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules. Each module performs one round of precursor extension and optional modification, followed by directed transfer of the intermediate to the next module. While enzymatic domains and even modules of PKSs are well understood, the higher-order modular architecture of PKS assembly lines remains elusive. Here, we visualize a PKS bimodule core using cryo-electron microscopy and resolve a two-dimensional meshwork of the bimodule core formed by homotypic interactions between modules. The sheet-like organization provides the framework for efficient substrate transfer and for sequestration of trans-acting enzymes required for polyketide production

Dark Matter in a Constrained NMSSM

We explore the parameter space of a Constrained Next-to-Minimal Supersymmetric Standard Model with GUT scale boundary conditions (CNMSSM) and find regions where the relic density of the lightest neutralino is compatible with the WMAP measurement. We emphasize differences with the MSSM: cases where annihilation of the LSP occurs via a Higgs resonance at low values of tan\beta and cases where the LSP has a large singlino component. The particle spectrum as well as theoretical and collider constraints are calculated with NMSSMTools. All neutralino annihilation and coannihilation processes are then computed with micrOMEGAs, taking into account higher order corrections to the Higgs sector.Comment: 17 pages, 6 figures, references added, some comments added, version to be published in JCA

From multiplicative noise to directed percolation in wetting transitions

A simple one-dimensional microscopic model of the depinning transition of an interface from an attractive hard wall is introduced and investigated. Upon varying a control parameter, the critical behaviour observed along the transition line changes from a directed-percolation to a multiplicative-noise type. Numerical simulations allow for a quantitative study of the multicritical point separating the two regions, Mean-field arguments and the mapping on a yet simpler model provide some further insight on the overall scenario.Comment: 4 pages, 3 figure